{"id":"https://openalex.org/W1965320642","doi":"https://doi.org/10.3310/hta15120","title":"A randomised controlled trial of post-operative radiotherapy following breast-conserving surgery in a minimum-risk population. Quality of life at 5 years in the PRIME trial","display_name":"A randomised controlled trial of post-operative radiotherapy following breast-conserving surgery in a minimum-risk population. Quality of life at 5 years in the PRIME trial","publication_year":2011,"publication_date":"2011-03-01","ids":{"openalex":"https://openalex.org/W1965320642","doi":"https://doi.org/10.3310/hta15120","mag":"1965320642","pmid":"https://pubmed.ncbi.nlm.nih.gov/21366974"},"language":"en","primary_location":{"id":"doi:10.3310/hta15120","doi":"https://doi.org/10.3310/hta15120","is_oa":true,"landing_page_url":"https://doi.org/10.3310/hta15120","pdf_url":"https://njl-admin.nihr.ac.uk/document/download/2002099","source":{"id":"https://openalex.org/S191206091","display_name":"Health Technology Assessment","issn_l":"1366-5278","issn":["1366-5278","2046-4924","2046-4932"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311817","host_organization_name":"NIHR Journals Library","host_organization_lineage":["https://openalex.org/P4310311817"],"host_organization_lineage_names":["NIHR Journals Library"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health Technology Assessment","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://njl-admin.nihr.ac.uk/document/download/2002099","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109918981","display_name":"LJ Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"LJ Williams","raw_affiliation_strings":["Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106182595","display_name":"IH Kunkler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"IH Kunkler","raw_affiliation_strings":["Edinburgh Cancer Centre , Western General Hospital , Edinburgh , UK","Western general Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Edinburgh Cancer Centre , Western General Hospital , Edinburgh , UK","institution_ids":["https://openalex.org/I2800150677"]},{"raw_affiliation_string":"Western general Hospital","institution_ids":["https://openalex.org/I2800150677"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111519757","display_name":"C.C. King","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"CC King","raw_affiliation_strings":["Centre for Population Health Sciences , University of Edinburgh , Edinburgh , UK","Univ Edinburgh, Ctr Populat Hlth Sci"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Population Health Sciences , University of Edinburgh , Edinburgh , UK","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"Univ Edinburgh, Ctr Populat Hlth Sci","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111650538","display_name":"Wilma J. L. Jack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"W Jack","raw_affiliation_strings":["Edinburgh Cancer Centre , Western General Hospital , Edinburgh , UK","Western general Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Edinburgh Cancer Centre , Western General Hospital , Edinburgh , UK","institution_ids":["https://openalex.org/I2800150677"]},{"raw_affiliation_string":"Western general Hospital","institution_ids":["https://openalex.org/I2800150677"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037450140","display_name":"Marjon M. Van Der Pol","orcid":"https://orcid.org/0000-0003-0636-1184","observed_orcids":["https://orcid.org/0000-0003-0636-1184"]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M van der Pol","raw_affiliation_strings":["Health Economics Research Unit , University of Aberdeen , Aberdeen , UK","Univ Aberdeen, Hlth Econ Res Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Economics Research Unit , University of Aberdeen , Aberdeen , UK","institution_ids":["https://openalex.org/I195460627"]},{"raw_affiliation_string":"Univ Aberdeen, Hlth Econ Res Unit","institution_ids":["https://openalex.org/I195460627"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5109918981"],"corresponding_institution_ids":["https://openalex.org/I98677209"],"apc_list":null,"apc_paid":null,"fwci":1.6879,"has_fulltext":true,"cited_by_count":81,"citation_normalized_percentile":{"value":0.83448686,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"15","issue":"12","first_page":"i","last_page":"xi, 1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-conserving-surgery","display_name":"breast-conserving