{"id":"https://openalex.org/W1965280002","doi":"https://doi.org/10.1111/j.1365-2125.1995.tb04558.x","title":"An unequal cross\u2010over event within the CYP2D gene cluster generates a chimeric CYP2D7/CYP2D6 gene which is associated with the poor metabolizer phenotype.","display_name":"An unequal cross\u2010over event within the CYP2D gene cluster generates a chimeric CYP2D7/CYP2D6 gene which is associated with the poor metabolizer phenotype.","publication_year":1995,"publication_date":"1995-10-01","ids":{"openalex":"https://openalex.org/W1965280002","doi":"https://doi.org/10.1111/j.1365-2125.1995.tb04558.x","mag":"1965280002","pmid":"https://pubmed.ncbi.nlm.nih.gov/8554938","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1365155"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2125.1995.tb04558.x","doi":"https://doi.org/10.1111/j.1365-2125.1995.tb04558.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.1995.tb04558.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.1995.tb04558.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.1995.tb04558.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076603275","display_name":"St\u00e9phane Panserat","orcid":"https://orcid.org/0000-0002-4479-9868","observed_orcids":["https://orcid.org/0000-0002-4479-9868"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210126712","display_name":"H\u00f4pital Robert-Debr\u00e9","ror":"https://ror.org/02dcqy320","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210126712"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S Panserat","raw_affiliation_strings":["INSERM U120, H\u00f4pital Robert Debr\u00e9, Paris, France","INSERM U120 Hopital Robert Debre Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U120, H\u00f4pital Robert Debr\u00e9, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210126712"]},{"raw_affiliation_string":"INSERM U120 Hopital Robert Debre Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210126712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036168448","display_name":"Catherine Mura","orcid":"https://orcid.org/0000-0002-8414-1139","observed_orcids":["https://orcid.org/0000-0002-8414-1139"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210126712","display_name":"H\u00f4pital Robert-Debr\u00e9","ror":"https://ror.org/02dcqy320","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210126712"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C Mura","raw_affiliation_strings":["INSERM U120, Hopital Robert Debre, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U120, Hopital Robert Debre, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210126712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062186392","display_name":"Nathalie G\u00e9rard","orcid":"https://orcid.org/0000-0002-8818-1736","observed_orcids":["https://orcid.org/0000-0002-8818-1736"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210126712","display_name":"H\u00f4pital Robert-Debr\u00e9","ror":"https://ror.org/02dcqy320","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210126712"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"N Gerard","raw_affiliation_strings":["INSERM U120, Hopital Robert Debre, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U120, Hopital Robert Debre, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210126712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043099409","display_name":"Monique Vincent\u2010Viry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210126712","display_name":"H\u00f4pital Robert-Debr\u00e9","ror":"https://ror.org/02dcqy320","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210126712"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M Vincent\u2010Viry","raw_affiliation_strings":["INSERM U120, Hopital Robert Debre, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U120, Hopital Robert Debre, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210126712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109945938","display_name":"M M Galteau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210126712","display_name":"H\u00f4pital Robert-Debr\u00e9","ror":"https://ror.org/02dcqy320","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210126712"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"MM Galteau","raw_affiliation_strings":["INSERM U120, Hopital Robert Debre, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U120, Hopital Robert Debre, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210126712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026079355","display_name":"\u00c9velyne Jacqz-Aigrain","orcid":"https://orcid.org/0000-0002-4285-7067","observed_orcids":["https://orcid.org/0000-0002-4285-7067"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210126712","display_name":"H\u00f4pital Robert-Debr\u00e9","ror":"https://ror.org/02dcqy320","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210126712"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"E Jacoz\u2010Aigrain","raw_affiliation_strings":["INSERM U120, Hopital Robert Debre, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U120, Hopital Robert Debre, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210126712"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100669774","display_name":"Rajagopal Krishnamoorthy","orcid":"https://orcid.org/0000-0001-5323-137X","observed_orcids":["https://orcid.org/0000-0001-5323-137X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210126712","display_name":"H\u00f4pital Robert-Debr\u00e9","ror":"https://ror.org/02dcqy320","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210126712"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"R Krishnamoorthy","raw_affiliation_strings":["INSERM U120, Hopital Robert Debre, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U120, Hopital Robert Debre, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210126712"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":0.7976,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.64676241,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"40","issue":"4","first_page":"361","last_page":"367"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp2d6","display_name":"CYP2D6","score":0.9129999876022339},{"id":"https://openalex.org/keywords/fusion-genes","display_name":"fusion