{"id":"https://openalex.org/W1965041525","doi":"https://doi.org/10.1007/s13539-011-0051-5","title":"The role of insulin resistance in the development of muscle wasting during cancer cachexia","display_name":"The role of insulin resistance in the development of muscle wasting during cancer cachexia","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W1965041525","doi":"https://doi.org/10.1007/s13539-011-0051-5","mag":"1965041525","pmid":"https://pubmed.ncbi.nlm.nih.gov/22450024","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3302982"},"language":"en","primary_location":{"id":"doi:10.1007/s13539-011-0051-5","doi":"https://doi.org/10.1007/s13539-011-0051-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13539-011-0051-5","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1007/s13539-011-0051-5","source":{"id":"https://openalex.org/S173726759","display_name":"Journal of Cachexia Sarcopenia and Muscle","issn_l":"2190-5991","issn":["2190-5991","2190-6009"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cachexia, Sarcopenia and Muscle","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1007/s13539-011-0051-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089668164","display_name":"Mary Ann Honors","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary A. Honors","raw_affiliation_strings":["Department of Psychological Sciences and Ingestive Behavior Research Center, Purdue University, 47907 West Lafayette, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychological Sciences and Ingestive Behavior Research Center, Purdue University, 47907 West Lafayette, IN","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110585034","display_name":"Kimberly P. Kinzig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kimberly P. Kinzig","raw_affiliation_strings":["Department of Psychological Sciences, Purdue University, 703 Third Street, 47907 West Lafayette, IN","Department of Psychological Sciences and Ingestive Behavior Research Center, Purdue University, 47907 West Lafayette, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychological Sciences, Purdue University, 703 Third Street, 47907 West Lafayette, IN","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Psychological Sciences and Ingestive Behavior Research Center, Purdue University, 47907 West Lafayette, IN","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110585034"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":{"value":5400,"currency":"USD","value_usd":5400},"fwci":4.3656,"has_fulltext":true,"cited_by_count":168,"citation_normalized_percentile":{"value":0.93912519,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"3","issue":"1","first_page":"5","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.017400000244379044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-cachexia","display_name":"cancer cachexia","score":0.8999999761581421},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9169999957084656},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.9869999885559082},{"id":"https://openalex.org/keywords/sarcopenia","display_name":"sarcopenia","score":0.9269999861717224},{"id":"https://openalex.org/keywords/metabolic-abnormalities","display_name":"metabolic abnormalities","score":0.7250000238418579},{"id":"https://openalex.org/keywords/cachexia-treatment","display_name":"cachexia treatment","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C2777704314","wikidata":"https://www.wikidata.org/wiki/Q6003455","display_name":"Cachexia","level":3,"score":0.9093488454818726},{"id":"https://openalex.org/C2779764123","wikidata":"https://www.wikidata.org/wiki/Q7972881","display_name":"Wasting","level":2,"score":0.8898866176605225},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.835046648979187},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7246882319450378},{"id":"https://openalex.org/C3020092424","wikidata":"https://www.wikidata.org/wiki/Q6003455","display_name":"Cancer cachexia","level":4,"score":0.5739384293556213},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5636247396469116},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5428204536437988},{"id":"https://openalex.org/C2911126609","wikidata":"https://www.wikidata.org/wiki/Q6003455","display_name":"Wasting Syndrome","level":3,"score":0.47931969165802},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42239201068878174},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40117979049682617},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32829469442367554}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1007/s13539-011-0051-5","doi":"https://doi.org/10.1007/s13539-011-0051-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13539-011-0051-5","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1007/s13539-011-0051-5","source":{"id":"https://openalex.org/S173726759","display_name":"Journal of Cachexia Sarcopenia and Muscle","issn_l":"2190-5991","issn":["2190-5991","2190-6009"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cachexia, Sarcopenia and Muscle","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3302982","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3302982","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cachexia Sarcopenia Muscle","raw_type":"Text"},{"id":"pmid:22450024","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22450024","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cachexia, sarcopenia