{"id":"https://openalex.org/W1965835313","doi":"https://doi.org/10.1101/sqb.2000.65.303","title":"Arrest, Adaptation, and Recovery following a Chromosome Double-strand Break in Saccharomyces cerevisiae","display_name":"Arrest, Adaptation, and Recovery following a Chromosome Double-strand Break in Saccharomyces cerevisiae","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W1965835313","doi":"https://doi.org/10.1101/sqb.2000.65.303","mag":"1965835313","pmid":"https://pubmed.ncbi.nlm.nih.gov/12760044"},"language":"en","primary_location":{"id":"doi:10.1101/sqb.2000.65.303","doi":"https://doi.org/10.1101/sqb.2000.65.303","is_oa":false,"landing_page_url":"https://doi.org/10.1101/sqb.2000.65.303","pdf_url":null,"source":{"id":"https://openalex.org/S78756772","display_name":"Cold Spring Harbor Symposia on Quantitative Biology","issn_l":"0091-7451","issn":["0091-7451","1943-4456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor Symposia on Quantitative Biology","raw_type":"journal-article"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080978265","display_name":"Seo-yeoung Lee","orcid":"https://orcid.org/0009-0004-1309-8876","observed_orcids":["https://orcid.org/0009-0004-1309-8876"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210114103","display_name":"IFOM","ror":"https://ror.org/02hcsa680","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210114103"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"S.E. LEE","raw_affiliation_strings":["Rosenstiel Center, Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110, USA","*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110","\u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy","\u2021Department of Genetics, Stanford University, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rosenstiel Center, Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110, USA","institution_ids":["https://openalex.org/I6902469"]},{"raw_affiliation_string":"*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110","institution_ids":["https://openalex.org/I6902469"]},{"raw_affiliation_string":"\u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210114103"]},{"raw_affiliation_string":"\u2021Department of Genetics, Stanford University, Stanford, California 94305","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088720621","display_name":"Achille Pellicioli","orcid":"https://orcid.org/0000-0002-1528-9009","observed_orcids":["https://orcid.org/0000-0002-1528-9009"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210114103","display_name":"IFOM","ror":"https://ror.org/02hcsa680","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210114103"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"A. PELLICIOLI","raw_affiliation_strings":["*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110;\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy; \u2021Department of Genetics, Stanford University, Stanford, California 94305; \u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110","\u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy","\u2021Department of Genetics, Stanford University, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110;\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy; \u2021Department of Genetics, Stanford University, Stanford, California 94305; \u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I189158943","https://openalex.org/I4210137306","https://openalex.org/I6902469","https://openalex.org/I97018004"]},{"raw_affiliation_string":"*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110","institution_ids":["https://openalex.org/I6902469"]},{"raw_affiliation_string":"\u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210114103"]},{"raw_affiliation_string":"\u2021Department of Genetics, Stanford University, Stanford, California 94305","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018153402","display_name":"J\u00e1nos Demeter","orcid":"https://orcid.org/0000-0002-7301-8055","observed_orcids":["https://orcid.org/0000-0002-7301-8055"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210114103","display_name":"IFOM","ror":"https://ror.org/02hcsa680","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210114103"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"J. DEMETER","raw_affiliation_strings":["*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110;\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy; \u2021Department of Genetics, Stanford University, Stanford, California 94305; \u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110","\u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy","\u2021Department of Genetics, Stanford University, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110;\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy; \u2021Department of Genetics, Stanford University, Stanford, California 94305; \u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I189158943","https://openalex.org/I4210137306","https://openalex.org/I6902469","https://openalex.org/I97018004"]},{"raw_affiliation_string":"*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110","institution_ids":["https://openalex.org/I6902469"]},{"raw_affiliation_string":"\u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210114103"]},{"raw_affiliation_string":"\u2021Department of Genetics, Stanford University, Stanford, California 94305","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011478864","display_name":"M.P. VAZE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210114103","display_name":"IFOM","ror":"https://ror.org/02hcsa680","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210114103"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"M.P. VAZE","raw_affiliation_strings":["*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110;\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy; \u2021Department of Genetics, Stanford University, Stanford, California 94305; \u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110","\u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy","\u2021Department of Genetics, Stanford University, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110;\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy; \u2021Department of Genetics, Stanford University, Stanford, California 94305; \u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I189158943","https://openalex.org/I4210137306","https://openalex.org/I6902469","https://openalex.org/I97018004"]},{"raw_affiliation_string":"*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110","institution_ids":["https://openalex.org/I6902469"]},{"raw_affiliation_string":"\u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210114103"]},{"raw_affiliation_string":"\u2021Department