{"id":"https://openalex.org/W1965801993","doi":"https://doi.org/10.3109/14397595.2013.854080","title":"Retreatment efficacy and safety of tocilizumab in patients with rheumatoid arthritis in recurrence (RESTORE) study","display_name":"Retreatment efficacy and safety of tocilizumab in patients with rheumatoid arthritis in recurrence (RESTORE) study","publication_year":2013,"publication_date":"2013-05-16","ids":{"openalex":"https://openalex.org/W1965801993","doi":"https://doi.org/10.3109/14397595.2013.854080","mag":"1965801993","pmid":"https://pubmed.ncbi.nlm.nih.gov/24261755"},"language":"en","primary_location":{"id":"doi:10.3109/14397595.2013.854080","doi":"https://doi.org/10.3109/14397595.2013.854080","is_oa":true,"landing_page_url":"https://doi.org/10.3109/14397595.2013.854080","pdf_url":"https://academic.oup.com/mr/article-pdf/24/1/26/39580277/mr0026.pdf","source":{"id":"https://openalex.org/S30446230","display_name":"Modern Rheumatology","issn_l":"1439-7595","issn":["1439-7595","1439-7609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Rheumatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/mr/article-pdf/24/1/26/39580277/mr0026.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102455574","display_name":"Norihiro Nishimoto","orcid":"https://orcid.org/0000-0001-8241-8010","observed_orcids":["https://orcid.org/0000-0001-8241-8010"]},"institutions":[{"id":"https://openalex.org/I158929114","display_name":"Tokyo Medical University","ror":"https://ror.org/00k5j5c86","country_code":"JP","type":"education","lineage":["https://openalex.org/I158929114"]},{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Norihiro Nishimoto","raw_affiliation_strings":["Department of Molecular Regulation for Intractable Diseases, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan","Laboratory of Immune Regulation, Wakayama Medical University, Wakayama, Japan","Osaka Rheumatology Clinic, Tatsuno-Sinsaibashi-Building 5th Floor, 4-4-10 Minamisenba Chuo-ku, Osaka, 542-0081, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Regulation for Intractable Diseases, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I158929114"]},{"raw_affiliation_string":"Laboratory of Immune Regulation, Wakayama Medical University, Wakayama, Japan","institution_ids":["https://openalex.org/I190805021"]},{"raw_affiliation_string":"Osaka Rheumatology Clinic, Tatsuno-Sinsaibashi-Building 5th Floor, 4-4-10 Minamisenba Chuo-ku, Osaka, 542-0081, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087307078","display_name":"Koichi Amano","orcid":"https://orcid.org/0000-0002-4228-2056","observed_orcids":["https://orcid.org/0000-0002-4228-2056"]},"institutions":[{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi Amano","raw_affiliation_strings":["Department of Rheumatology/Clinical Immunology, Saitama Medical Centre, Saitama Medical University, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology/Clinical Immunology, Saitama Medical Centre, Saitama Medical University, Saitama, Japan","institution_ids":["https://openalex.org/I8588240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103472477","display_name":"Yasuhiko Hirabayashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasuhiko Hirabayashi","raw_affiliation_strings":["Department of Rheumatology, Hikarigaoka Spellman Hospital, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Hikarigaoka Spellman Hospital, Sendai, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030740263","display_name":"Takahiko Horiuchi","orcid":"https://orcid.org/0000-0002-1770-1087","observed_orcids":["https://orcid.org/0000-0002-1770-1087"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiko Horiuchi","raw_affiliation_strings":["Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042340344","display_name":"Tomonori Ishii","orcid":"https://orcid.org/0000-0001-5361-5824","observed_orcids":["https://orcid.org/0000-0001-5361-5824"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomonori Ishii","raw_affiliation_strings":["Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Miyagi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Miyagi, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109055316","display_name":"Mitsuhiro Iwahashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126469","display_name":"Higashihiroshima Medical Center","ror":"https://ror.org/03bd22t26","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210126469","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuhiro Iwahashi","raw_affiliation_strings":["Higashihiroshima Memorial