{"id":"https://openalex.org/W1965680797","doi":"https://doi.org/10.1074/jbc.m404497200","title":"Identification and Functional Characterization of a Novel Human Misshapen/Nck Interacting Kinase-related Kinase, hMINK\u03b2","display_name":"Identification and Functional Characterization of a Novel Human Misshapen/Nck Interacting Kinase-related Kinase, hMINK\u03b2","publication_year":2004,"publication_date":"2004-10-07","ids":{"openalex":"https://openalex.org/W1965680797","doi":"https://doi.org/10.1074/jbc.m404497200","mag":"1965680797","pmid":"https://pubmed.ncbi.nlm.nih.gov/15469942"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m404497200","doi":"https://doi.org/10.1074/jbc.m404497200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m404497200","pdf_url":"http://www.jbc.org/article/S002192581963200X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S002192581963200X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yuanming Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159901","display_name":"Rigel (United States)","ror":"https://ror.org/05j0yvv31","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanming Hu","raw_affiliation_strings":["Rigel Pharmaceuticals, Inc., South San Francisco, California 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rigel Pharmaceuticals, Inc., South San Francisco, California 94080, USA","institution_ids":["https://openalex.org/I4210159901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017636588","display_name":"Cindy Leo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159901","display_name":"Rigel (United States)","ror":"https://ror.org/05j0yvv31","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cindy Leo","raw_affiliation_strings":["Rigel Pharmaceuticals, Inc., South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rigel Pharmaceuticals, Inc., South San Francisco, California 94080","institution_ids":["https://openalex.org/I4210159901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103353329","display_name":"Simon Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159901","display_name":"Rigel (United States)","ror":"https://ror.org/05j0yvv31","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simon Yu","raw_affiliation_strings":["Rigel Pharmaceuticals, Inc., South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rigel Pharmaceuticals, Inc., South San Francisco, California 94080","institution_ids":["https://openalex.org/I4210159901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073124878","display_name":"Betty C. B. Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159901","display_name":"Rigel (United States)","ror":"https://ror.org/05j0yvv31","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Betty C.B. Huang","raw_affiliation_strings":["Rigel Pharmaceuticals, Inc., South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rigel Pharmaceuticals, Inc., South San Francisco, California 94080","institution_ids":["https://openalex.org/I4210159901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034805812","display_name":"Hank Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159901","display_name":"Rigel (United States)","ror":"https://ror.org/05j0yvv31","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hank Wang","raw_affiliation_strings":["Rigel Pharmaceuticals, Inc., South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rigel Pharmaceuticals, Inc., South San Francisco, California 94080","institution_ids":["https://openalex.org/I4210159901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113665259","display_name":"Mary Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159901","display_name":"Rigel (United States)","ror":"https://ror.org/05j0yvv31","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Shen","raw_affiliation_strings":["Rigel Pharmaceuticals, Inc., South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rigel Pharmaceuticals, Inc., South San Francisco, California 94080","institution_ids":["https://openalex.org/I4210159901"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ying Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159901","display_name":"Rigel (United States)","ror":"https://ror.org/05j0yvv31","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Luo","raw_affiliation_strings":["Rigel Pharmaceuticals, Inc., South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rigel Pharmaceuticals, Inc., South San Francisco, California 94080","institution_ids":["https://openalex.org/I4210159901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080192004","display_name":"Sarkiz Daniel-Issakani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159901","display_name":"Rigel (United States)","ror":"https://ror.org/05j0yvv31","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarkiz Daniel-Issakani","raw_affiliation_strings":["Rigel Pharmaceuticals, Inc., South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rigel Pharmaceuticals, Inc., South San Francisco, California 94080","institution_ids":["https://openalex.org/I4210159901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113600276","display_name":"Donald G. Payan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159901","display_name":"Rigel (United States)","ror":"https://ror.org/05j0yvv31","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald G. Payan","raw_affiliation_strings":["Rigel Pharmaceuticals, Inc., South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rigel