{"id":"https://openalex.org/W1965593148","doi":"https://doi.org/10.1073/pnas.0603533103","title":"Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly","display_name":"Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly","publication_year":2006,"publication_date":"2006-10-18","ids":{"openalex":"https://openalex.org/W1965593148","doi":"https://doi.org/10.1073/pnas.0603533103","mag":"1965593148","pmid":"https://pubmed.ncbi.nlm.nih.gov/17050694"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0603533103","doi":"https://doi.org/10.1073/pnas.0603533103","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.0603533103","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.0603533103","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.0603533103","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Lei Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Chen","raw_affiliation_strings":["*Divisions of Experimental Hematology and","Molecular and Developmental Biology Graduate Program, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Divisions of Experimental Hematology and","institution_ids":[]},{"raw_affiliation_string":"Molecular and Developmental Biology Graduate Program, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038242383","display_name":"Guanghong Liao","orcid":"https://orcid.org/0009-0003-6425-8043","observed_orcids":["https://orcid.org/0009-0003-6425-8043"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guanghong Liao","raw_affiliation_strings":["Developmental Biology, Cincinnati Children's Hospital Medical Center and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Biology, Cincinnati Children's Hospital Medical Center and","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014128074","display_name":"Linda C. Yang","orcid":"https://orcid.org/0000-0002-0922-9384","observed_orcids":["https://orcid.org/0000-0002-0922-9384"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda Yang","raw_affiliation_strings":["*Divisions of Experimental Hematology and","Molecular and Developmental Biology Graduate Program, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Divisions of Experimental Hematology and","institution_ids":[]},{"raw_affiliation_string":"Molecular and Developmental Biology Graduate Program, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056950349","display_name":"Kenneth Campbell","orcid":"https://orcid.org/0000-0001-5666-8008","observed_orcids":["https://orcid.org/0000-0001-5666-8008"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Campbell","raw_affiliation_strings":["Developmental Biology, Cincinnati Children's Hospital Medical Center and","Molecular and Developmental Biology Graduate Program, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Biology, Cincinnati Children's Hospital Medical Center and","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Molecular and Developmental Biology Graduate Program, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044896974","display_name":"Masato Nakafuku","orcid":"https://orcid.org/0000-0001-7783-9005","observed_orcids":["https://orcid.org/0000-0001-7783-9005"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masato Nakafuku","raw_affiliation_strings":["Developmental Biology, Cincinnati Children's Hospital Medical Center and","Molecular and Developmental Biology Graduate Program, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Biology, Cincinnati Children's Hospital Medical Center and","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Molecular and Developmental Biology Graduate Program, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103176152","display_name":"Chia-Yi Kuan","orcid":"https://orcid.org/0000-0002-3453-863X","observed_orcids":["https://orcid.org/0000-0002-3453-863X"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chia-Yi Kuan","raw_affiliation_strings":["Developmental Biology, Cincinnati Children's Hospital Medical Center and","Molecular and Developmental Biology Graduate Program, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Biology, Cincinnati Children's Hospital Medical Center and","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Molecular and Developmental Biology Graduate Program, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020584779","display_name":"Yi Zheng","orcid":"https://orcid.org/0000-0001-7089-6074","observed_orcids":["https://orcid.org/0000-0001-7089-6074"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yi Zheng","raw_affiliation_strings":["*Divisions of Experimental Hematology and","Molecular and Developmental Biology Graduate Program, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Divisions of Experimental Hematology and","institution_ids":[]},{"raw_affiliation_string":"Molecular and Developmental Biology Graduate Program, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5020584779","https://openalex.org/A5103176152"],"corresponding_institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"],"apc_list":null,"apc_paid":null,"fwci":2.5603,"has_fulltext":true,"cited_by_count":126,"citation_normalized_percentile":{"value":0.88300127,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"103","issue":"44","first_page":"16520","last_page":"16525"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12552","display_name":"Fetal and Pediatric Neurological