{"id":"https://openalex.org/W1965877319","doi":"https://doi.org/10.1016/j.bpj.2014.01.003","title":"Mutational Robustness Accelerates the Origin of Novel RNA Phenotypes through Phenotypic Plasticity","display_name":"Mutational Robustness Accelerates the Origin of Novel RNA Phenotypes through Phenotypic Plasticity","publication_year":2014,"publication_date":"2014-02-01","ids":{"openalex":"https://openalex.org/W1965877319","doi":"https://doi.org/10.1016/j.bpj.2014.01.003","mag":"1965877319","pmid":"https://pubmed.ncbi.nlm.nih.gov/24559998","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3944620"},"language":"en","primary_location":{"id":"doi:10.1016/j.bpj.2014.01.003","doi":"https://doi.org/10.1016/j.bpj.2014.01.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2014.01.003","pdf_url":"http://www.cell.com/article/S0006349514000599/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0006349514000599/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079730045","display_name":"Andreas Wagner","orcid":"https://orcid.org/0000-0003-4299-3840","observed_orcids":["https://orcid.org/0000-0003-4299-3840"]},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1308548392","display_name":"Santa Fe Institute","ror":"https://ror.org/01arysc35","country_code":"US","type":"funder","lineage":["https://openalex.org/I1308548392"]},{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH","US"],"is_corresponding":true,"raw_author_name":"Andreas Wagner","raw_affiliation_strings":["Institute of Evolutionary Biology and Environmental Sciences, University of Zurich, CH-8057 Zurich, Switzerland; The Swiss Institute of Bioinformatics, Bioinformatics, Quartier Sorge, Batiment Genopode, 1015 Lausanne, Switzerland; The Santa Fe Institute, Santa Fe, NM. Electronic address: andreas.wagner@ieu.uzh.ch","Institute of Evolutionary Biology and Environmental Sciences, University of Zurich, CH-8057 Zurich, Switzerland","The Santa Fe Institute, Santa Fe, NM","The Swiss Institute of Bioinformatics, Bioinformatics, Quartier Sorge, Batiment Genopode, 1015 Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Evolutionary Biology and Environmental Sciences, University of Zurich, CH-8057 Zurich, Switzerland; The Swiss Institute of Bioinformatics, Bioinformatics, Quartier Sorge, Batiment Genopode, 1015 Lausanne, Switzerland; The Santa Fe Institute, Santa Fe, NM. Electronic address: andreas.wagner@ieu.uzh.ch","institution_ids":["https://openalex.org/I12708293","https://openalex.org/I1308548392","https://openalex.org/I202697423"]},{"raw_affiliation_string":"Institute of Evolutionary Biology and Environmental Sciences, University of Zurich, CH-8057 Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"The Santa Fe Institute, Santa Fe, NM","institution_ids":["https://openalex.org/I1308548392"]},{"raw_affiliation_string":"The Swiss Institute of Bioinformatics, Bioinformatics, Quartier Sorge, Batiment Genopode, 1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5079730045"],"corresponding_institution_ids":["https://openalex.org/I12708293","https://openalex.org/I1308548392","https://openalex.org/I202697423"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":2.0101,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.85433933,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"106","issue":"4","first_page":"955","last_page":"965"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.6176999807357788,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.6176999807357788,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.37869998812675476,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mutational-robustness","display_name":"mutational robustness","score":0.8379999995231628},{"id":"https://openalex.org/keywords/phenotypic-plasticity","display_name":"phenotypic plasticity","score":0.9900000095367432},{"id":"https://openalex.org/keywords/rna-secondary-structure","display_name":"RNA secondary structure","score":0.9049999713897705},{"id":"https://openalex.org/keywords/genotype-space","display_name":"genotype space","score":0.6259999871253967},{"id":"https://openalex.org/keywords/genotype-networks","display_name":"genotype networks","score":0.7850000262260437},{"id":"https://openalex.org/keywords/exaptation","display_name":"exaptation","score":0.7799999713897705}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7546627521514893},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7431414127349854},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.7005516290664673},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.689146876335144},{"id":"https://openalex.org/C62277055","wikidata":"https://www.wikidata.org/wiki/Q295130","display_name":"Phenotypic plasticity","level":2,"score":0.5495870113372803},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5319006443023682},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.501793622970581},{"id":"https://openalex.org/C198125213","wikidata":"https://www.wikidata.org/wiki/Q17155419","display_name":"Neutral network","level":3,"score":0.49166589975357056},{"id":"https://openalex.org/C2779341050","wikidata":"https://www.wikidata.org/wiki/Q24287527","display_name":"Small RNA","level":4,"score":0.44530314207077026},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37081819772720337},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.36443355679512024},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.09321492910385132},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.051490455865859985},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1016/j.bpj.2014.01.003","doi":"https://doi.org/10.1016/j.bpj.2014.01.