{"id":"https://openalex.org/W1965042952","doi":"https://doi.org/10.1097/brs.0b013e31816b1f1d","title":"Plasmin-Matrix Metalloproteinase Cascades in Spinal Response to an Experimental Disc Lesion in Pig","display_name":"Plasmin-Matrix Metalloproteinase Cascades in Spinal Response to an Experimental Disc Lesion in Pig","publication_year":2008,"publication_date":"2008-04-01","ids":{"openalex":"https://openalex.org/W1965042952","doi":"https://doi.org/10.1097/brs.0b013e31816b1f1d","mag":"1965042952","pmid":"https://pubmed.ncbi.nlm.nih.gov/18404101"},"language":"en","primary_location":{"id":"doi:10.1097/brs.0b013e31816b1f1d","doi":"https://doi.org/10.1097/brs.0b013e31816b1f1d","is_oa":false,"landing_page_url":"https://doi.org/10.1097/brs.0b013e31816b1f1d","pdf_url":null,"source":{"id":"https://openalex.org/S4026894","display_name":"Spine","issn_l":"0362-2436","issn":["0362-2436","1528-1159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Spine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jari Salo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Jari Salo","raw_affiliation_strings":["Department of Orthopedic Surgery, Helsinki University Central Hospital, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Helsinki University Central Hospital, Finland","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111487086","display_name":"Zygmunt Mackiewicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I170583851","display_name":"University of Opole","ror":"https://ror.org/04gbpnx96","country_code":"PL","type":"education","lineage":["https://openalex.org/I170583851"]},{"id":"https://openalex.org/I173212132","display_name":"Vilnius University","ror":"https://ror.org/03nadee84","country_code":"LT","type":"education","lineage":["https://openalex.org/I173212132"]}],"countries":["FI","LT","PL"],"is_corresponding":false,"raw_author_name":"Zygmunt Mackiewicz","raw_affiliation_strings":["Department of Cell Biology, Opole University, Poland","Faculty of Veterinary Medicine, University of Helsinki, Finland","Vilnius University Institute of Experimental and Clinical Medicine, Lithuania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Opole University, Poland","institution_ids":["https://openalex.org/I170583851"]},{"raw_affiliation_string":"Faculty of Veterinary Medicine, University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Vilnius University Institute of Experimental and Clinical Medicine, Lithuania","institution_ids":["https://openalex.org/I173212132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007799979","display_name":"Aage Indahl","orcid":"https://orcid.org/0009-0008-7997-2342","observed_orcids":["https://orcid.org/0009-0008-7997-2342"]},"institutions":[{"id":"https://openalex.org/I4210118096","display_name":"Coxa Hospital","ror":"https://ror.org/01r742665","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210118096"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Aage Indahl","raw_affiliation_strings":["COXA Hospital for Joint Replacement, Tampere, Finland","Department of Physical Medicine and Rehabilitation, Kusthospitalet, Stavern, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"COXA Hospital for Joint Replacement, Tampere, Finland","institution_ids":["https://openalex.org/I4210118096"]},{"raw_affiliation_string":"Department of Physical Medicine and Rehabilitation, Kusthospitalet, Stavern, Norway","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109209802","display_name":"Yrj\u00f6 Tapio Konttinen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"id":"https://openalex.org/I4210118096","display_name":"Coxa Hospital","ror":"https://ror.org/01r742665","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210118096"]},{"id":"https://openalex.org/I4405267039","display_name":"Tekonivelsairaala Orton","ror":"https://ror.org/00y3j9305","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4405267039"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Yrj\u00f6 T. Konttinen","raw_affiliation_strings":["COXA Hospital for Joint Replacement, Tampere, Finland","Department of Orthopedic Surgery, Helsinki University Central Hospital, Finland","Department of Physical Medicine and Rehabilitation, Kusthospitalet, Stavern, Norway","Inv\u00e4rtes medicin, Helsinki