{"id":"https://openalex.org/W1965015264","doi":"https://doi.org/10.1093/protein/gzn023","title":"Expression, purification and characterization of BGERII: a novel pan-TGF inhibitor","display_name":"Expression, purification and characterization of BGERII: a novel pan-TGF inhibitor","publication_year":2008,"publication_date":"2008-05-02","ids":{"openalex":"https://openalex.org/W1965015264","doi":"https://doi.org/10.1093/protein/gzn023","mag":"1965015264","pmid":"https://pubmed.ncbi.nlm.nih.gov/18499679","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2575055"},"language":"en","primary_location":{"id":"doi:10.1093/protein/gzn023","doi":"https://doi.org/10.1093/protein/gzn023","is_oa":true,"landing_page_url":"https://doi.org/10.1093/protein/gzn023","pdf_url":"https://academic.oup.com/peds/article-pdf/21/7/463/4399755/gzn023.pdf","source":{"id":"https://openalex.org/S44492648","display_name":"Protein Engineering Design and Selection","issn_l":"0269-2139","issn":["0269-2139","1460-213X","1741-0126","1741-0134"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Engineering Design and Selection","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/peds/article-pdf/21/7/463/4399755/gzn023.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012538599","display_name":"Erik V. Verona","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. V. Verona","raw_affiliation_strings":["Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229, USA","University of Texas Health Science Center at San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"University of Texas Health Science Center at San Antonio","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102751114","display_name":"Yuping Tang","orcid":"https://orcid.org/0000-0002-3029-7816","observed_orcids":["https://orcid.org/0000-0002-3029-7816"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Tang","raw_affiliation_strings":["Departments of Cellular and Structural Biology","University of Texas Health Science Center at San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cellular and Structural Biology","institution_ids":[]},{"raw_affiliation_string":"University of Texas Health Science Center at San Antonio","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036864935","display_name":"T. K. Millstead","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. K. Millstead","raw_affiliation_strings":["Biochemistry, The University of Texas Health Science Center, San Antonio, TX 78229, USA","University of Texas Health Science Center at San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry, The University of Texas Health Science Center, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"University of Texas Health Science Center at San Antonio","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038315454","display_name":"Andrew P. Hinck","orcid":"https://orcid.org/0000-0003-3320-8054","observed_orcids":["https://orcid.org/0000-0003-3320-8054"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. P. Hinck","raw_affiliation_strings":["Biochemistry, The University of Texas Health Science Center, San Antonio, TX 78229, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry, The University of Texas Health Science Center, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013296501","display_name":"Joseph K. Agyin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. K. Agyin","raw_affiliation_strings":["Departments of Cellular and Structural Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cellular and Structural Biology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056931880","display_name":"Lu\u2010Zhe Sun","orcid":"https://orcid.org/0000-0001-7117-4559","observed_orcids":["https://orcid.org/0000-0001-7117-4559"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L.-Z. Sun","raw_affiliation_strings":["Departments of Cellular and Structural Biology and 2 Biochemistry , The University of Texas Health Science Center , San Antonio , TX 78229 , USA","Departments of Cellular and Structural Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cellular and Structural Biology and 2 Biochemistry , The University of Texas Health Science Center , San Antonio , TX 78229 , USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Departments of Cellular and Structural Biology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4656,"currency":"USD","value_usd":4656},"apc_paid":null,"fwci":0.6332,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.63121929,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"21","issue":"7","first_page":"463","last_page":"473"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta-inhibitors","display_name":"TGF-\u03b2 inhibitors","score":0.7310000061988831},{"id":"https://openalex.org/keywords/tgf-beta-isoforms","display_name":"TGF-beta isoforms","score":0.6970000267028809},{"id":"https://openalex.org/keywords/betaglycan","display_name":"betaglycan","score":0.8220000267028809},{"id":"https://openalex.org/keywords/tgf-beta-receptor-ii","display_name":"TGFBR2","score":0.781000018119812},{"id":"https://openalex.org/keywords/smad2-phosphorylation","display_name":"Smad2 phosphorylation","score":0.8259999752044678},{"id":"https://openalex.org/keywords/smad3-phosphorylation","display_name":"Smad3 