{"id":"https://openalex.org/W1965606609","doi":"https://doi.org/10.1016/j.ygeno.2003.12.013","title":"Individual-specific variation of gene expression in peripheral blood leukocytes","display_name":"Individual-specific variation of gene expression in peripheral blood leukocytes","publication_year":2004,"publication_date":"2004-03-25","ids":{"openalex":"https://openalex.org/W1965606609","doi":"https://doi.org/10.1016/j.ygeno.2003.12.013","mag":"1965606609","pmid":"https://pubmed.ncbi.nlm.nih.gov/15177552"},"language":"en","primary_location":{"id":"doi:10.1016/j.ygeno.2003.12.013","doi":"https://doi.org/10.1016/j.ygeno.2003.12.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ygeno.2003.12.013","pdf_url":null,"source":{"id":"https://openalex.org/S146035217","display_name":"Genomics","issn_l":"0888-7543","issn":["0888-7543","1089-8646"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089541690","display_name":"Jerald P. Radich","orcid":"https://orcid.org/0000-0002-1618-230X","observed_orcids":["https://orcid.org/0000-0002-1618-230X"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jerald P. Radich","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D4-100, Seattle, WA 98109, USA. jradich@fhcrc.org","Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D4-100, Seattle, WA 98109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D4-100, Seattle, WA 98109, USA. jradich@fhcrc.org","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D4-100, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016460624","display_name":"Mao Mao","orcid":"https://orcid.org/0000-0003-1524-8853","observed_orcids":["https://orcid.org/0000-0003-1524-8853"]},"institutions":[{"id":"https://openalex.org/I4210155296","display_name":"Pfizer (Canada)","ror":"https://ror.org/059g90c15","country_code":"CA","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4210155296"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mao Mao","raw_affiliation_strings":["Rosetta Inpharmatics, Kirkland, WA 98034, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rosetta Inpharmatics, Kirkland, WA 98034, USA","institution_ids":["https://openalex.org/I4210155296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110062132","display_name":"Sergey B. Stepaniants","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155296","display_name":"Pfizer (Canada)","ror":"https://ror.org/059g90c15","country_code":"CA","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4210155296"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sergey Stepaniants","raw_affiliation_strings":["Rosetta Inpharmatics, Kirkland, WA 98034, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rosetta Inpharmatics, Kirkland, WA 98034, USA","institution_ids":["https://openalex.org/I4210155296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089680890","display_name":"Matthew C. Biery","orcid":"https://orcid.org/0000-0001-6152-3604","observed_orcids":["https://orcid.org/0000-0001-6152-3604"]},"institutions":[{"id":"https://openalex.org/I4210155296","display_name":"Pfizer (Canada)","ror":"https://ror.org/059g90c15","country_code":"CA","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4210155296"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Matt Biery","raw_affiliation_strings":["Rosetta Inpharmatics, Kirkland, WA 98034, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rosetta Inpharmatics, Kirkland, WA 98034, USA","institution_ids":["https://openalex.org/I4210155296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079846160","display_name":"John C. Castle","orcid":"https://orcid.org/0000-0001-8697-8955","observed_orcids":["https://orcid.org/0000-0001-8697-8955"]},"institutions":[{"id":"https://openalex.org/I4210155296","display_name":"Pfizer (Canada)","ror":"https://ror.org/059g90c15","country_code":"CA","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4210155296"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John Castle","raw_affiliation_strings":["Rosetta Inpharmatics, Kirkland, WA 98034, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rosetta Inpharmatics, Kirkland, WA 98034, USA","institution_ids":["https://openalex.org/I4210155296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012015235","display_name":"Terry Ward","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155296","display_name":"Pfizer (Canada)","ror":"https://ror.org/059g90c15","country_code":"CA","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4210155296"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Terry Ward","raw_affiliation_strings":["Rosetta Inpharmatics, Kirkland, WA 98034, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rosetta Inpharmatics, Kirkland, WA 98034, USA","institution_ids":["https://openalex.org/I4210155296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001694275","display_name":"Greg Schimmack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155296","display_name":"Pfizer (Canada)","ror":"https://ror.org/059g90c15","country_code":"CA","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4210155296"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Greg Schimmack","raw_affiliation_strings":["Rosetta Inpharmatics, Kirkland, WA 98034, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rosetta Inpharmatics, Kirkland, WA 98034, USA","institution_ids":["https://openalex.org/I4210155296"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sumire Kobayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155296","display_name":"Pfizer (Canada)","ror":"https://ror.org/059g90c15","country_code":"CA","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4210155296"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sumire Kobayashi","raw_affiliation_strings":["Rosetta Inpharmatics, Kirkland, WA 98034, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rosetta Inpharmatics, Kirkland, WA 98034, USA","institution_ids":["https://openalex.org/I4210155296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110966892","display_name":"Michael