genes","score":0.7820000052452087},{"id":"https://openalex.org/keywords/unequal-crossing-over","display_name":"unequal crossover","score":0.7039999961853027},{"id":"https://openalex.org/keywords/gene-rearrangement","display_name":"gene rearrangement","score":0.8100000023841858},{"id":"https://openalex.org/keywords/poor-metabolizer-phenotype","display_name":"poor metabolizer phenotype","score":0.9150000214576721},{"id":"https://openalex.org/keywords/reading-frame-shift","display_name":"reading frame shift","score":0.6890000104904175},{"id":"https://openalex.org/keywords/early-termination","display_name":"early termination","score":0.6620000004768372},{"id":"https://openalex.org/keywords/drug-metabolism-polymorphisms","display_name":"drug metabolism polymorphisms","score":0.49399998784065247},{"id":"https://openalex.org/keywords/genotype-phenotype-correlation","display_name":"genotype-phenotype correlation","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.7871353626251221},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7828893661499023},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.698762834072113},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.6151853799819946},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6100544929504395},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.600921094417572},{"id":"https://openalex.org/C2777563447","wikidata":"https://www.wikidata.org/wiki/Q7243397","display_name":"Primer (cosmetics)","level":2,"score":0.5596311092376709},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.5146828293800354},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.512421190738678},{"id":"https://openalex.org/C36857842","wikidata":"https://www.wikidata.org/wiki/Q1501261","display_name":"Gene cluster","level":3,"score":0.46865811944007874},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.45571115612983704},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.42829856276512146},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0508560836315155},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019389","descriptor_name":"Cytochrome P-450 CYP2D6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2125.1995.tb04558.x","doi":"https://doi.org/10.1111/j.1365-2125.1995.tb04558.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.1995.tb04558.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.1995.tb04558.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1365155","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1365155","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Clin Pharmacol","raw_type":"Text"},{"id":"pmid:8554938","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8554938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of clinical pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1365-2125.1995.tb04558.x","doi":"https://doi.org/10.1111/j.1365-2125.1995.tb04558.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.1995.tb04558.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.1995.tb04558.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1965280002.pdf","grobid_xml":"https://content.openalex.org/works/W1965280002.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1541002222","https://openalex.org/W1561723795","https://openalex.org/W1704586464","https://openalex.org/W1756143557","https://openalex.org/W1988007036","https://openalex.org/W1991969941","https://openalex.org/W1998527509","https://openalex.org/W2003410018","https://openalex.org/W2021755256","https://openalex.org/W2037085702","https://openalex.org/W2038188157","https://openalex.org/W2047817576","https://openalex.org/W2050613858","https://openalex.org/W2067693646","https://openalex.org/W2071332031","https://openalex.org/W2084686194","https://openalex.org/W2093139357","https://openalex.org/W2095280623","https://openalex.org/W2107472157","https://openalex.org/W2111731642","https://openalex.org/W2117918458","https://openalex.org/W2138270253"],"related_works":["https://openalex.org/W2085660015","https://openalex.org/W1988007036","https://openalex.org/W2163813533","https://openalex.org/W1973979477","https://openalex.org/W1966292821","https://openalex.org/W2315423633","https://openalex.org/W2107702110","https://openalex.org/W2037855670","https://openalex.org/W1785435186","https://openalex.org/W2117918458"],"abstract_inverted_index":{"1.":[0],"The":[1,157],"study":[2],"of":[3,9,56,69,76,104,134,141,171,175,190],"the":[4,22,35,46,53,57,63,70,77,88,125,135,172,176,184],"CYP2D":[5],"genotype":[6],"and":[7,40,73,109],"phenotype":[8,60],"a":[10,15,102,110,131,139,150,181],"Caucasian":[11],"family":[12],"revealed":[13,123],"that":[14,34,124],"XbaI-9":[16,47,64,126],"kb":[17,48,65,127],"allele":[18,128],"was":[19,80],"associated":[20,44,61],"with":[21,45,62,187],"poor":[23,58],"metabolizer":[24,59],"phenotype.":[25],"2.":[26],"A":[27],"Polymerase":[28],"Chain":[29],"Reaction":[30],"(PCR)-based":[31],"assay":[32],"showed":[33],"previously":[36],"described":[37],"mutations":[38],"D6A":[39],"D6B":[41],"are":[42],"not":[43],"allele.":[49],"3.":[50],"To":[51],"explore":[52],"molecular":[54],"basis":[55],"allele,":[66],"complete":[67],"sequencing":[68],"nine":[71],"exons":[72,89],"intron-exon":[74],"boundaries":[75],"CYP2D6":[78,94,111],"gene":[79,159],"undertaken":[81],"after":[82],"amplification":[83],"by":[84],"PCR.":[85],"4.":[86],"All":[87],"were":[90],"successfully":[91],"amplified":[92,121],"using":[93],"gene-specific":[95,106,112],"primers":[96],"except":[97],"exon":[98,168,173],"1":[99,169,174],"which":[100,179],"required":[101],"combination":[103],"CYP2D7":[105,177],"5'":[107,152],"primer":[108],"3'":[113,154],"primer.":[114],"5.":[115],"Sequence":[116],"data":[117],"derived":[118],"from":[119],"this":[120],"product":[122],"corresponds":[129],"to":[130,164],"novel":[132],"rearrangement":[133],"locus.":[136],"This":[137],"involved":[138],"deletion":[140],"an":[142,165],"approximately":[143],"20":[144],"kilobase":[145],"(kb)":[146],"DNA":[147],"segment":[148],"generating":[149],"hybrid":[151],"CYP2D7/CYP2D6":[153],"gene.":[155],"6.":[156],"chimeric":[158],"is":[160],"non-functional":[161],"presumably":[162],"due":[163],"insertion":[166],"in":[167,183],"(characteristic":[170],"gene)":[178],"causes":[180],"shift":[182],"reading":[185],"frame":[186],"premature":[188],"termination":[189],"translation.":[191]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}