{"id":"https://openalex.org/W1965779501","doi":"https://doi.org/10.1073/pnas.94.2.663","title":"Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets","display_name":"Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets","publication_year":1997,"publication_date":"1997-01-21","ids":{"openalex":"https://openalex.org/W1965779501","doi":"https://doi.org/10.1073/pnas.94.2.663","mag":"1965779501","pmid":"https://pubmed.ncbi.nlm.nih.gov/9012841","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/19570"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.94.2.663","doi":"https://doi.org/10.1073/pnas.94.2.663","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.94.2.663","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/19570","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021533208","display_name":"Robert M\u00f6hle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M\u00f6hle","raw_affiliation_strings":["Developmental Hematopoiesis Laboratory, Cell Biology and Genetics Program, Memorial Sloan\u2013Kettering Cancer Center, New York, NY 10021; and Division of Hematology and Oncology, Cornell University Medical College, New York, NY 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Hematopoiesis Laboratory, Cell Biology and Genetics Program, Memorial Sloan\u2013Kettering Cancer Center, New York, NY 10021; and Division of Hematology and Oncology, Cornell University Medical College, New York, NY 10021","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108100836","display_name":"David Green","orcid":"https://orcid.org/0009-0004-9572-9853","observed_orcids":["https://orcid.org/0009-0004-9572-9853"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Green","raw_affiliation_strings":["Developmental Hematopoiesis Laboratory, Cell Biology and Genetics Program, Memorial Sloan\u2013Kettering Cancer Center, New York, NY 10021; and  Division of Hematology and Oncology, Cornell University Medical College, New York, NY 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Hematopoiesis Laboratory, Cell Biology and Genetics Program, Memorial Sloan\u2013Kettering Cancer Center, New York, NY 10021; and  Division of Hematology and Oncology, Cornell University Medical College, New York, NY 10021","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110863459","display_name":"Malcolm A.S. Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malcolm\u2009A.\u2009S. Moore","raw_affiliation_strings":["Developmental Hematopoiesis Laboratory, Cell Biology and Genetics Program, Memorial Sloan\u2013Kettering Cancer Center, New York, NY 10021; and  Division of Hematology and Oncology, Cornell University Medical College, New York, NY 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Hematopoiesis Laboratory, Cell Biology and Genetics Program, Memorial Sloan\u2013Kettering Cancer Center, New York, NY 10021; and  Division of Hematology and Oncology, Cornell University Medical College, New York, NY 10021","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058411129","display_name":"Ralph L. Nachman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ralph\u2009L. Nachman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5090799132","display_name":"Shahin Rafii","orcid":"https://orcid.org/0000-0001-5605-1067","observed_orcids":["https://orcid.org/0000-0001-5605-1067"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shahin Rafii","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":19.0194,"has_fulltext":false,"cited_by_count":711,"citation_normalized_percentile":{"value":0.9968441,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"94","issue":"2","first_page":"663","last_page":"668"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.027799999341368675,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/megakaryocytes","display_name":"megakaryocytes","score":0.9779999852180481},{"id":"https://openalex.org/keywords/platelets","display_name":"platelets","score":0.9679999947547913},{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":0.7870000004768372},{"id":"https://openalex.org/keywords/vegf-isoforms","display_name":"VEGF isoforms","score":0.8629999756813049},{"id":"https://openalex.org/keywords/vegf165","display_name":"VEGF165","score":0.9390000104904175},{"id":"https://openalex.org/keywords/megakaryopoiesis","display_name":"megakaryopoiesis","score":0.7599999904632568},{"id":"https://openalex.org/keywords/bone-marrow-microenvironment","display_name":"bone marrow microenvironment","score":0.7009999752044678},{"id":"https://openalex.org/keywords/endothelial-cell-proliferation","display_name":"endothelial cell proliferation","score":0.7870000004768372},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/thrombopoietin","display_name":"thrombopoietin","score":0.8059999942779541},{"id":"https://openalex.org/keywords/interleukin-3","display_name":"interleukin-3","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cd41a","display_name":"CD41a","score":0.7059999704360962},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C2777863708","wikidata":"https://www.wikidata.org/wiki/Q424519","display_name":"Thrombopoietin","level":4,"score":0.7656482458114624},{"id":"https://openalex.org/C2779705218","wikidata":"https://www.wikidata.org/wiki/Q821701","display_name":"Megakaryocyte","level":4,"score":0.6800701022148132},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5822785496711731},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5733963847160339},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5514420866966248},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5079455971717834},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5003466606140137},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4886060357093811},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4846275746822357},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.43269768357276917},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.43264642357826233},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4319159686565399},{"id":"https://openalex.org/C2776958478","wikidata":"https://www.wikidata.org/wiki/Q14914622","display_name":"Thrombopoiesis","level":5,"score":0.4171741008758545},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3740725517272949},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2981240749359131},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.28132426738739014},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2179585099220276},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1188519299030304},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11396855115890503},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07372251152992249},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017978","descriptor_name":"Receptors, Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019039","descriptor_name":"Platelet