{"id":"https://openalex.org/W1965036073","doi":"https://doi.org/10.1111/j.1574-6968.2007.00924.x","title":"A novel leptospiral protein increases ICAM-1 and E-selectin expression in human umbilical vein endothelial cells","display_name":"A novel leptospiral protein increases ICAM-1 and E-selectin expression in human umbilical vein endothelial cells","publication_year":2007,"publication_date":"2007-10-04","ids":{"openalex":"https://openalex.org/W1965036073","doi":"https://doi.org/10.1111/j.1574-6968.2007.00924.x","mag":"1965036073","pmid":"https://pubmed.ncbi.nlm.nih.gov/17956423"},"language":"en","primary_location":{"id":"doi:10.1111/j.1574-6968.2007.00924.x","doi":"https://doi.org/10.1111/j.1574-6968.2007.00924.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1574-6968.2007.00924.x","pdf_url":"https://academic.oup.com/femsle/article-pdf/276/2/172/19117943/276-2-172.pdf","source":{"id":"https://openalex.org/S34954451","display_name":"FEMS Microbiology Letters","issn_l":"0378-1097","issn":["0378-1097","1574-6968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS Microbiology Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/femsle/article-pdf/276/2/172/19117943/276-2-172.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027249026","display_name":"M\u00f4nica L. Vieira","orcid":"https://orcid.org/0000-0002-4162-8086","observed_orcids":["https://orcid.org/0000-0002-4162-8086"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Monica L. Vieira","raw_affiliation_strings":["Centro de Biotecnologia, Instituto Butantan, Avenida Vital Brazil, S\u00e3o Paulo, SP, Brazil","Interunidades em Biotecnologia, Instituto de Ci\u00eancias Biom\u00e9dicas, USP, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Biotecnologia, Instituto Butantan, Avenida Vital Brazil, S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I2800423888"]},{"raw_affiliation_string":"Interunidades em Biotecnologia, Instituto de Ci\u00eancias Biom\u00e9dicas, USP, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008925296","display_name":"Lina Paola D\u2019Atri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14429277","display_name":"Academia Nacional de Medicina","ror":"https://ror.org/05k2xsz75","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I14429277"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Lina P. D'Atri","raw_affiliation_strings":["Instituto de Investigaciones Hematol\u00f3gicas, Academia Nacional de Medicina, CONICET, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Hematol\u00f3gicas, Academia Nacional de Medicina, CONICET, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I14429277","https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043100331","display_name":"Mirta A. Schattner","orcid":"https://orcid.org/0000-0001-9439-2161","observed_orcids":["https://orcid.org/0000-0001-9439-2161"]},"institutions":[{"id":"https://openalex.org/I14429277","display_name":"Academia Nacional de Medicina","ror":"https://ror.org/05k2xsz75","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I14429277"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Mirta Schattner","raw_affiliation_strings":["Instituto de Investigaciones Hematol\u00f3gicas, Academia Nacional de Medicina, CONICET, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Hematol\u00f3gicas, Academia Nacional de Medicina, CONICET, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I14429277","https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071171358","display_name":"Alejandra Habarta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Alejandra M. Habarta","raw_affiliation_strings":["Instituto de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina","Instituto de Bioqu\u0131\u0301mica y Biolog\u0131\u0301a Molecular, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina","institution_ids":["https://openalex.org/I874386039"]},{"raw_affiliation_string":"Instituto de Bioqu\u0131\u0301mica y Biolog\u0131\u0301a Molecular, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina","institution_ids":["https://openalex.org/I874386039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034695637","display_name":"Angela Silva Barbosa","orcid":"https://orcid.org/0000-0002-6458-9489","observed_orcids":["https://orcid.org/0000-0002-6458-9489"]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Angela S. Barbosa","raw_affiliation_strings":["Centro