Disorders","score":0.04360000044107437,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdc42","display_name":"Cdc42","score":1.0},{"id":"https://openalex.org/keywords/holoprosencephaly","display_name":"holoprosencephaly","score":0.996999979019165},{"id":"https://openalex.org/keywords/sonic-hedgehog","display_name":"Sonic hedgehog","score":0.7149999737739563},{"id":"https://openalex.org/keywords/apicobasal-polarity","display_name":"apical-basal polarity","score":0.9629999995231628},{"id":"https://openalex.org/keywords/neural-progenitor-cells","display_name":"neural progenitor cells","score":0.7630000114440918},{"id":"https://openalex.org/keywords/radial-glial-cells","display_name":"radial glia","score":0.8209999799728394},{"id":"https://openalex.org/keywords/cerebral-hemispheres","display_name":"cerebral hemispheres","score":0.7409999966621399},{"id":"https://openalex.org/keywords/par6","display_name":"Par6","score":0.6449999809265137},{"id":"https://openalex.org/keywords/atypical-protein-kinase-c","display_name":"atypical protein kinase C","score":0.9359999895095825},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9290000200271606},{"id":"https://openalex.org/keywords/numb","display_name":"Numb","score":0.9879999756813049},{"id":"https://openalex.org/keywords/adherens-junctions","display_name":"adherens junctions","score":0.7459999918937683},{"id":"https://openalex.org/keywords/dorsoventral-patterning","display_name":"dorsoventral patterning","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7482264041900635},{"id":"https://openalex.org/C533869091","wikidata":"https://www.wikidata.org/wiki/Q75855","display_name":"Cerebrum","level":3,"score":0.6941338181495667},{"id":"https://openalex.org/C200707615","wikidata":"https://www.wikidata.org/wiki/Q13652744","display_name":"Neuroepithelial cell","level":4,"score":0.5860886573791504},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5312390327453613},{"id":"https://openalex.org/C2776637008","wikidata":"https://www.wikidata.org/wiki/Q14860072","display_name":"Sonic hedgehog","level":3,"score":0.4775719940662384},{"id":"https://openalex.org/C2777222312","wikidata":"https://www.wikidata.org/wiki/Q726562","display_name":"Neocortex","level":2,"score":0.4770894944667816},{"id":"https://openalex.org/C2781374659","wikidata":"https://www.wikidata.org/wiki/Q1459821","display_name":"Holoprosencephaly","level":4,"score":0.46912145614624023},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4641064405441284},{"id":"https://openalex.org/C2780594696","wikidata":"https://www.wikidata.org/wiki/Q1127402","display_name":"Neural tube","level":3,"score":0.4524400234222412},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4388429820537567},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.2610638737678528},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.17811349034309387},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14813053607940674},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.11213478446006775},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.07783070206642151},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.06654700636863708},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016142","descriptor_name":"Holoprosencephaly","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D016142","descriptor_name":"Holoprosencephaly","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D016142","descriptor_name":"Holoprosencephaly","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D016142","descriptor_name":"Holoprosencephaly","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016142","descriptor_name":"Holoprosencephaly","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016142","descriptor_name":"Holoprosencephaly","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016142","descriptor_name":"Holoprosencephaly","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016142","descriptor_name":"Holoprosencephaly","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016142","descriptor_name":"Holoprosencephaly","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016142","descriptor_name":"Holoprosencephaly","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016142","descriptor_name":"Holoprosencephaly","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016142","descriptor_name":"Holoprosencephaly","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020764","descriptor_name":"cdc42 GTP-Binding Protein","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D020764","descriptor_name":"cdc42 GTP-Binding Protein","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D020764","descriptor_name":"cdc42 GTP-Binding Protein","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D020764","descriptor_name":"cdc42 GTP-Binding Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020764","descriptor_name":"cdc42 GTP-Binding Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020764","descriptor_name":"cdc42 GTP-Binding Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020764","descriptor_name":"cdc42 GTP-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020764","descriptor_name":"cdc42 GTP-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020764","descriptor_name":"cdc42 