{"id":"https://openalex.org/W1965449273","doi":"https://doi.org/10.1016/s0003-4975(01)02636-4","title":"Limitations of randomized clinical trials for evaluating emerging operations: the case of lung volume reduction surgery","display_name":"Limitations of randomized clinical trials for evaluating emerging operations: the case of lung volume reduction surgery","publication_year":2001,"publication_date":"2001-08-01","ids":{"openalex":"https://openalex.org/W1965449273","doi":"https://doi.org/10.1016/s0003-4975(01)02636-4","mag":"1965449273","pmid":"https://pubmed.ncbi.nlm.nih.gov/11515928"},"language":"en","primary_location":{"id":"doi:10.1016/s0003-4975(01)02636-4","doi":"https://doi.org/10.1016/s0003-4975(01)02636-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0003-4975(01)02636-4","pdf_url":null,"source":{"id":"https://openalex.org/S144860794","display_name":"The Annals of Thoracic Surgery","issn_l":"0003-4975","issn":["0003-4975","1552-6259"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Annals of Thoracic Surgery","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063026944","display_name":"Robert L. Berger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert L Berger","raw_affiliation_strings":["Clinical Services, Medical School of Boston University, Massachusetts, USA. robert_berger@hms.harvard.edu","The Overholt-BlueCross Emphysema Surgery Study Trial (OBEST), and the Clinical Services affiliated with the medical schools of Boston University, Harvard, Tufts, and University of Massachusetts, Boston and Worcester, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Services, Medical School of Boston University, Massachusetts, USA. robert_berger@hms.harvard.edu","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"The Overholt-BlueCross Emphysema Surgery Study Trial (OBEST), and the Clinical Services affiliated with the medical schools of Boston University, Harvard, Tufts, and University of Massachusetts, Boston and Worcester, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008555938","display_name":"Bartolom\u00e9 R. Celli","orcid":"https://orcid.org/0000-0002-7266-8371","observed_orcids":["https://orcid.org/0000-0002-7266-8371"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bartolome R Celli","raw_affiliation_strings":["The Overholt-BlueCross Emphysema Surgery Study Trial (OBEST), and the Clinical Services affiliated with the medical schools of Boston University, Harvard, Tufts, and University of Massachusetts, Boston and Worcester, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Overholt-BlueCross Emphysema Surgery Study Trial (OBEST), and the Clinical Services affiliated with the medical schools of Boston University, Harvard, Tufts, and University of Massachusetts, Boston and Worcester, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082357712","display_name":"Anne L Meneghetti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne L Meneghetti","raw_affiliation_strings":["The Overholt-BlueCross Emphysema Surgery Study Trial (OBEST), and the Clinical Services affiliated with the medical schools of Boston University, Harvard, Tufts, and University of Massachusetts, Boston and Worcester, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Overholt-BlueCross Emphysema Surgery Study Trial (OBEST), and the Clinical Services affiliated with the medical schools of Boston University, Harvard, Tufts, and University of Massachusetts, Boston and Worcester, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026244075","display_name":"Peter H. Bagley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter H Bagley","raw_affiliation_strings":["The Overholt-BlueCross Emphysema Surgery Study Trial (OBEST), and the Clinical Services affiliated with the medical schools of Boston University, Harvard, Tufts, and University of Massachusetts, Boston and Worcester, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Overholt-BlueCross Emphysema Surgery Study Trial (OBEST), and the Clinical Services affiliated with the medical schools of Boston University, Harvard, Tufts, and University of Massachusetts, Boston and Worcester, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102466820","display_name":"Cameron D. Wright","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cameron D Wright","raw_affiliation_strings":["The Overholt-BlueCross Emphysema Surgery Study Trial (OBEST), and the Clinical Services affiliated with the medical schools of Boston University, Harvard, Tufts, and University of Massachusetts, Boston and Worcester, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Overholt-BlueCross Emphysema Surgery Study Trial (OBEST), and the Clinical Services affiliated with the medical schools of Boston University, Harvard, Tufts, and University of Massachusetts, Boston and Worcester, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109808270","display_name":"Edward P. Ingenito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward P Ingenito","raw_affiliation_strings":["The Overholt-BlueCross Emphysema Surgery Study Trial (OBEST), and the Clinical Services affiliated with the medical schools of Boston University, Harvard, Tufts, and University of Massachusetts, Boston and Worcester, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Overholt-BlueCross Emphysema Surgery Study Trial (OBEST), and the Clinical Services affiliated with the medical schools of Boston University, Harvard, Tufts, and University of Massachusetts, Boston and Worcester, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108468227","display_name":"Anthony W. Gray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Gray","raw_affiliation_strings":["The Overholt-BlueCross Emphysema Surgery Study Trial (OBEST), and the Clinical Services affiliated with the medical schools of Boston University, Harvard, Tufts, and University of Massachusetts, Boston and Worcester, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Overholt-BlueCross Emphysema Surgery Study Trial (OBEST), and the Clinical Services affiliated with the medical schools of Boston University, Harvard, Tufts, and University of Massachusetts, Boston and Worcester, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111810360","display_name":"Gordon L. Snider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gordon L Snider","raw_affiliation_strings":["The Overholt-BlueCross Emphysema Surgery Study Trial (OBEST), and the Clinical Services affiliated with the medical schools of Boston University, Harvard, Tufts, and University of Massachusetts, Boston and Worcester, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Overholt-BlueCross