de Biotecnologia, Instituto Butantan, Avenida Vital Brazil, S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Biotecnologia, Instituto Butantan, Avenida Vital Brazil, S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111638853","display_name":"Zen\u00e1ide Maria de Morais","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Zenaide M. de Morais","raw_affiliation_strings":["Laborat\u00f3rio de Zoonoses Bacterianas do VPS, Faculdade de Medicina Veterin\u00e1ria e Zootecnia da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","Laboratorio de Zoonoses Bacterianas do VPS, Faculdade de Medicina Veterina\u0301ria e Zootecnia da Universidade de Sao Paulo, Sao Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Zoonoses Bacterianas do VPS, Faculdade de Medicina Veterin\u00e1ria e Zootecnia da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Laboratorio de Zoonoses Bacterianas do VPS, Faculdade de Medicina Veterina\u0301ria e Zootecnia da Universidade de Sao Paulo, Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017002489","display_name":"S\u00edlvio Arruda Vasconcellos","orcid":"https://orcid.org/0000-0002-7070-7920","observed_orcids":["https://orcid.org/0000-0002-7070-7920"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Silvio A. Vasconcellos","raw_affiliation_strings":["Laborat\u00f3rio de Zoonoses Bacterianas do VPS, Faculdade de Medicina Veterin\u00e1ria e Zootecnia da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","Laboratorio de Zoonoses Bacterianas do VPS, Faculdade de Medicina Veterina\u0301ria e Zootecnia da Universidade de Sao Paulo, Sao Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Zoonoses Bacterianas do VPS, Faculdade de Medicina Veterin\u00e1ria e Zootecnia da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Laboratorio de Zoonoses Bacterianas do VPS, Faculdade de Medicina Veterina\u0301ria e Zootecnia da Universidade de Sao Paulo, Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051823324","display_name":"Patr\u00edcia Ant\u00f4nia Estima Abreu","orcid":"https://orcid.org/0000-0002-7541-0341","observed_orcids":["https://orcid.org/0000-0002-7541-0341"]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Patricia A.E. Abreu","raw_affiliation_strings":["Centro de Biotecnologia, Instituto Butantan, Avenida Vital Brazil, S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Biotecnologia, Instituto Butantan, Avenida Vital Brazil, S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109918382","display_name":"Ricardo M. G\u00c3 mez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Ricardo M. G\u00c3\u00b3mez","raw_affiliation_strings":["Instituto de Bioqu\u0131\u0301mica y Biolog\u0131\u0301a Molecular, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Bioqu\u0131\u0301mica y Biolog\u0131\u0301a Molecular, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina","institution_ids":["https://openalex.org/I874386039"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046142910","display_name":"Ana L. T. O. Nascimento","orcid":"https://orcid.org/0000-0003-4851-0870","observed_orcids":["https://orcid.org/0000-0003-4851-0870"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana L.T.O. Nascimento","raw_affiliation_strings":["Centro de Biotecnologia, Instituto Butantan, Avenida Vital Brazil, S\u00e3o Paulo, SP, Brazil","Interunidades em Biotecnologia, Instituto de Ci\u00eancias Biom\u00e9dicas, USP, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Biotecnologia, Instituto Butantan, Avenida Vital Brazil, S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I2800423888"]},{"raw_affiliation_string":"Interunidades em Biotecnologia, Instituto de Ci\u00eancias Biom\u00e9dicas, USP, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"GBP","value_usd":3297},"apc_paid":null,"fwci":2.5826,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.88253594,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"276","issue":"2","first_page":"172","last_page":"180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12223","display_name":"Leptospirosis research and findings","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12223","display_name":"Leptospirosis research and findings","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptospira-interrogans","display_name":"Leptospira