{"id":"https://openalex.org/W1965196833","doi":"https://doi.org/10.1067/mpd.2001.117576","title":"Tyrosine supplementation in phenylketonuria: Diurnal blood tyrosine levels and presumptive brain influx of tyrosine and other large neutral amino acids","display_name":"Tyrosine supplementation in phenylketonuria: Diurnal blood tyrosine levels and presumptive brain influx of tyrosine and other large neutral amino acids","publication_year":2001,"publication_date":"2001-09-01","ids":{"openalex":"https://openalex.org/W1965196833","doi":"https://doi.org/10.1067/mpd.2001.117576","mag":"1965196833","pmid":"https://pubmed.ncbi.nlm.nih.gov/11562623"},"language":"en","primary_location":{"id":"doi:10.1067/mpd.2001.117576","doi":"https://doi.org/10.1067/mpd.2001.117576","is_oa":false,"landing_page_url":"https://doi.org/10.1067/mpd.2001.117576","pdf_url":null,"source":{"id":"https://openalex.org/S3774022","display_name":"The Journal of Pediatrics","issn_l":"0022-3476","issn":["0022-3476","1085-8695","1097-6833"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040528222","display_name":"Louisa R. Kalsner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louisa R. Kalsner","raw_affiliation_strings":["Division of Genetics and Department of Neurology, Children's Hospital, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genetics and Department of Neurology, Children's Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043640133","display_name":"Fran Rohr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frances J. Rohr","raw_affiliation_strings":["Division of Genetics and Department of Neurology, Children's Hospital, and Departments of Pediatrics and Neurology, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genetics and Department of Neurology, Children's Hospital, and Departments of Pediatrics and Neurology, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022288358","display_name":"Kevin A. Strauss","orcid":"https://orcid.org/0000-0002-6429-8657","observed_orcids":["https://orcid.org/0000-0002-6429-8657"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin A. Strauss","raw_affiliation_strings":["Division of Genetics and Department of Neurology, Children's Hospital, and Departments of Pediatrics and Neurology, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genetics and Department of Neurology, Children's Hospital, and Departments of Pediatrics and Neurology, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040355751","display_name":"Mark S. Korson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark S. Korson","raw_affiliation_strings":["Division of Genetics and Department of Neurology, Children's Hospital, and Departments of Pediatrics and Neurology, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genetics and Department of Neurology, Children's Hospital, and Departments of Pediatrics and Neurology, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112778417","display_name":"Harvey L. Levy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harvey L. Levy","raw_affiliation_strings":["Division of Genetics and Department of Neurology, Children's Hospital, and Departments of Pediatrics and Neurology, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genetics and Department of Neurology, Children's Hospital, and Departments of Pediatrics and Neurology, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4570,"currency":"USD","value_usd":4570},"apc_paid":null,"fwci":0.1852,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.49930844,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"139","issue":"3","first_page":"421","last_page":"427"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenylketonuria","display_name":"phenylketonuria","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tyrosine-supplementation","display_name":"tyrosine supplementation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/large-neutral-amino-acids","display_name":"large neutral amino acids","score":0.9929999709129333},{"id":"https://openalex.org/keywords/phenylalanine-restricted-diet","display_name":"phenylalanine-restricted diet","score":0.8939999938011169},{"id":"https://openalex.org/keywords/tryptophan","display_name":"tryptophan","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.9550943374633789},{"id":"https://openalex.org/C2777431362","wikidata":"https://www.wikidata.org/wiki/Q170545","display_name":"Phenylalanine","level":3,"score":0.7563453912734985},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.6493194103240967},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6465737223625183},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6333783864974976},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6047908067703247},{"id":"https://openalex.org/C2908963387","wikidata":"https://www.wikidata.org/wiki/Q194041","display_name":"Phenylketonurias","level":4,"score":0.5539921522140503},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.5212750434875488},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2614632844924927},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2374742329120636}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010661","descriptor_name":"Phenylketonurias","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1067/mpd.2001.117576","doi":"https://doi.org/10.1067/mpd.2001.117576","is_oa":false,"landing_page_url":"https://doi.org/10.1067/mpd.2001.117576","pdf_url":null,"source":{"id":"https://openalex.org/S3774022","display_name":"The Journal of Pediatrics","issn_l":"0022-3476","issn":["0022-3476","1085-8695","1097-6833"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pediatrics","raw_type":"journal-article"},{"id":"pmid:11562623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11562623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of pediatrics","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G2497555985","display_name":null,"funder_award_id":"N0 1-HD-2-3149","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G5524335007","display_name":"General Clinical Research Center","funder_award_id":"M01RR002172","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W22282067","https://openalex.org/W118912282","https://openalex.org/W1483242733","https://openalex.org/W1543947852","https://openalex.org/W1571650919","https://openalex.org/W1573692058","https://openalex.org/W1574524677","https://openalex.org/W1608588255","https://openalex.org/W1777662374","https://openalex.org/W1904068202","https://openalex.org/W1966343701","https://openalex.org/W1968685720","https://openalex.org/W1973353186","https://openalex.org/W1974608010","https://openalex.org/W1990498560","https://openalex.org/W2014883692","https://openalex.org/W2019159066","https://openalex.org/W2032375483","https://openalex.org/W2033084594","https://openalex.org/W2033720095","https://openalex.org/W2034462780","https://openalex.org/W2034910577","https://openalex.org/W2052438797","https://openalex.org/W2056584599","https://openalex.org/W2058396154","https://openalex.org/W2075349529","https://openalex.org/W2075662549","https://openalex.org/W2075807914","https://openalex.org/W2081486656","https://openalex.org/W2081868313","https://openalex.org/W2086932144","https://openalex.org/W2088913212","https://openalex.org/W2089281713","https://openalex.org/W2116316183","https://openalex.org/W2125687986","https://openalex.org/W2134108513","https://openalex.org/W2152208086","https://openalex.org/W2153495310","https://openalex.org/W2160823280","https://openalex.org/W2168667371","https://openalex.org/W2222866022","https://openalex.org/W2247750189","https://openalex.org/W2275753557","https://openalex.org/W2320537392","https://openalex.org/W2474947080","https://openalex.org/W2992150294","https://openalex.org/W3201762814","https://openalex.org/W4243508646","https://openalex.org/W4251038643"],"related_works":["https://openalex.org/W1974608010","https://openalex.org/W1906748580","https://openalex.org/W2116316183","https://openalex.org/W2247750189","https://openalex.org/W2171669814","https://openalex.org/W2106185002","https://openalex.org/W2143022717","https://openalex.org/W1777662374","https://openalex.org/W2075349529","https://openalex.org/W2759650484"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