Pharmaceuticals, Inc., South San Francisco, California 94080","institution_ids":["https://openalex.org/I4210159901"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018516855","display_name":"Xiang Ming Xu","orcid":"https://orcid.org/0000-0002-1026-2210","observed_orcids":["https://orcid.org/0000-0002-1026-2210"]},"institutions":[{"id":"https://openalex.org/I4210159901","display_name":"Rigel (United States)","ror":"https://ror.org/05j0yvv31","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159901"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiang Xu","raw_affiliation_strings":["Rigel Pharmaceuticals, Inc., South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rigel Pharmaceuticals, Inc., South San Francisco, California 94080","institution_ids":["https://openalex.org/I4210159901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018516855"],"corresponding_institution_ids":["https://openalex.org/I4210159901"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.0736,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.70928886,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"279","issue":"52","first_page":"54387","last_page":"54397"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ste20-like-kinase","display_name":"Ste20-like kinase","score":0.777999997138977},{"id":"https://openalex.org/keywords/nck","display_name":"Nck","score":0.6990000009536743},{"id":"https://openalex.org/keywords/c-jun-n-terminal-kinase","display_name":"c-Jun N-terminal kinase","score":0.7360000014305115},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.6759999990463257},{"id":"https://openalex.org/keywords/cell-spreading","display_name":"cell spreading","score":0.7310000061988831},{"id":"https://openalex.org/keywords/stress-fibers","display_name":"stress fibers","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cell-motility","display_name":"cell motility","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.9359999895095825},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9570000171661377},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.906000018119812},{"id":"https://openalex.org/keywords/golgi-apparatus","display_name":"Golgi apparatus","score":0.9679999947547913},{"id":"https://openalex.org/keywords/intracellular-protein-transport","display_name":"intracellular protein transport","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cytoskeletal-rearrangement","display_name":"cytoskeletal rearrangement","score":0.8420000076293945},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6209999918937683},{"id":"https://openalex.org/keywords/fibrosarcoma","display_name":"fibrosarcoma","score":0.9789999723434448}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7305499315261841},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5801731944084167},{"id":"https://openalex.org/C124160383","wikidata":"https://www.wikidata.org/wiki/Q14914383","display_name":"ASK1","level":5,"score":0.5059320330619812},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.501518964767456},{"id":"https://openalex.org/C66417403","wikidata":"https://www.wikidata.org/wiki/Q20970072","display_name":"Integrin-linked kinase","level":5,"score":0.49415257573127747},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.48841017484664917},{"id":"https://openalex.org/C159479382","wikidata":"https://www.wikidata.org/wiki/Q18030801","display_name":"MAP2K7","level":5,"score":0.4868742525577545},{"id":"https://openalex.org/C2777751087","wikidata":"https://www.wikidata.org/wiki/Q5636047","display_name":"HT1080","level":3,"score":0.48280417919158936},{"id":"https://openalex.org/C108391706","wikidata":"https://www.wikidata.org/wiki/Q15333532","display_name":"PTK2","level":5,"score":0.47187891602516174},{"id":"https://openalex.org/C51853150","wikidata":"https://www.wikidata.org/wiki/Q14911754","display_name":"Cyclin-dependent kinase 4","level":5,"score":0.4708613455295563},{"id":"https://openalex.org/C32619005","wikidata":"https://www.wikidata.org/wiki/Q24768234","display_name":"Protein kinase domain","level":4,"score":0.4558209180831909},{"id":"https://openalex.org/C137361374","wikidata":"https://www.wikidata.org/wiki/Q6714442","display_name":"MAP kinase kinase kinase","level":4,"score":0.4460606276988983},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.42422378063201904},{"id":"https://openalex.org/C59143045","wikidata":"https://www.wikidata.org/wiki/Q15314942","display_name":"Cyclin-dependent kinase 9","level":5,"score":0.41286370158195496},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.4093296229839325},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.36688143014907837},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2971073389053345},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2570769190788269},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.10713976621627808},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005354","descriptor_name":"Fibrosarcoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006056","descriptor_name":"Golgi Apparatus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017385","descriptor_name":"Sequence Homology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020798","descriptor_name":"Two-Hybrid System Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048670","descriptor_name":"MAP Kinase Kinase 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m404497200","doi":"https://doi.org/10.1074/jbc.m404497200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m404497200","pdf_url":"http://www.jbc.org/article/S002192581963200X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:15469942","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15469942","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m404497200","doi":"https://doi.org/10.1074/jbc.m404497200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m404497200","pdf_url":"http://www.jbc.org/article/S002192581963200X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1965680797.pdf","grobid_xml":"https://content.openalex.org/works/W1965680797.