{"id":"https://openalex.org/W1965663626","doi":"https://doi.org/10.1371/journal.pone.0002598","title":"Lifespan Mental Activity Predicts Diminished Rate of Hippocampal Atrophy","display_name":"Lifespan Mental Activity Predicts Diminished Rate of Hippocampal Atrophy","publication_year":2008,"publication_date":"2008-07-09","ids":{"openalex":"https://openalex.org/W1965663626","doi":"https://doi.org/10.1371/journal.pone.0002598","mag":"1965663626","pmid":"https://pubmed.ncbi.nlm.nih.gov/18612379","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2440814"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0002598","doi":"https://doi.org/10.1371/journal.pone.0002598","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0002598","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0002598&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1965663626"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0002598&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081354968","display_name":"Michael Valenzuela","orcid":"https://orcid.org/0000-0001-7162-6607","observed_orcids":["https://orcid.org/0000-0001-7162-6607"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210108821","display_name":"Prince of Wales Hospital","ror":"https://ror.org/022arq532","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210108821"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Michael J. Valenzuela","raw_affiliation_strings":["School of Psychiatry, University of New South Wales, Sydney, Australia. michaelv@unsw.edu.au","School of Psychiatry, University of New South Wales, Sydney, Australia","The Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Psychiatry, University of New South Wales, Sydney, Australia. michaelv@unsw.edu.au","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"School of Psychiatry, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"The Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia","institution_ids":["https://openalex.org/I4210108821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041083697","display_name":"Perminder Singh Sachdev","orcid":"https://orcid.org/0000-0002-9595-3220","observed_orcids":["https://orcid.org/0000-0002-9595-3220"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210108821","display_name":"Prince of Wales Hospital","ror":"https://ror.org/022arq532","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210108821"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Perminder Sachdev","raw_affiliation_strings":["School of Psychiatry, University of New South Wales, Sydney, Australia","The Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Psychiatry, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"The Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia","institution_ids":["https://openalex.org/I4210108821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100396390","display_name":"Wei Xiong Wen","orcid":"https://orcid.org/0000-0003-2753-3870","observed_orcids":["https://orcid.org/0000-0003-2753-3870"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210108821","display_name":"Prince of Wales Hospital","ror":"https://ror.org/022arq532","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210108821"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Wei Wen","raw_affiliation_strings":["School of Psychiatry, University of New South Wales, Sydney, Australia","The Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Psychiatry, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"The Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia","institution_ids":["https://openalex.org/I4210108821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100428772","display_name":"Xiaohua Chen","orcid":"https://orcid.org/0000-0002-5696-8315","observed_orcids":["https://orcid.org/0000-0002-5696-8315"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210108821","display_name":"Prince of Wales Hospital","ror":"https://ror.org/022arq532","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210108821"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Xiaohua Chen","raw_affiliation_strings":["School of Psychiatry, University of New South Wales, Sydney, Australia","The Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Psychiatry, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"The Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia","institution_ids":["https://openalex.org/I4210108821"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021571114","display_name":"Henry Brodaty","orcid":"https://orcid.org/0000-0001-9487-6617","observed_orcids":["https://orcid.org/0000-0001-9487-6617"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210108821","display_name":"Prince of Wales Hospital","ror":"https://ror.org/022arq532","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210108821"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Henry Brodaty","raw_affiliation_strings":["Aged Care Psychiatry, Prince of Wales Hospital, Sydney, Australia","Primary Dementia Collaborative Research Centre, University of New South Wales, Sydney, Australia","School of Psychiatry, University of New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aged Care Psychiatry, Prince of Wales