O. Carleton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155296","display_name":"Pfizer (Canada)","ror":"https://ror.org/059g90c15","country_code":"CA","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4210155296"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael Carleton","raw_affiliation_strings":["Rosetta Inpharmatics, Kirkland, WA 98034, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rosetta Inpharmatics, Kirkland, WA 98034, USA","institution_ids":["https://openalex.org/I4210155296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019716896","display_name":"Johanna W. Lampe","orcid":"https://orcid.org/0000-0003-2717-3780","observed_orcids":["https://orcid.org/0000-0003-2717-3780"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Johanna Lampe","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D4-100, Seattle, WA 98109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D4-100, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062610230","display_name":"Peter S. Linsley","orcid":"https://orcid.org/0000-0002-8960-4307","observed_orcids":["https://orcid.org/0000-0002-8960-4307"]},"institutions":[{"id":"https://openalex.org/I4210155296","display_name":"Pfizer (Canada)","ror":"https://ror.org/059g90c15","country_code":"CA","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4210155296"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Peter S. Linsley","raw_affiliation_strings":["Rosetta Inpharmatics, Kirkland, WA 98034, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rosetta Inpharmatics, Kirkland, WA 98034, USA","institution_ids":["https://openalex.org/I4210155296"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5089541690"],"corresponding_institution_ids":["https://openalex.org/I4210089486"],"apc_list":{"value":2980,"currency":"USD","value_usd":2980},"apc_paid":null,"fwci":4.101,"has_fulltext":false,"cited_by_count":131,"citation_normalized_percentile":{"value":0.95610684,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"83","issue":"6","first_page":"980","last_page":"988"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peripheral-blood-leukocytes","display_name":"peripheral blood leukocytes","score":0.8769999742507935},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.4399999976158142},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.871999979019165},{"id":"https://openalex.org/keywords/interferon-stimulated-genes","display_name":"interferon-stimulated genes","score":0.7099999785423279},{"id":"https://openalex.org/keywords/interferon-stimulation","display_name":"interferon stimulation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/baseline-gene-expression","display_name":"baseline gene expression","score":0.7670000195503235},{"id":"https://openalex.org/keywords/gene-expression-stability","display_name":"gene expression stability","score":0.6470000147819519},{"id":"https://openalex.org/keywords/dna-microarrays","display_name":"DNA microarrays","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9024471044540405},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.7490795254707336},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.735777735710144},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.7259982228279114},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.6697314977645874},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5729166865348816},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5143548250198364},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4751403331756592},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4298953711986542},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42799222469329834},{"id":"https://openalex.org/C3017910909","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Peripheral blood","level":2,"score":0.42060586810112},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3240300416946411}],"mesh":[{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ygeno.2003.12.013","doi":"https://doi.org/10.1016/j.ygeno.2003.12.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ygeno.2003.12.013","pdf_url":null,"source":{"id":"https://openalex.org/S146035217","display_name":"Genomics","issn_l":"0888-7543","issn":["0888-7543","1089-8646"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics","raw_type":"journal-article"},{"id":"pmid:15177552","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15177552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G5950083314","display_name":"GENE EXPRESSION PROFILE OF PROGRESSION &RESPONSE IN CML","funder_award_id":"U01CA085053","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306155","display_name":"Cancer Research Institute","ror":"https://ror.org/02f3xk561"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1502936039","https://openalex.org/W1995142070","https://openalex.org/W2006924047","https://openalex.org/W2009444355","https://openalex.org/W2010098285","https://openalex.org/W2013956757","https://openalex.org/W2017154320","https://openalex.org/W2036895735","https://openalex.org/W2037104948","https://openalex.org/W2046629546","https://openalex.org/W2051673779","https://openalex.org/W2053382138","https://openalex.org/W2056933088","https://openalex.org/W2070015764","https://openalex.org/W2078899906","https://openalex.org/W2081552372","https://openalex.org/W2094393226","https://openalex.org/W2109363337","https://openalex.org/W2118308505","https://openalex.org/W2122797075","https://openalex.org/W2128985829","https://openalex.org/W2139683115","https://openalex.org/W2153729223","https://openalex.org/W2163178236","https://openalex.org/W2188961409","https://openalex.org/W6648932668"],"related_works":["https://openalex.org/W2056933088","https://openalex.org/W2114502253","https://openalex.org/W2063767448","https://openalex.org/W2150107459","https://openalex.org/W2112850104","https://openalex.org/W7221824112","https://openalex.org/W1963531361","https://openalex.org/W2000078898","https://openalex.org/W2784045201","https://openalex.org/W2088960792"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}