{"id":"https://openalex.org/W1965429232","doi":"https://doi.org/10.1111/j.1439-0507.1988.tb03986.x","title":"Oral Itraconazole Therapy for Mycotic Keratitis/Orale Itraconazol\u2010Therapie bei mykotischer Keratitis","display_name":"Oral Itraconazole Therapy for Mycotic Keratitis/Orale Itraconazol\u2010Therapie bei mykotischer Keratitis","publication_year":1988,"publication_date":"1988-05-01","ids":{"openalex":"https://openalex.org/W1965429232","doi":"https://doi.org/10.1111/j.1439-0507.1988.tb03986.x","mag":"1965429232","pmid":"https://pubmed.ncbi.nlm.nih.gov/2843767"},"language":"en","primary_location":{"id":"doi:10.1111/j.1439-0507.1988.tb03986.x","doi":"https://doi.org/10.1111/j.1439-0507.1988.tb03986.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1439-0507.1988.tb03986.x","pdf_url":null,"source":{"id":"https://openalex.org/S80731565","display_name":"Mycoses","issn_l":"0027-5557","issn":["0027-5557","0933-7407","1439-0507"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mycoses","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035315976","display_name":"Philip Aloysius Thomas","orcid":"https://orcid.org/0000-0002-0585-0499","observed_orcids":["https://orcid.org/0000-0002-0585-0499"]},"institutions":[{"id":"https://openalex.org/I4210113901","display_name":"Joseph Eye Hospital","ror":"https://ror.org/01wcey047","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210113901"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"P. A. Thomas","raw_affiliation_strings":["Institute of Ophthalmology, Joseph Eye Hospital, Tiruchirapalli, 620 001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ophthalmology, Joseph Eye Hospital, Tiruchirapalli, 620 001, India","institution_ids":["https://openalex.org/I4210113901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013839021","display_name":"Delmy Abraham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113901","display_name":"Joseph Eye Hospital","ror":"https://ror.org/01wcey047","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210113901"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"D. J. Abraham","raw_affiliation_strings":["Institute of Ophthalmology, Joseph Eye Hospital, Tiruchirapalli, 620 001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ophthalmology, Joseph Eye Hospital, Tiruchirapalli, 620 001, India","institution_ids":["https://openalex.org/I4210113901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111617850","display_name":"C M Kalavathy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113901","display_name":"Joseph Eye Hospital","ror":"https://ror.org/01wcey047","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210113901"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"C. M. Kalavathy","raw_affiliation_strings":["Institute of Ophthalmology, Joseph Eye Hospital, Tiruchirapalli, 620 001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ophthalmology, Joseph Eye Hospital, Tiruchirapalli, 620 001, India","institution_ids":["https://openalex.org/I4210113901"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025355280","display_name":"J. Rajasekaran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113901","display_name":"Joseph Eye Hospital","ror":"https://ror.org/01wcey047","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210113901"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"J. Rajasekaran","raw_affiliation_strings":["Institute of Ophthalmology, Joseph Eye Hospital, Tiruchirapalli, 620 001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ophthalmology, Joseph Eye Hospital, Tiruchirapalli, 620 001, India","institution_ids":["https://openalex.org/I4210113901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035315976"],"corresponding_institution_ids":["https://openalex.org/I4210113901"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":3.6791,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.9225715,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"31","issue":"5","first_page":"271","last_page":"279"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fungal-keratitis","display_name":"fungal keratitis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/fusarium-solani","display_name":"Fusarium solani","score":0.8019999861717224},{"id":"https://openalex.org/keywords/aspergillus-fumigatus","display_name":"Aspergillus