surgery","score":0.8330000042915344},{"id":"https://openalex.org/keywords/postoperative-radiotherapy","display_name":"postoperative radiotherapy","score":0.8370000123977661},{"id":"https://openalex.org/keywords/whole-breast-irradiation","display_name":"whole breast irradiation","score":0.8259999752044678},{"id":"https://openalex.org/keywords/axillary-node-negative-breast-cancer","display_name":"axillary node-negative breast cancer","score":0.8410000205039978},{"id":"https://openalex.org/keywords/low-risk-breast-cancer","display_name":"low-risk breast cancer","score":0.9679999947547913},{"id":"https://openalex.org/keywords/radiotherapy-omission","display_name":"radiotherapy omission","score":0.7820000052452087},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9190000295639038},{"id":"https://openalex.org/keywords/breast-symptoms","display_name":"breast symptoms","score":0.6190000176429749},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.8560000061988831},{"id":"https://openalex.org/keywords/insomnia","display_name":"insomnia","score":0.9480000138282776},{"id":"https://openalex.org/keywords/endocrine-therapy","display_name":"endocrine therapy","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.8809999823570251},{"id":"https://openalex.org/keywords/prime-trial","display_name":"PRIME trial","score":0.6909999847412109},{"id":"https://openalex.org/keywords/older-women","display_name":"older women","score":0.6460000276565552},{"id":"https://openalex.org/keywords/local-recurrence","display_name":"local recurrence","score":0.6190000176429749},{"id":"https://openalex.org/keywords/treatment-related-morbidity","display_name":"treatment-related morbidity","score":0.7559999823570251},{"id":"https://openalex.org/keywords/anxiety-and-depression","display_name":"anxiety and depression","score":0.7379999756813049},{"id":"https://openalex.org/keywords/eortc-qlq-c30","display_name":"EORTC QLQ-C30","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.899598240852356},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.7053953409194946},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.6240049600601196},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4574754238128662},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45619848370552063},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4144122898578644},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.07072064280509949},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.06422322988510132}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011184","descriptor_name":"Postoperative Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011594","descriptor_name":"Psychometrics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011878","descriptor_name":"Radiotherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011878","descriptor_name":"Radiotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015412","descriptor_name":"Mastectomy, Segmental","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D015412","descriptor_name":"Mastectomy, Segmental","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016001","descriptor_name":"Confidence Intervals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3310/hta15120","doi":"https://doi.org/10.3310/hta15120","is_oa":true,"landing_page_url":"https://doi.org/10.3310/hta15120","pdf_url":"https://njl-admin.nihr.ac.uk/document/download/2002099","source":{"id":"https://openalex.org/S191206091","display_name":"Health Technology Assessment","issn_l":"1366-5278","issn":["1366-5278","2046-4924","2046-4932"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311817","host_organization_name":"NIHR Journals Library","host_organization_lineage":["https://openalex.org/P4310311817"],"host_organization_lineage_names":["NIHR Journals Library"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health Technology Assessment","raw_type":"journal-article"},{"id":"pmid:21366974","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21366974","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health technology assessment (Winchester, England)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:773b46d862404b1e8275acd7b51cc0b4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/773b46d862404b1e8275acd7b51cc0b4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Health Technology Assessment, Vol 15, Iss 12 (2011)","raw_type":"article"},{"id":"pmh:oai:pure.ed.ac.uk:openaire/c50f60be-bfe6-4079-9247-fcb9297c686a","doi":null,"is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/en/publications/c50f60be-bfe6-4079-9247-fcb9297c686a","pdf_url":null,"source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Williams, L J, Kunkler, I H, King, C C, Jack, W & van der Pol, M 2011, 'A randomised controlled trial of post-operative radiotherapy following breast-conserving surgery in a minimum-risk population. Quality of life at 5 years in the PRIME trial', Health Technology Assessment, vol. 15, no. 12, pp. 1-64. https://doi.org/10.3310/hta15120","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3310/hta15120","doi":"https://doi.org/10.3310/hta15120","is_oa":true,"landing_page_url":"https://doi.org/10.3310/hta15120","pdf_url":"https://njl-admin.nihr.ac.uk/document/download/2002099","source":{"id":"https://openalex.org/S191206091","display_name":"Health Technology Assessment","issn_l":"1366-5278","issn":["1366-5278","2046-4924","2046-4932"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311817","host_organization_name":"NIHR Journals Library","host_organization_lineage":["https://openalex.org/P4310311817"],"host_organization_lineage_names":["NIHR Journals Library"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health Technology Assessment","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1983646144","display_name":null,"funder_award_id":"96/03/01","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G5254652880","display_name":null,"funder_award_id":"96/03/99","funder_id":"https://openalex.org/F4320334661","funder_display_name":"Health Technology Assessment Programme"},{"id":"https://openalex.org/G7296487915","display_name":null,"funder_award_id":"96/03/99","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320334661","display_name":"Health Technology Assessment Programme","ror":"https://ror.org/0187kwz08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1965320642.pdf","grobid_xml":"https://content.openalex.org/works/W1965320642.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1748731440","https://openalex.org/W1830334259","https://openalex.org/W1976098744","https://openalex.org/W1982853521","https://openalex.org/W1983184866","https://openalex.org/W1983582163","https://openalex.org/W1989273383","https://openalex.org/W1993021249","https://openalex.org/W1993060137","https://openalex.org/W1996375113","https://openalex.org/W1997945004","https://openalex.org/W2020724792","https://openalex.org/W2027426882","https://openalex.org/W2031096462","https://openalex.org/W2044502883","https://openalex.org/W2046809995","https://openalex.org/W2051924473","https://openalex.org/W2070240958","https://openalex.org/W2080215179","https://openalex.org/W2103608035","https://openalex.org/W2103740220","https://openalex.org/W2109964544","https://openalex.org/W2133200842","https://openalex.org/W2158615473","https://openalex.org/W2166281097","https://openalex.org/W2473786944","https://openalex.org/W3021410191","https://openalex.org/W4237607997","https://openalex.org/W4255483444","https://openalex.org/W4406442031"],"related_works":["https://openalex.org/W1996375113","https://openalex.org/W1984204202","https://openalex.org/W2135781126","https://openalex.org/W2128585633","https://openalex.org/W4405230530","https://openalex.org/W4397006818","https://openalex.org/W4392285377","https://openalex.org/W4320892441","https://openalex.org/W3129239981","https://openalex.org/W2056343020"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1],"assess":[2],"whether":[3],"omission":[4,147,223],"of":[5,19,37,49,64,70,111,140,148,154,182,219,224,233,242,252,261,287,289,308,343,363,376,405,425,432,443],"post-operative":[6,141],"radiotherapy":[7],"(RT)":[8],"in":[9,85,88,216,229,239,318,352,359,470,472],"women":[10],"with":[11,162,191,221,295,300,305,347,366],"'low-risk'":[12],"axillary":[13],"node-negative":[14],"breast":[15,102,118,143,297,319,396],"cancer":[16,83,86,397],"[tumour":[17],"size":[18,33],"less":[20],"than":[21,336,378],"5":[22,208,325],"cm":[23],"(T0-2)":[24],"although":[25],"the":[26,31,89,146,157,222,230,234,240,253,259,267,276,285,360,367,379,423,438,460,481],"eligibility":[27],"criteria":[28],"further":[29,486],"reduce":[30],"eligible":[32,98],"to":[34,106,132,324,345,385],"a":[35,62,192],"maximum":[36],"3":[38,206],"cm]":[39],"treated":[40],"by":[41,67,186,202,266,271,275,393,459],"breast-conserving