of Genetics, Stanford University, Stanford, California 94305","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048778946","display_name":"Audrey P. Gasch","orcid":"https://orcid.org/0000-0002-8182-257X","observed_orcids":["https://orcid.org/0000-0002-8182-257X"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210114103","display_name":"IFOM","ror":"https://ror.org/02hcsa680","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210114103"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"A.P. GASCH","raw_affiliation_strings":["*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110;\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy; \u2021Department of Genetics, Stanford University, Stanford, California 94305; \u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110","\u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy","\u2021Department of Genetics, Stanford University, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110;\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy; \u2021Department of Genetics, Stanford University, Stanford, California 94305; \u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I189158943","https://openalex.org/I4210137306","https://openalex.org/I6902469","https://openalex.org/I97018004"]},{"raw_affiliation_string":"*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110","institution_ids":["https://openalex.org/I6902469"]},{"raw_affiliation_string":"\u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210114103"]},{"raw_affiliation_string":"\u2021Department of Genetics, Stanford University, Stanford, California 94305","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070502223","display_name":"Anna Malkova","orcid":"https://orcid.org/0000-0002-3880-1781","observed_orcids":["https://orcid.org/0000-0002-3880-1781"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210114103","display_name":"IFOM","ror":"https://ror.org/02hcsa680","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210114103"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"A. MALKOVA","raw_affiliation_strings":["*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110;\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy; \u2021Department of Genetics, Stanford University, Stanford, California 94305; \u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110","\u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy","\u2021Department of Genetics, Stanford University, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110;\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy; \u2021Department of Genetics, Stanford University, Stanford, California 94305; \u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I189158943","https://openalex.org/I4210137306","https://openalex.org/I6902469","https://openalex.org/I97018004"]},{"raw_affiliation_string":"*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110","institution_ids":["https://openalex.org/I6902469"]},{"raw_affiliation_string":"\u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210114103"]},{"raw_affiliation_string":"\u2021Department of Genetics, Stanford University, Stanford, California 94305","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065906655","display_name":"Patrick O. Brown","orcid":"https://orcid.org/0000-0002-9940-5993","observed_orcids":["https://orcid.org/0000-0002-9940-5993"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210114103","display_name":"IFOM","ror":"https://ror.org/02hcsa680","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210114103"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"P.O. BROWN","raw_affiliation_strings":["*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110;\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy; \u2021Department of Genetics, Stanford University, Stanford, California 94305; \u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110","\u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy","\u2021Department of Genetics, Stanford University, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110;\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy; \u2021Department of Genetics, Stanford University, Stanford, California 94305; \u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I189158943","https://openalex.org/I4210137306","https://openalex.org/I6902469","https://openalex.org/I97018004"]},{"raw_affiliation_string":"*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110","institution_ids":["https://openalex.org/I6902469"]},{"raw_affiliation_string":"\u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210114103"]},{"raw_affiliation_string":"\u2021Department of Genetics, Stanford University, Stanford, California 94305","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077542898","display_name":"David Botstein","orcid":"https://orcid.org/0000-0001-9499-4883","observed_orcids":["https://orcid.org/0000-0001-9499-4883"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210114103","display_name":"IFOM","ror":"https://ror.org/02hcsa680","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210114103"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"D. BOTSTEIN","raw_affiliation_strings":["*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110;\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy; \u2021Department of Genetics, Stanford University, Stanford, California 94305; \u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110","\u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy","\u2021Department of Genetics, Stanford University, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110;\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy; \u2021Department of Genetics, Stanford University, Stanford, California 94305; \u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I189158943","https://openalex.org/I4210137306","https://openalex.org/I6902469","https://openalex.org/I97018004"]},{"raw_affiliation_string":"*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110","institution_ids":["https://openalex.org/I6902469"]},{"raw_affiliation_string":"\u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210114103"]},{"raw_affiliation_string":"\u2021Department of Genetics, Stanford University, Stanford, California 94305","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041641025","display_name":"Tim