{"id":"https://openalex.org/W1965645696","doi":"https://doi.org/10.1080/00498250802509448","title":"Characterization of human cytochrome P450 enzymes involved in the biotransformation of eperisone","display_name":"Characterization of human cytochrome P450 enzymes involved in the biotransformation of eperisone","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W1965645696","doi":"https://doi.org/10.1080/00498250802509448","mag":"1965645696","pmid":"https://pubmed.ncbi.nlm.nih.gov/19219743"},"language":"en","primary_location":{"id":"doi:10.1080/00498250802509448","doi":"https://doi.org/10.1080/00498250802509448","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00498250802509448","pdf_url":null,"source":{"id":"https://openalex.org/S48760969","display_name":"Xenobiotica","issn_l":"0049-8254","issn":["0049-8254","1366-5928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xenobiotica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068541222","display_name":"Hye Hyun Yoo","orcid":"https://orcid.org/0000-0001-8282-852X","observed_orcids":["https://orcid.org/0000-0001-8282-852X"]},"institutions":[{"id":"https://openalex.org/I58716616","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883","country_code":"KR","type":"facility","lineage":["https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I58716616"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"H. H. Yoo","raw_affiliation_strings":["Korea Institute of Science and Technology (KIST), Doping Control Center, Seoul, Korea. behappy@kist.re.kr","Doping Control Center, Korea Institute of Science and Technology (KIST), Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korea Institute of Science and Technology (KIST), Doping Control Center, Seoul, Korea. behappy@kist.re.kr","institution_ids":["https://openalex.org/I58716616"]},{"raw_affiliation_string":"Doping Control Center, Korea Institute of Science and Technology (KIST), Seoul, Korea","institution_ids":["https://openalex.org/I58716616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079300296","display_name":"Nak-Seo KIM","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118406505","display_name":"Ministry of Food and Drug Safety","ror":"https://ror.org/01f7dp456","country_code":"KR","type":"government","lineage":["https://openalex.org/I118406505"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"N. S. Kim","raw_affiliation_strings":["Research Planning and Management Team, Korea Food & Drug Administration, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Planning and Management Team, Korea Food & Drug Administration, Seoul, Korea","institution_ids":["https://openalex.org/I118406505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000788344","display_name":"J. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58716616","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883","country_code":"KR","type":"facility","lineage":["https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I58716616"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"J. Lee","raw_affiliation_strings":["Doping Control Center, Korea Institute of Science and Technology (KIST), Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doping Control Center, Korea Institute of Science and Technology (KIST), Seoul, Korea","institution_ids":["https://openalex.org/I58716616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111520644","display_name":"Dong\u2010Ryul Sohn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24541011","display_name":"Soonchunhyang University","ror":"https://ror.org/03qjsrb10","country_code":"KR","type":"education","lineage":["https://openalex.org/I24541011"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"D. R. Sohn","raw_affiliation_strings":["Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University, Chonan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University, Chonan, Korea","institution_ids":["https://openalex.org/I24541011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031956506","display_name":"Changbae Jin","orcid":"https://orcid.org/0000-0002-4783-7671","observed_orcids":["https://orcid.org/0000-0002-4783-7671"]},"institutions":[{"id":"https://openalex.org/I58716616","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883","country_code":"KR","type":"facility","lineage":["https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I58716616"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"C. Jin","raw_affiliation_strings":["Doping Control Center, Korea Institute of Science and Technology (KIST), Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doping Control Center, Korea Institute of Science and Technology (KIST), Seoul, Korea","institution_ids":["https://openalex.org/I58716616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100454659","display_name":"Dong\u2010Hyun Kim","orcid":"https://orcid.org/0000-0001-9807-4064","observed_orcids":["https://orcid.org/0000-0001-9807-4064","https://orcid.org/0000-0001-5778-1264","https://orcid.org/0000-0002-6675-8872"]},"institutions":[{"id":"https://openalex.org/I58716616","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883","country_code":"KR","type":"facility","lineage":["https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I58716616"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"D. H. Kim","raw_affiliation_strings":["Doping Control Center, Korea Institute of Science and Technology (KIST), Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doping Control Center, Korea Institute of Science and Technology (KIST), Seoul, Korea","institution_ids":["https://openalex.org/I58716616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5068541222"],"corresponding_institution_ids":["https://openalex.org/I58716616"],"apc_list":null,"apc_paid":null,"fwci":0.7942,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.67227524,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"39","issue":"1","first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eperisone","display_name":"eperisone","score":1.0},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9100000262260437},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.8389999866485596},{"id":"https://openalex.org/keywords/cyp2j2","display_name":"CYP2J2","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":1.0},{"id":"https://openalex.org/keywords/stereoselectivity","display_name":"stereoselectivity","score":0.843999981880188},{"id":"https://openalex.org/keywords/hydroxylation","display_name":"hydroxylation","score":0.6489999890327454},{"id":"https://openalex.org/keywords/first-pass-metabolism","display_name":"first-pass metabolism","score":0.703000009059906},{"id":"https://openalex.org/keywords/intestinal-microsomes","display_name":"intestinal microsomes","score":0.9079999923706055},{"id":"https://openalex.org/keywords/liver-microsomes","display_name":"liver microsomes","score":0.8169999718666077},{"id":"https://openalex.org/keywords/muscle-relaxants","display_name":"muscle relaxants","score":0.7179999947547913},{"id":"https://openalex.org/keywords/metabolite-formation","display_name":"metabolite production","score":0.38499999046325684}],"concepts":[{"id":"https://openalex.org/C27881333","wikidata":"https://www.wikidata.org/wiki/Q864895","display_name":"Biotransformation","level":3,"score":0.918562114238739},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.7510712146759033},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.67064368724823},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.5163792371749878},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5028590559959412},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43541523814201355},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3371490240097046}],"mesh":[{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009125","descriptor_name":"Muscle Relaxants, Central","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009125","descriptor_name":"Muscle Relaxants, Central","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011427","descriptor_name":"Propiophenones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011427","descriptor_name":"Propiophenones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1080/00498250802509448","doi":"https://doi.org/10.1080/00498250802509448","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00498250802509448","pdf_url":null,"source":{"id":"https://openalex.org/S48760969","display_name":"Xenobiotica","issn_l":"0049-8254","issn":["0049-8254","1366-5928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xenobiotica","raw_type":"journal-article"},{"id":"pmid:19219743","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19219743","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xenobiotica; the fate of foreign compounds in biological systems","raw_type":"Journal Article"},{"id":"mag:2925681674","doi":null,"is_oa":false,"landing_page_url":"http://pubs.kist.re.kr/handle/201004/35270","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1531758039","https://openalex.org/W1976421128","https://openalex.org/W1981030128","https://openalex.org/W1986032362","https://openalex.org/W2024930705","https://openalex.org/W2111668019","https://openalex.org/W2111769481","https://openalex.org/W2123139119","https://openalex.org/W2144121527","https://openalex.org/W2439427934","https://openalex.org/W2515299170"],"related_works":["https://openalex.org/W2008451643","https://openalex.org/W2150393939","https://openalex.org/W1999876705","https://openalex.org/W1812103036","https://openalex.org/W1531758039","https://openalex.org/W1987729791","https://openalex.org/W2153492950","https://openalex.org/W2156031983","https://openalex.org/W4317888363","https://openalex.org/W2157627568"],"abstract_inverted_index":{"Eperisone":[0,47],"is":[1],"a":[2],"centrally":[3],"acting":[4],"muscle":[5,18],"relaxant":[6],"widely":[7],"used":[8],"for":[9,95],"the":[10,31,36],"therapeutic":[11],"treatment":[12],"of":[13,25,38,98,149],"spastic":[14],"patients":[15],"to":[16,29,50,69,132,144,146],"relieve":[17],"stiffness":[19],"and":[20,55,65,84,108,134,138],"back":[21],"pain.":[22],"The":[23,79],"objective":[24],"this":[26],"study":[27,81],"was":[28,48],"characterize":[30],"metabolic":[32,96],"pathway":[33],"involved":[34,116],"in":[35,58,117,123],"biotransformation":[37],"eperisone":[39,131],"mediated":[40],"by":[41,77],"human":[42,59],"cytochrome":[43],"P450":[44],"(CYP)":[45],"enzymes.":[46],"metabolized":[49,130],"seven":[51],"metabolites":[52,73],"via":[53,136],"oxidation":[54],"carbonyl":[56],"reduction":[57],"liver":[60],"microsome.":[61],"Among":[62],"them,":[63],"M3":[64,124,133],"M4":[66,118,135],"were":[67,75,115],"found":[68],"be":[70],"primary":[71],"major":[72],"which":[74,141],"generated":[76],"CYPs.":[78],"kinetics":[80],"with":[82,101],"(-)-R-":[83],"(+)-S-eperisones":[85],"revealed":[86],"that":[87,112],"CYPs-mediated":[88],"hydroxylation":[89],"did":[90],"not":[91],"have":[92],"significant":[93],"stereoselectivity":[94],"clearance":[97],"eperisone.":[99,150],"Incubation":[100],"recombinant":[102],"CYP":[103],"isozyme,":[104],"chemical":[105],"inhibition":[106],"assay,":[107],"immuno-inhibition":[109],"assay":[110],"showed":[111],"multiple":[113],"CYPs":[114],"formation,":[119],"but":[120],"mainly":[121],"CYP2J2":[122],"formation.":[125],"In":[126],"addition,":[127],"intestinal":[128],"microsomes":[129],"CYP2J2-":[137],"CYP3A4-mediated":[139],"reactions,":[140],"are":[142],"supposed":[143],"contribute":[145],"presystemic":[147],"metabolism":[148]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}