University Central Hospital","ORTON Orthopedic Hospital of the Invalid Foundation, Helsinki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"COXA Hospital for Joint Replacement, Tampere, Finland","institution_ids":["https://openalex.org/I4210118096"]},{"raw_affiliation_string":"Department of Orthopedic Surgery, Helsinki University Central Hospital, Finland","institution_ids":["https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Department of Physical Medicine and Rehabilitation, Kusthospitalet, Stavern, Norway","institution_ids":[]},{"raw_affiliation_string":"Inv\u00e4rtes medicin, Helsinki University Central Hospital","institution_ids":["https://openalex.org/I2800394112"]},{"raw_affiliation_string":"ORTON Orthopedic Hospital of the Invalid Foundation, Helsinki","institution_ids":["https://openalex.org/I4405267039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064891401","display_name":"Allison Kaigle Holm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173212132","display_name":"Vilnius University","ror":"https://ror.org/03nadee84","country_code":"LT","type":"education","lineage":["https://openalex.org/I173212132"]}],"countries":["LT"],"is_corresponding":false,"raw_author_name":"Allison Kaigle Holm","raw_affiliation_strings":["Vilnius University Institute of Experimental and Clinical Medicine, Lithuania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vilnius University Institute of Experimental and Clinical Medicine, Lithuania","institution_ids":["https://openalex.org/I173212132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012890854","display_name":"Antti Sukura","orcid":"https://orcid.org/0000-0002-8992-1695","observed_orcids":["https://orcid.org/0000-0002-8992-1695"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I170583851","display_name":"University of Opole","ror":"https://ror.org/04gbpnx96","country_code":"PL","type":"education","lineage":["https://openalex.org/I170583851"]}],"countries":["FI","PL"],"is_corresponding":false,"raw_author_name":"Antti Sukura","raw_affiliation_strings":["Department of Cell Biology, Opole University, Poland","Faculty of Veterinary Medicine, University of Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Opole University, Poland","institution_ids":["https://openalex.org/I170583851"]},{"raw_affiliation_string":"Faculty of Veterinary Medicine, University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103500655","display_name":"Sten H. Holm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Sten Holm","raw_affiliation_strings":["Department of Orthopedic Surgery, Helsinki University Central Hospital, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Helsinki University Central Hospital, Finland","institution_ids":["https://openalex.org/I2800394112"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5103500655","https://openalex.org/A5109209802"],"corresponding_institution_ids":["https://openalex.org/I2800394112","https://openalex.org/I4210118096","https://openalex.org/I4405267039"],"apc_list":null,"apc_paid":null,"fwci":0.7195,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.75528688,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"33","issue":"8","first_page":"839","last_page":"844"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12249","display_name":"Veterinary Orthopedics and Neurology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intervertebral-disc-degeneration","display_name":"intervertebral disc degeneration","score":0.949999988079071},{"id":"https://openalex.org/keywords/plasmin","display_name":"plasmin","score":0.9739999771118164},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":1.0},{"id":"https://openalex.org/keywords/mmp-1","display_name":"MMP-1","score":0.9800000190734863},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mmp-3","display_name":"MMP-3","score":0.9240000247955322},{"id":"https://openalex.org/keywords/mmp-7","display_name":"MMP-7","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.6179999709129333},{"id":"https://openalex.org/keywords/mmp-13","display_name":"MMP-13","score":0.9200000166893005},{"id":"https://openalex.org/keywords/mmp-14","display_name":"MMP-14","score":0.6890000104904175},{"id":"https://openalex.org/keywords/proteolysis","display_name":"proteolysis","score":0.6919999718666077},{"id":"https://openalex.org/keywords/pig-model","display_name":"porcine