Stearns","orcid":"https://orcid.org/0000-0002-0671-6582","observed_orcids":["https://orcid.org/0000-0002-0671-6582"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210114103","display_name":"IFOM","ror":"https://ror.org/02hcsa680","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210114103"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"T. STEARNS","raw_affiliation_strings":["*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110;\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy; \u2021Department of Genetics, Stanford University, Stanford, California 94305; \u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110","\u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy","\u2021Department of Genetics, Stanford University, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110;\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy; \u2021Department of Genetics, Stanford University, Stanford, California 94305; \u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I189158943","https://openalex.org/I4210137306","https://openalex.org/I6902469","https://openalex.org/I97018004"]},{"raw_affiliation_string":"*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110","institution_ids":["https://openalex.org/I6902469"]},{"raw_affiliation_string":"\u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210114103"]},{"raw_affiliation_string":"\u2021Department of Genetics, Stanford University, Stanford, California 94305","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035404530","display_name":"Marco Foiani","orcid":"https://orcid.org/0000-0003-4795-834X","observed_orcids":["https://orcid.org/0000-0003-4795-834X"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210114103","display_name":"IFOM","ror":"https://ror.org/02hcsa680","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210114103"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"M. FOIANI","raw_affiliation_strings":["*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110;\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy; \u2021Department of Genetics, Stanford University, Stanford, California 94305; \u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110","\u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy","\u2021Department of Genetics, Stanford University, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110;\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy; \u2021Department of Genetics, Stanford University, Stanford, California 94305; \u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I189158943","https://openalex.org/I4210137306","https://openalex.org/I6902469","https://openalex.org/I97018004"]},{"raw_affiliation_string":"*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110","institution_ids":["https://openalex.org/I6902469"]},{"raw_affiliation_string":"\u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210114103"]},{"raw_affiliation_string":"\u2021Department of Genetics, Stanford University, Stanford, California 94305","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048113506","display_name":"James E. Haber","orcid":"https://orcid.org/0000-0002-1878-0610","observed_orcids":["https://orcid.org/0000-0002-1878-0610"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210114103","display_name":"IFOM","ror":"https://ror.org/02hcsa680","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210114103"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"J.E. HABER","raw_affiliation_strings":["*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110;\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy; \u2021Department of Genetics, Stanford University, Stanford, California 94305; \u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110","\u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy","\u2021Department of Genetics, Stanford University, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110;\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy; \u2021Department of Genetics, Stanford University, Stanford, California 94305; \u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I189158943","https://openalex.org/I4210137306","https://openalex.org/I6902469","https://openalex.org/I97018004"]},{"raw_affiliation_string":"*Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110","institution_ids":["https://openalex.org/I6902469"]},{"raw_affiliation_string":"\u00a7Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, California\n                              94305","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"\u2020Dipartimento di Genetica e di Biologia dei Microrganismi, Universita' degli Studi di Milano, and Istituto F.I.R.C. di Oncologia\n                              Molecolare, 20122, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210114103"]},{"raw_affiliation_string":"\u2021Department of Genetics, Stanford University, Stanford, California 94305","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"65","issue":"0","first_page":"303","last_page":"314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9490000009536743},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8410000205039978},{"id":"https://openalex.org/keywords/checkpoint-kinase","display_name":"checkpoint kinase","score":0.6859999895095825},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9129999876022339},{"id":"https://openalex.org/keywords/mitosis","display_name":"mitosis","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C54086632","wikidata":"https://www.wikidata.org/wiki/Q5512671","display_name":"G2-M DNA damage checkpoint","level":5,"score":0.6432391405105591},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6269177198410034},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.5895105004310608},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5802754163742065},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.55094313621521},{"id":"https://openalex.org/C64894306","wikidata":"https://www.wikidata.org/wiki/Q849622","display_name":"Homologous chromosome","level":3,"score":0.5343208909034729},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.5214295387268066},{"id":"https://openalex.org/C2778354886","wikidata":"https://www.wikidata.org/wiki/Q5113927","display_name":"Chromosome segregation","level":4,"score":0.5092295408248901},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.48852694034576416},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.4723454713821411},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.4613912105560303},{"id":"https://openalex.org/C67419583","wikidata":"https://www.wikidata.org/wiki/Q5205768","display_name":"DNA