phosphorylation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tgf-beta-inhibition","display_name":"TGF-beta inhibition","score":0.8450000286102295},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6869999766349792},{"id":"https://openalex.org/keywords/protein-refolding","display_name":"protein refolding","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C6061869","wikidata":"https://www.wikidata.org/wiki/Q18250377","display_name":"Endoglin","level":4,"score":0.6407778859138489},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.623978316783905},{"id":"https://openalex.org/C179247698","wikidata":"https://www.wikidata.org/wiki/Q382799","display_name":"Affinity chromatography","level":3,"score":0.5966534614562988},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.5875828266143799},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5455470085144043},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.4982900619506836},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.48052987456321716},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.4513421058654785},{"id":"https://openalex.org/C171020997","wikidata":"https://www.wikidata.org/wiki/Q14911585","display_name":"TGF beta receptor 2","level":5,"score":0.4391523003578186},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43808478116989136},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.40098506212234497},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37468189001083374},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36526939272880554},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.33076879382133484},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31210029125213623},{"id":"https://openalex.org/C125555471","wikidata":"https://www.wikidata.org/wiki/Q14908037","display_name":"TGF alpha","level":4,"score":0.29773610830307007},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2786509394645691},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.17867621779441833},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09316942095756531},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08791449666023254},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051899","descriptor_name":"Smad2 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051900","descriptor_name":"Smad3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/protein/gzn023","doi":"https://doi.org/10.1093/protein/gzn023","is_oa":true,"landing_page_url":"https://doi.org/10.1093/protein/gzn023","pdf_url":"https://academic.oup.com/peds/article-pdf/21/7/463/4399755/gzn023.pdf","source":{"id":"https://openalex.org/S44492648","display_name":"Protein Engineering Design and Selection","issn_l":"0269-2139","issn":["0269-2139","1460-213X","1741-0126","1741-0134"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Engineering Design and Selection","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2575055","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2575055","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Eng Des Sel","raw_type":"Text"},{"id":"pmid:18499679","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18499679","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein engineering, design & selection : PEDS","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.528.7128","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.528.7128","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://peds.oxfordjournals.org/content/21/7/463.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.532.5162","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.532.5162","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://peds.oxfordjournals.org/content/early/2008/05/21/protein.gzn023.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1093/protein/gzn023","doi":"https://doi.org/10.1093/protein/gzn023","is_oa":true,"landing_page_url":"https://doi.org/10.1093/protein/gzn023","pdf_url":"https://academic.oup.com/peds/article-pdf/21/7/463/4399755/gzn023.pdf","source":{"id":"https://openalex.org/S44492648","display_name":"Protein Engineering Design and Selection","issn_l":"0269-2139","issn":["0269-2139","1460-213X","1741-0126","1741-0134"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Engineering Design and Selection","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2558708629","display_name":"Targeting transforming growth factor beta for cancer treatment","funder_award_id":"R01CA075253","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3894295811","display_name":"Effect of Tumors on the Skeleton","funder_award_id":"P01CA040035","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1965015264.pdf","grobid_xml":"https://content.openalex.org/works/W1965015264.