{"id":"https://openalex.org/W1965200427","doi":"https://doi.org/10.1073/pnas.93.20.11097","title":"The level of mRNA encoding the amphotropic retrovirus receptor in mouse and human hematopoietic stem cells is low and correlates with the efficiency of retrovirus transduction.","display_name":"The level of mRNA encoding the amphotropic retrovirus receptor in mouse and human hematopoietic stem cells is low and correlates with the efficiency of retrovirus transduction.","publication_year":1996,"publication_date":"1996-10-01","ids":{"openalex":"https://openalex.org/W1965200427","doi":"https://doi.org/10.1073/pnas.93.20.11097","mag":"1965200427","pmid":"https://pubmed.ncbi.nlm.nih.gov/8855315"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.93.20.11097","doi":"https://doi.org/10.1073/pnas.93.20.11097","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.93.20.11097","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/38290","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006750789","display_name":"Donald Orlic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Orlic","raw_affiliation_strings":["Hematopoiesis Section, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD 20892-4442, USA. dorlic@nchgr.nih.gov"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematopoiesis Section, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD 20892-4442, USA. dorlic@nchgr.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L J Girard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L J Girard","raw_affiliation_strings":["Hematopoiesis Section, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD 20892-4442, USA. dorlic@nchgr.nih.gov"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematopoiesis Section, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD 20892-4442, USA. dorlic@nchgr.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038867429","display_name":"Craig T. Jordan","orcid":"https://orcid.org/0000-0003-0869-3465","observed_orcids":["https://orcid.org/0000-0003-0869-3465"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C T Jordan","raw_affiliation_strings":["Hematopoiesis Section, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD 20892-4442, USA. dorlic@nchgr.nih.gov"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematopoiesis Section, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD 20892-4442, USA. dorlic@nchgr.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108699289","display_name":"Stacie M. Anderson","orcid":"https://orcid.org/0000-0002-9889-561X","observed_orcids":["https://orcid.org/0000-0002-9889-561X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S M Anderson","raw_affiliation_strings":["Hematopoiesis Section, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD 20892-4442, USA. dorlic@nchgr.nih.gov"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematopoiesis Section, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD 20892-4442, USA. dorlic@nchgr.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047988780","display_name":"Amanda P. Cline","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A P Cline","raw_affiliation_strings":["Hematopoiesis Section, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD 20892-4442, USA. dorlic@nchgr.nih.gov"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematopoiesis Section, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD 20892-4442, USA. dorlic@nchgr.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112149649","display_name":"David M. Bodine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D M Bodine","raw_affiliation_strings":["Hematopoiesis Section, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD 20892-4442, USA. dorlic@nchgr.nih.gov"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematopoiesis Section, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD 20892-4442, USA. dorlic@nchgr.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":13.8297,"has_fulltext":false,"cited_by_count":220,"citation_normalized_percentile":{"value":0.9923229,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"93","issue":"20","first_page":"11097","last_page":"11102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9869999885559082},{"id":"https://openalex.org/keywords/proviral-integration","display_name":"proviral integration","score":0.5669999718666077},{"id":"https://openalex.org/keywords/long-term-repopulation","display_name":"long-term repopulation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/cd34-cd38-cells","display_name":"CD34+CD38- cells","score":0.7799999713897705},{"id":"https://openalex.org/keywords/receptor-mrna-expression","display_name":"receptor mRNA expression","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C2778431562","wikidata":"https://www.wikidata.org/wiki/Q189308","display_name":"Retrovirus","level":3,"score":0.8733731508255005},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7982602119445801},{"id":"https://openalex.org/C102906071","wikidata":"https://www.wikidata.org/wiki/Q422467","display_name":"Provirus","level":4,"score":0.7261613607406616},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5733245611190796},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5728826522827148},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.5482301712036133},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.5457032918930054},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5418984889984131},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4950486719608307},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4507163465023041},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3154640793800354},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.19368624687194824},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1854029893875122},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12850752472877502},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011991","descriptor_name":"Receptors, Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011991","descriptor_name":"Receptors, Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011991","descriptor_name":"Receptors, Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027981","descriptor_name":"Symporters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D027981","descriptor_name":"Symporters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D027981","descriptor_name":"Symporters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D028061","descriptor_name":"Phosphate Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D028061","descriptor_name":"Phosphate Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D028061","descriptor_name":"Phosphate Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050608","descriptor_name":"Sodium-Phosphate