{"id":"https://openalex.org/W1965691209","doi":"https://doi.org/10.1158/1535-7163.targ-09-a227","title":"Abstract A227: Positron emission tomographic (PET) imaging of activated matriptase, a marker for cancer progression","display_name":"Abstract A227: Positron emission tomographic (PET) imaging of activated matriptase, a marker for cancer progression","publication_year":2009,"publication_date":"2009-12-01","ids":{"openalex":"https://openalex.org/W1965691209","doi":"https://doi.org/10.1158/1535-7163.targ-09-a227","mag":"1965691209"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.targ-09-a227","doi":"https://doi.org/10.1158/1535-7163.targ-09-a227","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-09-a227","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082396332","display_name":"Julia Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia C. Choi","raw_affiliation_strings":["1 University of California, Davis, Davis, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 University of California, Davis, Davis, CA;","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026077321","display_name":"Sven H. Hausner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sven H. Hausner","raw_affiliation_strings":["1 University of California, Davis, Davis, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 University of California, Davis, Davis, CA;","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089628276","display_name":"Marie-H\u00e9l\u00e8ne Gagnon","orcid":"https://orcid.org/0000-0001-7562-7500","observed_orcids":["https://orcid.org/0000-0001-7562-7500"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Karen J. Gagnon","raw_affiliation_strings":["1 University of California, Davis, Davis, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 University of California, Davis, Davis, CA;","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043106959","display_name":"David L. Kukis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. Kukis","raw_affiliation_strings":["1 University of California, Davis, Davis, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 University of California, Davis, Davis, CA;","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014626023","display_name":"Jason P. Holland","orcid":"https://orcid.org/0000-0002-0066-219X","observed_orcids":["https://orcid.org/0000-0002-0066-219X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason P. Holland","raw_affiliation_strings":["2 Memorial Sloan-Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Memorial Sloan-Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068928963","display_name":"Jason Stuart Lewis","orcid":"https://orcid.org/0000-0001-7065-4534","observed_orcids":["https://orcid.org/0000-0001-7065-4534"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason S. Lewis","raw_affiliation_strings":["2 Memorial Sloan-Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Memorial Sloan-Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102005468","display_name":"Chen\u2010Yong Lin","orcid":"https://orcid.org/0000-0002-6391-2571","observed_orcids":["https://orcid.org/0000-0002-6391-2571"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chen-Yong Lin","raw_affiliation_strings":["3 University of Maryland, Baltimore, Baltimore, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3 University of Maryland, Baltimore, Baltimore, MD;","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037103180","display_name":"Michael D. Johnson","orcid":"https://orcid.org/0000-0001-6260-7586","observed_orcids":["https://orcid.org/0000-0001-6260-7586"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael D. Johnson","raw_affiliation_strings":["4 Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4 Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069859736","display_name":"J. Sutcliffe-Goulden","orcid":"https://orcid.org/0000-0002-5485-4082","observed_orcids":["https://orcid.org/0000-0002-5485-4082"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie L. Sutcliffe","raw_affiliation_strings":["1 University of California, Davis, Davis, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 University of California, Davis, Davis, CA;","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"12_Supplement","first_page":"A227","last_page":"A227"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/matriptase","display_name":"matriptase","score":0.9319999814033508},{"id":"https://openalex.org/keywords/pet-radiotracer","display_name":"PET radiotracer","score":0.8370000123977661},{"id":"https://openalex.org/keywords/copper-64","display_name":"copper-64","score":0.7300000190734863},{"id":"https://openalex.org/keywords/zirconium-89","display_name":"zirconium-89","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antibody-radiolabeling","display_name":"antibody radiolabeling","score":0.7450000047683716},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8069999814033508},{"id":"https://openalex.org/keywords/tumor-progression-markers","display_name":"tumor progression markers","score":0.8820000290870667},{"id":"https://openalex.org/keywords/tumor-to-liver-ratio","display_name":"tumor-to-liver ratio","score":0.6740000247955322},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.8840000033378601},{"id":"https://openalex.org/keywords/metastasis-imaging","display_name":"metastasis