Hospital, Higashihiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Higashihiroshima Memorial Hospital, Higashihiroshima, Japan","institution_ids":["https://openalex.org/I4210126469"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Masahiro Iwamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Iwamoto","raw_affiliation_strings":["Division of Rheumatology and Clinical Immunology, Jichi Medical University, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology and Clinical Immunology, Jichi Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013526431","display_name":"Hitoshi Kohsaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitoshi Kohsaka","raw_affiliation_strings":["Department of Medicine and Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Masakazu Kondo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masakazu Kondo","raw_affiliation_strings":["Kondo Clinic of Rheumatology and Orthopaedic Surgery, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kondo Clinic of Rheumatology and Orthopaedic Surgery, Fukuoka, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006840017","display_name":"Tsukasa Matsubara","orcid":"https://orcid.org/0000-0002-3342-3419","observed_orcids":["https://orcid.org/0000-0002-3342-3419"]},"institutions":[{"id":"https://openalex.org/I4210117698","display_name":"Matsubara Mayflower Hospital","ror":"https://ror.org/02haqm712","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210117698"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsukasa Matsubara","raw_affiliation_strings":["Matsubara Mayflower Hospital, Hyogo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Matsubara Mayflower Hospital, Hyogo, Japan","institution_ids":["https://openalex.org/I4210117698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080767944","display_name":"Toshihide Mimura","orcid":"https://orcid.org/0000-0002-9050-0855","observed_orcids":["https://orcid.org/0000-0002-9050-0855"]},"institutions":[{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihide Mimura","raw_affiliation_strings":["Department of Rheumatology and Applied Immunology, Saitama Medical University, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Applied Immunology, Saitama Medical University, Saitama, Japan","institution_ids":["https://openalex.org/I8588240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090740323","display_name":"Hisaaki Miyahara","orcid":"https://orcid.org/0000-0002-6646-4452","observed_orcids":["https://orcid.org/0000-0002-6646-4452"]},"institutions":[{"id":"https://openalex.org/I3018397740","display_name":"National Kyushu Medical Center","ror":"https://ror.org/022296476","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I3018397740","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisaaki Miyahara","raw_affiliation_strings":["National Hospital Organization Kyushu Medical Center, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Hospital Organization Kyushu Medical Center, Fukuoka, Japan","institution_ids":["https://openalex.org/I3018397740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108218040","display_name":"Shuji Ohta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuji Ohta","raw_affiliation_strings":["Department of Rheumatology, Taga General Hospital, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Taga General Hospital, Ibaraki, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086977819","display_name":"Yukihiko Saeki","orcid":"https://orcid.org/0000-0003-3870-0275","observed_orcids":["https://orcid.org/0000-0003-3870-0275"]},"institutions":[{"id":"https://openalex.org/I4210121381","display_name":"Osaka Minami Medical Center","ror":"https://ror.org/02k3rdd90","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210121381","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukihiko Saeki","raw_affiliation_strings":["National Hospital Organization Osaka-Minami Medical Center, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Hospital Organization Osaka-Minami Medical Center, Osaka, Japan","institution_ids":["https://openalex.org/I4210121381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041976581","display_name":"Kazuyoshi Saito","orcid":"https://orcid.org/0000-0002-3300-3764","observed_orcids":["https://orcid.org/0000-0002-3300-3764"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuyoshi Saito","raw_affiliation_strings":["The First Department of Internal Medicine, University of Occupational and Environmental Health Japan, Kitakyushu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Department of Internal Medicine, University of Occupational