{"id":"https://openalex.org/W1965366994","doi":"https://doi.org/10.1152/ajpheart.00228.2004","title":"A comparison of oxidized LDL-induced collagen secretion by graft and aortic SMCs: role of PDGF","display_name":"A comparison of oxidized LDL-induced collagen secretion by graft and aortic SMCs: role of PDGF","publication_year":2004,"publication_date":"2004-05-18","ids":{"openalex":"https://openalex.org/W1965366994","doi":"https://doi.org/10.1152/ajpheart.00228.2004","mag":"1965366994","pmid":"https://pubmed.ncbi.nlm.nih.gov/15142849"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.00228.2004","doi":"https://doi.org/10.1152/ajpheart.00228.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.00228.2004","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049307963","display_name":"Afaf Absood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210122509","display_name":"Ann Arbor VA Medical Center","ror":"https://ror.org/039n0s143","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210102099","https://openalex.org/I4210122509","https://openalex.org/I4210127612"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Afaf Absood","raw_affiliation_strings":["Department of Surgery, University of Michigan and Department of Veterans Affairs Medical Center, Ann Arbor, Michigan 48019, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Michigan and Department of Veterans Affairs Medical Center, Ann Arbor, Michigan 48019, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210122509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102901232","display_name":"Akira Furutani","orcid":"https://orcid.org/0000-0002-7631-0836","observed_orcids":["https://orcid.org/0000-0002-7631-0836"]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Furutani","raw_affiliation_strings":["","Yamaguchi  University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Yamaguchi  University","institution_ids":["https://openalex.org/I173915773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111519889","display_name":"Tsutomu Kawamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tsutomu Kawamura","raw_affiliation_strings":["","Cleveland Clinic Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Cleveland Clinic Foundation","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044527267","display_name":"Linda M. Graham","orcid":"https://orcid.org/0000-0003-0531-2153","observed_orcids":["https://orcid.org/0000-0003-0531-2153"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Linda M. Graham","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.115,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.4606638,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"287","issue":"3","first_page":"H1200","last_page":"H1206"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.6201000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.6201000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.29170000553131104,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxidized-ldl","display_name":"oxidized LDL","score":0.8619999885559082},{"id":"https://openalex.org/keywords/collagen-secretion","display_name":"collagen secretion","score":0.7509999871253967},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.8550000190734863},{"id":"https://openalex.org/keywords/prosthetic-vascular-grafts","display_name":"prosthetic vascular grafts","score":0.9980000257492065},{"id":"https://openalex.org/keywords/aortic-smooth-muscle-cells","display_name":"aortic smooth muscle cells","score":0.8629999756813049},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.9399999976158142},{"id":"https://openalex.org/keywords/lipid-oxidation","display_name":"lipid oxidation","score":0.718999981880188},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8510000109672546},{"id":"https://openalex.org/keywords/neointimal-hyperplasia","display_name":"intimal hyperplasia","score":0.9210000038146973},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.7540000081062317},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.5839999914169312},{"id":"https://openalex.org/keywords/dacron-graft","display_name":"Dacron graft","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6338257789611816},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.5721856951713562},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5674928426742554},{"id":"https://openalex.org/C2780644872","wikidata":"https://www.wikidata.org/wiki/Q14881714","display_name":"Type I collagen","level":2,"score":0.5203525424003601},{"id":"https://openalex.org/C2781294074","wikidata":"https://www.wikidata.org/wiki/Q22327352","display_name":"Platelet-derived growth factor","level":5,"score":0.4704398512840271},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.468589723110199},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.41540732979774475},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41501298546791077},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41010504961013794},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30454134941101074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1768971085548401},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.16410773992538452},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16281282901763916},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07699543237686157}],"mesh":[{"descriptor_ui":"D000634","descriptor_name":"Aminoquinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001807","descriptor_name":"Blood Vessel Prosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D024042","descriptor_name":"Collagen Type I","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D024042","descriptor_name":"Collagen Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpheart.00228.2004","doi":"https://doi.org/10.1152/ajpheart.00228.