re-replication","level":5,"score":0.4521796703338623},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4344038963317871},{"id":"https://openalex.org/C50001416","wikidata":"https://www.wikidata.org/wiki/Q17861750","display_name":"CHEK1","level":5,"score":0.4330870509147644},{"id":"https://openalex.org/C63491729","wikidata":"https://www.wikidata.org/wiki/Q14762596","display_name":"Centromere","level":4,"score":0.43216612935066223},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.42630618810653687},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.418856143951416},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40905505418777466},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.40483254194259644},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.40247559547424316},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.29083335399627686},{"id":"https://openalex.org/C104690221","wikidata":"https://www.wikidata.org/wiki/Q5165872","display_name":"Control of chromosome duplication","level":4,"score":0.2595447599887848}],"mesh":[{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004277","descriptor_name":"DNA, Single-Stranded","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015825","descriptor_name":"Chromosomes, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1101/sqb.2000.65.303","doi":"https://doi.org/10.1101/sqb.2000.65.303","is_oa":false,"landing_page_url":"https://doi.org/10.1101/sqb.2000.65.303","pdf_url":null,"source":{"id":"https://openalex.org/S78756772","display_name":"Cold Spring Harbor Symposia on Quantitative Biology","issn_l":"0091-7451","issn":["0091-7451","1943-4456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor Symposia on Quantitative Biology","raw_type":"journal-article"},{"id":"pmid:12760044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12760044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor symposia on quantitative biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.420.4368","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.420.4368","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.princeton.edu/genomics/botstein/publications/2000_Lee_Arrest.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1547501665","display_name":null,"funder_award_id":"HG-00983","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G2481016289","display_name":"FUNCTIONAL MAP OF THE YEAST GENOME","funder_award_id":"R01HG000983","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G253774738","display_name":null,"funder_award_id":"GM-20056","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4193625431","display_name":null,"funder_award_id":"HG-00450","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G5829215194","display_name":null,"funder_award_id":"CA-09302-22","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000870024","display_name":"Leveraging innovative technologies in basic and clinical cancer research","funder_award_id":"T32CA009302","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1488992604","https://openalex.org/W1520947267","https://openalex.org/W1532653491","https://openalex.org/W1604305208","https://openalex.org/W1676891985","https://openalex.org/W1694178424","https://openalex.org/W1788572206","https://openalex.org/W1832288685","https://openalex.org/W1850802407","https://openalex.org/W1899289062","https://openalex.org/W1958548845","https://openalex.org/W1974425687","https://openalex.org/W1980725176","https://openalex.org/W1986108211","https://openalex.org/W1987664752","https://openalex.org/W1998993673","https://openalex.org/W2000657327","https://openalex.org/W2004008931","https://openalex.org/W2009825306","https://openalex.org/W2018705198","https://openalex.org/W2025972514","https://openalex.org/W2028084970","https://openalex.org/W2031292590","https://openalex.org/W2033950216","https://openalex.org/W2041731996","https://openalex.org/W2048729396","https://openalex.org/W2049356496","https://openalex.org/W2053437486","https://openalex.org/W2055604308","https://openalex.org/W2060787001","https://openalex.org/W2082941148","https://openalex.org/W2084825928","https://openalex.org/W2091204939","https://openalex.org/W2091536217","https://openalex.org/W2093785124","https://openalex.org/W2096679672","https://openalex.org/W2102433010","https://openalex.org/W2110112613","https://openalex.org/W2115416778","https://openalex.org/W2117417095","https://openalex.org/W2118438547","https://openalex.org/W2119827462","https://openalex.org/W2121887331","https://openalex.org/W2124055215","https://openalex.org/W2133279612","https://openalex.org/W2140289804","https://openalex.org/W2143403010","https://openalex.org/W2144393305","https://openalex.org/W2145347327","https://openalex.org/W2147600141","https://openalex.org/W2149424329","https://openalex.org/W2154052847","https://openalex.org/W2155675863","https://openalex.org/W2159895537","https://openalex.org/W2170144902","https://openalex.org/W7100502720"],"related_works":["https://openalex.org/W2011792017","https://openalex.org/W2121664774","https://openalex.org/W2169911836","https://openalex.org/W6910752408","https://openalex.org/W4403546714","https://openalex.org/W54899440","https://openalex.org/W1511491010","https://openalex.org/W3012151639","https://openalex.org/W3175992906","https://openalex.org/W1986787917"],"abstract_inverted_index":{"DNA":[0,28,42],"damage":[1,29,80],"such":[2],"as":[3],"a":[4,9,21,54,72,95],"double-strand":[5],"break":[6],"(DSB)":[7],"of":[8,74,86,91,97,104],"chromosome":[10,51],"causes":[11],"eukaryotic":[12],"cells":[13,25,36],"to":[14,26,31,37,119],"arrest":[15,68],"cell":[16],"cycle":[17],"progression.":[18],"Arrest":[19],"provides":[20],"greater":[22],"opportunity":[23],"for":[24],"repair":[27],"prior":[30],"mitosis,":[32],"which":[33,41,49],"might":[34],"cause":[35],"inherit":[38],"chromosomes":[39],"in":[40,48],"replication":[43],"was":[44],"not":[45],"complete":[46],"or":[47],"broken":[50],"segments,":[52],"lacking":[53],"centromere,":[55],"would":[56],"be":[57],"lost":[58],"(Hartwell":[59],"and":[60,81,88,116],"Weinert":[61,65],"1989;":[62],"Elledge":[63],"1996;":[64],"1998).":[66],"DNAdamage-induced":[67],"is":[69,114],"enforced":[70],"by":[71],"network":[73],"checkpoint":[75,108],"proteins":[76],"that":[77],"detect":[78],"the":[79,84,89,105],"signal":[82],"both":[83],"inhibition":[85],"mitosis":[87],"induction":[90],"damage-inducible":[92],"genes":[93],"through":[94],"cascade":[96],"protein":[98],"kinases,":[99],"including":[100],"Mec1p":[101],"(a":[102],"homolog":[103,113],"mammalian":[106],"ATM/ATR":[107],"kinases),":[109],"Rad53p":[110],"(whose":[111],"human":[112,120],"Cds1p),":[115],"Chk1p":[117],"(homologous":[118],"Chk1p)":[121]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}