{"id":"https://openalex.org/W1965037091","doi":"https://doi.org/10.1021/bi102020s","title":"A Conserved Surface Loop in Type I Dehydroquinate Dehydratases Positions an Active Site Arginine and Functions in Substrate Binding","display_name":"A Conserved Surface Loop in Type I Dehydroquinate Dehydratases Positions an Active Site Arginine and Functions in Substrate Binding","publication_year":2011,"publication_date":"2011-02-03","ids":{"openalex":"https://openalex.org/W1965037091","doi":"https://doi.org/10.1021/bi102020s","mag":"1965037091","pmid":"https://pubmed.ncbi.nlm.nih.gov/21291284","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3062685"},"language":"en","primary_location":{"id":"doi:10.1021/bi102020s","doi":"https://doi.org/10.1021/bi102020s","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi102020s","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3062685","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039646991","display_name":"Samuel H. Light","orcid":"https://orcid.org/0000-0002-8074-1348","observed_orcids":["https://orcid.org/0000-0002-8074-1348"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel H. Light","raw_affiliation_strings":["Center for Structural Genomics of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Structural Genomics of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046083677","display_name":"G. Minasov","orcid":"https://orcid.org/0000-0001-5460-3462","observed_orcids":["https://orcid.org/0000-0001-5460-3462"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1301553790","display_name":"J. Craig Venter Institute","ror":"https://ror.org/049r1ts75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1301553790"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Minasov","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois 60607, United States","Pathogen Functional Genomics Resource Center, The J. Craig Venter Institute, 9712 Medical Center Drive, Rockville, Maryland 20850, United States","\u2020 Center for Structural Genomics of Infectious Diseases and \u2021 Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States","Northwestern University****"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois 60607, United States","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Pathogen Functional Genomics Resource Center, The J. Craig Venter Institute, 9712 Medical Center Drive, Rockville, Maryland 20850, United States","institution_ids":["https://openalex.org/I1301553790"]},{"raw_affiliation_string":"\u2020 Center for Structural Genomics of Infectious Diseases and \u2021 Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Northwestern University****","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056811121","display_name":"L. Shuvalova","orcid":"https://orcid.org/0000-0003-1702-6998","observed_orcids":["https://orcid.org/0000-0003-1702-6998"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1301553790","display_name":"J. Craig Venter Institute","ror":"https://ror.org/049r1ts75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1301553790"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ludmilla Shuvalova","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois 60607, United States","Pathogen Functional Genomics Resource Center, The J. Craig Venter Institute, 9712 Medical Center Drive, Rockville, Maryland 20850, United States","\u2020 Center for Structural Genomics of Infectious Diseases and \u2021 Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States","Northwestern University****"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois 60607, United States","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Pathogen Functional Genomics Resource Center, The J. Craig Venter Institute, 9712 Medical Center Drive, Rockville, Maryland 20850, United States","institution_ids":["https://openalex.org/I1301553790"]},{"raw_affiliation_string":"\u2020 Center for Structural Genomics of Infectious Diseases and \u2021 Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Northwestern University****","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108382215","display_name":"Scott N. Peterson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1301553790","display_name":"J. Craig Venter Institute","ror":"https://ror.org/049r1ts75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1301553790"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott N. Peterson","raw_affiliation_strings":["Pathogen Functional Genomics Resource Center, The J. Craig Venter Institute, 9712 Medical Center Drive, Rockville, Maryland 20850, United States","Northwestern University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathogen Functional Genomics Resource Center, The J. Craig Venter Institute, 9712 Medical Center Drive, Rockville, Maryland 20850, United States","institution_ids":["https://openalex.org/I1301553790"]},{"raw_affiliation_string":"Northwestern University","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019348558","display_name":"Michael S. Caffrey","orcid":"https://orcid.org/0000-0002-6119-1336","observed_orcids":["https://orcid.org/0000-0002-6119-1336"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Caffrey","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois 60607, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois 60607, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057424046","display_name":"W.F. Anderson","orcid":"https://orcid.org/0000-0003-4181-8127","observed_orcids":["https://orcid.org/0000-0003-4181-8127"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1301553790","display_name":"J. Craig Venter Institute","ror":"https://ror.org/049r1ts75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1301553790"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wayne F. Anderson","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois 60607, United States","Pathogen Functional Genomics Resource Center, The J. Craig Venter Institute, 9712 Medical Center Drive, Rockville, Maryland 20850, United States","\u2020 Center for Structural Genomics of Infectious Diseases and \u2021 Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States","Northwestern University****"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois 60607, United States","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Pathogen Functional Genomics Resource Center, The J. Craig Venter Institute, 9712 Medical Center Drive, Rockville, Maryland 20850, United States","institution_ids":["https://openalex.org/I1301553790"]},{"raw_affiliation_string":"\u2020 Center for Structural Genomics of Infectious Diseases and \u2021 Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Northwestern University****","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042486255","display_name":"Arnon