fumigatus","score":0.9309999942779541},{"id":"https://openalex.org/keywords/aspergillus-flavus","display_name":"Aspergillus flavus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/triazole-antifungal-therapy","display_name":"triazole antifungal therapy","score":0.8209999799728394},{"id":"https://openalex.org/keywords/corneal-ulcer","display_name":"corneal ulcer","score":0.984000027179718},{"id":"https://openalex.org/keywords/fungal-eradication","display_name":"fungal eradication","score":0.7680000066757202},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6970000267028809},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8640000224113464},{"id":"https://openalex.org/keywords/corneal-surgery","display_name":"corneal surgery","score":0.6430000066757202},{"id":"https://openalex.org/keywords/ocular-fungal-infection","display_name":"fungal eye infection","score":0.5550000071525574},{"id":"https://openalex.org/keywords/antifungal-resistance","display_name":"antifungal resistance","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C2777071850","wikidata":"https://www.wikidata.org/wiki/Q411229","display_name":"Itraconazole","level":3,"score":0.768724799156189},{"id":"https://openalex.org/C2778342517","wikidata":"https://www.wikidata.org/wiki/Q5509914","display_name":"Fusarium solani","level":2,"score":0.7558990716934204},{"id":"https://openalex.org/C2776079991","wikidata":"https://www.wikidata.org/wiki/Q5509171","display_name":"Fungal keratitis","level":3,"score":0.7163143157958984},{"id":"https://openalex.org/C2778560704","wikidata":"https://www.wikidata.org/wiki/Q757838","display_name":"Keratitis","level":2,"score":0.688834011554718},{"id":"https://openalex.org/C2779787849","wikidata":"https://www.wikidata.org/wiki/Q134359","display_name":"Aspergillus fumigatus","level":2,"score":0.6443374156951904},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6394766569137573},{"id":"https://openalex.org/C2778867309","wikidata":"https://www.wikidata.org/wiki/Q131672","display_name":"Fusarium","level":2,"score":0.5702602863311768},{"id":"https://openalex.org/C2777292910","wikidata":"https://www.wikidata.org/wiki/Q137096","display_name":"Aspergillus flavus","level":2,"score":0.48551392555236816},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.4025324881076813},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.37613001465797424},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23850810527801514},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.18537893891334534},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14786922931671143},{"id":"https://openalex.org/C144027150","wikidata":"https://www.wikidata.org/wiki/Q48803","display_name":"Horticulture","level":1,"score":0.06091967225074768}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001228","descriptor_name":"Aspergillosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005670","descriptor_name":"Fusarium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007634","descriptor_name":"Keratitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007654","descriptor_name":"Ketoconazole","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D007654","descriptor_name":"Ketoconazole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009181","descriptor_name":"Mycoses","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017964","descriptor_name":"Itraconazole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1439-0507.1988.tb03986.x","doi":"https://doi.org/10.1111/j.1439-0507.1988.tb03986.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1439-0507.1988.tb03986.x","pdf_url":null,"source":{"id":"https://openalex.org/S80731565","display_name":"Mycoses","issn_l":"0027-5557","issn":["0027-5557","0933-7407","1439-0507"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mycoses","raw_type":"journal-article"},{"id":"pmid:2843767","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2843767","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mycoses","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W79174299","https://openalex.org/W580262438","https://openalex.org/W1965219674","https://openalex.org/W1978433810","https://openalex.org/W1980058585","https://openalex.org/W1996827204","https://openalex.org/W2014945394","https://openalex.org/W2029609900","https://openalex.org/W2036171561","https://openalex.org/W2072670165","https://openalex.org/W2082249758","https://openalex.org/W2089503824","https://openalex.org/W2323110106","https://openalex.org/W2331445992","https://openalex.org/W2334249669"],"related_works":["https://openalex.org/W104857136","https://openalex.org/W2113097274","https://openalex.org/W117766903","https://openalex.org/W2354556437","https://openalex.org/W2409601826","https://openalex.org/W2091636955","https://openalex.org/W3156658432","https://openalex.org/W3115360144","https://openalex.org/W2063990723","https://openalex.org/W2061549163"],"abstract_inverted_index":{"Summary:":[0],"Forty":[1],"consecutive":[2],"patients":[3],"suffering":[4],"from":[5,79,93,150],"mycotic":[6],"keratitis":[7,166,174],"(19":[8,197],"due":[9,18,28,103,167,175],"to":[10,19,29,100,104,157,168,176],"Fusarium":[11,15,127,200],"solani":[12,124,201,297],"and":[13,22,25,65,73,119,125,141],"other":[14,30,126],"spp.,":[16],"15":[17,205],"Aspergillus":[20,23,169,207],"flavus":[21,138,208,310],"fumigatus":[24,133,211,305],"six":[26],"cases":[27,164,172],"fungi)":[31],"were":[32,91,147],"treated":[33],"with":[34],"itraconazole,":[35],"a":[36,47,53],"triazole":[37],"derivative.":[38],"The":[39],"compound":[40],"was":[41,67,159,179],"administered":[42],"orally":[43],"once":[44],"daily":[45],"in":[46,82,129,134,139,144,163,171,186,228,314],"dose":[48],"of":[49,56,58,70,75,107,165,173,182,188],"200":[50,232],"mg":[51,233],"for":[52],"median":[54],"duration":[55],"treatment":[57],"17":[59,239],"days.":[60],"Progressive":[61],"corneal":[62,116],"ulceration":[63,117],"stopped":[64],"there":[66],"complete":[68],"resolution":[69,106],"all":[71],"lesions":[72,81,95],"eradication":[74],"the":[76,80,88,94,108,111,120,151,189],"infecting":[77,89,121],"fungus":[78],"22":[83,243],"patients.":[84,190],"In":[85,110],"five":[86],"patients,":[87,114,131,136],"fungi":[90,122],"eradicated":[92,149],"but":[96],"ultimately":[97],"surgery":[98],"had":[99],"be":[101],"performed":[102],"incomplete":[105],"lesions.":[109],"remaining":[112],"13":[113,286],"progressive":[115],"continued":[118],"(F.":[123,296],"spp.":[128,143],"nine":[130],"A.":[132,137,210,304,309],"two":[135],"one":[140,145],"Cladosporium":[142,312],"patient)":[146],"not":[148],"lesion.":[152],"Excellent":[153],"or":[154],"moderate":[155],"responsiveness":[156],"therapy":[158],"observed":[160],"more":[161],"frequently":[162],"than":[170],"Fusarium.":[177],"There":[178],"no":[180],"evidence":[181],"serious":[183],"adverse":[184],"reactions":[185],"any":[187],"Zusammenfassung:":[191],"Vierzig":[192],"Patienten":[193,244,265,287,347],"mit":[194,218],"mykotischer":[195],"Keratitis":[196,339],"verursacht":[198],"durch":[199,206,214],"und":[202,209,212,258,293,298,308,311,326],"andere":[203,215,299],"Fusarium\u2010Arten,":[204],"6":[213],"Pilze)":[216],"wurden":[217,343],"dem":[219],"Triazol\u2010Derivat":[220],"Itraconazol":[221],"behandelt.":[222],"Das":[223],"Mittel":[224],"wurde":[225,332],"einmal":[226],"t\u00e4glich":[227],"einer":[229,235],"Dosis":[230],"von":[231,238],"bei":[234,301,306,334,337,344],"mittleren":[236],"Behandlungsdauer":[237],"d":[240],"gegeben.":[241],"Bei":[242,263,283],"kam":[245,252],"die":[246,289,330],"progrediente":[247],"Hornhautulzeration":[248,290],"zum":[249],"Still\u2010stand,":[250],"es":[251],"zur":[253,259],"vollst\u00e4ndigen":[254],"Ausheilung":[255],"aller":[256],"L\u00e4sionen":[257,279,322],"Eliminierung":[260],"des":[261],"Pilzes.":[262],"5":[264],"konnte":[266],"der":[267,274,278,294,346],"Pilz":[268],"eliminiert":[269,323],"werden,":[270],"jedoch":[271],"mu\u00dfte":[272],"wegen":[273],"nur":[275],"unvollst\u00e4ndigen":[276],"Abheilung":[277],"chirurgisch":[280],"nachbehandelt":[281],"werden.":[282,324],"den":[284,321],"restlichen":[285],"schritt":[288],"weiter":[291],"fort":[292],"Erreger":[295],"Fusarium\u2010Arten":[300],"9":[302],"Patienten,":[303],"2":[307],"spec.":[313],"je":[315],"einem":[316],"Patienten)":[317],"konnten":[318],"nicht":[319],"aus":[320],"Hervorragendes":[325],"m\u00e4\u00dfiges":[327],"Ansprechen":[328],"auf":[329],"Therapie":[331],"\u00d6fter":[333],"Aspergillus\u2010bedingter":[335],"als":[336],"Fusarium\u2010bedingter":[338],"beobachtet.":[340],"Ernsthafte":[341],"Nebenwirkungen":[342],"keinem":[345],"gesehen.":[348]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