and Environmental Health Japan, Kitakyushu, Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028034286","display_name":"Hajime Sano","orcid":"https://orcid.org/0000-0002-0645-2521","observed_orcids":["https://orcid.org/0000-0002-0645-2521"]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hajime Sano","raw_affiliation_strings":["Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100804520","display_name":"Kiyoshi Takasugi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128702","display_name":"Dogo Onsen Hospital","ror":"https://ror.org/031dgzs07","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210128702"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoshi Takasugi","raw_affiliation_strings":["Dohgo Spa Hospital, Ehime, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dohgo Spa Hospital, Ehime, Japan","institution_ids":["https://openalex.org/I4210128702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083314956","display_name":"Tsutomu Takeuchi","orcid":"https://orcid.org/0000-0003-1111-8218","observed_orcids":["https://orcid.org/0000-0003-1111-8218"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsutomu Takeuchi","raw_affiliation_strings":["Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Faculty of Medicine, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Faculty of Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019331714","display_name":"Shigeto Tohma","orcid":"https://orcid.org/0000-0003-4945-7629","observed_orcids":["https://orcid.org/0000-0003-4945-7629"]},"institutions":[{"id":"https://openalex.org/I4210115833","display_name":"National Sagamihara Hospital","ror":"https://ror.org/01gvfxs59","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115833","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeto Tohma","raw_affiliation_strings":["Sagamihara National Hospital, National Hospital Organization, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sagamihara National Hospital, National Hospital Organization, Kanagawa, Japan","institution_ids":["https://openalex.org/I4210115833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112729967","display_name":"Tomomi Tsuru","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomomi Tsuru","raw_affiliation_strings":["PS Clinic, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PS Clinic, Fukuoka, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000556430","display_name":"Yukitaka Ueki","orcid":"https://orcid.org/0000-0002-3028-568X","observed_orcids":["https://orcid.org/0000-0002-3028-568X"]},"institutions":[{"id":"https://openalex.org/I4405253956","display_name":"Sasebo Chuo Hospital","ror":"https://ror.org/018bw0k35","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405253956"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukitaka Ueki","raw_affiliation_strings":["Sasebo Chuo Hospital, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sasebo Chuo Hospital, Nagasaki, Japan","institution_ids":["https://openalex.org/I4405253956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069643339","display_name":"Jiro Yamana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126469","display_name":"Higashihiroshima Medical Center","ror":"https://ror.org/03bd22t26","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210126469","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jiro Yamana","raw_affiliation_strings":["Higashihiroshima Memorial Hospital, Higashihiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Higashihiroshima Memorial Hospital, Higashihiroshima, Japan","institution_ids":["https://openalex.org/I4210126469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101586844","display_name":"Jun Hashi\u00admoto","orcid":"https://orcid.org/0000-0002-5816-4599","observed_orcids":["https://orcid.org/0000-0002-5816-4599"]},"institutions":[{"id":"https://openalex.org/I4210121381","display_name":"Osaka Minami Medical Center","ror":"https://ror.org/02k3rdd90","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210121381","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Hashimoto","raw_affiliation_strings":["National Hospital Organization Osaka-Minami Medical Center, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Hospital Organization Osaka-Minami Medical Center, Osaka, Japan","institution_ids":["https://openalex.org/I4210121381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053192443","display_name":"Takaji Matsutani","orcid":"https://orcid.org/0000-0002-4836-3375","observed_orcids":["https://orcid.org/0000-0002-4836-3375"]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takaji