and muscle","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s13539-011-0051-5","doi":"https://doi.org/10.1007/s13539-011-0051-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13539-011-0051-5","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1007/s13539-011-0051-5","source":{"id":"https://openalex.org/S173726759","display_name":"Journal of Cachexia Sarcopenia and Muscle","issn_l":"2190-5991","issn":["2190-5991","2190-6009"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cachexia, Sarcopenia and Muscle","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2725445263","display_name":"Effects of Dietary Macronutrients on Regulation of Energy Balance","funder_award_id":"R01DK078654","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3142028969","display_name":"Interdisciplinary Cancer Prevention Research Internship Program","funder_award_id":"R25CA128770","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309036","display_name":"Purdue University","ror":"https://ror.org/02dqehb95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1965041525.pdf","grobid_xml":"https://content.openalex.org/works/W1965041525.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W133347577","https://openalex.org/W1560639362","https://openalex.org/W1565478474","https://openalex.org/W1608783988","https://openalex.org/W1659378382","https://openalex.org/W1804745580","https://openalex.org/W1880398352","https://openalex.org/W1901274456","https://openalex.org/W1964440334","https://openalex.org/W1966755400","https://openalex.org/W1966920013","https://openalex.org/W1968028970","https://openalex.org/W1968272322","https://openalex.org/W1981337582","https://openalex.org/W1982251020","https://openalex.org/W1982832379","https://openalex.org/W1988848089","https://openalex.org/W1988924200","https://openalex.org/W1996110540","https://openalex.org/W2008517729","https://openalex.org/W2008869575","https://openalex.org/W2011419421","https://openalex.org/W2012804398","https://openalex.org/W2014193488","https://openalex.org/W2014575668","https://openalex.org/W2018681830","https://openalex.org/W2026836401","https://openalex.org/W2046794579","https://openalex.org/W2050047690","https://openalex.org/W2055099205","https://openalex.org/W2060641274","https://openalex.org/W2068810503","https://openalex.org/W2075117075","https://openalex.org/W2079279499","https://openalex.org/W2084961392","https://openalex.org/W2090987516","https://openalex.org/W2091899259","https://openalex.org/W2095295489","https://openalex.org/W2102615617","https://openalex.org/W2102619048","https://openalex.org/W2112448671","https://openalex.org/W2122649002","https://openalex.org/W2123718150","https://openalex.org/W2125776650","https://openalex.org/W2127037921","https://openalex.org/W2141377922","https://openalex.org/W2149225384","https://openalex.org/W2155744138","https://openalex.org/W2157115138","https://openalex.org/W2159664830","https://openalex.org/W2159744672","https://openalex.org/W2163321812","https://openalex.org/W2170775996","https://openalex.org/W2171071516","https://openalex.org/W2178128098","https://openalex.org/W2327515307","https://openalex.org/W2340067062","https://openalex.org/W2410342189","https://openalex.org/W2413070508","https://openalex.org/W2808288870","https://openalex.org/W4230894377","https://openalex.org/W4240449862","https://openalex.org/W4248195705"],"related_works":["https://openalex.org/W1981337582","https://openalex.org/W7146463870","https://openalex.org/W3095597642","https://openalex.org/W1562499847","https://openalex.org/W2794350505","https://openalex.org/W7136761446","https://openalex.org/W4387296247","https://openalex.org/W4409072294","https://openalex.org/W4225006170","https://openalex.org/W4313474884"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cancer":[1],"cachexia":[2,54,65,81,97,110],"is":[3,14,111,121],"a":[4,41],"complex":[5],"syndrome":[6],"associated":[7],"with":[8],"multiple":[9],"metabolic":[10],"abnormalities.":[11],"Insulin":[12],"resistance":[13,45,70,75,89,107],"present":[15,34],"in":[16,38,46,73,108,118],"many":[17],"cancer":[18,53,64,109,137],"patients":[19],"and":[20,55,71,124,131,134],"may":[21,90],"be":[22],"one":[23],"mechanism":[24],"through":[25],"which":[26],"muscle":[27,50],"wasting":[28,51],"occurs.":[29],"METHODS":[30],"AND":[31],"RESULTS:":[32],"The":[33,113],"review":[35],"examines":[36],"evidence":[37,85],"support":[39],"of":[40,49,96,102,105,115,136],"role":[42,104],"for":[43,58,128],"insulin":[44,69,74,88,106],"the":[47,77,94,103,132],"development":[48],"during":[52],"identifies":[56],"areas":[57],"future":[59],"research.":[60],"Patients":[61],"suffering":[62],"from":[63],"tend":[66],"to":[67,79,93],"exhibit":[68],"improvements":[72],"have":[76],"potential":[78],"improve":[80],"symptoms.":[82,98],"In":[83],"addition,":[84],"suggests":[86],"that":[87],"occur":[91],"prior":[92],"onset":[95],"CONCLUSIONS:":[99],"Further":[100],"investigation":[101],"needed.":[112],"use":[114],"translational":[116],"research":[117,130],"this":[119],"area":[120],"strongly":[122],"encouraged,":[123],"has":[125],"important":[126],"implications":[127],"clinical":[129],"treatment":[133],"prevention":[135],"cachexia.":[138]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}