imaging","score":0.8560000061988831},{"id":"https://openalex.org/keywords/tumor-retention","display_name":"tumor retention","score":0.44200000166893005},{"id":"https://openalex.org/keywords/her2-neu","display_name":"HER2/neu","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6838318109512329},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6561360359191895},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6413813233375549},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5695837736129761},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5145034790039062},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4925402104854584},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.46498769521713257},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.4478706121444702},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3785400986671448},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36283251643180847},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3586800992488861},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26447930932044983},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.2214139699935913},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14346089959144592},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.targ-09-a227","doi":"https://doi.org/10.1158/1535-7163.targ-09-a227","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-09-a227","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2299036375","https://openalex.org/W303260259","https://openalex.org/W2114543573","https://openalex.org/W233026254","https://openalex.org/W156964360","https://openalex.org/W2142846457","https://openalex.org/W2135937876","https://openalex.org/W2075830235","https://openalex.org/W2175310130","https://openalex.org/W2948324385"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"serine":[2],"protease":[3],"matriptase":[4,64,80,92,206],"has":[5,11,232],"been":[6,12],"implicated":[7],"in":[8,14,35,60,67,71,94,117,208,224,243],"epithelial":[9],"cancers,":[10],"found":[13],"\u223c45%":[15],"of":[16,32,48,63,74,121,128,227,241],"node-negative":[17],"breast":[18,41,49,123,244],"cancers":[19],"at":[20,156,175,196,253,283],"high":[21],"levels,":[22],"and":[23,113,141,159,180,220],"is":[24,81],"indicated":[25,170],"as":[26],"a":[27,118],"biomarker":[28],"for":[29,54,93,162,186,198,235,255,285],"survival":[30],"independent":[31],"HER-2/neu.":[33],"While":[34],"vitro":[36],"methods":[37],"are":[38,52],"invaluable,":[39],"few":[40],"cancer":[42,50,84,245],"cell-lines":[43,130],"express":[44],"matriptase,":[45,104],"though":[46],"83%":[47],"patients":[51],"positive":[53,188,210],"matriptase\u2014this":[55],"suggests":[56],"that":[57],"imaging":[58,96,226,236],"the":[59,72,75,187,209,222,233,238],"vivo":[61,95,225],"behavior":[62],"may":[65],"aid":[66],"understanding":[68],"its":[69],"role":[70],"context":[73],"tumor":[76,172,189,260,262,290,292],"system.":[77],"Specifically,":[78],"activated":[79,91,103,228,256,286],"associated":[82],"with":[83],"progression.":[85],"We":[86],"have":[87,215],"developed":[88,216],"radiotracers":[89,219],"against":[90,102],"using":[97,154],"PET.":[98],"M69,":[99],"an":[100],"antibody":[101],"was":[105,131,166,193],"functionalized":[106],"to":[107,138],"capture":[108],"[64Cu]copper":[109],"or":[110],"[89Zr]zirconium:":[111],"64Cu-TETA-M69":[112,179,263,293],"89Zr-DF-M69":[114,181,270,300],"were":[115,145],"evaluated":[116],"mouse":[119],"model":[120],"human":[122,205],"cancer.":[124],"A":[125],"dox-regulable":[126],"pair":[127],"PyVmT":[129],"bilaterally":[132],"introduced":[133],"into":[134],"nude":[135],"female":[136],"mice":[137],"generate":[139],"matriptase-positive":[140],"control":[142],"tumors.":[143],"Mice":[144],"fed":[146],"dox":[147],"chow":[148],"ad":[149],"libitum,":[150],"administered":[151],"radiotracer,":[152],"imaged":[153],"microPET":[155],"1\u20134d":[157],"p.i.;":[158],"through":[160],"336h":[161,197],"89Zr;":[163],"corresponding":[164],"biodistribution":[165,252,282],"performed.":[167],"PET":[168],"images":[169],"specific":[171],"retention.":[173],"Biodistribution":[174],"4d":[176],"revealed":[177],"both":[178],"retained":[182],"two-fold":[183],"uptake":[184],"ratios":[185,250,280],"over":[190],"control;":[191],"this":[192],"also":[194],"observed":[195],"89Zr-DF-M69.":[199],"Immunohistochemistry":[200],"on":[201],"FFPE":[202],"tissues":[203],"confirmed":[204],"expression":[207],"tumor.":[211],"In":[212],"summary,":[213],"we":[214],"two":[217],"novel":[218],"performed":[221],"first":[223],"matriptase.":[229,257,287],"This":[230],"approach":[231],"potential":[234],"metastasis,":[237],"primary":[239],"cause":[240],"mortality":[242],"patients.":[246],"Table":[247,277],"1":[248],"Tumor-to-liver":[249],"from":[251,281],"96h":[254,284],"Radiotracer":[258,288],"Matriptase-positive":[259,289],"Control":[261,291],"2.55":[264],"\u00b1":[265,268,272,275,295,298,302,305],"0.41":[266],"1.54":[267],"0.33":[269,276],"3.79":[271],"0.25":[273],"1.88":[274],"2":[278],"Tumor-to-blood":[279],"1.67":[294],"0.39":[296],"1.01":[297],"0.30":[299],"1.97":[301],"0.40":[303],"0.98":[304],"0.45":[306],"Citation":[307],"Information:":[308],"Mol":[309],"Cancer":[310],"Ther":[311],"2009;8(12":[312],"Suppl):A227.":[313]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
