{"id":"https://openalex.org/W1965746576","doi":"https://doi.org/10.1111/exd.12071","title":"The biodisposition and hypertrichotic effects of bimatoprost in mouse skin","display_name":"The biodisposition and hypertrichotic effects of bimatoprost in mouse skin","publication_year":2013,"publication_date":"2013-01-02","ids":{"openalex":"https://openalex.org/W1965746576","doi":"https://doi.org/10.1111/exd.12071","mag":"1965746576","pmid":"https://pubmed.ncbi.nlm.nih.gov/23278986","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3594970"},"language":"en","primary_location":{"id":"doi:10.1111/exd.12071","doi":"https://doi.org/10.1111/exd.12071","is_oa":true,"landing_page_url":"https://doi.org/10.1111/exd.12071","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/exd.12071","source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/exd.12071","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064256590","display_name":"David F. Woodward","orcid":"https://orcid.org/0000-0002-3596-8578","observed_orcids":["https://orcid.org/0000-0002-3596-8578"]},"institutions":[{"id":"https://openalex.org/I4210139498","display_name":"Allergan (United States)","ror":"https://ror.org/03pfqk412","country_code":"US","type":"company","lineage":["https://openalex.org/I2948728702","https://openalex.org/I4210139498"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David F. Woodward","raw_affiliation_strings":["Department of Biological Sciences Allergan, Inc. Irvine CA USA","Dept of Biological Sciences, Allergan, Inc., Irvine, CA 92612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences Allergan, Inc. Irvine CA USA","institution_ids":["https://openalex.org/I4210139498"]},{"raw_affiliation_string":"Dept of Biological Sciences, Allergan, Inc., Irvine, CA 92612, USA","institution_ids":["https://openalex.org/I4210139498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075689857","display_name":"Elaine S.\u2010H. Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139498","display_name":"Allergan (United States)","ror":"https://ror.org/03pfqk412","country_code":"US","type":"company","lineage":["https://openalex.org/I2948728702","https://openalex.org/I4210139498"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elaine S.\u2010H. Tang","raw_affiliation_strings":["Department of Biological Sciences Allergan, Inc. Irvine CA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences Allergan, Inc. Irvine CA USA","institution_ids":["https://openalex.org/I4210139498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113120984","display_name":"Mayssa Attar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139498","display_name":"Allergan (United States)","ror":"https://ror.org/03pfqk412","country_code":"US","type":"company","lineage":["https://openalex.org/I2948728702","https://openalex.org/I4210139498"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mayssa Attar","raw_affiliation_strings":["Department of Pharmacokinetics and Disposition Allergan, Inc. Irvine CA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacokinetics and Disposition Allergan, Inc. Irvine CA USA","institution_ids":["https://openalex.org/I4210139498"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047444345","display_name":"Jenny W. Wang","orcid":"https://orcid.org/0000-0003-0217-7275","observed_orcids":["https://orcid.org/0000-0003-0217-7275"]},"institutions":[{"id":"https://openalex.org/I4210139498","display_name":"Allergan (United States)","ror":"https://ror.org/03pfqk412","country_code":"US","type":"company","lineage":["https://openalex.org/I2948728702","https://openalex.org/I4210139498"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jenny W. Wang","raw_affiliation_strings":["Department of Biological Sciences Allergan, Inc. Irvine CA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences Allergan, Inc. Irvine CA USA","institution_ids":["https://openalex.org/I4210139498"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5047444345"],"corresponding_institution_ids":["https://openalex.org/I4210139498"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":1.7603,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.82571666,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"22","issue":"2","first_page":"145","last_page":"148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bimatoprost","display_name":"bimatoprost","score":1.0},{"id":"https://openalex.org/keywords/hypertrichosis","display_name":"hypertrichosis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/eyelash-growth","display_name":"eyelash growth","score":0.8640000224113464},{"id":"https://openalex.org/keywords/hair-growth-promotion","display_name":"hair growth promotion","score":0.8379999995231628},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.6200000047683716},{"id":"https://openalex.org/keywords/cmax","display_name":"Cmax","score":0.4129999876022339},{"id":"https://openalex.org/keywords/dose-dependence","display_name":"dose dependence","score":0.4970000088214874},{"id":"https://openalex.org/keywords/mouse-skin","display_name":"mouse skin","score":0.31700000166893005}],"concepts":[{"id":"https://openalex.org/C2777336333","wikidata":"https://www.wikidata.org/wiki/Q2393348","display_name":"Bimatoprost","level":4,"score":0.9977724552154541},{"id":"https://openalex.org/C2779884382","wikidata":"https://www.wikidata.org/wiki/Q160108","display_name":"Eyelash","level":2,"score":0.9324272871017456},{"id":"https://openalex.org/C2775876775","wikidata":"https://www.wikidata.org/wiki/Q595010","display_name":"Hypertrichosis","level":2,"score":0.8984158039093018},{"id":"https://openalex.org/C3020618081","wikidata":"https://www.wikidata.org/wiki/Q5937811","display_name":"Hair growth","level":2,"score":0.6471264362335205},{"id":"https://openalex.org/C156300145","wikidata":"https://www.wikidata.org/wiki/Q1435091","display_name":"Vellus