Glycoprotein GPIIb-IIIa Complex","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042442","descriptor_name":"Vascular Endothelial Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.94.2.663","doi":"https://doi.org/10.1073/pnas.94.2.663","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.94.2.663","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:19570","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/19570","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:9012841","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9012841","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:19570","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/19570","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4312958506","display_name":"REGULATION OF THROMBOPOIESIS BY BONE MARROW ENDOTHELIUM","funder_award_id":"K08HL002926","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W10096759","https://openalex.org/W32167704","https://openalex.org/W214380766","https://openalex.org/W260231802","https://openalex.org/W426067948","https://openalex.org/W1484212696","https://openalex.org/W1507160997","https://openalex.org/W1530655559","https://openalex.org/W1552383593","https://openalex.org/W1565284612","https://openalex.org/W1600542667","https://openalex.org/W1624346216","https://openalex.org/W1826880678","https://openalex.org/W1864286509","https://openalex.org/W1968422435","https://openalex.org/W1974682692","https://openalex.org/W1976041714","https://openalex.org/W1981612052","https://openalex.org/W1987500055","https://openalex.org/W2003598961","https://openalex.org/W2013038209","https://openalex.org/W2015344488","https://openalex.org/W2017520393","https://openalex.org/W2023957032","https://openalex.org/W2025742672","https://openalex.org/W2049827480","https://openalex.org/W2056146626","https://openalex.org/W2056242981","https://openalex.org/W2062594120","https://openalex.org/W2065482230","https://openalex.org/W2082947037","https://openalex.org/W2084506573","https://openalex.org/W2093498435","https://openalex.org/W2108145145","https://openalex.org/W2121594719","https://openalex.org/W2144640067","https://openalex.org/W2155783433","https://openalex.org/W2253716135","https://openalex.org/W2258879728","https://openalex.org/W2405352184","https://openalex.org/W2412863297"],"related_works":["https://openalex.org/W1988125179","https://openalex.org/W7071900124","https://openalex.org/W2575000651","https://openalex.org/W146965809","https://openalex.org/W1988547391","https://openalex.org/W2796339782","https://openalex.org/W34270861","https://openalex.org/W2276322160","https://openalex.org/W1993232218","https://openalex.org/W4206464390"],"abstract_inverted_index":{"We":[0,206],"have":[1],"shown":[2],"that":[3,103,208],"coculture":[4],"of":[5,20,39,51,59,67,81,114,127,139,155,165,174,193,201,233,240],"bone":[6,26,150,221],"marrow":[7,27,222],"microvascular":[8,28],"endothelial":[9,29,41,69,234],"cells":[10,14,56,64,84,147,159],"with":[11,85,95],"hematopoietic":[12,82],"progenitor":[13,83],"results":[15],"in":[16,36,136,188,198,215],"proliferation":[17,232],"and":[18,87,92,109,121,145,195,212],"differentiation":[19],"megakaryocytes.":[21,190],"In":[22,182],"these":[23],"long-term":[24],"cultures,":[25],"cell":[30,105],"monolayers":[31],"maintain":[32],"their":[33],"cellular":[34],"integrity":[35],"the":[37,115,137,166,179,220,231],"absence":[38],"exogenous":[40],"growth":[42,70,163],"factors.":[43],"Because":[44],"this":[45],"interaction":[46],"may":[47,228,246],"involve":[48],"paracrine":[49],"secretion":[50,58,66,154],"cytokines,":[52,60],"we":[53,61,101],"evaluated":[54,62],"megakaryocytic":[55,63,104,167],"for":[57,65,89],"vascular":[68,241],"factor":[71],"(VEGF).":[72],"Megakaryocytes":[73],"(CD41a+)":[74],"were":[75,134],"generated":[76],"by":[77,157,162,226,243],"ex":[78,142],"vivo":[79],"expansion":[80],"kit-ligand":[86],"thrombopoietin":[88],"10":[90],"days":[91],"further":[93],"purified":[94,110],"immunomagnetic":[96],"microbeads.":[97],"Using":[98],"reverse":[99],"transcription-PCR,":[100],"showed":[102,185],"lines":[106],"(Dami,":[107],"HEL)":[108],"megakaryocytes":[111,194,210,227],"expressed":[112],"mRNA":[113],"three":[116],"VEGF":[117,128,156,187,202,214,224,236],"isoforms":[118],"(121,":[119],"165,":[120],"189":[122],"amino":[123],"acids).":[124],"Large":[125],"quantities":[126],"(>":[129],"1":[130],"ng/10(6)":[131],"cells/3":[132],"days)":[133],"detected":[135,178],"supernatant":[138,176],"Dami":[140],"cells,":[141],"vivo-generated":[143],"megakaryocytes,":[144],"CD41a+":[146,158],"isolated":[148],"from":[149],"marrow.":[151],"The":[152],"constitutive":[153],"was":[160],"stimulated":[161],"factors":[164],"lineage":[168],"(interleukin":[169],"3,":[170],"thrombopoietin).":[171],"Western":[172],"blotting":[173],"heparin-Sepharose-enriched":[175],"mainly":[177],"isoform":[180],"VEGF165.":[181],"addition,":[183],"immunohistochemistry":[184],"intracytoplasmic":[186],"polyploid":[189],"Thrombin":[191],"stimulation":[192],"platelets":[196,245],"resulted":[197],"rapid":[199],"release":[200],"within":[203],"30":[204],"min.":[205],"conclude":[207],"human":[209],"produce":[211],"secrete":[213],"an":[216],"inducible":[217],"manner.":[218],"Within":[219],"microenvironment,":[223],"secreted":[225],"contribute":[229],"to":[230,238],"cells.":[235],"delivered":[237],"sites":[239],"injury":[242],"activated":[244],"initiate":[247],"angiogenesis.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":26},{"year":2017,"cited_by_count":21},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":27},{"year":2012,"cited_by_count":42}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
