{"id":"https://openalex.org/W1965009930","doi":"https://doi.org/10.1074/jbc.m109.019448","title":"The Sodium-Hydrogen Exchanger NHE1 Is an Akt Substrate Necessary for Actin Filament Reorganization by Growth Factors","display_name":"The Sodium-Hydrogen Exchanger NHE1 Is an Akt Substrate Necessary for Actin Filament Reorganization by Growth Factors","publication_year":2009,"publication_date":"2009-07-22","ids":{"openalex":"https://openalex.org/W1965009930","doi":"https://doi.org/10.1074/jbc.m109.019448","mag":"1965009930","pmid":"https://pubmed.ncbi.nlm.nih.gov/19622752","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2785354"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m109.019448","doi":"https://doi.org/10.1074/jbc.m109.019448","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.019448","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m109.019448","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013469844","display_name":"Marcel E. Meima","orcid":"https://orcid.org/0000-0002-5392-0519","observed_orcids":["https://orcid.org/0000-0002-5392-0519"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcel E. Meima","raw_affiliation_strings":["Department of Cell and Tissue Biology, University of California, San Francisco, California 94143, USA","Department of Cell and Tissue Biology, University of California, San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Tissue Biology, University of California, San Francisco, California 94143, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Cell and Tissue Biology, University of California, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078551237","display_name":"Bradley A. Webb","orcid":"https://orcid.org/0000-0002-5299-2852","observed_orcids":["https://orcid.org/0000-0002-5299-2852"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradley A. Webb","raw_affiliation_strings":["Department of Cell and Tissue Biology, University of California, San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Tissue Biology, University of California, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110206821","display_name":"Halina Ewa Witkowska","orcid":"https://orcid.org/0000-0003-0175-0367","observed_orcids":["https://orcid.org/0000-0003-0175-0367"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H.Ewa Witkowska","raw_affiliation_strings":["Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042219792","display_name":"Diane L. Barber","orcid":"https://orcid.org/0000-0001-7185-9435","observed_orcids":["https://orcid.org/0000-0001-7185-9435"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Diane L. Barber","raw_affiliation_strings":["Department of Cell and Tissue Biology, University of California, San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Tissue Biology, University of California, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042219792"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.4612,"has_fulltext":false,"cited_by_count":106,"citation_normalized_percentile":{"value":0.93171202,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"284","issue":"39","first_page":"26666","last_page":"26675"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.7538999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.7538999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.17710000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.02590000070631504,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nhe1","display_name":"NHE1","score":0.9210000038146973},{"id":"https://openalex.org/keywords/na-h-exchanger","display_name":"Na+/H+ exchanger","score":0.9900000095367432},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.8389999866485596},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.7509999871253967},{"id":"https://openalex.org/keywords/actin-cytoskeleton-reorganization","display_name":"actin cytoskeleton remodeling","score":0.7910000085830688},{"id":"https://openalex.org/keywords/stress-fibers","display_name":"stress fibers","score":0.7850000262260437},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.8429999947547913},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.968999981880188},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.6639999747276306},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7129999995231628},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6119999885559082},{"id":"https://openalex.org/keywords/h-efflux","display_name":"H+ efflux","score":0.7350000143051147},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.7549999952316284},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C114574056","wikidata":"https://www.wikidata.org/wiki/Q7553395","display_name":"Sodium\u2013hydrogen antiporter","level":3,"score":0.5661783218383789},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.5408115983009338},{"id":"https://openalex.org/C14228908","wikidata":"https://www.wikidata.org/wiki/Q2920483","display_name":"Protein filament","level":2,"score":0.5351821780204773},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.5341989398002625},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.5122491717338562},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4858402907848358},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4073716104030609},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.33691203594207764},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3342873752117157},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2666992247104645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18733760714530945},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0625852644443512},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000074082","descriptor_name":"Sodium-Hydrogen Exchanger 