{"id":"https://openalex.org/W1965499489","doi":"https://doi.org/10.1159/000215989","title":"High-Dose Cytosine-Arabinoside and Mitoxantrone in Refractory Acute Myeloid Leukemia: A Clinical Phase I/II-Study","display_name":"High-Dose Cytosine-Arabinoside and Mitoxantrone in Refractory Acute Myeloid Leukemia: A Clinical Phase I/II-Study","publication_year":2009,"publication_date":"2009-04-24","ids":{"openalex":"https://openalex.org/W1965499489","doi":"https://doi.org/10.1159/000215989","mag":"1965499489","pmid":"https://pubmed.ncbi.nlm.nih.gov/3528960"},"language":"en","primary_location":{"id":"doi:10.1159/000215989","doi":"https://doi.org/10.1159/000215989","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000215989","pdf_url":null,"source":{"id":"https://openalex.org/S4210228507","display_name":"Onkologie","issn_l":"0378-584X","issn":["0378-584X","1423-0240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Onkologie","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108511937","display_name":"Wolfgang Hiddemann","orcid":"https://orcid.org/0000-0003-3634-2558","observed_orcids":["https://orcid.org/0000-0003-3634-2558","https://orcid.org/0000-0001-7208-4117"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"W. Hiddemann","raw_affiliation_strings":["Department of Internal Medicine, University of M\u00fcnster"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of M\u00fcnster","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045145638","display_name":"H. Kreutzmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Kreutzmann","raw_affiliation_strings":["Department of Internal Medicine, Evangelisches Krankenhaus Essen-Werden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Evangelisches Krankenhaus Essen-Werden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079199364","display_name":"Kurt Stra\u00edf","orcid":"https://orcid.org/0000-0003-1402-2406","observed_orcids":["https://orcid.org/0000-0003-1402-2406"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Straif","raw_affiliation_strings":["Department of Internal Medicine, University of Bonn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Bonn","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110682119","display_name":"W. D. Ludwig","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W.D. Ludwig","raw_affiliation_strings":["Department of Internal Medicine, University of Berlin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Berlin","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112129988","display_name":"R. Donhuijsen\u2010Ant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103230","display_name":"St. Josefs Hospital","ror":"https://ror.org/019jjbt65","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103230"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R. Donhuijsen-Ant","raw_affiliation_strings":["Department of Internal Medicine, St.-Josefs-Hospital, Duisburg-Hamborn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, St.-Josefs-Hospital, Duisburg-Hamborn","institution_ids":["https://openalex.org/I4210103230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011827144","display_name":"Eva Lengfelder","orcid":"https://orcid.org/0000-0002-2785-8168","observed_orcids":["https://orcid.org/0000-0002-2785-8168"]},"institutions":[{"id":"https://openalex.org/I177802217","display_name":"University of Mannheim","ror":"https://ror.org/031bsb921","country_code":"DE","type":"education","lineage":["https://openalex.org/I177802217"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"E. Lengfelder","raw_affiliation_strings":["Department of Internal Medicine, University of Mannheim-Heidelberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Mannheim-Heidelberg","institution_ids":["https://openalex.org/I177802217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079990758","display_name":"Z Arlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z. Arlin","raw_affiliation_strings":["Department of Medicine, New York Medical College, Valhalla, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, New York Medical College, Valhalla, NY, USA","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071091625","display_name":"Thomas B\u00fcchner","orcid":"https://orcid.org/0000-0003-1803-3196","observed_orcids":["https://orcid.org/0000-0003-1803-3196"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. B\u00fcchner","raw_affiliation_strings":["Department of Internal Medicine, University of M\u00fcnster"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of M\u00fcnster","institution_ids":["https://openalex.org/I22465464"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.07847882,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"3","first_page":"144","last_page":"146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/refractory-acute-myeloid-leukemia","display_name":"refractory