{"id":"https://openalex.org/W1965397665","doi":"https://doi.org/10.1111/j.1749-6632.1998.tb11169.x","title":"PACAP Protects Hippocampal Neurons against Apoptosis: Involvement of JNK/SAPK Signaling Pathwaya","display_name":"PACAP Protects Hippocampal Neurons against Apoptosis: Involvement of JNK/SAPK Signaling Pathwaya","publication_year":1998,"publication_date":"1998-12-01","ids":{"openalex":"https://openalex.org/W1965397665","doi":"https://doi.org/10.1111/j.1749-6632.1998.tb11169.x","mag":"1965397665","pmid":"https://pubmed.ncbi.nlm.nih.gov/9928003"},"language":"en","primary_location":{"id":"doi:10.1111/j.1749-6632.1998.tb11169.x","doi":"https://doi.org/10.1111/j.1749-6632.1998.tb11169.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1998.tb11169.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020196813","display_name":"Seiji Shioda","orcid":"https://orcid.org/0000-0002-4164-6743","observed_orcids":["https://orcid.org/0000-0002-4164-6743"]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"SEIJI SHIODA","raw_affiliation_strings":["Department of Anatomy, Showa University School of Medicine, Tokyo, Japan. shioda@med.showa-u.ac.jp","Department of Anatomy, Showa University School of Medicine, Tokyo, 142-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Showa University School of Medicine, Tokyo, Japan. shioda@med.showa-u.ac.jp","institution_ids":["https://openalex.org/I119182057"]},{"raw_affiliation_string":"Department of Anatomy, Showa University School of Medicine, Tokyo, 142-8555, Japan","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008683099","display_name":"Hiroshi Ozawa","orcid":"https://orcid.org/0000-0002-6991-0948","observed_orcids":["https://orcid.org/0000-0002-6991-0948"]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIROSHI OZAWA","raw_affiliation_strings":["Department of Neurosurgery, Showa University School of Medicine, Tokyo 142\u20138555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Showa University School of Medicine, Tokyo 142\u20138555, Japan","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037373569","display_name":"Kenji Dohi","orcid":"https://orcid.org/0000-0002-4451-0382","observed_orcids":["https://orcid.org/0000-0002-4451-0382"]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KENJI DOHI","raw_affiliation_strings":["Department of Neurosurgery, Showa University School of Medicine, Tokyo 142\u20138555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Showa University School of Medicine, Tokyo 142\u20138555, Japan","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108401056","display_name":"Hidekatsu Mizushima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIDEKATSU MIZUSHIMA","raw_affiliation_strings":["Department of Neurosurgery, Showa University School of Medicine, Tokyo 142\u20138555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Showa University School of Medicine, Tokyo 142\u20138555, Japan","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084309021","display_name":"Kiyoshi Matsumoto","orcid":"https://orcid.org/0000-0001-8390-2701","observed_orcids":["https://orcid.org/0000-0001-8390-2701"]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KIYOSHI MATSUMOTO","raw_affiliation_strings":["Department of Neurosurgery, Showa University School of Medicine, Tokyo 142\u20138555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Showa University School of Medicine, Tokyo 142\u20138555, Japan","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041429126","display_name":"Shigeo Nakajo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SHIGEO NAKAJO","raw_affiliation_strings":["Laboratory of Biological Chemistry, Showa University School of Pharmaceutical Sciences, Tokyo 142\u20138555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biological Chemistry, Showa University School of Pharmaceutical Sciences, Tokyo 142\u20138555, Japan","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108488235","display_name":"Atsushi Takaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"ATSUSHI TAKAKI","raw_affiliation_strings":["Department of Physiology, Kyushu University Faculty of Medicine, Fukuoka 812\u201382, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Kyushu University Faculty of Medicine, Fukuoka 812\u201382, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007431527","display_name":"Chengji J. Zhou","orcid":"https://orcid.org/0000-0001-8592-4680","observed_orcids":["https://orcid.org/0000-0001-8592-4680"]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"CHENG JI ZHOU","raw_affiliation_strings":["Department of Anatomy, Showa University School of Medicine, Tokyo 142\u20138555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Showa University School of Medicine, Tokyo 142\u20138555, Japan","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106038147","display_name":"Yasumitsu Nakai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"YASUMITSU NAKAI","raw_affiliation_strings":["Department of Anatomy, Showa University School of Medicine, Tokyo 142\u20138555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Showa University School of Medicine, Tokyo 142\u20138555, Japan","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078024136","display_name":"Akira Arimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"AKIRA ARIMURA","raw_affiliation_strings":["U.S.-Japan Biomedical Research Laboratories, Tulane University Hebert Center, Belle Chasse, Louisiana 70037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.S.