GTP-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.0603533103","doi":"https://doi.org/10.1073/pnas.0603533103","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.0603533103","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.0603533103","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:17050694","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17050694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1637614","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1637614","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1073/pnas.0603533103","doi":"https://doi.org/10.1073/pnas.0603533103","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.0603533103","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.0603533103","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5600000023841858,"id":"https://metadata.un.org/sdg/15","display_name":"Life on land"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G219987558","display_name":null,"funder_award_id":"NS 44315","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2385115435","display_name":null,"funder_award_id":"CA105117","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2846610251","display_name":null,"funder_award_id":"HL 085362","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5179677902","display_name":"Cell Type and Stimulus-Specific Signaling Role of CDC42 in Blood","funder_award_id":"R01HL085362","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6476111006","display_name":null,"funder_award_id":"R01 CA105117","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8239494125","display_name":null,"funder_award_id":"R01 NS044315","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1965593148.pdf","grobid_xml":"https://content.openalex.org/works/W1965593148.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1503727145","https://openalex.org/W1744742580","https://openalex.org/W1975087758","https://openalex.org/W1975286770","https://openalex.org/W1977282931","https://openalex.org/W1987145582","https://openalex.org/W1988183526","https://openalex.org/W1988976106","https://openalex.org/W1989170134","https://openalex.org/W1998454877","https://openalex.org/W2001851378","https://openalex.org/W2007354846","https://openalex.org/W2017844779","https://openalex.org/W2031928696","https://openalex.org/W2056986410","https://openalex.org/W2059400753","https://openalex.org/W2059614045","https://openalex.org/W2071629914","https://openalex.org/W2092550529","https://openalex.org/W2097670513","https://openalex.org/W2109067831","https://openalex.org/W2119402894","https://openalex.org/W2120909571","https://openalex.org/W2131215325","https://openalex.org/W2147369750","https://openalex.org/W2153185706","https://openalex.org/W2154192657","https://openalex.org/W2154665940","https://openalex.org/W2170574208","https://openalex.org/W2170616123","https://openalex.org/W2171761187"],"related_works":["https://openalex.org/W2980337175","https://openalex.org/W2787478172","https://openalex.org/W3031663322","https://openalex.org/W2047475767","https://openalex.org/W2417848373","https://openalex.org/W2438827594","https://openalex.org/W2064233112","https://openalex.org/W1998616729","https://openalex.org/W2014586674","https://openalex.org/W2005487923"],"abstract_inverted_index":{"The":[0,38],"telencephalic":[1,94,193],"neuroepithelium":[2],"(NE)":[3],"of":[4,17,30,46,108,124,137,161,168,191,203],"mammalian":[5],"brain":[6],"has":[7,182],"an":[8,183],"apical-basal":[9,44,189],"polarity":[10,45,70,190],"that":[11,41,102,180],"is":[12,48,196],"marked":[13],"by":[14,79,84,173],"the":[15,24,28,35,53,86,93,105,117,122,134,138,141,158,165,169,188,192,199],"positioning":[16],"neural":[18,95,129],"progenitors":[19,96,130],"and":[20,27,68,113,119,140,201],"adherens":[21],"junctions":[22,67],"on":[23],"apical/ventricular":[25],"surface":[26],"ascending":[29],"radial":[31,126],"glia/progenitor":[32],"fibers":[33],"toward":[34],"pial/basal":[36],"surface.":[37],"signaling":[39],"pathway":[40],"establishes":[42],"this":[43,77],"NE":[47],"not":[49],"completely":[50],"understood,":[51],"but":[52],"Rho-family":[54],"GTPase":[55],"Cdc42":[56,91,181],"may":[57],"play":[58],"a":[59,80],"critical":[60],"role":[61,185],"because":[62],"it":[63],"controls":[64],"cadherin-based":[65],"intercellular":[66],"cell":[69],"in":[71,92,97,116,154,186],"many":[72],"species.":[73],"Here,":[74],"we":[75],"tested":[76],"hypothesis":[78],"conditional":[81],"gene-targeting":[82],"strategy":[83],"using":[85],"Foxg1-Cre":[87],"line":[88],"to":[89,145],"delete":[90],"mouse":[98],"embryos.":[99],"We":[100],"found":[101],"Cdc42-deletion":[103],"abolishes":[104],"apical":[106],"localization":[107],"PAR6,":[109],"aPKC,":[110],"E-cadherin,":[111],"beta-catenin,":[112],"Numb":[114],"proteins":[115],"NE,":[118,139,194],"severely":[120],"impairs":[121],"extension":[123],"nestin-positive":[125],"fibers.":[127],"Consequently,":[128],"were":[131],"scattered":[132],"throughout":[133],"entire":[135],"depth":[136],"Cdc42-deficient":[142],"telencephalon":[143,170],"failed":[144],"bulge":[146],"or":[147],"separate":[148],"into":[149],"two":[150],"cerebral":[151,204],"hemispheres,":[152],"resulting":[153],"holoprosencephaly.":[155],"However,":[156],"neither":[157],"midline":[159],"expression":[160],"Sonic":[162],"hedgehog":[163],"nor":[164],"dorso-ventral":[166],"patterning":[167],"was":[171],"affected":[172],"Cdc42-deletion.":[174],"Taken":[175],"together,":[176],"these":[177],"results":[178],"indicate":[179],"essential":[184],"establishing":[187],"which":[195],"needed":[197],"for":[198],"expansion":[200],"bifurcation":[202],"hemispheres.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}