interrogans","score":0.9890000224113464},{"id":"https://openalex.org/keywords/lipoproteins","display_name":"lipoproteins","score":0.8109999895095825},{"id":"https://openalex.org/keywords/endothelial-activation","display_name":"endothelial activation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9300000071525574},{"id":"https://openalex.org/keywords/e-selectin","display_name":"E-selectin","score":1.0},{"id":"https://openalex.org/keywords/endothelial-cell-adhesion-molecules","display_name":"endothelial adhesion molecules","score":0.8450000286102295},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.9729999899864197},{"id":"https://openalex.org/keywords/renal-tubules","display_name":"renal tubules","score":0.7730000019073486},{"id":"https://openalex.org/keywords/host-inflammatory-response","display_name":"host inflammatory response","score":0.8679999709129333}],"concepts":[{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.6623026132583618},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6205863356590271},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.5672592520713806},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5349823832511902},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5093408823013306},{"id":"https://openalex.org/C2777834122","wikidata":"https://www.wikidata.org/wiki/Q5939177","display_name":"Human umbilical vein endothelial cell","level":4,"score":0.49770691990852356},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.47060853242874146},{"id":"https://openalex.org/C185946421","wikidata":"https://www.wikidata.org/wiki/Q3146527","display_name":"ICAM-1","level":3,"score":0.45686954259872437},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44618645310401917},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.43934139609336853},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.4303883910179138},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.414835661649704},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3739751875400543},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23310691118240356},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.20322605967521667},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20197734236717224},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12298017740249634},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007921","descriptor_name":"Leptospira interrogans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007921","descriptor_name":"Leptospira interrogans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007922","descriptor_name":"Leptospirosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D014471","descriptor_name":"Umbilical Veins","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014471","descriptor_name":"Umbilical Veins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019040","descriptor_name":"E-Selectin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1574-6968.2007.00924.x","doi":"https://doi.org/10.1111/j.1574-6968.2007.00924.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1574-6968.2007.00924.x","pdf_url":"https://academic.oup.com/femsle/article-pdf/276/2/172/19117943/276-2-172.pdf","source":{"id":"https://openalex.org/S34954451","display_name":"FEMS Microbiology Letters","issn_l":"0378-1097","issn":["0378-1097","1574-6968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS Microbiology Letters","raw_type":"journal-article"},{"id":"pmh:oai:americanae.aecid.es:3922557","doi":null,"is_oa":true,"landing_page_url":"http://sedici.unlp.edu.ar/handle/10915/83440","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:SEDICI (UNLP)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmid:17956423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17956423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS microbiology letters","raw_type":"Journal Article"},{"id":"pmh:oai:sedici.unlp.edu.ar:10915/83440","doi":null,"is_oa":true,"landing_page_url":"http://sedici.unlp.edu.ar/handle/10915/83440","pdf_url":"http://sedici.unlp.edu.ar/handle/10915/83440","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:SEDICI (UNLP)","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"doi:10.1111/j.1574-6968.2007.00924.x","doi":"https://doi.org/10.1111/j.1574-6968.2007.00924.