-Japan Biomedical Research Laboratories, Tulane University Hebert Center, Belle Chasse, Louisiana 70037, USA","institution_ids":["https://openalex.org/I114832834"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5020196813"],"corresponding_institution_ids":["https://openalex.org/I119182057"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":1.649,"has_fulltext":false,"cited_by_count":119,"citation_normalized_percentile":{"value":0.82981437,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"865","issue":"1","first_page":"111","last_page":"117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13505","display_name":"Apelin-related biomedical research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pacap","display_name":"PACAP","score":0.8379999995231628},{"id":"https://openalex.org/keywords/pituitary-adenylate-cyclase-activating-polypeptide","display_name":"pituitary adenylate cyclase-activating polypeptide","score":0.9319999814033508},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.7279999852180481},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.8489999771118164},{"id":"https://openalex.org/keywords/jnk-signaling","display_name":"JNK signaling","score":0.8759999871253967},{"id":"https://openalex.org/keywords/erk","display_name":"ERK","score":0.8600000143051147},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.953000009059906},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8740000128746033},{"id":"https://openalex.org/keywords/ca1-region","display_name":"CA1 region","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.9160000085830688}],"concepts":[{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.7299418449401855},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6496168375015259},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.618547797203064},{"id":"https://openalex.org/C132149769","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"Mitogen-activated protein kinase","level":3,"score":0.5909581184387207},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5539167523384094},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5467180609703064},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.5195460915565491},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5106213688850403},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.49979090690612793},{"id":"https://openalex.org/C124160383","wikidata":"https://www.wikidata.org/wiki/Q14914383","display_name":"ASK1","level":5,"score":0.48348551988601685},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4531658887863159},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.4423365294933319},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41778242588043213},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40260931849479675},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.36221498250961304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2733767628669739},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16110706329345703},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12079134583473206},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08671393990516663}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002552","descriptor_name":"Cerebral Ventricles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002552","descriptor_name":"Cerebral Ventricles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002552","descriptor_name":"Cerebral Ventricles","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007263","descriptor_name":"Infusions, Parenteral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051219","descriptor_name":"Pituitary Adenylate Cyclase-Activating Polypeptide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1749-6632.1998.tb11169.x","doi":"https://doi.org/10.1111/j.1749-6632.1998.tb11169.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1998.tb11169.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:9928003","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9928003","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1886438078","https://openalex.org/W1968479883","https://openalex.org/W1970328692","https://openalex.org/W1976385326","https://openalex.org/W1979697286","https://openalex.org/W1982892406","https://openalex.org/W1991156858","https://openalex.org/W2020622209","https://openalex.org/W2028563627","https://openalex.org/W2034355463","https://openalex.org/W2049059486","https://openalex.org/W2063271495","https://openalex.org/W2066502546","https://openalex.org/W2082474268","https://openalex.org/W2089822614","https://openalex.org/W2111929320","https://openalex.org/W2154745705","https://openalex.org/W2411421247"],"related_works":["https://openalex.org/W1979276130","https://openalex.org/W2088124338","https://openalex.org/W1561552242","https://openalex.org/W2002783887","https://openalex.org/W2031389208","https://openalex.org/W1995595961","https://openalex.org/W2093785115","https://openalex.org/W2040585119","https://openalex.org/W2012045243","https://openalex.org/W2089822614"],"abstract_inverted_index":{"We":[0],"have":[1],"demonstrated":[2],"that":[3,131],"the":[4,10,14,32,36,50,55,78,88,97,109,120,138],"ischemia-induced":[5],"apoptosis":[6],"of":[7,13,25,39,52,54,99,105,122],"neurons":[8,144],"in":[9,77],"CA1":[11],"region":[12],"rat":[15],"hippocampus":[16],"was":[17,112],"prevented":[18],"by":[19],"either":[20],"intracerebroventricular":[21],"or":[22],"intravenous":[23],"infusion":[24],"pituitary":[26],"adenylate":[27],"cyclase-activating":[28],"polypeptide":[29],"(PACAP).":[30],"However,":[31],"molecular":[33],"mechanisms":[34],"underlying":[35],"anti-apoptotic":[37],"effect":[38],"PACAP":[40,95,116,132],"remain":[41],"to":[42,136],"be":[43],"determined.":[44],"Within":[45],"3-6":[46],"h":[47],"after":[48,101,115],"ischemia,":[49],"activities":[51],"members":[53],"mitogen-activated":[56],"protein":[57,70],"(MAP)":[58],"kinase":[59,64,68,71,90],"family,":[60,91],"including":[61],"extracellular":[62],"signal-regulated":[63],"(ERK),":[65],"Jun":[66],"N-terminal":[67],"(JNK)/stress-activated":[69],"(SAPK),":[72],"and":[73,133],"p38":[74],"were":[75],"increased":[76],"hippocampus.":[79],"The":[80],"ischemic":[81,102],"stress":[82],"had":[83],"a":[84],"potent":[85],"influence":[86],"on":[87,93],"MAP":[89],"especially":[92],"JNK/SAPK.":[94],"inhibited":[96,119],"activation":[98,121],"JNK/SAPK":[100,139],"stress.":[103],"Secretion":[104],"interleukin-6":[106],"(IL-6)":[107],"into":[108],"cerebrospinal":[110],"fluid":[111],"intensely":[113],"stimulated":[114],"infusion.":[117],"IL-6":[118,134],"JNK/SAPK,":[123],"while":[124],"it":[125],"activated":[126],"ERK.":[127],"These":[128],"observations":[129],"suggest":[130],"act":[135],"inhibit":[137],"signaling":[140],"pathway,":[141],"thereby":[142],"protecting":[143],"against":[145],"apoptosis.":[146]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