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W161910285","https://openalex.org/W1500886454","https://openalex.org/W1662447390","https://openalex.org/W1717675949","https://openalex.org/W1811565239","https://openalex.org/W1971227936","https://openalex.org/W1972805802","https://openalex.org/W1981957327","https://openalex.org/W1983643278","https://openalex.org/W1983917564","https://openalex.org/W1984473379","https://openalex.org/W1990747492","https://openalex.org/W1996063901","https://openalex.org/W2014862668","https://openalex.org/W2031442174","https://openalex.org/W2032335304","https://openalex.org/W2034018110","https://openalex.org/W2039031863","https://openalex.org/W2044778337","https://openalex.org/W2051439103","https://openalex.org/W2054172043","https://openalex.org/W2055437587","https://openalex.org/W2055971016","https://openalex.org/W2061013276","https://openalex.org/W2065114189","https://openalex.org/W2077431077","https://openalex.org/W2088350408","https://openalex.org/W2090956156","https://openalex.org/W2103665862","https://openalex.org/W2113245366","https://openalex.org/W2114650821","https://openalex.org/W2120492537","https://openalex.org/W2123125895","https://openalex.org/W2129133276","https://openalex.org/W2130114526","https://openalex.org/W2138747143","https://openalex.org/W2143204111","https://openalex.org/W2149453003","https://openalex.org/W2154142433","https://openalex.org/W2167096785","https://openalex.org/W2335866695","https://openalex.org/W4233070887","https://openalex.org/W4237567990"],"related_works":["https://openalex.org/W2114650821","https://openalex.org/W1610418297","https://openalex.org/W4405067681","https://openalex.org/W2041120201","https://openalex.org/W1964211098","https://openalex.org/W2011355386","https://openalex.org/W2061013276","https://openalex.org/W2154142433","https://openalex.org/W2337128216","https://openalex.org/W2135719307"],"abstract_inverted_index":{"Misshapen/NIKs-related":[0,50],"kinase":[1,51,82,88,96,123],"(MINK)":[2],"is":[3,65],"a":[4,25,47,57,113,183],"member":[5],"of":[6,11,28,46,59,121,129,181,218],"the":[7,17,41,103,107,122,200,216],"germinal":[8],"center":[9],"family":[10],"kinases":[12,22],"that":[13,55,204,227],"are":[14],"homologous":[15],"to":[16,79,146,197],"yeast":[18,108],"sterile":[19],"20":[20],"(Ste20)":[21],"and":[23,36,43,84,86,98,111,126,144,155,177,239],"regulate":[24],"wide":[26],"variety":[27],"cellular":[29],"processes,":[30],"including":[31],"cell":[32,138,153,156,173,189,237,240],"morphology,":[33],"cytoskeletal":[34],"rearrangement,":[35],"survival.":[37],"Here,":[38],"we":[39],"present":[40],"cloning":[42],"functional":[44],"characterization":[45],"novel":[48],"human":[49,133,166],"beta":[52,64,91,131,193,206,229],"(hMINK":[53],"beta)":[54],"encodes":[56],"polypeptide":[58],"1312":[60],"amino":[61],"acids.":[62],"hMINK":[63,90,130,192,205,228],"ubiquitously":[66],"expressed":[67],"in":[68,106,112,132,165,175,187,213,234],"most":[69],"tissues":[70],"with":[71,100,172,199],"at":[72,211],"least":[73,212],"five":[74],"alternatively":[75],"spliced":[76],"isoforms.":[77],"Similar":[78],"Nck":[80,101],"interacting":[81],"(NIK)":[83],"Traf2":[85],"Nck-interacting":[87],"(TNIK),":[89],"moderately":[92],"activates":[93],"c-Jun":[94],"N-terminal":[95],"(JNK)":[97],"associates":[99],"via":[102],"intermediate":[104],"domain":[105,124],"two-hybrid":[109],"system":[110],"glutathione":[114],"S-transferase":[115],"(GST)":[116],"pull-down":[117],"assay.":[118],"Interestingly,":[119],"overexpression":[120],"deleted":[125],"kinase-inactive":[127],"mutants":[128,160],"fibrosarcoma":[134],"HT1080":[135],"cells":[136],"enhanced":[137],"spreading,":[139],"actin":[140],"stress":[141],"fiber":[142],"formation,":[143],"adhesion":[145,164],"extracellular":[147],"matrix,":[148],"as":[149,151],"well":[150],"decreased":[152],"motility":[154],"invasion.":[157],"Furthermore,":[158],"these":[159,224],"also":[161],"promoted":[162],"cell-cell":[163],"breast":[167],"carcinoma":[168],"MCF7":[169],"cells,":[170],"evidenced":[171],"growth":[174],"clusters":[176],"increased":[178],"membrane":[179],"localization":[180],"beta-catenin,":[182],"multifunctional":[184],"protein":[185,194,220],"involved":[186],"E-cadherin-mediated":[188],"adhesion.":[190],"Finally,":[191],"was":[195],"found":[196],"colocalize":[198],"Golgi":[201],"apparatus,":[202],"implicating":[203],"might":[207],"exert":[208],"its":[209],"functions,":[210],"part,":[214],"through":[215],"modulation":[217],"intracellular":[219],"transport.":[221],"Taken":[222],"together,":[223],"results":[225],"suggest":[226],"plays":[230],"an":[231],"important":[232],"role":[233],"cytoskeleton":[235],"reorganization,":[236],"adhesion,":[238],"motility.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}