{"id":"https://openalex.org/W1965119043","doi":"https://doi.org/10.1002/ptr.1074","title":"Chemistry and pharmacology of the citrus bioflavonoid hesperidin","display_name":"Chemistry and pharmacology of the citrus bioflavonoid hesperidin","publication_year":2001,"publication_date":"2001-10-23","ids":{"openalex":"https://openalex.org/W1965119043","doi":"https://doi.org/10.1002/ptr.1074","mag":"1965119043","pmid":"https://pubmed.ncbi.nlm.nih.gov/11746857"},"language":"en","primary_location":{"id":"doi:10.1002/ptr.1074","doi":"https://doi.org/10.1002/ptr.1074","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ptr.1074","pdf_url":null,"source":{"id":"https://openalex.org/S206789554","display_name":"Phytotherapy Research","issn_l":"0951-418X","issn":["0951-418X","1099-1573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1965119043"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054588816","display_name":"Alka B. Garg","orcid":"https://orcid.org/0000-0003-4050-8469","observed_orcids":["https://orcid.org/0000-0003-4050-8469"]},"institutions":[{"id":"https://openalex.org/I51452335","display_name":"Panjab University","ror":"https://ror.org/04p2sbk06","country_code":"IN","type":"education","lineage":["https://openalex.org/I51452335"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"A. Garg","raw_affiliation_strings":["University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India","institution_ids":["https://openalex.org/I51452335"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026486245","display_name":"Sanjay Garg","orcid":"https://orcid.org/0000-0001-7253-2629","observed_orcids":["https://orcid.org/0000-0001-7253-2629"]},"institutions":[{"id":"https://openalex.org/I4210152674","display_name":"National Institute of Pharmaceutical Education and Research","ror":"https://ror.org/0418yqg16","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210152674"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S. Garg","raw_affiliation_strings":["National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S Nagar, Punjab 160062, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S Nagar, Punjab 160062, India","institution_ids":["https://openalex.org/I4210152674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074048534","display_name":"Lourens J. D. Zaneveld","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. J. D. Zaneveld","raw_affiliation_strings":["Rush Presbyterian St. Luke's Medical Centre, 1653, West Congress Parkway, Chicago, IL 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush Presbyterian St. Luke's Medical Centre, 1653, West Congress Parkway, Chicago, IL 60612, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"A. K. Singla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51452335","display_name":"Panjab University","ror":"https://ror.org/04p2sbk06","country_code":"IN","type":"education","lineage":["https://openalex.org/I51452335"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"A. K. Singla","raw_affiliation_strings":["University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India","institution_ids":["https://openalex.org/I51452335"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I51452335"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":0.5459,"has_fulltext":false,"cited_by_count":873,"citation_normalized_percentile":{"value":0.38983051,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"15","issue":"8","first_page":"655","last_page":"669"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14194","display_name":"Bioactive Compounds in Plants","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14194","display_name":"Bioactive Compounds in Plants","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hesperidin","display_name":"hesperidin","score":1.0},{"id":"https://openalex.org/keywords/hesperetin","display_name":"hesperetin","score":0.9819999933242798},{"id":"https://openalex.org/keywords/citrus-flavonoids","display_name":"citrus flavonoids","score":0.9169999957084656},{"id":"https://openalex.org/keywords/bioflavonoids","display_name":"bioflavonoids","score":0.7559999823570251},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7239999771118164},{"id":"https://openalex.org/keywords/toxicity","display_name":"toxicity","score":0.621999979019165},{"id":"https://openalex.org/keywords/therapeutic-use","display_name":"therapeutic applications","score":0.6240000128746033},{"id":"https://openalex.org/keywords/dietary-deficiency","display_name":"dietary deficiency","score":0.5070000290870667},{"id":"https://openalex.org/keywords/citrus-by-products","display_name":"citrus by-products","score":0.6110000014305115},{"id":"https://openalex.org/keywords/flavonoid-analysis","display_name":"flavonoid