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W174053276","https://openalex.org/W201653061","https://openalex.org/W1247235447","https://openalex.org/W1524314479","https://openalex.org/W1577437560","https://openalex.org/W1702338498","https://openalex.org/W1850804182","https://openalex.org/W1966507279","https://openalex.org/W1968070070","https://openalex.org/W1968881409","https://openalex.org/W1969619516","https://openalex.org/W1972535443","https://openalex.org/W1975918285","https://openalex.org/W1980615784","https://openalex.org/W1986704160","https://openalex.org/W1987449859","https://openalex.org/W1989043630","https://openalex.org/W1995065040","https://openalex.org/W1996383717","https://openalex.org/W2000369256","https://openalex.org/W2003276061","https://openalex.org/W2003381909","https://openalex.org/W2011243140","https://openalex.org/W2013301383","https://openalex.org/W2015959969","https://openalex.org/W2017940718","https://openalex.org/W2018075165","https://openalex.org/W2025029681","https://openalex.org/W2033260397","https://openalex.org/W2035504341","https://openalex.org/W2039275948","https://openalex.org/W2045417346","https://openalex.org/W2053007262","https://openalex.org/W2053882786","https://openalex.org/W2068657265","https://openalex.org/W2070647506","https://openalex.org/W2077970533","https://openalex.org/W2078216015","https://openalex.org/W2086286077","https://openalex.org/W2089857483","https://openalex.org/W2095605427","https://openalex.org/W2097823157","https://openalex.org/W2098435910","https://openalex.org/W2103031848","https://openalex.org/W2103484049","https://openalex.org/W2107944268","https://openalex.org/W2108009579","https://openalex.org/W2111949892","https://openalex.org/W2111952057","https://openalex.org/W2118916648","https://openalex.org/W2119949309","https://openalex.org/W2120575866","https://openalex.org/W2125925643","https://openalex.org/W2138050968","https://openalex.org/W2138143990","https://openalex.org/W2144464740","https://openalex.org/W2149433387","https://openalex.org/W2149852376","https://openalex.org/W2163120774","https://openalex.org/W2167504764","https://openalex.org/W2172210601","https://openalex.org/W2246378037","https://openalex.org/W2296293854","https://openalex.org/W2316067769","https://openalex.org/W2319635879","https://openalex.org/W3024136902"],"related_works":["https://openalex.org/W2799099820","https://openalex.org/W1996990711","https://openalex.org/W1999638271","https://openalex.org/W1972890803","https://openalex.org/W2350924088","https://openalex.org/W1510205966","https://openalex.org/W2089852973","https://openalex.org/W2155979459","https://openalex.org/W2590214733","https://openalex.org/W1974755012"],"abstract_inverted_index":{"Transforming":[0],"growth":[1],"factor":[2],"beta":[3],"(TGFbeta)":[4],"isoforms":[5,46,75],"are":[6],"known":[7],"to":[8,21,84,90,144,155,221],"be":[9],"upregulated":[10],"during":[11,26],"the":[12,108,115,178,232],"progression":[13],"of":[14,55,111,118,180,191,206,234],"some":[15],"diseases.":[16],"They":[17],"have":[18,63,98,222],"been":[19,64],"shown":[20],"stimulate":[22],"invasion":[23],"and":[24,28,41,60,92,101,114,137,146,154,183,193,195,236,247],"metastasis":[25],"carcinogenesis":[27],"promote":[29],"many":[30],"pathological":[31,42],"fibrotic":[32],"diseases":[33],"when":[34],"overstimulated.":[35],"This":[36],"involvement":[37],"in":[38,185,230,245,254],"late-stage":[39],"carcinoma":[40],"fibrosis":[43],"makes":[44],"TGFbeta":[45,56,67,74,228],"prime":[47],"targets":[48],"for":[49,250],"therapeutic":[50],"intervention.":[51],"Although":[52],"soluble":[53,152,161],"ectodomains":[54],"type":[57],"II":[58],"(RII)":[59],"betaglycan":[61],"(BG)":[62],"utilized":[65],"as":[66],"inhibitors,":[68],"their":[69],"antagonistic":[70,172],"potency":[71],"against":[72],"different":[73],"varies":[76],"considerably":[77],"because":[78],"RII":[79,153,168,208],"does":[80],"not":[81],"appreciably":[82],"bind":[83],"TGFbeta2":[85,156,184],"whereas":[86,165],"BG":[87,112],"binds":[88],"weakly":[89],"TGFbeta1":[91,145,182,235],"TGFbeta3.":[93,237],"In":[94],"this":[95],"study,":[96],"we":[97],"successfully":[99],"constructed":[100],"expressed":[102],"a":[103,149,158,198,241],"recombinant":[104],"fusion":[105,121],"protein":[106,122],"containing":[107],"endoglin":[109],"domain":[110,117],"(BG(E))":[113],"extracellular":[116],"RII.":[119],"The":[120],"(named":[123],"BG(E)RII)":[124],"was":[125,219],"purified":[126],"from":[127,197],"bacterial":[128],"inclusion":[129],"bodies":[130],"by":[131,214],"immobilized":[132],"metal":[133],"ion":[134],"chromatography,":[135,217],"refolded":[136],"characterized.":[138],"It":[139],"bound":[140],"with":[141],"higher":[142],"affinity":[143],"TGFbeta3":[147],"than":[148,157,203,225],"commercially":[150,159],"available":[151,160],"BG.":[162,210],"More":[163],"significantly,":[164],"BG(E)":[166],"or":[167,209],"alone":[169],"showed":[170],"no":[171],"activity":[173,224],"towards":[174],"TGFbeta2,":[175],"BG(E)RII":[176,218,239],"inhibited":[177],"signaling":[179,233],"both":[181],"cell-based":[186],"assays":[187],"including":[188],"TGFbeta-induced":[189,252],"phosphorylation":[190],"Smad2":[192],"Smad3,":[194],"transcription":[196],"TGFbeta-responsive":[199],"promoter":[200],"more":[201],"effectively":[202],"equimolar":[204],"concentrations":[205],"either":[207],"After":[211],"further":[212],"purification":[213],"gel":[215],"filtration":[216],"found":[220],"greater":[223],"other":[226],"potent":[227,242],"inhibitors":[229],"blocking":[231,251],"Thus,":[238],"is":[240],"pan-TGFbeta":[243],"inhibitor":[244],"vitro":[246],"has":[248],"potential":[249],"pathogenesis":[253],"vivo.":[255]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