Hospital, Sydney, Australia","institution_ids":["https://openalex.org/I4210108821"]},{"raw_affiliation_string":"Primary Dementia Collaborative Research Centre, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"School of Psychiatry, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5081354968"],"corresponding_institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210108821"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":6.0424,"has_fulltext":true,"cited_by_count":269,"citation_normalized_percentile":{"value":0.96351931,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"3","issue":"7","first_page":"e2598","last_page":"e2598"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11577","display_name":"Cognitive Abilities and Testing","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11265","display_name":"Aging and Gerontology Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3204","display_name":"Developmental and Educational Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hippocampal-atrophy","display_name":"hippocampal atrophy","score":0.847000002861023},{"id":"https://openalex.org/keywords/hippocampal-volume","display_name":"hippocampal volume","score":0.8339999914169312},{"id":"https://openalex.org/keywords/dementia-risk","display_name":"dementia risk","score":0.7020000219345093},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9380000233650208},{"id":"https://openalex.org/keywords/white-matter-hyperintensities","display_name":"white matter hyperintensities","score":0.9160000085830688},{"id":"https://openalex.org/keywords/total-brain-volume","display_name":"total brain volume","score":0.9190000295639038},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7699999809265137},{"id":"https://openalex.org/keywords/medial-temporal-lobe","display_name":"medial temporal lobe","score":0.8960000276565552}],"concepts":[{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.7360920906066895},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.713180422782898},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6743812561035156},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5327995419502258},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5236485004425049},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.5142607092857361},{"id":"https://openalex.org/C146638467","wikidata":"https://www.wikidata.org/wiki/Q10529587","display_name":"Hyperintensity","level":3,"score":0.5004940032958984},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4827927350997925},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4813717007637024},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.45639297366142273},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4119272828102112},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40554118156433105},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.28449350595474243},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.20276334881782532},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.08086395263671875},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008606","descriptor_name":"Mental Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0002598","doi":"https://doi.org/10.1371/journal.pone.0002598","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0002598","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0002598&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmid:18612379","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18612379","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2440814","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2440814/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:unsworks.library.unsw.edu.au:1959.4/unsworks_38295","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1959.4/unsworks_38295","pdf_url":"https://unsworks.unsw.edu.au/bitstreams/68bddf07-035a-45bf-84eb-3ce82100b9aa/download","source":{"id":"https://openalex.org/S4306401737","display_name":"UNSWorks (University of New South Wales, Sydney, Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I40053085","host_organization_name":"Australian Defence Force Academy","host_organization_lineage":["https://openalex.org/I40053085"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS One, 3, 7, 1-6","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.275.6981","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.275.6981","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/81/75/PLoS_ONE_2008_Jul_9_3(7)_e2598.tar.gz","raw_type":"text"},{"id":"pmh:oai:unsworks.unsw.edu.au:1959.4/unsworks_38295","doi":null,"is_oa":true,"landing_page_url":"http://handle.unsw.edu.au/1959.4/unsworks_38295","pdf_url":null,"source":{"id":"https://openalex.org/S4377196481","display_name":"UNSWorks (UNSW Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I31746571","host_organization_name":"UNSW Sydney","host_organization_lineage":["https://openalex.org/I31746571"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:5c698bf854764612998e827e3ac00772","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5c698bf854764612998e827e3ac00772","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 3, Iss 7, p e2598 (2008)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0002598","doi":"https://doi.org/10.1371/journal.pone.0002598","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0002598","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0002598&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G8173276495","display_name":"Neurocognitive disorders in the elderly","funder_award_id":"350833","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1965663626.pdf","grobid_xml":"https://content.openalex.org/works/W1965663626.