{"id":"https://openalex.org/W1965212418","doi":"https://doi.org/10.1002/art.1780380507","title":"Sulfasalazine in the treatment of spondylarthropathy","display_name":"Sulfasalazine in the treatment of spondylarthropathy","publication_year":1995,"publication_date":"1995-05-01","ids":{"openalex":"https://openalex.org/W1965212418","doi":"https://doi.org/10.1002/art.1780380507","mag":"1965212418","pmid":"https://pubmed.ncbi.nlm.nih.gov/7748217"},"language":"en","primary_location":{"id":"doi:10.1002/art.1780380507","doi":"https://doi.org/10.1002/art.1780380507","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.1780380507","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis & Rheumatism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104491150","display_name":"Maxime Dougados","orcid":"https://orcid.org/0000-0003-3009-6229","observed_orcids":["https://orcid.org/0000-0003-3009-6229"]},"institutions":[{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Maxime Dougados","raw_affiliation_strings":["Universit\u00e9 Ren\u00e9 Descartes, H\u00f4pital Cochin, Paris, France","Universit\u00e9 Ren\u00e9 Descartes, H\u01d2pital Cochin, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Ren\u00e9 Descartes, H\u00f4pital Cochin, Paris, France","institution_ids":["https://openalex.org/I4210092774","https://openalex.org/I4387156284"]},{"raw_affiliation_string":"Universit\u00e9 Ren\u00e9 Descartes, H\u01d2pital Cochin, Paris, France","institution_ids":["https://openalex.org/I4210092774","https://openalex.org/I4387156284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110865997","display_name":"Sjef van der Linden","orcid":"https://orcid.org/0000-0002-0087-0351","observed_orcids":["https://orcid.org/0000-0002-0087-0351"]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sjef VAN DER Linden","raw_affiliation_strings":["Academisch Ziekenhuis Maastricht, Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academisch Ziekenhuis Maastricht, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I2800191616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006623618","display_name":"Marjatta Leirisalo\u2010Repo","orcid":"https://orcid.org/0000-0002-1568-9045","observed_orcids":["https://orcid.org/0000-0002-1568-9045"]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Marjatta Leirisalo\u2010Repo","raw_affiliation_strings":["Helsinki University Central Hospital, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helsinki University Central Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109140547","display_name":"Bernhard Huitfeldt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernhard Huitfeldt","raw_affiliation_strings":["Kabi Pharmacia AB Therapeutics, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kabi Pharmacia AB Therapeutics, Uppsala, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081673045","display_name":"Roger Juhlin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roger Juhlin","raw_affiliation_strings":["Kabi Pharmacia AB Therapeutics, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kabi Pharmacia AB Therapeutics, Uppsala, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109071322","display_name":"ERIC M. VEYS","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Eric Veys","raw_affiliation_strings":["University Hospital, Ghent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital, Ghent, Belgium","institution_ids":["https://openalex.org/I2801227569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101772802","display_name":"Henning K. Zeidler","orcid":"https://orcid.org/0000-0001-6354-6949","observed_orcids":["https://orcid.org/0000-0001-6354-6949"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Henning Zeidler","raw_affiliation_strings":["Medizinische Hochschule, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Hochschule, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035671675","display_name":"Tore Kristian Kvien","orcid":"https://orcid.org/0000-0002-8441-3093","observed_orcids":["https://orcid.org/0000-0002-8441-3093"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Tore K. Kvien","raw_affiliation_strings":["Norwegian Lutheran Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Norwegian Lutheran Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048448384","display_name":"Ignazio Olivieri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ignazio Olivieri","raw_affiliation_strings":["Universita\u0300 degli Studi, Pisa, Italy","Universit\u00e0 degli Studi, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universita\u0300 degli Studi, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Universit\u00e0 degli Studi, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108476892","display_name":"Ben A. C. Dijkmans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ben Dijkmans","raw_affiliation_strings":["Academisch Ziekenhuis Leiden, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academisch Ziekenhuis Leiden, Leiden, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110880955","display_name":"Jim V. Bertouch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108821","display_name":"Prince of Wales Hospital","ror":"https://ror.org/022arq532","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210108821"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jim Bertouch","raw_affiliation_strings":["Prince of Wales Hospital, Randwick, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince of Wales Hospital, Randwick, NSW, Australia","institution_ids":["https://openalex.org/I4210108821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030544708","display_name":"Peter