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.00228.2004","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:15142849","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15142849","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Heart and circulatory physiology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3131939943","display_name":null,"funder_award_id":"HL-64357","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7281795032","display_name":"Role of Smooth Muscle Cells in Graft Intimal Hyperplasia","funder_award_id":"R01HL041178","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1479677432","https://openalex.org/W1599970242","https://openalex.org/W1965109940","https://openalex.org/W1966489575","https://openalex.org/W1968529156","https://openalex.org/W1977779461","https://openalex.org/W1986724768","https://openalex.org/W1992873457","https://openalex.org/W1995285367","https://openalex.org/W2006247509","https://openalex.org/W2007303151","https://openalex.org/W2008120093","https://openalex.org/W2009560671","https://openalex.org/W2014751729","https://openalex.org/W2020770717","https://openalex.org/W2021081597","https://openalex.org/W2021701797","https://openalex.org/W2031267451","https://openalex.org/W2033071783","https://openalex.org/W2050329050","https://openalex.org/W2054045818","https://openalex.org/W2058496846","https://openalex.org/W2059618963","https://openalex.org/W2070951814","https://openalex.org/W2078713011","https://openalex.org/W2085909939","https://openalex.org/W2099789417","https://openalex.org/W2109296003","https://openalex.org/W2121905685","https://openalex.org/W2131006154","https://openalex.org/W2131526700","https://openalex.org/W2140620071","https://openalex.org/W2145799136","https://openalex.org/W2150231536","https://openalex.org/W2154636701","https://openalex.org/W2155582185","https://openalex.org/W2168595038","https://openalex.org/W2168990938","https://openalex.org/W2272399158","https://openalex.org/W2330044445","https://openalex.org/W2331488822","https://openalex.org/W2411553887","https://openalex.org/W2418095536","https://openalex.org/W2468773989"],"related_works":["https://openalex.org/W2331488822","https://openalex.org/W2099960919","https://openalex.org/W2031267451","https://openalex.org/W2061402815","https://openalex.org/W3140228491","https://openalex.org/W2026643114","https://openalex.org/W2060123608","https://openalex.org/W2093839331","https://openalex.org/W1978226176","https://openalex.org/W2022123585"],"abstract_inverted_index":{"Smooth":[0],"muscle":[1],"cells":[2],"(SMCs)":[3],"from":[4,54,97,111],"prosthetic":[5,197],"vascular":[6,198],"grafts":[7,62,199],"constitutively":[8],"secrete":[9],"higher":[10],"levels":[11],"of":[12,31,35,187,222],"collagen":[13,43,81,92,135,164,172,189,216],"than":[14],"aortic":[15,46,109,147],"SMCs.":[16,148],"Lipid":[17,191],"oxidation":[18,192],"products":[19,193],"accumulate":[20,195],"in":[21,82,134,171,196,213],"grafts,":[22],"and":[23,47,107,140,160],"we":[24],"postulated":[25],"that":[26,177,194,205,212],"they":[27],"stimulate":[28,163],"SMC":[29],"production":[30,93,156,173,208],"collagen.":[32],"The":[33],"effect":[34],"oxidized":[36],"low-density":[37],"lipoprotein":[38],"(oxLDL)":[39],"on":[40],"type":[41],"I":[42,80],"secretion":[44,136],"by":[45,88,94,108,137,146,157,174,180,209],"graft":[48,95,138,158,175,210],"SMCs":[49,52,96,110,139,176,211],"was":[50,86,178],"compared.":[51],"isolated":[53],"the":[55,83,169,220],"canine":[56],"thoracic":[57],"aorta":[58],"or":[59,71],"Dacron":[60],"thoracoabdominal":[61],"(n":[63],"=":[64],"10)":[65],"were":[66],"incubated":[67],"with":[68],"native":[69],"LDL":[70,122],"oxLDL":[72],"(0-400":[73],"microg":[74],"cholesterol/ml)":[75],"for":[76],"72":[77],"h.":[78],"Type":[79],"conditioned":[84],"medium":[85],"measured":[87],"ELISA.":[89],"OxLDL":[90,149],"increased":[91],"4.1":[98],"+/-":[99,103,113,117],"0.3":[100],"to":[101,115,153,219],"11.0":[102],"0.4":[104],"ng/microg":[105,119],"DNA":[106],"2.3":[112],"0.1":[114],"3.5":[116],"0.2":[118],"DNA.":[120],"Native":[121],"had":[123],"little":[124],"effect.":[125],"LY-83583,":[126],"a":[127,131,141],"superoxide":[128],"generator,":[129],"stimulated":[130,179],"dramatic":[132],"increase":[133,154,170],"smaller":[142],"but":[143],"significant":[144],"elevation":[145],"has":[150],"been":[151],"shown":[152],"PDGF":[155,161,183,207],"SMCs,":[159],"can":[162,200],"production.":[165,190],"Anti-PDGF":[166],"antibody":[167],"inhibited":[168],"oxLDL,":[181],"implicating":[182],"as":[184],"one":[185],"mechanism":[186],"oxLDL-induced":[188],"cause":[201],"an":[202],"oxidative":[203],"stress":[204],"stimulates":[206,215],"turn":[214],"production,":[217],"contributing":[218],"progression":[221],"intimal":[223],"hyperplasia.":[224]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}