Lavie","orcid":"https://orcid.org/0000-0001-5591-8722","observed_orcids":["https://orcid.org/0000-0001-5591-8722"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arnon Lavie","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois 60607, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois 60607, United States","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5042486255"],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.5679,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.81182633,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"50","issue":"12","first_page":"2357","last_page":"2363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salmonella-enterica","display_name":"Salmonella enterica","score":0.8930000066757202},{"id":"https://openalex.org/keywords/shikimate-pathway","display_name":"shikimate pathway","score":0.9100000262260437},{"id":"https://openalex.org/keywords/surface-loops","display_name":"surface loops","score":0.640999972820282},{"id":"https://openalex.org/keywords/active-site-arginine","display_name":"active site arginine","score":0.9259999990463257},{"id":"https://openalex.org/keywords/substrate-binding","display_name":"substrate binding","score":0.9340000152587891},{"id":"https://openalex.org/keywords/loop-conformational-change","display_name":"loop conformational change","score":0.7990000247955322},{"id":"https://openalex.org/keywords/enzyme-crystal-structure","display_name":"enzyme crystal structure","score":0.5379999876022339},{"id":"https://openalex.org/keywords/enzyme-inhibitors","display_name":"enzyme inhibitors","score":0.5440000295639038},{"id":"https://openalex.org/keywords/antimicrobial-targets","display_name":"antimicrobial drug targets","score":0.6600000262260437},{"id":"https://openalex.org/keywords/aromatic-amino-acid-biosynthesis","display_name":"aromatic amino acid biosynthesis","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.728162944316864},{"id":"https://openalex.org/C2781374117","wikidata":"https://www.wikidata.org/wiki/Q5252382","display_name":"Dehydratase","level":3,"score":0.6330797672271729},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.565392017364502},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5252898931503296},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5154129266738892},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5077091455459595},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.46976184844970703},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4615175426006317},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4211767911911011},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3736008405685425},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3587706983089447},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23792123794555664},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006836","descriptor_name":"Hydro-Lyases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006836","descriptor_name":"Hydro-Lyases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006836","descriptor_name":"Hydro-Lyases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019779","descriptor_name":"Salmonella enterica","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/bi102020s","doi":"https://doi.org/10.1021/bi102020s","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi102020s","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:21291284","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21291284","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3062685","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3062685","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3062685","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3062685","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7312179196","display_name":null,"funder_award_id":"HHSN272200700058C","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1506290062","https://openalex.org/W1539796472","https://openalex.org/W1782216406","https://openalex.org/W1963512442","https://openalex.org/W2008820924","https://openalex.org/W2012985142","https://openalex.org/W2026073321","https://openalex.org/W2049839234","https://openalex.org/W2092312220","https://openalex.org/W2107144562","https://openalex.org/W2108020804","https://openalex.org/W2114105555","https://openalex.org/W2121749642","https://openalex.org/W2141888123","https://openalex.org/W2142302280","https://openalex.org/W2163848338","https://openalex.org/W2196549155","https://openalex.org/W2199092812","https://openalex.org/W2951971926"],"related_works":["https://openalex.org/W2107144562","https://openalex.org/W2089003765","https://openalex.org/W2031275555","https://openalex.org/W2036720351","https://openalex.org/W2005387171","https://openalex.org/W2033623165","https://openalex.org/W2078870977","https://openalex.org/W4390348037","https://openalex.org/W2061138540","https://openalex.org/W2075659089"],"abstract_inverted_index":{"Dehydroquinate":[0],"dehydratase":[1],"(DHQD)":[2],"catalyzes":[3],"the":[4,8,18,26,38,70,89,93,109,126,131,146],"third":[5],"step":[6],"in":[7,72,106,116,121],"biosynthetic":[9],"shikimate":[10],"pathway.":[11],"We":[12],"present":[13],"three":[14],"crystal":[15],"structures":[16,46,137],"of":[17,28,56,61,67,69,92,99,114,133,148],"Salmonella":[19],"enterica":[20],"type":[21,150],"I":[22,151],"DHQD":[23,115,152],"that":[24,32],"address":[25],"functionality":[27],"a":[29,57,85,96,100,128],"surface":[30],"loop":[31,49,71,94],"is":[33],"observed":[34],"to":[35,77,83],"close":[36],"over":[37],"active":[39,102],"site":[40,103],"following":[41],"substrate":[42,73,110],"binding.":[43,74],"Two":[44],"wild-type":[45],"with":[47,88],"differing":[48],"conformations":[50],"and":[51,53,64,118,138],"kinetic":[52],"structural":[54],"studies":[55],"mutant":[58],"provide":[59],"evidence":[60],"both":[62],"direct":[63,86],"indirect":[65],"mechanisms":[66],"involvement":[68],"In":[75],"addition":[76],"allowing":[78],"amino":[79],"acid":[80],"side":[81],"chains":[82],"establish":[84],"interaction":[87],"substrate,":[90],"closure":[91],"necessitates":[95],"conformational":[97],"change":[98],"key":[101],"arginine,":[104],"which":[105],"turn":[107],"positions":[108],"productively.":[111],"The":[112,136],"absence":[113],"humans":[117],"its":[119],"essentiality":[120],"many":[122],"pathogenic":[123],"bacteria":[124],"make":[125],"enzyme":[127],"target":[129],"for":[130],"development":[132],"nontoxic":[134],"antimicrobials.":[135],"ligand":[139],"binding":[140],"insights":[141],"presented":[142],"here":[143],"may":[144],"inform":[145],"design":[147],"novel":[149],"inhibiting":[153],"molecules.":[154]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}