analysis","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C2776128092","wikidata":"https://www.wikidata.org/wiki/Q385937","display_name":"Hesperidin","level":3,"score":0.9795762300491333},{"id":"https://openalex.org/C2777252647","wikidata":"https://www.wikidata.org/wiki/Q411310","display_name":"Hesperetin","level":4,"score":0.6982303857803345},{"id":"https://openalex.org/C2779396346","wikidata":"https://www.wikidata.org/wiki/Q394316","display_name":"Aglycone","level":3,"score":0.6364660859107971},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5903694033622742},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5563037395477295},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5325718522071838},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46167585253715515},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4282084107398987},{"id":"https://openalex.org/C194671627","wikidata":"https://www.wikidata.org/wiki/Q192639","display_name":"Glycoside","level":2,"score":0.16822361946105957},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07339000701904297},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.07196789979934692},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002957","descriptor_name":"Citrus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006569","descriptor_name":"Hesperidin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D006569","descriptor_name":"Hesperidin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006569","descriptor_name":"Hesperidin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/ptr.1074","doi":"https://doi.org/10.1002/ptr.1074","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ptr.1074","pdf_url":null,"source":{"id":"https://openalex.org/S206789554","display_name":"Phytotherapy Research","issn_l":"0951-418X","issn":["0951-418X","1099-1573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy Research","raw_type":"journal-article"},{"id":"pmid:11746857","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11746857","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy research : PTR","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":157,"referenced_works":["https://openalex.org/W7140339","https://openalex.org/W19039631","https://openalex.org/W165375045","https://openalex.org/W168083411","https://openalex.org/W172653785","https://openalex.org/W185833805","https://openalex.org/W861313480","https://openalex.org/W1009959473","https://openalex.org/W1206787950","https://openalex.org/W1267514699","https://openalex.org/W1431225489","https://openalex.org/W1485641996","https://openalex.org/W1520446226","https://openalex.org/W1522849484","https://openalex.org/W1582391037","https://openalex.org/W1599939606","https://openalex.org/W1830830895","https://openalex.org/W1834067661","https://openalex.org/W1883148027","https://openalex.org/W1905852409","https://openalex.org/W1921905237","https://openalex.org/W1929522529","https://openalex.org/W1964132876","https://openalex.org/W1964842672","https://openalex.org/W1964849014","https://openalex.org/W1964994058","https://openalex.org/W1965106760","https://openalex.org/W1969987349","https://openalex.org/W1970183505","https://openalex.org/W1970693756","https://openalex.org/W1972932252","https://openalex.org/W1973560367","https://openalex.org/W1974856924","https://openalex.org/W1975084586","https://openalex.org/W1975940812","https://openalex.org/W1976762528","https://openalex.org/W1977317329","https://openalex.org/W1978020415","https://openalex.org/W1978132751","https://openalex.org/W1979689323","https://openalex.org/W1982676267","https://openalex.org/W1983107157","https://openalex.org/W1987771657","https://openalex.org/W1987874226","https://openalex.org/W1988570463","https://openalex.org/W1989204056","https://openalex.org/W1989709113","https://openalex.org/W1993308870","https://openalex.org/W1993679919","https://openalex.org/W1997105844","https://openalex.org/W1997808642","https://openalex.org/W1998178455","https://openalex.org/W2000189967","https://openalex.org/W2000825796","https://openalex.org/W2003211264","https://openalex.org/W2003353137","https://openalex.org/W2003366674","https://openalex.org/W2005769381","https://openalex.org/W2008761510","https://openalex.org/W2008868622","https://openalex.org/W2010632696","https://openalex.org/W2012273666","https://openalex.org/W2012387037","https://openalex.org/W2012933167","https://openalex.org/W2013704098","https://openalex.org/W2015776166","https://openalex.org/W2016860024","https://openalex.org/W2017164046","https://openalex.org/W2021037937","https://openalex.org/W2025947708","https://openalex.org/W2026405968","https://openalex.org/W2027764017","https://openalex.org/W2032376562","https://openalex.org/W2036464399","https://openalex.org/W2038435336","https://openalex.org/W2046014610","https://openalex.org/W2052074748","https://openalex.org/W2052855134","https://openalex.org/W2052875009","https://openalex.org/W2053083929","https://openalex.org/W2053566500","https://openalex.org/W2053761967","https://openalex