{"id":"https://openalex.org/W1965199845","doi":"https://doi.org/10.1111/j.1365-2133.2004.06198.x","title":"Expression of the peripheral benzodiazepine receptor is decreased in skin cancers in comparison with normal skin","display_name":"Expression of the peripheral benzodiazepine receptor is decreased in skin cancers in comparison with normal skin","publication_year":2004,"publication_date":"2004-10-01","ids":{"openalex":"https://openalex.org/W1965199845","doi":"https://doi.org/10.1111/j.1365-2133.2004.06198.x","mag":"1965199845","pmid":"https://pubmed.ncbi.nlm.nih.gov/15491426"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2133.2004.06198.x","doi":"https://doi.org/10.1111/j.1365-2133.2004.06198.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2133.2004.06198.x","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085632337","display_name":"Janet Morgan","orcid":"https://orcid.org/0000-0002-5069-1669","observed_orcids":["https://orcid.org/0000-0002-5069-1669"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. Morgan","raw_affiliation_strings":["Department of Dermatology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. Janet.Morgan@Roswell.Park.org","Department of Dermatology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. Janet.Morgan@Roswell.Park.org","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Dermatology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069143717","display_name":"Allan Roy Oseroff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.R. Oseroff","raw_affiliation_strings":["Departments of Dermatology and Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology and Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, U.S.A","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108628636","display_name":"Richard T. Cheney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.T. Cheney","raw_affiliation_strings":["Departments of Dermatology and Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology and Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, U.S.A","institution_ids":["https://openalex.org/I1292894508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085632337"],"corresponding_institution_ids":["https://openalex.org/I1292894508"],"apc_list":{"value":3731,"currency":"GBP","value_usd":4920},"apc_paid":null,"fwci":2.2448,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.85689963,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"151","issue":"4","first_page":"846","last_page":"856"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11868","display_name":"Cancer and Skin Lesions","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/translocator-protein-tspo","display_name":"translocator protein (TSPO)","score":0.9990000128746033},{"id":"https://openalex.org/keywords/skin-cancer","display_name":"skin cancer","score":0.8100000023841858},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.8730000257492065},{"id":"https://openalex.org/keywords/basal-cell-carcinoma","display_name":"basal cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/actinic-keratosis","display_name":"actinic keratosis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/heme-biosynthesis","display_name":"heme biosynthesis","score":0.7609999775886536},{"id":"https://openalex.org/keywords/protoporphyrin-ix","display_name":"protoporphyrin IX","score":0.8429999947547913},{"id":"https://openalex.org/keywords/aminolaevulinic-acid","display_name":"aminolaevulinic acid","score":0.878000020980835},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.8059999942779541},{"id":"https://openalex.org/keywords/skin-carcinogenesis","display_name":"skin carcinogenesis","score":0.44200000166893005},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.460999995470047},{"id":"https://openalex.org/keywords/photodamage","display_name":"photodamage","score":0.44999998807907104},{"id":"https://openalex.org/keywords/outer-mitochondrial-membrane","display_name":"mitochondrial outer membrane","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.7507290840148926},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6685601472854614},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5418248176574707},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5335450768470764},{"id":"https://openalex.org/C2777873816","wikidata":"https://www.wikidata.org/wiki/Q422225","display_name":"Actinic keratosis","level":3,"score":0.5287377834320068},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4905204176902771},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.46274808049201965},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4368078410625458},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2319319248199463},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15480175614356995},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.11725804209709167},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002280","descriptor_name":"Basal Cell Carcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007642","descriptor_name":"Keratosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010787","descriptor_name":"Photosensitivity Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2133.2004.06198.x","doi":"https://doi.org/10.1111/j.1365-2133.2004.06198.