{"id":"https://openalex.org/W1965607359","doi":"https://doi.org/10.1111/j.1749-6632.2002.tb02804.x","title":"Extraocular Muscle: Cellular Adaptations for a Diverse Functional Repertoire","display_name":"Extraocular Muscle: Cellular Adaptations for a Diverse Functional Repertoire","publication_year":2002,"publication_date":"2002-04-01","ids":{"openalex":"https://openalex.org/W1965607359","doi":"https://doi.org/10.1111/j.1749-6632.2002.tb02804.x","mag":"1965607359","pmid":"https://pubmed.ncbi.nlm.nih.gov/11960789"},"language":"en","primary_location":{"id":"doi:10.1111/j.1749-6632.2002.tb02804.x","doi":"https://doi.org/10.1111/j.1749-6632.2002.tb02804.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.2002.tb02804.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090301579","display_name":"John D. Porter","orcid":"https://orcid.org/0000-0001-6724-6409","observed_orcids":["https://orcid.org/0000-0001-6724-6409"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"JOHN D. PORTER","raw_affiliation_strings":["Department of Ophthalmology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, Cleveland, Ohio 44106-5068, USA. jdp7@po.cwru.edu","Departments of Ophthalmology, Neurology, and Neurosciences, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, Cleveland, Ohio 44106\u20105068, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, Cleveland, Ohio 44106-5068, USA. jdp7@po.cwru.edu","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I58956616"]},{"raw_affiliation_string":"Departments of Ophthalmology, Neurology, and Neurosciences, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, Cleveland, Ohio 44106\u20105068, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5090301579"],"corresponding_institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I58956616"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":0.2893,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.27243995,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"956","issue":"1","first_page":"7","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11538","display_name":"Ophthalmology and Eye Disorders","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10784","display_name":"Muscle activation and electromyography studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extraocular-muscles","display_name":"extraocular muscles","score":0.9950000047683716},{"id":"https://openalex.org/keywords/oculomotor-control","display_name":"oculomotor control","score":0.625},{"id":"https://openalex.org/keywords/muscle-innervation","display_name":"muscle innervation","score":0.6110000014305115},{"id":"https://openalex.org/keywords/contractile-proteins","display_name":"contractile proteins","score":0.9129999876022339},{"id":"https://openalex.org/keywords/muscle-fiber-type","display_name":"muscle fiber type","score":0.7440000176429749},{"id":"https://openalex.org/keywords/rectus-muscles","display_name":"rectus muscles","score":0.7749999761581421},{"id":"https://openalex.org/keywords/oblique-muscles","display_name":"oblique muscles","score":1.0},{"id":"https://openalex.org/keywords/neuromuscular-disorders","display_name":"neuromuscular disorders","score":0.9340000152587891},{"id":"https://openalex.org/keywords/endocrine-disorders","display_name":"endocrine disorders","score":0.9549999833106995},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.9020000100135803},{"id":"https://openalex.org/keywords/skeletal-muscle-adaptation","display_name":"skeletal muscle adaptation","score":0.5070000290870667},{"id":"https://openalex.org/keywords/visuomotor-system","display_name":"visuomotor system","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C2776807875","wikidata":"https://www.wikidata.org/wiki/Q533979","display_name":"Extraocular muscles","level":2,"score":0.9688204526901245},{"id":"https://openalex.org/C52679818","wikidata":"https://www.wikidata.org/wiki/Q674407","display_name":"Myology","level":2,"score":0.7381676435470581},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6560660600662231},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6454244256019592},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.49566805362701416},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4614805579185486},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4581654667854309},{"id":"https://openalex.org/C153050134","wikidata":"https://www.wikidata.org/wiki/Q760256","display_name":"Eye movement","level":2,"score":0.4218590557575226},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2118997871875763},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.150231271982193}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009801","descriptor_name":"Oculomotor Muscles","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D009801","descriptor_name":"Oculomotor Muscles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1749-6632.2002.tb02804.x","doi":"https://doi.org/10.1111/j.1749-6632.2002.tb02804.