.org/W2054597855","https://openalex.org/W2056248302","https://openalex.org/W2056627834","https://openalex.org/W2060521885","https://openalex.org/W2060933497","https://openalex.org/W2061579836","https://openalex.org/W2061636950","https://openalex.org/W2063156558","https://openalex.org/W2063831821","https://openalex.org/W2068370169","https://openalex.org/W2068873084","https://openalex.org/W2068969974","https://openalex.org/W2072682565","https://openalex.org/W2074390958","https://openalex.org/W2075955552","https://openalex.org/W2077314102","https://openalex.org/W2077448202","https://openalex.org/W2078621312","https://openalex.org/W2079197405","https://openalex.org/W2080084509","https://openalex.org/W2080807409","https://openalex.org/W2081248090","https://openalex.org/W2081561608","https://openalex.org/W2082117058","https://openalex.org/W2082610122","https://openalex.org/W2084300290","https://openalex.org/W2084449405","https://openalex.org/W2085427233","https://openalex.org/W2087361475","https://openalex.org/W2088166099","https://openalex.org/W2089243368","https://openalex.org/W2090853482","https://openalex.org/W2093309119","https://openalex.org/W2093617433","https://openalex.org/W2094251887","https://openalex.org/W2094269335","https://openalex.org/W2094785753","https://openalex.org/W2106326135","https://openalex.org/W2108203302","https://openalex.org/W2114591238","https://openalex.org/W2122173517","https://openalex.org/W2138123574","https://openalex.org/W2138229899","https://openalex.org/W2147387541","https://openalex.org/W2148371226","https://openalex.org/W2154835882","https://openalex.org/W2156216189","https://openalex.org/W2161436707","https://openalex.org/W2165013659","https://openalex.org/W2168428725","https://openalex.org/W2210468241","https://openalex.org/W2299216290","https://openalex.org/W2315019193","https://openalex.org/W2321222617","https://openalex.org/W2325114514","https://openalex.org/W2366365235","https://openalex.org/W2396003521","https://openalex.org/W2396535001","https://openalex.org/W2407488670","https://openalex.org/W2411241154","https://openalex.org/W2412968479","https://openalex.org/W2414647804","https://openalex.org/W2415546736","https://openalex.org/W2419012816","https://openalex.org/W2472188678","https://openalex.org/W2473292215","https://openalex.org/W2498539491","https://openalex.org/W2517148849","https://openalex.org/W2605792971","https://openalex.org/W2619263953","https://openalex.org/W4205889027","https://openalex.org/W4238923285","https://openalex.org/W4285719527","https://openalex.org/W4290986345","https://openalex.org/W6600819523"],"related_works":["https://openalex.org/W4383103691","https://openalex.org/W7105685447","https://openalex.org/W2039005183","https://openalex.org/W4386094103","https://openalex.org/W7160873914","https://openalex.org/W4385953547","https://openalex.org/W4403845531","https://openalex.org/W7212568354","https://openalex.org/W4392391150","https://openalex.org/W2387654197"],"abstract_inverted_index":{"Hesperidin,":[0],"a":[1,68],"bioflavonoid,":[2],"is":[3],"an":[4],"abundant":[5],"and":[6,37,59,81,89,95,97,112],"inexpensive":[7],"by-product":[8],"of":[9,14,43,52,71,79,115],"Citrus":[10],"cultivation.":[11],"A":[12,102],"deficiency":[13],"this":[15],"substance":[16],"in":[17,31],"the":[18,32,49,98,109],"diet":[19],"has":[20,105],"been":[21,46,64,106],"linked":[22],"with":[23,48],"abnormal":[24],"capillary":[25],"leakiness":[26],"as":[27,29],"well":[28],"pain":[30],"extremities":[33],"causing":[34],"aches,":[35],"weakness":[36],"night":[38],"leg":[39],"cramps.":[40],"No":[41],"signs":[42],"toxicity":[44,96],"have":[45,63],"observed":[47],"normal":[50],"intake":[51],"hesperidin":[53,58,80],"or":[54],"related":[55,83],"compounds.":[56,117],"Both":[57],"its":[60,82],"aglycone":[61],"hesperetin":[62],"reported":[65],"to":[66],"possess":[67],"wide":[69],"range":[70],"pharmacological":[72,110],"properties.":[73],"This":[74],"paper":[75],"reviews":[76],"various":[77],"aspects":[78],"compounds,":[84],"including":[85],"their":[86],"occurrence,":[87],"physical":[88],"chemical":[90],"properties,":[91],"analysis,":[92],"pharmacokinetics,":[93],"safety":[94],"marketed":[99],"products":[100],"available.":[101],"special":[103],"emphasis":[104],"laid":[107],"on":[108],"properties":[111],"medicinal":[113],"uses":[114],"these":[116]},"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":49},{"year":2024,"cited_by_count":52},{"year":2023,"cited_by_count":70},{"year":2022,"cited_by_count":64},{"year":2021,"cited_by_count":64},{"year":2020,"cited_by_count":52},{"year":2019,"cited_by_count":50},{"year":2018,"cited_by_count":46},{"year":2017,"cited_by_count":36},{"year":2016,"cited_by_count":36},{"year":2015,"cited_by_count":52},{"year":2014,"cited_by_count":45},{"year":2013,"cited_by_count":31},{"year":2012,"cited_by_count":33}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