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2133.2004.06198.x","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},{"id":"pmid:15491426","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15491426","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of dermatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2124458638","display_name":"PDT Optimization and Mechanisms","funder_award_id":"P01CA055791","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000888465","display_name":"Roswell Park Cancer Center Support Grant","funder_award_id":"P30CA016056","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W12859958","https://openalex.org/W140452898","https://openalex.org/W1504186761","https://openalex.org/W1537418123","https://openalex.org/W1588037221","https://openalex.org/W1596638623","https://openalex.org/W1702029570","https://openalex.org/W1807206695","https://openalex.org/W1965133186","https://openalex.org/W1969306782","https://openalex.org/W1969831402","https://openalex.org/W1970399739","https://openalex.org/W1973446493","https://openalex.org/W1979826023","https://openalex.org/W1982904143","https://openalex.org/W1995117245","https://openalex.org/W1996401496","https://openalex.org/W1999958164","https://openalex.org/W2003896342","https://openalex.org/W2004027740","https://openalex.org/W2007399388","https://openalex.org/W2009155423","https://openalex.org/W2009461852","https://openalex.org/W2011027022","https://openalex.org/W2011341002","https://openalex.org/W2013204455","https://openalex.org/W2013294070","https://openalex.org/W2013588209","https://openalex.org/W2014313252","https://openalex.org/W2018301186","https://openalex.org/W2019443838","https://openalex.org/W2021156022","https://openalex.org/W2040858046","https://openalex.org/W2055052769","https://openalex.org/W2075624130","https://openalex.org/W2081606553","https://openalex.org/W2083504824","https://openalex.org/W2085257424","https://openalex.org/W2087384563","https://openalex.org/W2091070477","https://openalex.org/W2097891254","https://openalex.org/W2111992174","https://openalex.org/W2142761929","https://openalex.org/W2142949499","https://openalex.org/W2155572724","https://openalex.org/W2169152979","https://openalex.org/W2232615064","https://openalex.org/W2320795531","https://openalex.org/W2396340985","https://openalex.org/W2403725722","https://openalex.org/W2412153317","https://openalex.org/W2416191734","https://openalex.org/W2416982058","https://openalex.org/W2461975597","https://openalex.org/W3133924569","https://openalex.org/W4211024586"],"related_works":["https://openalex.org/W2097891254","https://openalex.org/W2259165196","https://openalex.org/W7005056258","https://openalex.org/W2408219434","https://openalex.org/W2051606276","https://openalex.org/W2719009405","https://openalex.org/W2170999966","https://openalex.org/W2006856271","https://openalex.org/W2273399671","https://openalex.org/W6943719306"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,20,171,294],"peripheral":[2],"benzodiazepine":[3],"receptor":[4,10],"(PBR)":[5],"is":[6],"an":[7],"18-kDa":[8],"protein":[9],"mainly":[11],"found":[12],"on":[13,260],"the":[14,157,217,229,276,314,322,347],"outer":[15],"mitochondrial":[16],"membrane":[17],"of":[18,58,156,251,265,303,308,324,329,346],"cells.":[19],"PBR":[21,41,59,85,111,158,252,267,277,325,335],"plays":[22],"a":[23,152,186,210,223,247,327,344],"role":[24,323],"in":[25,43,66,83,115,216,271,281,286,332,339,357],"several":[26,67,142],"cellular":[27,52],"functions":[28],"including":[29,70],"haem":[30,295,330,333],"synthesis,":[31,34,334],"steroidogenesis,":[32],"DNA":[33],"cell":[35,129,139],"growth":[36],"and":[37,39,50,73,76,113,117,126,131,135,141,161,167,178,199,219,237,243,263,284,289,337,352],"differentiation,":[38],"apoptosis.":[40],"expression":[42,57,112,253,268,278],"normal":[44,84,116,282],"skin":[45,93,119,122,207,245,304,340,358],"correlates":[46],"with":[47,63,209,275],"proliferating,":[48],"secretory":[49],"differentiated":[51,288],"structures.":[53],"Increased":[54],"or":[55,95],"aberrant":[56],"has":[60,298],"been":[61,299],"associated":[62],"aggressive":[64],"behaviour":[65],"tumour":[68,261,291],"types":[69],"ovarian,":[71],"colon":[72],"breast":[74],"adenocarcinomas":[75],"glioblastoma.":[77],"OBJECTIVES:":[78],"To":[79],"determine":[80],"whether":[81],"changes":[82],"distribution":[86,114,197,338],"would":[87],"be":[88,343],"useful":[89],"as":[90,102,326],"markers":[91],"for":[92,99,194,301,349],"cancers":[94,123,341],"possible":[96],"target":[97],"sites":[98],"therapies":[100],"such":[101],"photodynamic":[103],"therapy":[104],"(PDT),":[105],"we":[106],"used":[107,174],"immunohistochemistry":[108],"to":[109,151,175,203,226,312,321,355],"evaluate":[110],"photodamaged":[118],"(actinic":[120],"keratoses),":[121],"(in":[124],"situ":[125],"invasive":[127],"squamous":[128],"carcinomas":[130,305],"superficial,":[132],"nodular,":[133],"morphoeiform":[134],"mixed":[136],"pattern":[137,249],"basal":[138],"carcinomas)":[140],"benign":[143],"epithelial":[144],"proliferations.":[145],"METHODS:":[146],"A":[147],"rabbit":[148],"polyclonal":[149],"antibody":[150,172,195],"synthetic":[153],"peptide":[154],"fragment":[155],"was":[159,173,257,269],"developed":[160],"characterized":[162],"by":[163,185,306],"enzyme-linked":[164],"immunosorbent":[165],"assay":[166],"Western":[168],"blot":[169],"analysis.":[170],"stain":[176],"formalin-fixed":[177],"paraffin-embedded":[179],"tissue":[180],"samples":[181],"(n":[182],"=":[183],"157)":[184],"routine":[187],"avidin-biotin":[188],"immunohistochemical":[189],"technique.":[190],"Sections":[191],"were":[192],"evaluated":[193],"localization,":[196],"(0-4+)":[198,250],"reaction":[200,214],"intensity":[201,256],"(negative":[202],"strong).":[204],"RESULTS:":[205],"Normal":[206],"stained":[208],"strong":[211],"homogeneous":[212],"positive":[213],"(3-4+)":[215],"spinous":[218],"granular":[220],"layers":[221],"(with":[222],"gradient":[224,279],"corresponding":[225],"increasing":[227],"differentiation),":[228],"pilosebaceous":[230],"units,":[231],"eccrine":[232],"gland":[233],"ducts,":[234],"endothelial":[235],"cells":[236],"pilar":[238],"muscle.":[239],"In":[240],"cutaneous":[241],"neoplasms":[242],"other":[244],"diseases,":[246],"heterogeneous":[248],"at":[254],"lower":[255],"seen":[258,280],"depending":[259],"type":[262],"degree":[264],"differentiation.":[266],"greatest":[270],"well-differentiated":[272],"tumours,":[273],"synonymous":[274],"skin;":[283],"least":[285],"poorly":[287],"infiltrative":[290],"types.":[292],"CONCLUSIONS:":[293],"biosynthetic":[296],"pathway":[297],"harnessed":[300],"PDT":[302,356],"application":[307],"exogenous":[309],"aminolaevulinic":[310],"acid":[311],"generate":[313],"endogenous":[315],"photosensitizer":[316],"protoporphyrin":[317],"IX":[318],"(PpIX).":[319],"Owing":[320],"transporter":[328],"precursors":[331],"density":[336],"could":[342],"predictor":[345],"capacity":[348],"PpIX":[350],"production":[351],"subsequent":[353],"response":[354],"cancers.":[359]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}