Cotransporter Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050608","descriptor_name":"Sodium-Phosphate Cotransporter Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050608","descriptor_name":"Sodium-Phosphate Cotransporter Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.93.20.11097","doi":"https://doi.org/10.1073/pnas.93.20.11097","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.93.20.11097","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:8855315","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8855315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:71284","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC38290","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:38290","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/38290","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:38290","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/38290","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W5576066","https://openalex.org/W74017565","https://openalex.org/W145886036","https://openalex.org/W193514409","https://openalex.org/W1607225057","https://openalex.org/W1868517480","https://openalex.org/W1908249423","https://openalex.org/W1931238275","https://openalex.org/W1973035870","https://openalex.org/W2008634652","https://openalex.org/W2008685326","https://openalex.org/W2013188793","https://openalex.org/W2016176753","https://openalex.org/W2016647073","https://openalex.org/W2022205235","https://openalex.org/W2028272667","https://openalex.org/W2050602931","https://openalex.org/W2052337124","https://openalex.org/W2057436316","https://openalex.org/W2061120310","https://openalex.org/W2064166253","https://openalex.org/W2066027429","https://openalex.org/W2067379696","https://openalex.org/W2068414038","https://openalex.org/W2070981327","https://openalex.org/W2075227748","https://openalex.org/W2080589169","https://openalex.org/W2099369209","https://openalex.org/W2103872763","https://openalex.org/W2129924213","https://openalex.org/W2144634347","https://openalex.org/W2145623185","https://openalex.org/W2150951349","https://openalex.org/W2158800860","https://openalex.org/W2267663149","https://openalex.org/W2292512535","https://openalex.org/W2305289606","https://openalex.org/W2398696413","https://openalex.org/W2401369637","https://openalex.org/W2403853262","https://openalex.org/W2406172744","https://openalex.org/W2413806342","https://openalex.org/W2414665599","https://openalex.org/W2418956613","https://openalex.org/W4253511719"],"related_works":["https://openalex.org/W2419222093","https://openalex.org/W1990614617","https://openalex.org/W3132976081","https://openalex.org/W1985545058","https://openalex.org/W4376111324","https://openalex.org/W1812483684","https://openalex.org/W2035984955","https://openalex.org/W4242742655","https://openalex.org/W2531493050","https://openalex.org/W2021989717"],"abstract_inverted_index":{"The":[0],"low":[1,54,200],"level":[2,183,229],"of":[3,46,58,65,91,110,120,136,145,170,184,202,209],"amphotropic":[4,32,81,97,132,148,156,192,234],"retrovirus-mediated":[5],"gene":[6,20],"transfer":[7],"into":[8],"human":[9,49,203,210],"hematopoietic":[10,23],"stem":[11],"cells":[12,220],"(HSC)":[13],"has":[14],"been":[15],"a":[16,151,195],"major":[17],"impediment":[18],"to":[19,55],"therapy":[21],"for":[22,78,129],"diseases.":[24],"In":[25,194],"the":[26,155,167,178,181,226],"present":[27,172],"study,":[28,197],"we":[29,198],"have":[30],"examined":[31],"retrovirus":[33,38,67,82,133,157,235],"receptor":[34,39,68],"(amphoR)":[35],"and":[36,48,61,80,131,143,214],"ecotropic":[37,66,79,84,130,141],"mRNA":[40,60,69,186,205,228],"expression":[41],"in":[42,89,102,154,173,206,217,230],"highly":[43],"purified":[44,207],"populations":[45,169,208],"mouse":[47,175],"HSC.":[50],"Murine":[51],"HSC":[52,74,112,125,171,211,231],"with":[53,180,233],"undetectable":[56],"levels":[57,64,119,201,216],"amphoR":[59,121,185,204,227],"relatively":[62],"high":[63],"were":[70,75,87,100,113,126],"studied.":[71],"When":[72,123],"these":[73,124],"analyzed":[76,127],"simultaneously":[77,128],"transduction,":[83,134],"provirus":[85,142,149],"sequences":[86,99],"detected":[88,101],"10":[90],"13":[92],"long-term":[93],"repopulated":[94,138],"animals,":[95],"while":[96],"proviral":[98],"only":[103],"one":[104],"recipient.":[105],"A":[106],"second":[107],"distinct":[108],"population":[109],"murine":[111],"isolated":[114],"that":[115,225],"express":[116],"3-fold":[117],"higher":[118,215],"mRNA.":[122],"11":[135,137,146],"mice":[139],"contained":[140,147],"6":[144],"sequences,":[150],"significant":[152],"increase":[153],"transduction":[158,236],"(P":[159],"=":[160],"0.018).":[161],"These":[162],"results":[163],"indicate":[164],"that,":[165],"among":[166],"heterogeneous":[168],"adult":[174],"bone":[176],"marrow,":[177],"subpopulation":[179],"highest":[182],"is":[187],"more":[188],"efficiently":[189],"transduced":[190],"by":[191],"retrovirus.":[193],"related":[196],"found":[199],"(CD34+":[212,221],"CD38-)":[213],"committed":[218],"progenitor":[219],"CD38+).":[222],"We":[223],"conclude":[224],"correlates":[232],"efficiency.":[237]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}