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1484512841","https://openalex.org/W1688033190","https://openalex.org/W1967830806","https://openalex.org/W1974759530","https://openalex.org/W1987430929","https://openalex.org/W1990257603","https://openalex.org/W1997237275","https://openalex.org/W2008679344","https://openalex.org/W2010269783","https://openalex.org/W2010856791","https://openalex.org/W2015241097","https://openalex.org/W2025806545","https://openalex.org/W2028989537","https://openalex.org/W2036234078","https://openalex.org/W2038391431","https://openalex.org/W2044715983","https://openalex.org/W2048525192","https://openalex.org/W2052742260","https://openalex.org/W2054282296","https://openalex.org/W2058873342","https://openalex.org/W2059212904","https://openalex.org/W2061440472","https://openalex.org/W2070268750","https://openalex.org/W2077555834","https://openalex.org/W2086978209","https://openalex.org/W2087651523","https://openalex.org/W2110669420","https://openalex.org/W2119021669","https://openalex.org/W2130726893","https://openalex.org/W2133188546","https://openalex.org/W2134613265","https://openalex.org/W2143338978","https://openalex.org/W2147767173","https://openalex.org/W2147864699","https://openalex.org/W2155476557","https://openalex.org/W2220219545","https://openalex.org/W4240149198"],"related_works":["https://openalex.org/W2157360610","https://openalex.org/W3022742571","https://openalex.org/W2151774608","https://openalex.org/W4412538858","https://openalex.org/W3118665513","https://openalex.org/W7166729257","https://openalex.org/W2061440472","https://openalex.org/W4212953100","https://openalex.org/W2765947792","https://openalex.org/W2140186645"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Epidemiological":[1],"studies":[2,251],"suggest":[3,224],"that":[4,225],"complex":[5,30,55,183],"mental":[6,31,56,184,239],"activity":[7,32,57,185,240],"may":[8,231],"reduce":[9],"the":[10,61,112,134,150,187,236],"risk":[11],"for":[12],"dementia,":[13],"however":[14],"an":[15],"underlying":[16,235],"mechanism":[17,234],"remains":[18],"unclear.":[19],"Our":[20,222],"objective":[21],"was":[22,189],"to":[23,35,254],"determine":[24],"whether":[25],"individual":[26],"differences":[27,206],"in":[28,158,173,207,227,247],"lifespan":[29,188],"are":[33,252],"linked":[34],"altered":[36],"rates":[37,243],"of":[38,42,45,63,83,109,154,175,182,195,215,244],"hippocampal":[39,106,131,151,196],"atrophy":[40,132],"independent":[41,108],"global":[43],"measures":[44,174],"neurodegeneration.":[46],"METHODS:":[47],"Thirty":[48],"seven":[49],"healthy":[50],"older":[51],"individuals":[52,145,157],"had":[53,146],"their":[54],"levels":[58],"estimated":[59],"using":[60],"Lifetime":[62],"Experiences":[64],"Questionnaire":[65],"(LEQ)":[66],"and":[67,74,80,88,177,241],"completed":[68],"serial":[69],"MRI":[70],"investigations":[71],"at":[72,95,111,212],"baseline":[73],"three":[75,113],"years":[76],"follow-up.":[77],"Hippocampal":[78],"volume":[79,86,107,152],"semi-automatic":[81],"quantitation":[82],"whole":[84],"brain":[85],"(WBV)":[87],"white":[89],"matter":[90],"hyperintensities":[91],"(WMHs)":[92],"were":[93,103,171],"compared":[94],"both":[96],"time":[97],"points.":[98],"RESULTS:":[99],"Higher":[100],"LEQ":[101,127,144,156],"scores":[102,128],"correlated":[104,190],"with":[105,125,191],"covariates":[110],"year":[114],"follow-up":[115,135],"stage":[116],"(r":[117,137],"=":[118,121,138,141,163,166],"0.43,":[119],"p":[120,140,165],"0.012).":[122],"Moreover,":[123],"those":[124],"higher":[126],"experienced":[129],"less":[130,147],"over":[133],"period":[136],"0.41,":[139],"0.02).":[142],"High":[143,180],"than":[148],"half":[149],"decline":[153],"low":[155,220],"a":[159,192],"multivariate":[160],"analysis":[161],"(F":[162],"4.47,":[164],"0.042).":[167],"No":[168],"parallel":[169],"changes":[170],"found":[172],"WBV":[176],"WMHs.":[178],"CONCLUSIONS:":[179],"level":[181],"across":[186],"reduced":[193],"rate":[194],"atrophy.":[197],"This":[198],"finding":[199],"could":[200],"not":[201],"be":[202,232],"explained":[203],"by":[204],"general":[205],"intracranial":[208],"volume,":[209],"larger":[210],"hippocampi":[211],"baseline,":[213],"presence":[214],"hypertensive":[216],"disease,":[217],"gender":[218],"or":[219],"mood.":[221],"results":[223],"neuroprotection":[226],"medial":[228],"temporal":[229],"lobe":[230],"one":[233],"link":[237],"between":[238],"lower":[242],"dementia":[245],"observed":[246],"population-based":[248],"studies.":[249],"Additional":[250],"required":[253],"further":[255],"explore":[256],"this":[257],"novel":[258],"finding.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":26},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":24},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}