Brooks","orcid":"https://orcid.org/0000-0001-7733-7750","observed_orcids":["https://orcid.org/0000-0001-7733-7750","https://orcid.org/0000-0003-4915-4986"]},"institutions":[{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Peter Brooks","raw_affiliation_strings":["St. Vincent's Hospital, Darlinghurst, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Vincent's Hospital, Darlinghurst, NSW, Australia","institution_ids":["https://openalex.org/I4210087284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111592935","display_name":"John P Edmonds","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123059","display_name":"St George Hospital","ror":"https://ror.org/02pk13h45","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210123059"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"John Edmonds","raw_affiliation_strings":["St. George Hospital, Kogarah, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. George Hospital, Kogarah, NSW, Australia","institution_ids":["https://openalex.org/I4210123059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089003620","display_name":"Gabor A. C. Major","orcid":"https://orcid.org/0000-0003-3464-7438","observed_orcids":["https://orcid.org/0000-0003-3464-7438"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabor Major","raw_affiliation_strings":["Royal Newcastle Hospital, Newcastle, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Newcastle Hospital, Newcastle, NSW, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050622812","display_name":"Bernard Amor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bernard Amor","raw_affiliation_strings":["Universite\u0301 Rene\u0301 Descartes, Ho\u030cpital Cochin, Paris, France","Universit\u00e9 Ren\u00e9 Descartes, H\u01d2pital Cochin, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universite\u0301 Rene\u0301 Descartes, Ho\u030cpital Cochin, Paris, France","institution_ids":["https://openalex.org/I4210092774"]},{"raw_affiliation_string":"Universit\u00e9 Ren\u00e9 Descartes, H\u01d2pital Cochin, Paris, France","institution_ids":["https://openalex.org/I4210092774","https://openalex.org/I4387156284"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081680633","display_name":"Andrei C\u0103lin","orcid":"https://orcid.org/0000-0002-1728-4666","observed_orcids":["https://orcid.org/0000-0002-1728-4666"]},"institutions":[{"id":"https://openalex.org/I1291344717","display_name":"Royal National Hospital for Rheumatic Diseases","ror":"https://ror.org/05va5gy74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1291344717","https://openalex.org/I4210161895"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrei Calin","raw_affiliation_strings":["Royal National Hospital for Rheumatic Diseases, Bath, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal National Hospital for Rheumatic Diseases, Bath, England","institution_ids":["https://openalex.org/I1291344717"]}]}],"institutions":[],"countries_distinct_count":9,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5104491150"],"corresponding_institution_ids":["https://openalex.org/I4210092774","https://openalex.org/I4387156284"],"apc_list":null,"apc_paid":null,"fwci":9.3384,"has_fulltext":false,"cited_by_count":388,"citation_normalized_percentile":{"value":0.98524489,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"38","issue":"5","first_page":"618","last_page":"627"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sulfasalazine","display_name":"sulfasalazine","score":1.0},{"id":"https://openalex.org/keywords/spondylarthropathy","display_name":"spondylarthropathy","score":0.9800000190734863},{"id":"https://openalex.org/keywords/psoriatic-arthritis","display_name":"psoriatic arthritis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.6940000057220459},{"id":"https://openalex.org/keywords/pain","display_name":"pain","score":0.6489999890327454},{"id":"https://openalex.org/keywords/morning-stiffness","display_name":"morning stiffness","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.8309999704360962},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7990000247955322},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9204349517822266},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7521512508392334},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7366299033164978},{"id":"https://openalex.org/C2779383735","wikidata":"https://www.wikidata.org/wiki/Q420035","display_name":"Sulfasalazine","level":4,"score":0.6416061520576477},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5738351345062256},{"id":"https://openalex.org/C2776260265","wikidata":"https://www.wikidata.org/wiki/Q511097","display_name":"Psoriatic arthritis","level":3,"score":0.5684962868690491},{"id":"https://openalex.org/C2779146052","wikidata":"https://www.wikidata.org/wiki/Q708176","display_name":"Arthropathy","level":4,"score":0.5273082256317139},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4962936043739319},{"id":"https://openalex.org/C65409693","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Statistical significance","level":2,"score":0.4490177035331726},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.43931788206100464},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.43539977073669434},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.43234962224960327},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.3900079131126404},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.35792380571365356},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.35522186756134033},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1840924620628357},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010342","descriptor_name":"Patient Acceptance of Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012460","descriptor_name":"Sulfasalazine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012460","descriptor_name":"Sulfasalazine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013167","descriptor_name":"Spondylitis, Ankylosing","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D013167","descriptor_name":"Spondylitis, Ankylosing","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015535","descriptor_name":"Arthritis, Psoriatic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D015535","descriptor_name":"Arthritis, Psoriatic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016918","descriptor_name":"Arthritis, Reactive","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D016918","descriptor_name":"Arthritis, Reactive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/art.1780380507","doi":"https://doi.org/10.1002/art.1780380507","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.1780380507","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis & Rheumatism","raw_type":"journal-article"},{"id":"pmid:7748217","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7748217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis and rheumatism","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W143191285","https://openalex.org/W303553237","https://openalex.org/W1492940207","https://openalex.org/W1900283937","https://openalex.org/W1966756689","https://openalex.org/W1969280409","https://openalex.org/W1989485050","https://openalex.org/W1990588479","https://openalex.org/W1996161702","https://openalex.org/W1999359514","https://openalex.org/W2006593810","https://openalex.org/W2028983784","https://openalex.org/W2035787474","https://openalex.org/W2036058087","https://openalex.org/W2037976962","https://openalex.org/W2050077474","https://openalex.org/W2053380345","https://openalex.org/W2070051129","https://openalex.org/W2088158803","https://openalex.org/W2089404439","https://openalex.org/W2094632762","https://openalex.org/W2102746593","https://openalex.org/W2125580228","https://openalex.org/W2154766871","https://openalex.org/W2409512111","https://openalex.org/W2410294551","https://openalex.org/W2411276370","https://openalex.org/W2425295427","https://openalex.org/W2434633196","https://openalex.org/W2462933103","https://openalex.org/W2468464143","https://openalex.org/W4252154999","https://openalex.org/W4299420989"],"related_works":["https://openalex.org/W1986200978","https://openalex.org/W1976217778","https://openalex.org/W1969280409","https://openalex.org/W2414637416","https://openalex.org/W2070051129","https://openalex.org/W2000652739","https://openalex.org/W2035612894","https://openalex.org/W2110517604","https://openalex.org/W7096082136","https://openalex.org/W2032653457"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"assess":[2],"the":[3,11,54,69,75,83,89,96,110,117,124,134,139,150,169,189,202,214,225,229,257],"efficacy":[4,51,205,210,253],"and":[5,56,61,71,106,112,207],"tolerability":[6],"of":[7,13,25,78,120,133,143,149,168,175,184,216,240,245,259],"sulfasalazine":[8],"(SSZ)":[9],"in":[10,68,82,109,164,182,195,224,256,263],"treatment":[12,35,98,258],"spondylarthropathy.":[14],"METHODS:":[15],"We":[16],"conducted":[17],"a":[18,161],"6-month":[19,97],"randomized,":[20],"placebo-controlled,":[21],"double-blind,":[22],"multicenter":[23],"study":[24,247],"patients":[26,91,151,170,196,264],"with":[27,36,43,197,265],"spondylarthropathy":[28],"whose":[29],"disease":[30,144],"had":[31,251],"remained":[32],"active":[33,260],"despite":[34],"nonsteroidal":[37],"antiinflammatory":[38],"drugs.":[39],"Patients":[40],"were":[41,53,66,103,193,221,234],"treated":[42],"SSZ":[44,113,153,226,250],"(3":[45],"gm/day)":[46],"or":[47,236],"placebo.":[48,172],"The":[49,100,243],"primary":[50,136,204],"variables":[52,206,211],"physician's":[55],"patient's":[57,140],"overall":[58,141],"assessments,":[59],"pain,":[60],"morning":[62],"stiffness.":[63],"End":[64],"points":[65],"analyzed":[67,81],"intent-to-treat":[70,118],"completer":[72,84],"patient":[73,85],"populations;":[74],"time":[76],"course":[77],"effect":[79],"was":[80],"population.":[86],"RESULTS:":[87],"Of":[88],"351":[90],"enrolled,":[92],"263":[93],"(75%)":[94],"completed":[95],"period.":[99],"withdrawal":[101],"rates":[102],"35":[104],"(20%)":[105],"53":[107],"(30%)":[108],"placebo":[111,230,255],"groups,":[114],"respectively.":[115],"In":[116,186],"analysis":[119],"end":[121],"point":[122,159],"efficacy,":[123],"between-treatment":[125],"difference":[126],"reached":[127],"statistical":[128],"significance":[129],"only":[130],"for":[131,146,201,208],"1":[132,158],"4":[135,203],"outcome":[137],"variables,":[138],"assessment":[142],"activity,":[145],"which":[147],"60%":[148],"taking":[152,171],"improved":[154],"by":[155],"at":[156],"least":[157],"on":[160],"5-point":[162],"scale,":[163],"contrast":[165],"to":[166],"44%":[167],"Laboratory":[173],"markers":[174],"inflammation":[176],"also":[177],"showed":[178],"statistically":[179],"significant":[180],"change":[181],"favor":[183],"SSZ.":[185],"subgroup":[187],"analysis,":[188],"most":[190],"impressive":[191],"effects":[192],"seen":[194],"psoriatic":[198,266],"arthritis,":[199],"both":[200],"secondary":[209],"such":[212],"as":[213],"number":[215],"inflamed":[217],"joints.":[218],"Adverse":[219],"events":[220],"more":[222],"frequent":[223],"group":[227],"than":[228,254],"group,":[231],"but":[232],"all":[233],"transient":[235],"reversible":[237],"after":[238],"cessation":[239],"treatment.":[241],"CONCLUSION:":[242],"results":[244],"this":[246],"show":[248],"that":[249],"greater":[252],"spondylarthropathy,":[261],"notably":[262],"arthritis.":[267]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}