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m109.019448","doi":"https://doi.org/10.1074/jbc.m109.019448","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.019448","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2785354","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2785354","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:19622752","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19622752","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m109.019448","doi":"https://doi.org/10.1074/jbc.m109.019448","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.019448","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1350517785","display_name":"Mechanisms of Receptor Regulated Na+-H+ Exchange","funder_award_id":"R01GM047413","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1603214163","display_name":null,"funder_award_id":"GM 47413","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2239365256","display_name":"PROGRAM IN CRANIOFACIAL &SKELETAL BIO","funder_award_id":"C06RR016490","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3414562540","display_name":null,"funder_award_id":"GRANT T32-DE7306-11","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G9000872476","display_name":"Oral and Craniofacial Sciences Health Research Training","funder_award_id":"T32DE007306","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W109074058","https://openalex.org/W320595952","https://openalex.org/W1500729563","https://openalex.org/W1509669696","https://openalex.org/W1540067706","https://openalex.org/W1572775048","https://openalex.org/W1584726943","https://openalex.org/W1602747859","https://openalex.org/W1607892649","https://openalex.org/W1678800844","https://openalex.org/W1967773832","https://openalex.org/W1973837499","https://openalex.org/W1975208228","https://openalex.org/W1976624783","https://openalex.org/W1976965279","https://openalex.org/W1977055673","https://openalex.org/W1979147887","https://openalex.org/W1981243271","https://openalex.org/W1981517713","https://openalex.org/W1984621921","https://openalex.org/W1995482311","https://openalex.org/W1996695017","https://openalex.org/W2000096284","https://openalex.org/W2001870992","https://openalex.org/W2007650170","https://openalex.org/W2011282245","https://openalex.org/W2015820342","https://openalex.org/W2017851669","https://openalex.org/W2021752473","https://openalex.org/W2030573603","https://openalex.org/W2035141411","https://openalex.org/W2046461084","https://openalex.org/W2047984068","https://openalex.org/W2052938761","https://openalex.org/W2054683873","https://openalex.org/W2055671120","https://openalex.org/W2057547625","https://openalex.org/W2057689931","https://openalex.org/W2058138221","https://openalex.org/W2059492700","https://openalex.org/W2060315853","https://openalex.org/W2075260399","https://openalex.org/W2081095441","https://openalex.org/W2082365634","https://openalex.org/W2086680916","https://openalex.org/W2087216698","https://openalex.org/W2094277516","https://openalex.org/W2095349122","https://openalex.org/W2097586379","https://openalex.org/W2097767970","https://openalex.org/W2098105439","https://openalex.org/W2101964821","https://openalex.org/W2109493256","https://openalex.org/W2113439647","https://openalex.org/W2117262983","https://openalex.org/W2123960570","https://openalex.org/W2124781995","https://openalex.org/W2125588561","https://openalex.org/W2137035181","https://openalex.org/W2138198341","https://openalex.org/W2139339609","https://openalex.org/W2145822440","https://openalex.org/W2153264233","https://openalex.org/W2153864507","https://openalex.org/W2164160141","https://openalex.org/W2165863663","https://openalex.org/W2169232755","https://openalex.org/W2184293178"],"related_works":["https://openalex.org/W1814943537","https://openalex.org/W2072167188","https://openalex.org/W3165998690","https://openalex.org/W4389022283","https://openalex.org/W1530129745","https://openalex.org/W2025800972","https://openalex.org/W1554264637","https://openalex.org/W1518461235","https://openalex.org/W3170797063","https://openalex.org/W1984104020"],"abstract_inverted_index":{"The":[0],"kinase":[1],"Akt":[2,23,47,63,74,82,106,152],"mediates":[3],"signals":[4],"from":[5],"growth":[6,97,129,137,157],"factor":[7,98,130],"receptors":[8],"for":[9,57],"increased":[10,88,134,164],"cell":[11,113,117,156],"proliferation,":[12],"survival,":[13,159],"and":[14,73,85,91,95,115,131,133,153,158],"migration,":[15],"which":[16],"contribute":[17],"to":[18,77,111],"the":[19,40,81],"positive":[20],"effects":[21],"of":[22,39,87,123],"in":[24,68,99,136,141],"cancer":[25],"progression.":[26],"Substrates":[27],"are":[28,139],"generally":[29],"inhibited":[30,140],"when":[31],"phosphorylated":[32],"by":[33,46,93,127,151,163],"Akt;":[34],"however,":[35],"we":[36],"show":[37],"phosphorylation":[38,67,83,90],"plasma":[41],"membrane":[42],"sodium-hydrogen":[43],"exchanger":[44,49,89],"NHE1":[45,58],"increases":[48],"activity":[50,92],"(H(+)":[51],"efflux).":[52],"Our":[53],"data":[54],"fulfill":[55],"criteria":[56],"being":[59],"a":[60,102],"bona":[61],"fide":[62],"substrate,":[64],"including":[65,155],"direct":[66],"vitro,":[69],"using":[70],"mass":[71],"spectrometry":[72],"phospho-substrate":[75],"antibodies":[76],"identify":[78],"Ser(648)":[79],"as":[80],"site":[84],"loss":[86],"insulin":[94,132],"platelet-derived":[96,128],"fibroblasts":[100,142],"expressing":[101,143],"mutant":[103],"NHE1-S648A.":[104,144],"How":[105],"induces":[107],"actin":[108,124],"cytoskeleton":[109],"remodeling":[110],"promote":[112],"migration":[114],"tumor":[116],"metastasis":[118],"is":[119],"unclear,":[120],"but":[121],"disassembly":[122],"stress":[125],"fibers":[126],"proliferation":[135],"medium":[138],"We":[145],"predict":[146],"that":[147],"other":[148],"functions":[149],"shared":[150],"NHE1,":[154],"might":[160],"be":[161],"regulated":[162],"H(+)":[165],"efflux.":[166]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}