{"id":"https://openalex.org/W1965408541","doi":"https://doi.org/10.1128/aem.03710-13","title":"Reduction of Ethanol Yield and Improvement of Glycerol Formation by Adaptive Evolution of the Wine Yeast Saccharomyces cerevisiae under Hyperosmotic Conditions","display_name":"Reduction of Ethanol Yield and Improvement of Glycerol Formation by Adaptive Evolution of the Wine Yeast Saccharomyces cerevisiae under Hyperosmotic Conditions","publication_year":2014,"publication_date":"2014-02-15","ids":{"openalex":"https://openalex.org/W1965408541","doi":"https://doi.org/10.1128/aem.03710-13","mag":"1965408541","pmid":"https://pubmed.ncbi.nlm.nih.gov/24532067","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3993162"},"language":"en","primary_location":{"id":"doi:10.1128/aem.03710-13","doi":"https://doi.org/10.1128/aem.03710-13","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aem.03710-13","pdf_url":"https://aem.asm.org/content/aem/80/8/2623.full.pdf","source":{"id":"https://openalex.org/S158228368","display_name":"Applied and Environmental Microbiology","issn_l":"0099-2240","issn":["0099-2240","1070-6291","1098-5336"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and Environmental Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aem.asm.org/content/aem/80/8/2623.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087906565","display_name":"Valentin Tilloy","orcid":"https://orcid.org/0000-0002-2967-8670","observed_orcids":["https://orcid.org/0000-0002-2967-8670"]},"institutions":[{"id":"https://openalex.org/I24906876","display_name":"Institut Agro Montpellier","ror":"https://ror.org/03rnk6m14","country_code":"FR","type":"education","lineage":["https://openalex.org/I24906876","https://openalex.org/I4210117091","https://openalex.org/I4399657933"]},{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210098871","display_name":"Lallemand (France)","ror":"https://ror.org/014cdjz51","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210098871","https://openalex.org/I4210145371"]},{"id":"https://openalex.org/I4210147867","display_name":"Sciences pour L\u2019\u0152nologie","ror":"https://ror.org/04w07sc25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I19894307","https://openalex.org/I24906876","https://openalex.org/I4210088668","https://openalex.org/I4210117091","https://openalex.org/I4210147867","https://openalex.org/I4399657933"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Valentin Tilloy","raw_affiliation_strings":["INRA, UMR1083 SPO, Montpellier, France","Lallemand SAS, Blagnac, France","SupAgro, UMR1083 SPO, Montpellier, France","UM1, UMR1083 SPO, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INRA, UMR1083 SPO, Montpellier, France","institution_ids":["https://openalex.org/I4210088668","https://openalex.org/I4210147867"]},{"raw_affiliation_string":"Lallemand SAS, Blagnac, France","institution_ids":["https://openalex.org/I4210098871"]},{"raw_affiliation_string":"SupAgro, UMR1083 SPO, Montpellier, France","institution_ids":["https://openalex.org/I24906876","https://openalex.org/I4210147867"]},{"raw_affiliation_string":"UM1, UMR1083 SPO, Montpellier, France","institution_ids":["https://openalex.org/I4210147867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013189134","display_name":"Anne Ortiz-Julien","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098871","display_name":"Lallemand (France)","ror":"https://ror.org/014cdjz51","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210098871","https://openalex.org/I4210145371"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anne Ortiz-Julien","raw_affiliation_strings":["Lallemand SAS, Blagnac, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lallemand SAS, Blagnac, France","institution_ids":["https://openalex.org/I4210098871"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036568788","display_name":"Sylvie Dequin","orcid":"https://orcid.org/0000-0002-9114-2324","observed_orcids":["https://orcid.org/0000-0002-9114-2324"]},"institutions":[{"id":"https://openalex.org/I24906876","display_name":"Institut Agro Montpellier","ror":"https://ror.org/03rnk6m14","country_code":"FR","type":"education","lineage":["https://openalex.org/I24906876","https://openalex.org/I4210117091","https://openalex.org/I4399657933"]},{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210147867","display_name":"Sciences pour L\u2019\u0152nologie","ror":"https://ror.org/04w07sc25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I19894307","https://openalex.org/I24906876","https://openalex.org/I4210088668","https://openalex.org/I4210117091","https://openalex.org/I4210147867","https://openalex.org/I4399657933"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sylvie Dequin","raw_affiliation_strings":["INRA, UMR1083 SPO, Montpellier, France","SupAgro, UMR1083 SPO, Montpellier, France","UM1, UMR1083 SPO, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INRA, UMR1083 SPO, Montpellier, France","institution_ids":["https://openalex.org/I4210088668","https://openalex.org/I4210147867"]},{"raw_affiliation_string":"SupAgro, UMR1083 SPO, Montpellier, France","institution_ids":["https://openalex.org/I24906876","https://openalex.org/I4210147867"]},{"raw_affiliation_string":"UM1, UMR1083 