{"id":"https://openalex.org/W1965673106","doi":"https://doi.org/10.2337/db14-1132","title":"Metformin and Rapamycin Reduce Pancreatic Cancer Growth in Obese Prediabetic Mice by Distinct MicroRNA-Regulated Mechanisms","display_name":"Metformin and Rapamycin Reduce Pancreatic Cancer Growth in Obese Prediabetic Mice by Distinct MicroRNA-Regulated Mechanisms","publication_year":2015,"publication_date":"2015-01-09","ids":{"openalex":"https://openalex.org/W1965673106","doi":"https://doi.org/10.2337/db14-1132","mag":"1965673106","pmid":"https://pubmed.ncbi.nlm.nih.gov/25576058","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4407853"},"language":"en","primary_location":{"id":"doi:10.2337/db14-1132","doi":"https://doi.org/10.2337/db14-1132","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db14-1132","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4407853","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013123509","display_name":"Vincenza Cifarelli","orcid":"https://orcid.org/0000-0002-9940-4106","observed_orcids":["https://orcid.org/0000-0002-9940-4106"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincenza Cifarelli","raw_affiliation_strings":["Department of Medicine, Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033974723","display_name":"Laura M. Lashinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura M. Lashinger","raw_affiliation_strings":["Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048433402","display_name":"Kaylyn L. Devlin","orcid":"https://orcid.org/0000-0001-5842-0591","observed_orcids":["https://orcid.org/0000-0001-5842-0591"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaylyn L. Devlin","raw_affiliation_strings":["Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080856244","display_name":"Sarah M. Dunlap","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah M. Dunlap","raw_affiliation_strings":["Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103011103","display_name":"Jennifer Chunyan Huang","orcid":"https://orcid.org/0000-0003-1971-3310","observed_orcids":["https://orcid.org/0000-0003-1971-3310"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Huang","raw_affiliation_strings":["Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033124357","display_name":"Rudolf Kaaks","orcid":"https://orcid.org/0000-0003-3751-3929","observed_orcids":["https://orcid.org/0000-0003-3751-3929"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rudolf Kaaks","raw_affiliation_strings":["Division of Epidemiology, German Cancer Research Center, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology, German Cancer Research Center, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005616347","display_name":"Micha\u00ebl Pollak","orcid":"https://orcid.org/0000-0003-3047-0604","observed_orcids":["https://orcid.org/0000-0003-3047-0604"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael N. Pollak","raw_affiliation_strings":["Departments of Medicine and Oncology, McGill University, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Oncology, McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036400845","display_name":"Stephen David Hursting","orcid":"https://orcid.org/0000-0003-3605-2833","observed_orcids":["https://orcid.org/0000-0003-3605-2833"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]},{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen D. Hursting","raw_affiliation_strings":["Department of Nutrition, University of North Carolina, Chapel Hill, NC","Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX","Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, University of North Carolina, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5036400845"],"corresponding_institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329","https://openalex.org/I86519309"],"apc_list":null,"apc_paid":null,"fwci":4.6149,"has_fulltext":true,"cited_by_count":85,"citation_normalized_percentile":{"value":0.96266834,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"64","issue":"5","first_page":"1632","last_page":"1642"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.996999979019165},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":1.0},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.843999981880188},{"id":"https://openalex.org/keywords/prediabetes","display_name":"prediabetes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.7730000019073486},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.8420000076293945},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9120000004768372},{"id":"https://openalex.org/keywords/mir-34a","display_name":"miR-34a","score":0.9210000038146973},{"id":"https://openalex.org/keywords/mir-7","display_name":"miR-7","score":0.6809999942779541},{"id":"https://openalex.org/keywords/notches","display_name":"notches","score":0.7910000085830688},{"id":"https://openalex.org/keywords/slug","display_name":"Slug","score":0.9200000166893005},{"id":"https://openalex.org/keywords/snails","display_name":"snails","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.7720000147819519},{"id":"https://openalex.org/keywords/glucose-regulation","display_name":"glucose regulation","score":0.6119999885559082},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.8059999942779541},{"id":"https://openalex.org/keywords/tumor-spheroids","display_name":"tumor spheroids","score":0.6930000185966492},{"id":"https://openalex.org/keywords/panc02-cells","display_name":"Panc02 cells","score":0.6259999871253967},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.9564657807350159},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6976791024208069},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5769672989845276},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5749397277832031},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5569742918014526},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.47611814737319946},{"id":"https://openalex.org/C2779855799","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic islets","level":4,"score":0.46519529819488525},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4507640600204468},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43449223041534424},{"id":"https://openalex.org/C2780609358","wikidata":"https://www.wikidata.org/wiki/Q2087205","display_name":"Impaired glucose tolerance","level":4,"score":0.42032283544540405},{"id":"https://openalex.org/C2777921159","wikidata":"https://www.wikidata.org/wiki/Q32089","display_name":"Sirolimus","level":2,"score":0.4139823615550995},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3826477527618408},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36535319685935974},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.3547733426094055},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.344347208738327},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32124119997024536},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.22622710466384888},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1743062138557434}],"mesh":[{"descriptor_ui":"D000071250","descriptor_name":"Snail