Emphysema Surgery Study Trial (OBEST), and the Clinical Services affiliated with the medical schools of Boston University, Harvard, Tufts, and University of Massachusetts, Boston and Worcester, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5063026944"],"corresponding_institution_ids":["https://openalex.org/I111088046"],"apc_list":{"value":3200,"currency":"USD","value_usd":3200},"apc_paid":null,"fwci":1.2032,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.73990499,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"72","issue":"2","first_page":"649","last_page":"657"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-volume-reduction-surgery","display_name":"lung volume reduction surgery","score":0.996999979019165},{"id":"https://openalex.org/keywords/advanced-emphysema","display_name":"advanced emphysema","score":0.8320000171661377},{"id":"https://openalex.org/keywords/randomized-controlled-trials","display_name":"randomized controlled trials","score":0.7179999947547913},{"id":"https://openalex.org/keywords/observational-studies","display_name":"observational studies","score":0.6420000195503235},{"id":"https://openalex.org/keywords/national-emphysema-treatment-trial","display_name":"National Emphysema Treatment Trial","score":0.8700000047683716},{"id":"https://openalex.org/keywords/medicare-reimbursement","display_name":"Medicare reimbursement","score":0.6639999747276306},{"id":"https://openalex.org/keywords/access-to-surgical-care","display_name":"access to surgical care","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8691908121109009},{"id":"https://openalex.org/C2775982285","wikidata":"https://www.wikidata.org/wiki/Q2964004","display_name":"Lung volume reduction surgery","level":4,"score":0.8646061420440674},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.8553516864776611},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.802749514579773},{"id":"https://openalex.org/C2779703844","wikidata":"https://www.wikidata.org/wiki/Q760125","display_name":"Reimbursement","level":3,"score":0.5793692469596863},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.47883203625679016},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4722570478916168},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4633629024028778},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4442659616470337},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.39643800258636475},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.2810360789299011},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14524438977241516},{"id":"https://openalex.org/C27101514","wikidata":"https://www.wikidata.org/wiki/Q206120","display_name":"Lung volumes","level":3,"score":0.11819052696228027},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.10089737176895142},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003363","descriptor_name":"Cost Control","qualifier_ui":"Q000331","qualifier_name":"legislation & jurisprudence","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011013","descriptor_name":"Pneumonectomy","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D011656","descriptor_name":"Pulmonary Emphysema","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D011656","descriptor_name":"Pulmonary Emphysema","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D012051","descriptor_name":"Reimbursement Mechanisms","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015982","descriptor_name":"Bias","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0003-4975(01)02636-4","doi":"https://doi.org/10.1016/s0003-4975(01)02636-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0003-4975(01)02636-4","pdf_url":null,"source":{"id":"https://openalex.org/S144860794","display_name":"The Annals of Thoracic Surgery","issn_l":"0003-4975","issn":["0003-4975","1552-6259"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Annals of Thoracic Surgery","raw_type":"journal-article"},{"id":"pmid:11515928","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11515928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Annals of thoracic surgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W139487516","https://openalex.org/W1835043506","https://openalex.org/W1964898744","https://openalex.org/W1967753102","https://openalex.org/W1977742001","https://openalex.org/W1979712504","https://openalex.org/W1986612665","https://openalex.org/W1995211893","https://openalex.org/W1999410718","https://openalex.org/W1999682706","https://openalex.org/W2003112722","https://openalex.org/W2006551785","https://openalex.org/W2012963664","https://openalex.org/W2022089704","https://openalex.org/W2026217381","https://openalex.org/W2028693905","https://openalex.org/W2030133458","https://openalex.org/W2033611773","https://openalex.org/W2041532866","https://openalex.org/W2042243203","https://openalex.org/W2052984045","https://openalex.org/W2056138385","https://openalex.org/W2061308024","https://openalex.org/W2062670892","https://openalex.org/W2071615442","https://openalex.org/W2075911324","https://openalex.org/W2078669720","https://openalex.org/W2079993901","https://openalex.org/W2085354996","https://openalex.org/W2085549511","https://openalex.org/W2088438184","https://openalex.org/W2092573892","https://openalex.org/W2093704154","https://openalex.org/W2119348698","https://openalex.org/W2123299715","https://openalex.org/W2124604393","https://openalex.org/W2125368643","https://openalex.org/W2125802463","https://openalex.org/W2138833086","https://openalex.org/W2141298921","https://openalex.org/W2144618929","https://openalex.org/W2178278047","https://openalex.org/W2186362802","https://openalex.org/W2319413950","https://openalex.org/W2319983832","https://openalex.org/W2328147592","https://openalex.org/W2394980422","https://openalex.org/W2410362368","https://openalex.org/W2414144489","https://openalex.org/W2417142792","https://openalex.org/W2437629304","https://openalex.org/W2599341248","https://openalex.org/W2616141209","https://openalex.org/W2911916911","https://openalex.org/W4242361095","https://openalex.org/W4248137956","https://openalex.org/W4321429205","https://openalex.org/W6639183639"],"related_works":["https://openalex.org/W2118449295","https://openalex.org/W7098415655","https://openalex.org/W1990374830","https://openalex.org/W2022558509","https://openalex.org/W3000300198","https://openalex.org/W1964723459","https://openalex.org/W2153833649","https://openalex.org/W1851493883","https://openalex.org/W4240274908","https://openalex.org/W2037907615"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
