{"id":"https://openalex.org/W1965626425","doi":"https://doi.org/10.1517/14656566.4.12.2193","title":"Cyclooxygenase inhibition in cancer prevention and treatment","display_name":"Cyclooxygenase inhibition in cancer prevention and treatment","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W1965626425","doi":"https://doi.org/10.1517/14656566.4.12.2193","mag":"1965626425","pmid":"https://pubmed.ncbi.nlm.nih.gov/14640918"},"language":"en","primary_location":{"id":"doi:10.1517/14656566.4.12.2193","doi":"https://doi.org/10.1517/14656566.4.12.2193","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14656566.4.12.2193","pdf_url":null,"source":{"id":"https://openalex.org/S52020611","display_name":"Expert Opinion on Pharmacotherapy","issn_l":"1465-6566","issn":["1465-6566","1744-7666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015096957","display_name":"William F. Anderson","orcid":"https://orcid.org/0000-0002-7888-9642","observed_orcids":["https://orcid.org/0000-0002-7888-9642"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William F Anderson","raw_affiliation_strings":["Gastrointestinal & Other Cancers Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, EPN, Room 2141, 6130 Executive Boulevard, Bethesda, MD 20892-7317, USA","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal & Other Cancers Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, EPN, Room 2141, 6130 Executive Boulevard, Bethesda, MD 20892-7317, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008765045","display_name":"Asad Umar","orcid":"https://orcid.org/0000-0002-6239-8494","observed_orcids":["https://orcid.org/0000-0002-6239-8494"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asad Umar","raw_affiliation_strings":["Gastrointestinal & Other Cancers Research Group, National Cancer Institute, Division of Cancer Prevention, EPN, Room 2141, 6130 Executive Boulevard, Bethesda, MD 20892-7317, USA. eh51p@nih.gov"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal & Other Cancers Research Group, National Cancer Institute, Division of Cancer Prevention, EPN, Room 2141, 6130 Executive Boulevard, Bethesda, MD 20892-7317, USA. eh51p@nih.gov","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015008352","display_name":"Ernest T. Hawk","orcid":"https://orcid.org/0000-0002-9062-7338","observed_orcids":["https://orcid.org/0000-0002-9062-7338"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ernest T Hawk","raw_affiliation_strings":["Gastrointestinal & Other Cancers Research Group, National Cancer Institute, Division of Cancer Prevention, EPN, Room 2141, 6130 Executive Boulevard, Bethesda, MD 20892-7317, USA. eh51p@nih.gov","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal & Other Cancers Research Group, National Cancer Institute, Division of Cancer Prevention, EPN, Room 2141, 6130 Executive Boulevard, Bethesda, MD 20892-7317, USA. eh51p@nih.gov","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.312,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.30424528,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"4","issue":"12","first_page":"2193","last_page":"2204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9039999842643738},{"id":"https://openalex.org/keywords/cox-2-inhibitors","display_name":"COX-2 inhibitors","score":0.7860000133514404},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cox-2-selective-inhibitors","display_name":"COX-2 selective inhibitors","score":0.8539999723434448},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.6520000100135803},{"id":"https://openalex.org/keywords/tumor-initiation","display_name":"tumor initiation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/tumor-promotion","display_name":"tumor promotion","score":0.9879999756813049},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9039999842643738},{"id":"https://openalex.org/keywords/pharmacoeconomics","display_name":"pharmacoeconomics","score":0.9660000205039978},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.9169999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.889742910861969},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.6993207931518555},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6388429403305054},{"id":"https://openalex.org/C2780234812","wikidata":"https://www.wikidata.org/wiki/Q1787013","display_name":"Cancer prevention","level":3,"score":0.5773096680641174},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.5402791500091553},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5143729448318481},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3752520680427551},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3692570924758911},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36243993043899536},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.255888432264328},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.07109835743904114},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052246","descriptor_name":"Cyclooxygenase 2 Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1517/14656566.4.12.2193","doi":"https://doi.org/10.1517/14656566.4.12.2193","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14656566.4.12.2193","pdf_url":null,"source":{"id":"https://openalex.org/S52020611","display_name":"Expert Opinion on Pharmacotherapy","issn_l":"1465-6566","issn":["1465-6566","1744-7666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Pharmacotherapy","raw_type":"journal-article"},{"id":"doi:10.1517/eoph.4.12.2193.22425","doi":"https://doi.org/10.1517/eoph.4.12.2193.22425","is_oa":false,"landing_page_url":"https://doi.org/10.1517/eoph.4.12.2193.22425","pdf_url":null,"source":{"id":"https://openalex.org/S52020611","display_name":"Expert Opinion on