Family Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002149","descriptor_name":"Energy Intake","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003927","descriptor_name":"Diet, Diabetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011236","descriptor_name":"Prediabetic State","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014746","descriptor_name":"Vimentin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014746","descriptor_name":"Vimentin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018149","descriptor_name":"Glucose Intolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.2337/db14-1132","doi":"https://doi.org/10.2337/db14-1132","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db14-1132","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3818274","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4407853","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4407853","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4407853","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Text"},{"id":"pmid:25576058","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25576058","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:9g54xq49s","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/mjag-1h23","pdf_url":"https://doi.org/10.17615/mjag-1h23","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diabetes, 64(5)","raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.869.1500","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.869.1500","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://diabetes.diabetesjournals.org/content/64/5/1632.full.pdf","raw_type":"text"},{"id":"doi:10.17615/mjag-1h23","doi":"https://doi.org/10.17615/mjag-1h23","is_oa":true,"landing_page_url":"https://doi.org/10.17615/mjag-1h23","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3818274","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4407853","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G807660109","display_name":"Obesity and Pancreatic Cancer: The Role of IGF-1","funder_award_id":"R01CA135386","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1965673106.pdf","grobid_xml":"https://content.openalex.org/works/W1965673106.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W6617257","https://openalex.org/W58143305","https://openalex.org/W144423133","https://openalex.org/W1497663772","https://openalex.org/W1596556260","https://openalex.org/W1970102311","https://openalex.org/W1974792145","https://openalex.org/W1979782841","https://openalex.org/W1980484515","https://openalex.org/W1987041848","https://openalex.org/W1990063646","https://openalex.org/W2000977663","https://openalex.org/W2001437338","https://openalex.org/W2013047715","https://openalex.org/W2014691022","https://openalex.org/W2016752484","https://openalex.org/W2026967508","https://openalex.org/W2033487998","https://openalex.org/W2035396934","https://openalex.org/W2036650467","https://openalex.org/W2043152532","https://openalex.org/W2066809635","https://openalex.org/W2080331765","https://openalex.org/W2083547817","https://openalex.org/W2085135295","https://openalex.org/W2088469990","https://openalex.org/W2090836265","https://openalex.org/W2093464881","https://openalex.org/W2098082928","https://openalex.org/W2104987742","https://openalex.org/W2106900078","https://openalex.org/W2108608698","https://openalex.org/W2112456128","https://openalex.org/W2113091319","https://openalex.org/W2116504531","https://openalex.org/W2121117803","https://openalex.org/W2122092089","https://openalex.org/W2124488916","https://openalex.org/W2126446022","https://openalex.org/W2126811493","https://openalex.org/W2129466351","https://openalex.org/W2136383161","https://openalex.org/W2142489285","https://openalex.org/W2144038313","https://openalex.org/W2144399303","https://openalex.org/W2146241268","https://openalex.org/W2152561870","https://openalex.org/W2159558399","https://openalex.org/W2160483366","https://openalex.org/W2162673078","https://openalex.org/W2169214947","https://openalex.org/W2169273935","https://openalex.org/W2186795520","https://openalex.org/W6675913145"],"related_works":["https://openalex.org/W2768374000","https://openalex.org/W2031191632","https://openalex.org/W3048374256","https://openalex.org/W3030833389","https://openalex.org/W2324786944","https://openalex.org/W1978119991","https://openalex.org/W2102473689","https://openalex.org/W2217747537","https://openalex.org/W2233772383","https://openalex.org/W7095961091"],"abstract_inverted_index":{"Metformin":[0,116,137,180],"treatment":[1],"is":[2,36],"associated":[3],"with":[4,17],"a":[5,33,40],"decreased":[6,101],"risk":[7],"and":[8,59,77,86,93,104,112,122,125,129,135,142,150,163,177,181],"better":[9],"prognosis":[10],"of":[11,24,32,57,64,110,127,144,154],"pancreatic":[12,42,90,168],"cancer":[13],"(PC)":[14],"in":[15,29,47,148,156,171,188],"patients":[16],"type":[18],"2":[19],"diabetes,":[20],"but":[21],"the":[22,30,55,60,140,152,196],"mechanism":[23],"metformin's":[25],"PC":[26,70],"growth":[27,92,103,170],"inhibition":[28],"context":[31],"prediabetic":[34,173],"state":[35],"unknown.":[37],"We":[38],"used":[39],"Panc02":[41,145],"tumor":[43,91,146,169],"cell":[44,113],"transplant":[45],"model":[46],"diet-induced":[48],"obese":[49],"(DIO)":[50],"C57BL/6":[51],"mice":[52,174],"to":[53],"compare":[54],"effects":[56,98],"metformin":[58,85,162],"direct":[61,131,182],"mammalian":[62],"target":[63],"rapamycin":[65,68,87,97,164],"(mTOR)":[66],"inhibitor":[67],"on":[69,100],"growth,":[71],"glucose":[72,121],"regulation,":[73],"mTOR":[74,183],"pathway":[75],"signaling,":[76,106],"candidate":[78],"microRNA":[79],"(miR)":[80],"expression.":[81],"In":[82],"DIO/prediabetic":[83],"mice,":[84],"significantly":[88],"reduced":[89,120,139],"mTOR-related":[94],"signaling.":[95],"The":[96],"centered":[99],"mTOR-regulated":[102],"survival":[105],"including":[107],"increased":[108],"expression":[109,126,153],"let-7b":[111],"cycle-regulating":[114],"miRs.":[115],"(but":[117],"not":[118],"rapamycin)":[119],"insulin":[123],"levels":[124],"miR-34a":[128],"its":[130],"targets":[132],"Notch,":[133],"Slug,":[134],"Snail.":[136],"also":[138],"number":[141],"size":[143],"spheres":[147],"vitro":[149],"inhibited":[151],"Notch":[155],"spheroids.":[157],"Our":[158],"results":[159],"suggest":[160],"that":[161],"can":[165],"both":[166],"inhibit":[167],"obese,":[172],"through":[175],"shared":[176],"distinct":[178],"mechanisms.":[179],"inhibitors,":[184],"alone":[185],"or":[186],"possibly":[187],"combination,":[189],"represent":[190],"promising":[191],"intervention":[192],"strategies":[193],"for":[194],"breaking":[195],"diabetes-PC":[197],"link.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}