model","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.8872841000556946},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7076065540313721},{"id":"https://openalex.org/C2776223131","wikidata":"https://www.wikidata.org/wiki/Q13033733","display_name":"Gelatinase A","level":3,"score":0.7020734548568726},{"id":"https://openalex.org/C2777755357","wikidata":"https://www.wikidata.org/wiki/Q502781","display_name":"Intervertebral disc","level":2,"score":0.6791915893554688},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.675942599773407},{"id":"https://openalex.org/C2781071845","wikidata":"https://www.wikidata.org/wiki/Q21173374","display_name":"Plasmin","level":3,"score":0.6088059544563293},{"id":"https://openalex.org/C2778394429","wikidata":"https://www.wikidata.org/wiki/Q304956","display_name":"Collagenase","level":3,"score":0.5733950138092041},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5700109004974365},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5144441723823547},{"id":"https://openalex.org/C2776232661","wikidata":"https://www.wikidata.org/wiki/Q5530373","display_name":"Gelatinase","level":3,"score":0.47506019473075867},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4642202854156494},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.44354745745658875},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.43019434809684753},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21942764520645142},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1737593710422516},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10263568162918091},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09056365489959717},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08273905515670776},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005341","descriptor_name":"Fibrinolysin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007403","descriptor_name":"Intervertebral Disc","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007403","descriptor_name":"Intervertebral Disc","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D007403","descriptor_name":"Intervertebral Disc","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007405","descriptor_name":"Intervertebral Disc Displacement","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007405","descriptor_name":"Intervertebral Disc Displacement","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007405","descriptor_name":"Intervertebral Disc Displacement","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008159","descriptor_name":"Lumbar Vertebrae","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D013131","descriptor_name":"Spine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013131","descriptor_name":"Spine","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019084","descriptor_name":"Fluorescent Antibody Technique, Indirect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020782","descriptor_name":"Matrix Metalloproteinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/brs.0b013e31816b1f1d","doi":"https://doi.org/10.1097/brs.0b013e31816b1f1d","is_oa":false,"landing_page_url":"https://doi.org/10.1097/brs.0b013e31816b1f1d","pdf_url":null,"source":{"id":"https://openalex.org/S4026894","display_name":"Spine","issn_l":"0362-2436","issn":["0362-2436","1528-1159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Spine","raw_type":"journal-article"},{"id":"pmid:18404101","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18404101","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Spine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W143623202","https://openalex.org/W1565818905","https://openalex.org/W1841858344","https://openalex.org/W1966260445","https://openalex.org/W1972146443","https://openalex.org/W1976282528","https://openalex.org/W1977006949","https://openalex.org/W1977127210","https://openalex.org/W1980157244","https://openalex.org/W1986556559","https://openalex.org/W1996732521","https://openalex.org/W1998231486","https://openalex.org/W2001167958","https://openalex.org/W2024585159","https://openalex.org/W2034271959","https://