":[42],"surgery":[43],"and":[44,51,75,126,130,164,166,174,176,207,256,299,310,441,466],"endocrine":[45,77,124,311],"therapy":[46,78,125],"improves":[47],"quality":[48,218,362,375,404,431],"life":[50,155,220,364,377,406],"is":[52,390,446],"more":[53],"cost-effective.":[54],"DESIGN:":[55],"A":[56],"randomised":[57],"controlled":[58],"clinical":[59],"trial,":[60],"using":[61],"method":[63,181],"minimisation":[65],"balanced":[66],"centre,":[68],"grade":[69],"cancer,":[71],"age,":[72],"lymphovascular":[73],"invasion":[74],"preoperative":[76],"was":[79,156,185,226,292,332,357,457],"performed.":[80],"SETTING:":[81],"Breast":[82,388],"clinics":[84],"centres":[87],"UK.":[90],"PARTICIPANTS:":[91],"Patients":[92],"aged":[93],"\u2265":[94],"65":[95],"years":[96,209,326],"were":[97,104,115,122,128,171,248,263,280],"provided":[99,265],"that":[100,422],"their":[101,401],"cancers":[103],"considered":[105],"be":[107,412,468],"at":[108,189,205],"low":[109],"risk":[110],"local":[112],"recurrence,":[113],"they":[114,121,127],"suitable":[116],"for":[117,237,322,485],"conservation":[119],"surgery,":[120],"receiving":[123],"willing":[129],"able":[131],"give":[133],"informed":[134],"consent.":[135],"INTERVENTIONS:":[136],"The":[137,179,213],"standard":[138],"treatment":[139,262],"whole":[142],"irradiation":[144],"or":[145],"RT.":[149,290],"MAIN":[150],"OUTCOME":[151],"MEASURES:":[152],"Quality":[153],"primary":[158],"outcome":[159,169],"measure,":[160,365],"together":[161],"anxiety":[163],"depression":[165],"cost-effectiveness.":[167],"Secondary":[168],"measures":[170],"recurrence":[172],"rates":[173],"survival,":[175],"treatment-related":[177],"morbidity.":[178],"principal":[180],"data":[183,269],"collection":[184],"questionnaire,":[187],"completed":[188],"home":[190],"research":[193],"nurse":[194],"on":[195,437],"four":[196],"occasions":[197],"over":[198],"15":[199],"months,":[200],"then":[201,293],"postal":[203],"questionnaire":[204],"after":[210,284,327],"surgery.":[211],"RESULTS:":[212],"hypothesised":[214],"improvement":[215],"overall":[217,361,402,430],"RT":[225,291,328,331,369,380,389,426,445],"not":[227,428],"seen":[228],"summary":[231],"domains":[232],"European":[235],"Organisation":[236],"Research":[238],"Treatment":[241],"Cancer":[243],"(EORTC)":[244],"scales.":[245],"Some":[246],"differences":[247,317],"apparent":[249,282],"within":[250],"subscales":[251],"EORTC":[254],"questionnaires,":[255],"insights":[257],"into":[258,414],"impact":[260],"also":[264],"qualitative":[268],"obtained":[270],"open-ended":[272],"questions":[273],"added":[274],"trial":[277],"team.":[278],"Differences":[279],"most":[281,394],"shortly":[283],"time":[286],"completion":[288],"associated":[294],"increased":[296],"symptoms":[298,320],"greater":[301,335,374],"(self-reported)":[302],"fatigue,":[303],"but":[304],"lower":[306],"levels":[307],"insomnia":[309],"side":[312],"effects.":[313],"These":[314],"statistically":[315],"significant":[316,355],"persisted":[321],"up":[323],"[mean":[329],"difference,":[330],"5.27":[333],"units":[334,373],"no":[337,368],"RT,":[338],"95%":[339],"confidence":[340],"interval":[341],"(CI)":[342],"1.46":[344],"9.07],":[346],"similar,":[348],"though":[349],"non-significant,":[350],"trends":[351],"insomnia.":[353],"No":[354],"difference":[356],"found":[358],"group":[370,381],"having":[371],"0.36":[372],"(95%":[382],"CI":[383],"-5.09":[384],"5.81).":[386],"CONCLUSIONS:":[387],"tolerated":[391],"well":[392],"older":[395],"patients":[398],"without":[399],"impairing":[400],"health-related":[403],"(HRQoL).":[407],"Although":[408],"HRQoL":[409],"should":[410],"always":[411],"taken":[413],"account":[415],"when":[416],"determining":[417],"treatment,":[418],"our":[419],"results":[420],"show":[421],"addition":[424],"does":[427],"impair":[429],"life.":[433],"Further":[434],"economic":[435],"modelling":[436],"longer-term":[439],"costs":[440],"consequences":[442],"omitting":[444],"required.":[447],"TRIAL":[448],"REGISTRATION:":[449],"Current":[450],"Controlled":[451],"Trials":[452],"ISRCTN14817328.":[453],"FUNDING:":[454],"This":[455],"project":[456,487],"funded":[458],"NIHR":[461],"Health":[462,473],"Technology":[463,474],"Assessment":[464],"programme":[465,483],"will":[467],"published":[469],"full":[471],"Assessment;":[475],"Vol":[476],"15,":[477],"No.":[478],"12.":[479],"See":[480],"HTA":[482],"website":[484],"information.":[488]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}