SPO, Montpellier, France","institution_ids":["https://openalex.org/I4210147867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":21.6242,"has_fulltext":false,"cited_by_count":196,"citation_normalized_percentile":{"value":0.9982693,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"80","issue":"8","first_page":"2623","last_page":"2632"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10750","display_name":"Fermentation and Sensory Analysis","score":0.823199987411499,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10750","display_name":"Fermentation and Sensory Analysis","score":0.823199987411499,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.1412000060081482,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.014600000344216824,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9620000123977661},{"id":"https://openalex.org/keywords/wine-yeast","display_name":"wine yeast","score":0.9539999961853027},{"id":"https://openalex.org/keywords/adaptive-laboratory-evolution","display_name":"adaptive laboratory evolution","score":0.8230000138282776},{"id":"https://openalex.org/keywords/hyperosmotic-stress","display_name":"hyperosmotic stress","score":0.9729999899864197},{"id":"https://openalex.org/keywords/glycerol-production","display_name":"glycerol production","score":0.8700000047683716},{"id":"https://openalex.org/keywords/2-3-butanediol","display_name":"2,3-butanediol","score":0.8169999718666077},{"id":"https://openalex.org/keywords/succinic-acid","display_name":"succinic acid","score":0.890999972820282},{"id":"https://openalex.org/keywords/carbon-flux-redirection","display_name":"carbon flux redirection","score":0.6510000228881836},{"id":"https://openalex.org/keywords/salt-stress","display_name":"salt stress","score":0.5509999990463257},{"id":"https://openalex.org/keywords/glucose-deprivation","display_name":"glucose deprivation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/wine-alcohol-content","display_name":"wine alcohol content","score":0.4690000116825104},{"id":"https://openalex.org/keywords/acetate","display_name":"acetate","score":0.49300000071525574},{"id":"https://openalex.org/keywords/acetaldehyde","display_name":"acetaldehyde","score":0.8529999852180481},{"id":"https://openalex.org/keywords/acetoin","display_name":"acetoin","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.8185932636260986},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.8033153414726257},{"id":"https://openalex.org/C55952523","wikidata":"https://www.wikidata.org/wiki/Q3014419","display_name":"Wine","level":2,"score":0.7384222745895386},{"id":"https://openalex.org/C2780881558","wikidata":"https://www.wikidata.org/wiki/Q132501","display_name":"Glycerol","level":2,"score":0.6711605787277222},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.5919784903526306},{"id":"https://openalex.org/C36442339","wikidata":"https://www.wikidata.org/wiki/Q3237250","display_name":"Yeast in winemaking","level":4,"score":0.5656399130821228},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.5315859913825989},{"id":"https://openalex.org/C129900496","wikidata":"https://www.wikidata.org/wiki/Q643555","display_name":"Osmotic concentration","level":2,"score":0.49776437878608704},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4719221591949463},{"id":"https://openalex.org/C65183824","wikidata":"https://www.wikidata.org/wiki/Q194361","display_name":"Ethanol fuel","level":3,"score":0.4562056064605713},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.44480711221694946},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44411009550094604},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41836920380592346},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.33977413177490234},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.07308638095855713},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003433","descriptor_name":"Crosses, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005990","descriptor_name":"Glycerol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009997","descriptor_name":"Osmotic Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012692","descriptor_name":"Serial Passage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014920","descriptor_name":"Wine","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/aem.03710-13","doi":"https://doi.org/10.1128/aem.03710-13","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aem.03710-13","pdf_url":"https://aem.asm.org/content/aem/80/8/2623.full.pdf","source":{"id":"https://openalex.org/S158228368","display_name":"Applied and Environmental Microbiology","issn_l":"0099-2240","issn":["0099-2240","1070-6291","1098-5336"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and Environmental Microbiology","raw_type":"journal-article"},{"id":"pmid:24532067","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24532067","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and environmental microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3993162","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3993162/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Appl Environ Microbiol","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-01837704v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-01837704","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Applied and Environmental Microbiology, 2014, 80 (8), pp.2623-2632. &#x27E8;10.1128/AEM.03710-13&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2188278441","doi":null,"is_oa":false,"landing_page_url":"https://aem.asm.org/content/early/2014/02/10/AEM.03710-13.