Pharmacotherapy","issn_l":"1465-6566","issn":["1465-6566","1744-7666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:14640918","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14640918","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on pharmacotherapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":106,"referenced_works":["https://openalex.org/W155792476","https://openalex.org/W165834514","https://openalex.org/W179667441","https://openalex.org/W1482218984","https://openalex.org/W1490261790","https://openalex.org/W1514189093","https://openalex.org/W1516374185","https://openalex.org/W1552442738","https://openalex.org/W1554678066","https://openalex.org/W1596781203","https://openalex.org/W1597643123","https://openalex.org/W1606022491","https://openalex.org/W1606885912","https://openalex.org/W1633918478","https://openalex.org/W1783009344","https://openalex.org/W1815431626","https://openalex.org/W1903126779","https://openalex.org/W1970700328","https://openalex.org/W1971370481","https://openalex.org/W1975076018","https://openalex.org/W1975993620","https://openalex.org/W1976516830","https://openalex.org/W1981816788","https://openalex.org/W1988548909","https://openalex.org/W1990084553","https://openalex.org/W1990606472","https://openalex.org/W1991106719","https://openalex.org/W1992752027","https://openalex.org/W1994183468","https://openalex.org/W1995903736","https://openalex.org/W1996188779","https://openalex.org/W2002876988","https://openalex.org/W2003518242","https://openalex.org/W2007014392","https://openalex.org/W2007796985","https://openalex.org/W2009093593","https://openalex.org/W2009623805","https://openalex.org/W2017370410","https://openalex.org/W2024233889","https://openalex.org/W2035768602","https://openalex.org/W2041140906","https://openalex.org/W2043707891","https://openalex.org/W2049279480","https://openalex.org/W2051336007","https://openalex.org/W2051686420","https://openalex.org/W2053230224","https://openalex.org/W2053461052","https://openalex.org/W2056271391","https://openalex.org/W2056820936","https://openalex.org/W2057830803","https://openalex.org/W2058118671","https://openalex.org/W2059813946","https://openalex.org/W2062335942","https://openalex.org/W2067346046","https://openalex.org/W2070386840","https://openalex.org/W2073738021","https://openalex.org/W2075039358","https://openalex.org/W2076092023","https://openalex.org/W2077257239","https://openalex.org/W2079344363","https://openalex.org/W2082410314","https://openalex.org/W2083256941","https://openalex.org/W2085316933","https://openalex.org/W2095495320","https://openalex.org/W2096410299","https://openalex.org/W2097903769","https://openalex.org/W2100822604","https://openalex.org/W2105978932","https://openalex.org/W2106293055","https://openalex.org/W2109549744","https://openalex.org/W2114237338","https://openalex.org/W2114537688","https://openalex.org/W2115522061","https://openalex.org/W2116471973","https://openalex.org/W2117580825","https://openalex.org/W2119214221","https://openalex.org/W2119504955","https://openalex.org/W2120226344","https://openalex.org/W2127558096","https://openalex.org/W2134815136","https://openalex.org/W2135374295","https://openalex.org/W2138533953","https://openalex.org/W2140842285","https://openalex.org/W2145149010","https://openalex.org/W2146708145","https://openalex.org/W2150484958","https://openalex.org/W2150966393","https://openalex.org/W2152016833","https://openalex.org/W2157782064","https://openalex.org/W2158256320","https://openalex.org/W2160292264","https://openalex.org/W2162230360","https://openalex.org/W2163756514","https://openalex.org/W2171680338","https://openalex.org/W2247504452","https://openalex.org/W2263192284","https://openalex.org/W2314805921","https://openalex.org/W2316386966","https://openalex.org/W2330496155","https://openalex.org/W2336169581","https://openalex.org/W2362630236","https://openalex.org/W2424257540","https://openalex.org/W2505820266","https://openalex.org/W2626800913","https://openalex.org/W4211149743","https://openalex.org/W4239021161"],"related_works":["https://openalex.org/W428115674","https://openalex.org/W2152216448","https://openalex.org/W2123274778","https://openalex.org/W1975601342","https://openalex.org/W2157878113","https://openalex.org/W2158842383","https://openalex.org/W2030765289","https://openalex.org/W2281233856","https://openalex.org/W1977535902","https://openalex.org/W2068442010"],"abstract_inverted_index":{"Several":[0],"lines":[1],"of":[2,20,28,67,92,106],"evidence":[3],"suggest":[4],"that":[5,100],"the":[6,18,65,89,104],"cyclooxygenase":[7],"enzymes":[8],"(specifically":[9],"COX-2)":[10],"might":[11],"be":[12,109],"an":[13,32],"important":[14],"molecular":[15],"target":[16],"for":[17,34],"intervention":[19],"cancer":[21,36],"at":[22],"both":[23,35,52],"early":[24],"and":[25,38,45,55,57,80,94,97],"late":[26],"stages":[27],"some":[29],"cancers,":[30],"providing":[31],"opportunity":[33],"prevention":[37],"therapy.":[39],"COX-2":[40,75,81],"is":[41,58],"overexpressed":[42],"during":[43],"carcinogenesis,":[44],"appears":[46],"to":[47,60],"have":[48,101],"a":[49],"role":[50],"in":[51],"tumour":[53],"initiation":[54],"promotion":[56],"amenable":[59],"intervention.":[61],"This":[62],"review":[63],"discusses":[64],"importance":[66],"COX":[68,77],"modulation":[69],"via":[70],"non-specific,":[71],"as":[72,74],"well":[73],"specific":[76],"inhibitors":[78,83],"(NSAIDs":[79],"selective":[82],"[COXIB]).":[84],"A":[85],"brief":[86],"discussion":[87],"on":[88],"pharmacoeconomic":[90],"considerations":[91],"NSAID":[93],"COXIB":[95],"use":[96],"safety":[98],"issues":[99],"recently":[102],"been":[103],"focus":[105],"debate,":[107],"will":[108],"presented.":[110]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