Matsutani","raw_affiliation_strings":["Laboratory of Immune Regulation, Wakayama Medical University, Wakayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immune Regulation, Wakayama Medical University, Wakayama, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032838648","display_name":"Miho Murakami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158929114","display_name":"Tokyo Medical University","ror":"https://ror.org/00k5j5c86","country_code":"JP","type":"education","lineage":["https://openalex.org/I158929114"]},{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Miho Murakami","raw_affiliation_strings":["Department of Molecular Regulation for Intractable Diseases, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan","Laboratory of Immune Regulation, Wakayama Medical University, Wakayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Regulation for Intractable Diseases, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I158929114"]},{"raw_affiliation_string":"Laboratory of Immune Regulation, Wakayama Medical University, Wakayama, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009246406","display_name":"Nobuhiro Takagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuhiro Takagi","raw_affiliation_strings":["Chugai Pharmaceutical Co. Ltd., Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chugai Pharmaceutical Co. Ltd., Tokyo, Japan","institution_ids":["https://openalex.org/I4405254473"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":18,"corresponding_author_ids":["https://openalex.org/A5102455574"],"corresponding_institution_ids":["https://openalex.org/I158929114","https://openalex.org/I190805021"],"apc_list":{"value":3208,"currency":"USD","value_usd":3208},"apc_paid":{"value":3208,"currency":"USD","value_usd":3208},"fwci":1.7896,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.82899608,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"24","issue":"1","first_page":"26","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tocilizumab","display_name":"tocilizumab","score":0.996999979019165},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.5350000262260437},{"id":"https://openalex.org/keywords/retreatment","display_name":"retreatment","score":0.7639999985694885},{"id":"https://openalex.org/keywords/loss-of-efficacy","display_name":"loss of efficacy","score":0.8009999990463257},{"id":"https://openalex.org/keywords/dream-study","display_name":"DREAM study","score":0.7429999709129333},{"id":"https://openalex.org/keywords/das28","display_name":"DAS28","score":0.7789999842643738},{"id":"https://openalex.org/keywords/infliximab","display_name":"infliximab","score":0.8740000128746033},{"id":"https://openalex.org/keywords/disease-modifying-antirheumatic-drugs","display_name":"disease-modifying antirheumatic drugs","score":0.8679999709129333},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7020000219345093},{"id":"https://openalex.org/keywords/il-6-inhibition","display_name":"IL-6 inhibition","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9811477065086365},{"id":"https://openalex.org/C2777178219","wikidata":"https://www.wikidata.org/wiki/Q425154","display_name":"Tocilizumab","level":3,"score":0.9677071571350098},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7569882869720459},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6927127838134766},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5866745710372925},{"id":"https://openalex.org/C2777138892","wikidata":"https://www.wikidata.org/wiki/Q415264","display_name":"Infliximab","level":3,"score":0.5206529498100281},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.4639401435852051},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.28611570596694946}],"mesh":[{"descriptor_ui":"D000069285","descriptor_name":"Infliximab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019233","descriptor_name":"Retreatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3109/14397595.2013.854080","doi":"https://doi.org/10.3109/14397595.2013.854080","is_oa":true,"landing_page_url":"https://doi.org/10.3109/14397595.2013.854080","pdf_url":"https://academic.oup.com/mr/article-pdf/24/1/26/39580277/mr0026.pdf","source":{"id":"https://openalex.org/S30446230","display_name":"Modern Rheumatology","issn_l":"1439-7595","issn":["1439-7595","1439-7609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Rheumatology","raw_type":"journal-article"},{"id":"doi:10.1007/s10165-013-0895-y","doi":"https://doi.org/10.1007/s10165-013-0895-y","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10165-013-0895-y","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10165-013-0895-y.pdf","source":{"id":"https://openalex.org/S30446230","display_name":"Modern