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2014.01.003","pdf_url":"http://www.cell.com/article/S0006349514000599/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3295548","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3944620","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3944620","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3944620","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophys J","raw_type":"Text"},{"id":"pmid:24559998","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24559998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical journal","raw_type":"Journal Article"},{"id":"pmh:oai:www.zora.uzh.ch:107391","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/id/eprint/107391/1/Exaptation_RNA_v4_main_figs.pdf","pdf_url":"https://www.zora.uzh.ch/id/eprint/107391/1/Exaptation_RNA_v4_main_figs.pdf","source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Wagner, Andreas (2014). Mutational robustness accelerates the origin of novel RNA phenotypes through phenotypic plasticity. Biophysical Journal, 106(4):955-965.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.zora.uzh.ch:20.500.14742/85351","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/handle/20.500.14742/85351","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wagner, A. (2014). Mutational robustness accelerates the origin of novel RNA phenotypes through phenotypic plasticity. Biophysical Journal, 106, 955\u2013965. https://doi.org/10.1016/j.bpj.2014.01.003","raw_type":"Journal Article"},{"id":"doi:10.5167/uzh-107391","doi":"https://doi.org/10.5167/uzh-107391","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-107391","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1016/j.bpj.2014.01.003","doi":"https://doi.org/10.1016/j.bpj.2014.01.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2014.01.003","pdf_url":"http://www.cell.com/article/S0006349514000599/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4966013024","display_name":null,"funder_award_id":"315230","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G8000199768","display_name":"Metabolic network analysis, design, and optimization through Metropolis sampling of network space.","funder_award_id":"129708","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1965877319.pdf"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W84039749","https://openalex.org/W1490558618","https://openalex.org/W1540898082","https://openalex.org/W1543796220","https://openalex.org/W1545357156","https://openalex.org/W1551334274","https://openalex.org/W1564741789","https://openalex.org/W1569069879","https://openalex.org/W1691583558","https://openalex.org/W1816614902","https://openalex.org/W1823239410","https://openalex.org/W1865748464","https://openalex.org/W1877068375","https://openalex.org/W1892019602","https://openalex.org/W1967681616","https://openalex.org/W1971013467","https://openalex.org/W1971399377","https://openalex.org/W1972708527","https://openalex.org/W1974183989","https://openalex.org/W1977940795","https://openalex.org/W1984675364","https://openalex.org/W1991708137","https://openalex.org/W1998008148","https://openalex.org/W1998238795","https://openalex.org/W2007789333","https://openalex.org/W2008250873","https://openalex.org/W2014230422","https://openalex.org/W2028443325","https://openalex.org/W2033830649","https://openalex.org/W2045391589","https://openalex.org/W2046094044","https://openalex.org/W2049888624","https://openalex.org/W2051603200","https://openalex.org/W2053095510","https://openalex.org/W2065225159","https://openalex.org/W2065800250","https://openalex.org/W2065991225","https://openalex.org/W2070004581","https://openalex.org/W2078236617","https://openalex.org/W2080249432","https://openalex.org/W2090393235","https://openalex.org/W2091161969","https://openalex.org/W2098508116","https://openalex.org/W2104989261","https://openalex.org/W2105557836","https://openalex.org/W2106533942","https://openalex.org/W2109441358","https://openalex.org/W2113368761","https://openalex.org/W2113389229","https://openalex.org/W2117431427","https://openalex.org/W2122133011","https://openalex.org/W2122350660","https://openalex.org/W2123481481","https://openalex.org/W2124015221","https://openalex.org/W2126074998","https://openalex.org/W2126214820","https://openalex.org/W2128312954","https://openalex.org/W2140012758","https://openalex.org/W2141789570","https://openalex.org/W2141846102","https://openalex.org/W2146473657","https://openalex.org/W2161050896","https://openalex.org/W2162674813","https://openalex.org/W2575306271","https://openalex.org/W4239403073","https://openalex.org/W4242729757","https://openalex.org/W4293743756","https://openalex.org/W6652172779"],"related_works":["https://openalex.org/W4403090256","https://openalex.org/W3125083691","https://openalex.org/W2400325797","https://openalex.org/W2065915320","https://openalex.org/W2409750997","https://openalex.org/W7096061751","https://openalex.org/W4233758394","https://openalex.org/W2105557836","https://openalex.org/W7138835157","https://openalex.org/W2036871747"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}