openalex.org/W2052605451","https://openalex.org/W2056420432","https://openalex.org/W2057200339","https://openalex.org/W2061401525","https://openalex.org/W2067800125","https://openalex.org/W2078774951","https://openalex.org/W2082089678","https://openalex.org/W2094875212","https://openalex.org/W2121164372","https://openalex.org/W2122802605","https://openalex.org/W2135649915","https://openalex.org/W2145709015","https://openalex.org/W2153969760","https://openalex.org/W2164319357","https://openalex.org/W2165503499","https://openalex.org/W2402073029","https://openalex.org/W4230932862"],"related_works":["https://openalex.org/W2062712136","https://openalex.org/W2024585159","https://openalex.org/W2049811048","https://openalex.org/W3175970728","https://openalex.org/W2066306645","https://openalex.org/W2305243519","https://openalex.org/W2044797133","https://openalex.org/W1508090190","https://openalex.org/W2604030180","https://openalex.org/W2405964370"],"abstract_inverted_index":{"STUDY":[0],"DESIGN:":[1],"Proteinases":[2],"were":[3,107,122,150,198],"immunohistochemically":[4],"stained":[5],"to":[6,15,32,38,97,126,228,240,250],"analyze":[7,33],"degenerated":[8,51,145],"discs":[9,52],"and":[10,35,53,63,70,81,109,112,124,128,139,144,161,187,195,214,247,266,268,287],"paradiscal":[11,54,155,223],"tissues":[12,18,58],"in":[13,19,40,72,79,141,153,166,200,252,271],"comparison":[14],"contiguous":[16,114],"control":[17,57,115],"an":[20,206],"experimental":[21,111,207],"porcine":[22],"model":[23,208],"of":[24,49,61,65,137,181,192,205,216,236,244],"intervertebral":[25,120,146,202],"disc":[26,218],"degeneration.":[27],"OBJECTIVE:":[28],"The":[29,170],"aim":[30],"was":[31,95,179],"plasmin":[34,62,258],"metalloproteinases":[36,67],"known":[37,249],"participate":[39,251],"mutual":[41,253,279],"activation":[42,254,281],"cascades.":[43],"SUMMARY":[44],"OF":[45],"BACKGROUND":[46],"DATA:":[47],"Comparison":[48],"the":[50,73,91,99,105,110,113,142,175,217,237],"structures":[55,156],"with":[56,118,273],"disclosed":[59,134],"accumulation":[60,180],"induction":[64],"matrix":[66],"(MMP),":[68],"MMP-1":[69,138],"MMP-2":[71,140],"discs,":[74,121],"but":[75],"some":[76],"other":[77,222],"MMPs":[78,149,246,280],"reactive":[80],"remodeling":[82,235],"tissues.":[83],"MATERIAL":[84],"AND":[85],"METHODS:":[86],"In":[87],"6":[88],"domestic":[89],"pigs,":[90],"cranial":[92],"L4":[93],"endplate":[94],"perforated":[96],"penetrate":[98],"nucleus":[100],"pulposus.":[101],"Three":[102],"months":[103],"later,":[104],"animals":[106],"killed":[108],"vertebrae,":[116],"complete":[117],"their":[119],"excised":[123],"subjected":[125,227,239],"histologic":[127],"immunohistochemical":[129],"examinations.":[130],"RESULTS:":[131],"Immunohistochemical":[132],"analysis":[133],"increased":[135],"expression":[136],"traumatized":[143],"discs.":[147,203],"Some":[148],"also":[151,219],"induced":[152,199],"all":[154,174,221],"(bone":[157],"marrow,":[158],"vertebral":[159],"bone,":[160],"spinal":[162],"ligaments),":[163],"or":[164],"decreased":[165],"already":[167],"scarred":[168],"areas.":[169],"common":[171],"denominator":[172],"for":[173],"anatomic":[176],"sites":[177],"studied":[178],"plasmin.":[182],"CONCLUSION:":[183],"Fibroblast":[184],"collagenase":[185],"(MMP-1)":[186],"gelatinase":[188],"A":[189],"(MMP-2),":[190],"capable":[191],"degrading":[193],"native":[194],"denatured":[196],"collagen,":[197],"degenerating":[201],"Use":[204],"enabled":[209],"demonstration":[210],"that":[211,257],"biomechanical":[212],"destabilization":[213],"degeneration":[215],"affects":[220],"structures,":[224],"which":[225],"are":[226],"proteolysis":[229],"and/or":[230],"reparative":[231],"fibrosis":[232],"apparently":[233],"representing":[234],"spine":[238],"pathologic":[241],"stress.":[242],"Profiling":[243],"various":[245],"plasmin,":[248],"cascades,":[255],"suggests":[256],"could":[259],"activate":[260],"pro-MMP-1,":[261],"pro-MMP-2,":[262],"pro-MMP-3,":[263],"pro-MMP-7,":[264],"pro-MMP-9,":[265],"pro-MMP-13":[267],"alone":[269],"or/and":[270],"cooperation":[272],"MMP-3":[274,286],"initiate":[275],"at":[276],"least":[277],"2":[278],"cascades":[282],"driven":[283],"by":[284],"activated":[285],"MMP-7.":[288]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