Rheumatology","issn_l":"1439-7595","issn":["1439-7595","1439-7609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Rheumatology","raw_type":"journal-article"},{"id":"pmid:24261755","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24261755","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern rheumatology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3109/14397595.2013.854080","doi":"https://doi.org/10.3109/14397595.2013.854080","is_oa":true,"landing_page_url":"https://doi.org/10.3109/14397595.2013.854080","pdf_url":"https://academic.oup.com/mr/article-pdf/24/1/26/39580277/mr0026.pdf","source":{"id":"https://openalex.org/S30446230","display_name":"Modern Rheumatology","issn_l":"1439-7595","issn":["1439-7595","1439-7609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Rheumatology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7161579756","display_name":"The difference of immune modification in rheumatoid arthritis patients between IL-6 blockade with tocilizumab and T cell inactivation with abatacept","funder_award_id":"25461481","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320333003","display_name":"Chugai Pharmaceutical","ror":"https://ror.org/01vepzj85"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1965801993.pdf","grobid_xml":"https://content.openalex.org/works/W1965801993.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1913294952","https://openalex.org/W1926278991","https://openalex.org/W1973739470","https://openalex.org/W2000253156","https://openalex.org/W2000846863","https://openalex.org/W2022713850","https://openalex.org/W2054059257","https://openalex.org/W2063485775","https://openalex.org/W2069473482","https://openalex.org/W2096862304","https://openalex.org/W2114308202","https://openalex.org/W2125212735","https://openalex.org/W2139339400","https://openalex.org/W2148357532","https://openalex.org/W2150952126","https://openalex.org/W2152015928","https://openalex.org/W2152553239","https://openalex.org/W2280934856","https://openalex.org/W2607079988","https://openalex.org/W4249063051","https://openalex.org/W4295125684","https://openalex.org/W4308769923"],"related_works":["https://openalex.org/W1926278991","https://openalex.org/W3018210964","https://openalex.org/W2783716243","https://openalex.org/W2766308452","https://openalex.org/W4381622862","https://openalex.org/W2409452102","https://openalex.org/W67724359","https://openalex.org/W1911738367","https://openalex.org/W4386305354","https://openalex.org/W2415714378"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1],"evaluate":[2],"the":[3,18,57,84,158],"safety":[4],"and":[5,33,92,150],"efficacy":[6,79,167],"of":[7,28,37,69,78,83,166,170],"retreatment":[8],"with":[9,43,90,94,115,146],"tocilizumab":[10,29],"(TCZ)":[11],"in":[12,17,131,152],"patients":[13,113,134,153],"who":[14,75,154],"had":[15,34,155,163],"participated":[16],"DREAM":[19,85],"study":[20],"(Drug":[21],"free":[22],"remission/low":[23],"disease":[24,47,59],"activity":[25,53,60],"after":[26,168],"cessation":[27,169],"[Actemar]":[30],"monotherapy":[31,161],"study)":[32],"experienced":[35,76,164],"loss":[36,77,165],"efficacy.":[38],"METHODS:":[39],"Patients":[40],"were":[41,129,142],"retreated":[42],"TCZ":[44,91,147,160],"or":[45],"other":[46],"modifying":[48],"antirheumatic":[49],"drugs":[50],"(DMARDs).":[51],"Disease":[52],"was":[54,148],"measured":[55],"using":[56],"28-joint":[58],"score":[61],"(DAS28)":[62],"for":[63],"12":[64,109],"weeks.":[65],"RESULTS:":[66],"A":[67],"total":[68],"164":[70],"eligible":[71],"patients,":[72,100],"including":[73],"161":[74],"within":[80,108],"52":[81],"weeks":[82],"study,":[86],"resumed":[87],"treatment:":[88],"157":[89],"7":[93],"DMARDs":[95,116],"and/or":[96,117],"infliximab.":[97],"Of":[98],"TCZ-treated":[99,133],"88.5":[101],"%":[102,121],"(139":[103],"patients)":[104],"achieved":[105,124],"DAS28":[106,125],"<2.6":[107],"weeks,":[110],"whereas":[111],"among":[112],"treated":[114],"infliximab":[118],"only":[119],"14.3":[120],"(1":[122],"patient)":[123],"<2.6.":[126],"Adverse":[127],"events":[128],"observed":[130],"70":[132],"(44.0":[135],"%),":[136],"but":[137,162],"no":[138],"serious":[139],"infusion":[140],"reactions":[141],"observed.":[143],"CONCLUSIONS:":[144],"Retreatment":[145],"well-tolerated":[149],"effective":[151],"responded":[156],"to":[157],"preceding":[159],"TCZ.":[171]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}