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1128/aem.03710-13","doi":"https://doi.org/10.1128/aem.03710-13","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aem.03710-13","pdf_url":"https://aem.asm.org/content/aem/80/8/2623.full.pdf","source":{"id":"https://openalex.org/S158228368","display_name":"Applied and Environmental Microbiology","issn_l":"0099-2240","issn":["0099-2240","1070-6291","1098-5336"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and Environmental Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.40450000762939453,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1965408541.pdf"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W11688870","https://openalex.org/W1791345326","https://openalex.org/W1805449453","https://openalex.org/W1858024074","https://openalex.org/W1880340734","https://openalex.org/W1898627216","https://openalex.org/W1973327968","https://openalex.org/W1992655930","https://openalex.org/W1994049972","https://openalex.org/W2000502765","https://openalex.org/W2004622897","https://openalex.org/W2007193968","https://openalex.org/W2010339347","https://openalex.org/W2032367220","https://openalex.org/W2034864965","https://openalex.org/W2037199255","https://openalex.org/W2043356571","https://openalex.org/W2045512550","https://openalex.org/W2046280415","https://openalex.org/W2046897971","https://openalex.org/W2050633946","https://openalex.org/W2056481919","https://openalex.org/W2058737346","https://openalex.org/W2072982091","https://openalex.org/W2083550290","https://openalex.org/W2083778258","https://openalex.org/W2084314118","https://openalex.org/W2090716252","https://openalex.org/W2105404303","https://openalex.org/W2113516488","https://openalex.org/W2140412033","https://openalex.org/W2146497852","https://openalex.org/W2146506602","https://openalex.org/W2149498104","https://openalex.org/W2150665430","https://openalex.org/W2159218555","https://openalex.org/W2167114748","https://openalex.org/W2167952851","https://openalex.org/W2276927837","https://openalex.org/W2514006561","https://openalex.org/W2588682731"],"related_works":["https://openalex.org/W2071938961","https://openalex.org/W841900734","https://openalex.org/W4401538702","https://openalex.org/W7223424863","https://openalex.org/W4379986444","https://openalex.org/W2037199255","https://openalex.org/W2883164266","https://openalex.org/W3093067936","https://openalex.org/W7037212198","https://openalex.org/W2043481759"],"abstract_inverted_index":{"There":[0],"is":[1,224],"a":[2,83,151,167,225],"strong":[3],"demand":[4],"from":[5],"the":[6,13,25,69,109,136,141,145,164,180,210,217,233],"wine":[7,17,40,193],"industry":[8],"for":[9,35,231],"methodologies":[10],"to":[11,228],"reduce":[12],"alcohol":[14],"content":[15],"of":[16,27,37,147,153,219],"without":[18],"compromising":[19],"wine's":[20],"sensory":[21],"characteristics.":[22],"We":[23],"assessed":[24],"potential":[26],"adaptive":[28,220],"laboratory":[29],"evolution":[30,51,221],"strategies":[31],"under":[32,128],"hyperosmotic":[33],"stress":[34,130],"generation":[36],"Saccharomyces":[38],"cerevisiae":[39],"yeast":[41,234],"strains":[42,59,94,102,191],"with":[43,194],"enhanced":[44],"glycerol":[45,63,87,178,203],"and":[46,64,89,106,112,131,155,158,189,197,204,206,222],"reduced":[47,79],"ethanol":[48,66,165],"yields.":[49],"Experimental":[50],"on":[52,185],"KCl":[53],"resulted,":[54],"after":[55],"200":[56],"generations,":[57],"in":[58],"that":[60,140,143,175,216],"had":[61],"higher":[62],"lower":[65],"production":[67,88],"than":[68,108,135,179,209],"ancestral":[70,110,137,211],"strain.":[71,182,212],"This":[72,213],"major":[73],"metabolic":[74,235],"shift":[75],"was":[76,170],"accompanied":[77],"by":[78],"fermentative":[80],"capacities,":[81],"suggesting":[82,139],"trade-off":[84],"between":[85],"high":[86],"fermentation":[90,97,184],"rate.":[91],"Several":[92],"evolved":[93,181,188],"retaining":[95],"good":[96],"performance":[98],"were":[99],"selected.":[100],"These":[101],"produced":[103,176,192],"more":[104,177,202],"succinate":[105],"2,3-butanediol":[107],"strain":[111],"did":[113],"not":[114],"accumulate":[115],"undesirable":[116],"organoleptic":[117],"compounds,":[118],"such":[119],"as":[120],"acetate,":[121],"acetaldehyde,":[122],"or":[123],"acetoin.":[124],"They":[125],"survived":[126],"better":[127],"osmotic":[129,154],"glucose":[132],"starvation":[133],"conditions":[134],"strain,":[138],"forces":[142],"drove":[144],"redirection":[146],"carbon":[148,159],"fluxes":[149],"involved":[150],"combination":[152,218],"salt":[156],"stresses":[157],"limitation.":[160],"To":[161],"further":[162],"decrease":[163],"yield,":[166],"breeding":[168,223],"strategy":[169],"used,":[171],"generating":[172],"intrastrain":[173],"hybrids":[174],"Pilot-scale":[183],"Syrah":[186],"using":[187],"hybrid":[190],"0.6%":[195],"(vol/vol)":[196,199],"1.3%":[198],"less":[200,207],"ethanol,":[201],"2,3-butanediol,":[205],"acetate":[208],"work":[214],"demonstrates":[215],"valuable":[226],"alternative":[227],"rational":[229],"design":[230],"remodeling":[232],"network.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":23},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":9}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