hair","level":3,"score":0.5309020280838013},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49061909317970276},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.4617152214050293},{"id":"https://openalex.org/C2779805795","wikidata":"https://www.wikidata.org/wiki/Q1645189","display_name":"Cabello","level":3,"score":0.42509379982948303},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3485490083694458},{"id":"https://openalex.org/C2776740260","wikidata":"https://www.wikidata.org/wiki/Q634959","display_name":"Latanoprost","level":3,"score":0.3391822278499603},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32507243752479553},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17890474200248718},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.10521849989891052},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.055063873529434204},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2778515351","wikidata":"https://www.wikidata.org/wiki/Q9622","display_name":"Scalp","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069580","descriptor_name":"Bimatoprost","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003008","descriptor_name":"Cloprostenol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003008","descriptor_name":"Cloprostenol","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D003008","descriptor_name":"Cloprostenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005140","descriptor_name":"Eyelashes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006197","descriptor_name":"Hair","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006983","descriptor_name":"Hypertrichosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006983","descriptor_name":"Hypertrichosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/exd.12071","doi":"https://doi.org/10.1111/exd.12071","is_oa":true,"landing_page_url":"https://doi.org/10.1111/exd.12071","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/exd.12071","source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2595937","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3594970","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3594970","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3594970","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exp Dermatol","raw_type":"Text"},{"id":"pmid:23278986","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23278986","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental dermatology","raw_type":"Letter"}],"best_oa_location":{"id":"doi:10.1111/exd.12071","doi":"https://doi.org/10.1111/exd.12071","is_oa":true,"landing_page_url":"https://doi.org/10.1111/exd.12071","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/exd.12071","source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1965746576.pdf","grobid_xml":"https://content.openalex.org/works/W1965746576.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1711622231","https://openalex.org/W1907645840","https://openalex.org/W1964872204","https://openalex.org/W1972345417","https://openalex.org/W1973122654","https://openalex.org/W1992417737","https://openalex.org/W1993823998","https://openalex.org/W1995636548","https://openalex.org/W1997483973","https://openalex.org/W2038089954","https://openalex.org/W2042096548","https://openalex.org/W2072213636","https://openalex.org/W2074994063","https://openalex.org/W2084319252","https://openalex.org/W2086364264","https://openalex.org/W2087080372","https://openalex.org/W2100006930","https://openalex.org/W2111015948","https://openalex.org/W2119551996","https://openalex.org/W2139833082","https://openalex.org/W2157455965"],"related_works":["https://openalex.org/W4249594147","https://openalex.org/W4206389311","https://openalex.org/W1922430691","https://openalex.org/W7169887803","https://openalex.org/W6990525032","https://openalex.org/W2269303511","https://openalex.org/W74690859","https://openalex.org/W7203978736","https://openalex.org/W2069794340","https://openalex.org/W4220873281"],"abstract_inverted_index":{"Studies":[0],"on":[1],"bimatoprost":[2,12,27,115,144],"were":[3,106],"performed":[4],"with":[5,137],"two":[6],"objectives:":[7],"(i)":[8],"to":[9,22,77,83],"determine":[10],"whether":[11],"possesses":[13],"hair":[14,53,68,80],"growth-stimulating":[15],"properties":[16],"beyond":[17],"eyelash":[18,41],"hypertrichosis":[19,146],"and":[20,44,73,86,101,113],"(ii)":[21],"investigate":[23],"the":[24,31,36,74,92,130,134,148],"biodisposition":[25,90],"of":[26,66,141],"in":[28,55,70,91],"skin":[29,93,131],"for":[30,40,48,119],"first":[32],"time.":[33],"Bimatoprost,":[34],"at":[35,96],"dose":[37],"used":[38],"clinically":[39],"growth":[42,54,69],"(0.03%)":[43],"given":[45],"once":[46],"daily":[47],"14":[49],"days,":[50],"increased":[51],"pelage":[52],"C57/black":[56],"6":[57],"mice.":[58],"This":[59],"occurred":[60],"as":[61,133,147],"a":[62,123],"much":[63],"earlier":[64],"onset":[65],"new":[67],"shaved":[71],"mice":[72],"time":[75],"taken":[76],"achieve":[78],"complete":[79],"regrowth,":[81],"according":[82],"photographic":[84],"documentation":[85],"visual":[87],"assessment.":[88],"Bimatoprost":[89,126],"was":[94,116,127],"determined":[95],"three":[97],"concentrations:":[98],"0.01%,":[99],"0.03%":[100],"0.06%.":[102],"Dose-dependent":[103],"C(max)":[104],"values":[105],"obtained":[107],"(3.41,":[108],"6.74,":[109],"12.3":[110],"\u03bcg/g":[111],"tissue),":[112],"cutaneous":[114],"well":[117],"maintained":[118],"24":[120],"h":[121],"following":[122],"single":[124],"dose.":[125],"recovered":[128],"from":[129],"only":[132],"intact":[135,149],"molecule,":[136],"no":[138],"detectable":[139],"levels":[140],"metabolites.":[142],"Thus,":[143],"produces":[145],"molecule.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}