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1574-6968.2007.00924.x","pdf_url":"https://academic.oup.com/femsle/article-pdf/276/2/172/19117943/276-2-172.pdf","source":{"id":"https://openalex.org/S34954451","display_name":"FEMS Microbiology Letters","issn_l":"0378-1097","issn":["0378-1097","1574-6968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS Microbiology Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1965036073.pdf","grobid_xml":"https://content.openalex.org/works/W1965036073.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1913343791","https://openalex.org/W1969547642","https://openalex.org/W1977922844","https://openalex.org/W1986449553","https://openalex.org/W1993399069","https://openalex.org/W2017154234","https://openalex.org/W2035713881","https://openalex.org/W2046292404","https://openalex.org/W2052977786","https://openalex.org/W2058235643","https://openalex.org/W2070407853","https://openalex.org/W2073831807","https://openalex.org/W2090163045","https://openalex.org/W2101871915","https://openalex.org/W2102676061","https://openalex.org/W2103764811","https://openalex.org/W2112752075","https://openalex.org/W2120497357","https://openalex.org/W2124306486","https://openalex.org/W2125433188","https://openalex.org/W2130503929","https://openalex.org/W2131778683","https://openalex.org/W2133312664","https://openalex.org/W2136280642","https://openalex.org/W2144888379","https://openalex.org/W2152311433","https://openalex.org/W2152936708","https://openalex.org/W2157603347","https://openalex.org/W2157801459","https://openalex.org/W2158714788","https://openalex.org/W2161746138","https://openalex.org/W2162705236","https://openalex.org/W2164913268","https://openalex.org/W2166754169","https://openalex.org/W2202462723","https://openalex.org/W2257774780","https://openalex.org/W4211105424","https://openalex.org/W4248695140"],"related_works":["https://openalex.org/W2010834346","https://openalex.org/W2090708024","https://openalex.org/W2257774780","https://openalex.org/W2728824033","https://openalex.org/W2149206763","https://openalex.org/W2419127471","https://openalex.org/W2006717074","https://openalex.org/W2102676061","https://openalex.org/W4417146222","https://openalex.org/W4405330642"],"abstract_inverted_index":{"It":[0],"has":[1],"been":[2],"reported":[3],"previously":[4],"that":[5,57,119],"activation":[6],"of":[7,14,26,35,61,144,159,170,180,185,189],"vascular":[8],"endothelium":[9,114],"by":[10,45,93],"outer":[11],"membrane":[12],"proteins":[13,37],"the":[15,33,46,71,81,141,156,168,177,187],"spirochetes":[16],"Borrelia":[17],"sp.":[18,21],"and":[19,70,96,121,195],"Treponema":[20],"resulted":[22],"in":[23,38,74,115,129,138,140,167],"enhanced":[24],"expression":[25,188],"endothelial":[27,109,190],"cell":[28,191],"adhesion":[29,123,192],"molecules.":[30],"To":[31],"investigate":[32],"role":[34],"leptospiral":[36,182],"this":[39],"process,":[40],"a":[41,54,59,117,130,163,171,181],"predicted":[42],"lipoprotein":[43],"encoded":[44],"gene":[47,67],"LIC10365":[48,66],"was":[49,68,91,97,136],"selected,":[50],"which":[51],"belongs":[52],"to":[53,99,103],"paralogous":[55],"family":[56],"presents":[58],"domain":[60],"unknown":[62],"function,":[63],"DUF1565.":[64],"The":[65,84,111,133],"cloned":[69],"protein":[72,86,135,158,183],"expressed":[73],"Escherichia":[75],"coli":[76],"C43":[77],"(DE3)":[78],"strain":[79],"using":[80],"vector":[82],"pAE.":[83],"recombinant":[85],"tagged":[87],"with":[88,149],"N-terminal":[89],"hexahistidine":[90],"purified":[92],"metal-charged":[94],"chromatography":[95],"used":[98],"assess":[100],"its":[101],"ability":[102],"activate":[104],"cultured":[105],"human":[106],"umbilical":[107],"vein":[108],"cells.":[110],"rLIC10365":[112],"activated":[113],"such":[116],"manner":[118],"E-selectin":[120],"intercellular":[122],"molecule":[124,166],"1":[125],"(ICAM-1)":[126],"became":[127],"upregulated":[128],"dose-dependent":[131],"fashion.":[132],"LIC10365-encoded":[134],"identified":[137],"vivo":[139],"renal":[142],"tubules":[143],"animal":[145],"during":[146],"experimental":[147],"infection":[148],"Leptospira":[150],"interrogans.":[151],"Collectively,":[152],"these":[153],"results":[154],"implicate":[155],"LIC10365-coding":[157],"L.":[160],"interrogans":[161],"as":[162],"potential":[164],"effector":[165],"promotion":[169],"host":[172],"inflammatory":[173],"response.":[174],"This":[175],"is":[176],"first":[178],"report":[179],"capable":[184],"up-regulating":[186],"molecules":[193],"ICAM-1":[194],"E-selectin.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}