acute myeloid leukemia","score":0.8999999761581421},{"id":"https://openalex.org/keywords/high-dose-cytarabine","display_name":"high-dose cytarabine","score":0.9639999866485596},{"id":"https://openalex.org/keywords/mitoxantrone","display_name":"mitoxantrone","score":0.9700000286102295},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.8550000190734863},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.8320000171661377},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.5929999947547913},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.7559999823570251},{"id":"https://openalex.org/keywords/mucositis","display_name":"mucositis","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C2780923524","wikidata":"https://www.wikidata.org/wiki/Q239426","display_name":"Mitoxantrone","level":3,"score":0.8669476509094238},{"id":"https://openalex.org/C2778496288","wikidata":"https://www.wikidata.org/wiki/Q6931269","display_name":"Mucositis","level":3,"score":0.8280308842658997},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7433141469955444},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.7063251733779907},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.6904693841934204},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.6849962472915649},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6344817876815796},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.5838140249252319},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5836815237998962},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.560187816619873},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4647449851036072},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4584926664829254},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.43983757495880127},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000880","descriptor_name":"Anthraquinones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003561","descriptor_name":"Cytarabine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004341","descriptor_name":"Drug Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008942","descriptor_name":"Mitoxantrone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000215989","doi":"https://doi.org/10.1159/000215989","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000215989","pdf_url":null,"source":{"id":"https://openalex.org/S4210228507","display_name":"Onkologie","issn_l":"0378-584X","issn":["0378-584X","1423-0240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Onkologie","raw_type":"journal-article"},{"id":"pmid:3528960","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3528960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Onkologie","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W24153442","https://openalex.org/W1591796471","https://openalex.org/W2077237194","https://openalex.org/W2048312112","https://openalex.org/W1992016424","https://openalex.org/W2188337530","https://openalex.org/W2125769788","https://openalex.org/W107183160","https://openalex.org/W2074821846","https://openalex.org/W2033902902"],"abstract_inverted_index":{"In":[0],"a":[1,14,72,76,124],"multi-institutional":[2],"study":[3,17],"26":[4],"patients":[5,65,79],"with":[6],"refractory":[7,132],"acute":[8,106],"myeloid":[9],"leukemia":[10],"were":[11],"entered":[12],"into":[13],"phase":[15],"I/II":[16],"of":[18,54,81,89,114,128],"HD-ara-C":[19,22],"and":[20,45,47,51,60,74,116,119],"mitox.":[21],"3":[23,97],"g/m2":[24],"q":[25],"12h":[26],"was":[27,36,94,109],"given":[28],"by":[29],"3h":[30],"infusion":[31],"on":[32,41,57],"days":[33,42,58],"1-4.":[34],"Mitox":[35],"started":[37],"at":[38],"12":[39,70],"mg/m2/d":[40,56],"3,":[43],"4":[44,50,87],"5,":[46],"escalated":[48],"to":[49,105,111],"5":[52],"doses":[53],"10":[55],"2-5":[59],"2-6,":[61],"respectively.":[62],"From":[63],"24":[64],"presently":[66],"evaluable":[67],"for":[68,100],"response,":[69],"achieved":[71],"CR":[73],"2":[75],"PR.":[77],"7":[78],"died":[80],"infectious":[82],"complications":[83],"within":[84],"the":[85],"first":[86],"weeks":[88],"treatment":[90],"while":[91],"persistent":[92],"AML":[93,131],"found":[95],"in":[96,130],"cases.":[98],"Except":[99],"one":[101],"death,":[102],"possibly":[103],"related":[104],"cardiomyopathy,":[107],"toxicity":[108],"mild":[110],"moderate":[112],"consisting":[113],"nausea":[115],"vomiting,":[117],"mucositis":[118],"diarrhea.":[120],"These":[121],"data":[122],"indicate":[123],"high":[125],"anti-leukemic":[126],"activity":[127],"HD-ara-C/mitox":[129],"against":[133],"conventional":[134],"chemotherapy.":[135]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