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.2002.tb02804.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:11960789","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11960789","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1068103557","display_name":"CELL AMD MOLECULAR DIVERSITY OF EXTRAOCULAR MUSCLE","funder_award_id":"5r01ey009834-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1985086712","display_name":null,"funder_award_id":"EY12779","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G3818152535","display_name":null,"funder_award_id":"EY-09834","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G870117396","display_name":"SARCOLEMMAL ORGANIZATION OF EXTRACULAR MUSCLE","funder_award_id":"R01EY012779","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000887781","display_name":"CWRU NEI Vision Center Core Grant","funder_award_id":"P30EY011373","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W72937681","https://openalex.org/W124228646","https://openalex.org/W1550119477","https://openalex.org/W1570894851","https://openalex.org/W1590760590","https://openalex.org/W1600355634","https://openalex.org/W1634992353","https://openalex.org/W1834051471","https://openalex.org/W1968669317","https://openalex.org/W1972515162","https://openalex.org/W1976484430","https://openalex.org/W1977317296","https://openalex.org/W1988306677","https://openalex.org/W1988792743","https://openalex.org/W2000083624","https://openalex.org/W2010525997","https://openalex.org/W2019378998","https://openalex.org/W2028457094","https://openalex.org/W2060575360","https://openalex.org/W2064268092","https://openalex.org/W2071947207","https://openalex.org/W2089653703","https://openalex.org/W2094115573","https://openalex.org/W2097737847","https://openalex.org/W2109372489","https://openalex.org/W2138321124","https://openalex.org/W2139606081","https://openalex.org/W2145751901","https://openalex.org/W2151408385","https://openalex.org/W2155918643","https://openalex.org/W2176236028","https://openalex.org/W2183870014","https://openalex.org/W2416142200","https://openalex.org/W4252652290"],"related_works":["https://openalex.org/W1486113765","https://openalex.org/W1988792743","https://openalex.org/W3098491324","https://openalex.org/W2139606081","https://openalex.org/W4406568933","https://openalex.org/W1181851249","https://openalex.org/W169804619","https://openalex.org/W3200627397","https://openalex.org/W4396617823","https://openalex.org/W36253452"],"abstract_inverted_index":{"Oculomotor":[0],"control":[1],"systems":[2],"are":[3,10,18,138,155],"considerably":[4],"more":[5,77],"complex":[6],"and":[7,94,100,110,118,127],"diverse":[8],"than":[9],"spinal":[11],"skeletomotor":[12],"systems.":[13,186],"Moreover,":[14],"individual":[15],"skeletal":[16,79,160,178],"muscles":[17,25,42,124,154],"frequently":[19],"functional":[20,49,95],"role-specific,":[21],"while":[22],"all":[23],"extraocular":[24,41,69,106,153],"operate":[26],"across":[27],"a":[28,44],"very":[29],"wide":[30],"dynamic":[31],"range.":[32],"We":[33],"contend":[34],"that":[35,72,151,170],"the":[36,40,48,57,82,98,114,119,149,152,172,182],"novel":[37,84,115,163],"phenotype":[38,117,166],"of":[39,47,68,97,105,122,175,184],"is":[43],"direct":[45],"consequence":[46],"demands":[50],"imposed":[51],"upon":[52],"this":[53],"muscle":[54,70,107,116,165,179],"group":[55],"by":[56],"central":[58],"eye":[59,164],"movement":[60],"controllers.":[61],"This":[62,162],"review":[63],"highlights":[64],"five":[65],"basic":[66],"themes":[67],"biology":[71],"set":[73],"them":[74],"apart":[75],"from":[76,133,158],"typical":[78],"muscles,":[80,102],"specifically,":[81],"(a)":[83],"innervation":[85],"pattern,":[86],"(b)":[87],"heterogeneity":[88],"in":[89,125,177],"contractile":[90],"proteins,":[91],"(c)":[92],"structural":[93],"compartmentalization":[96],"rectus":[99],"oblique":[101],"(d)":[103],"diversity":[104],"fiber":[108],"types,":[109],"(e)":[111],"relationship":[112],"between":[113],"differential":[120],"response":[121],"these":[123],"neuromuscular":[126],"endocrine":[128],"disease.":[129],"Finally,":[130],"new":[131],"data":[132],"broad":[134],"genome-wide":[135],"profiling":[136],"studies":[137],"reviewed,":[139],"with":[140],"global":[141],"gene":[142],"expression":[143],"patterns":[144],"lending":[145],"substantial":[146],"support":[147],"to":[148,180],"notion":[150],"fundamentally":[156],"different":[157],"traditional":[159],"muscle.":[161],"represents":[167],"an":[168],"adaptation":[169],"exploits":[171],"full":[173],"range":[174],"variability":[176],"meet":[181],"needs":[183],"visuomotor":[185]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}