{"id":"https://openalex.org/W1964985138","doi":"https://doi.org/10.3389/fphar.2014.00063","title":"Age-related changes of protein SUMOylation balance in the A\u03b2PP Tg2576 mouse model of Alzheimer's disease","display_name":"Age-related changes of protein SUMOylation balance in the A\u03b2PP Tg2576 mouse model of Alzheimer's disease","publication_year":2014,"publication_date":"2014-04-07","ids":{"openalex":"https://openalex.org/W1964985138","doi":"https://doi.org/10.3389/fphar.2014.00063","mag":"1964985138","pmid":"https://pubmed.ncbi.nlm.nih.gov/24778618","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3985012"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2014.00063","doi":"https://doi.org/10.3389/fphar.2014.00063","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2014.00063","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2014.00063/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphar.2014.00063/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081499325","display_name":"Robert Nistic\u00f2","orcid":"https://orcid.org/0000-0003-3433-9232","observed_orcids":["https://orcid.org/0000-0003-3433-9232"]},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Robert Nistic\u00c3\u00b2","raw_affiliation_strings":["Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy","IRCCS Fondazione Santa Lucia, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"IRCCS Fondazione Santa Lucia, Rome, Italy","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057795100","display_name":"Caterina Ferraina","orcid":"https://orcid.org/0000-0002-3770-4437","observed_orcids":["https://orcid.org/0000-0002-3770-4437"]},"institutions":[{"id":"https://openalex.org/I4210142264","display_name":"European Brain Research Institute","ror":"https://ror.org/03ay27p09","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210142264"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Caterina Ferraina","raw_affiliation_strings":["Laboratory of Pharmacology of Synaptic Plasticity, EBRI \"Rita Levi-Montalcini\" Foundation, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacology of Synaptic Plasticity, EBRI \"Rita Levi-Montalcini\" Foundation, Rome, Italy","institution_ids":["https://openalex.org/I4210142264"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Veronica Marconi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Veronica Marconi","raw_affiliation_strings":["Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007019878","display_name":"Fabio Blandini","orcid":"https://orcid.org/0000-0002-0178-1289","observed_orcids":["https://orcid.org/0000-0002-0178-1289"]},"institutions":[{"id":"https://openalex.org/I4210095701","display_name":"Fondazione Istituto Neurologico Nazionale Casimiro Mondino","ror":"https://ror.org/009h0v784","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210095701","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio Blandini","raw_affiliation_strings":["Center for Research in Neurodegenerative Diseases, C. Mondino National Neurological Institute, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research in Neurodegenerative Diseases, C. Mondino National Neurological Institute, Pavia, Italy","institution_ids":["https://openalex.org/I4210095701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111702350","display_name":"Lucia Negri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lucia Negri","raw_affiliation_strings":["Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028134179","display_name":"Jan Egebjerg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133593841","display_name":"Lundbeck (Denmark)","ror":"https://ror.org/0564cd633","country_code":"DK","type":"company","lineage":["https://openalex.org/I133593841"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jan Egebjerg","raw_affiliation_strings":["Neuroscience Drug Discovery DK, H. Lundbeck A/S, Valby, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Drug Discovery DK, H. Lundbeck A/S, Valby, Denmark","institution_ids":["https://openalex.org/I133593841"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029889770","display_name":"Marco Feligioni","orcid":"https://orcid.org/0000-0001-7070-9662","observed_orcids":["https://orcid.org/0000-0001-7070-9662"]},"institutions":[{"id":"https://openalex.org/I4210142264","display_name":"European Brain Research Institute","ror":"https://ror.org/03ay27p09","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210142264"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Marco Feligioni","raw_affiliation_strings":["Laboratory of Pharmacology of Synaptic Plasticity, EBRI \"Rita Levi-Montalcini\" Foundation, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacology of Synaptic Plasticity, EBRI \"Rita Levi-Montalcini\" Foundation, Rome, Italy","institution_ids":["https://openalex.org/I4210142264"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5029889770"],"corresponding_institution_ids":["https://openalex.org/I4210142264"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":2.9073,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.91576039,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"5","issue":null,"first_page":"63","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/protein-sumoylation","display_name":"protein sumoylation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/desumoylation","display_name":"deSUMOylation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/sumo1","display_name":"SUMO1","score":0.9750000238418579},{"id":"https://openalex.org/keywords/sumo2","display_name":"SUMO2","score":1.0},{"id":"https://openalex.org/keywords/ube2i","display_name":"Ubc9","score":0.8529999852180481},{"id":"https://openalex.org/keywords/senp1","display_name":"SENP1","score":1.0},{"id":"https://openalex.org/keywords/app-transgenic-mice","display_name":"APP transgenic mice","score":0.6940000057220459},{"id":"https://openalex.org/keywords/tg2576-mice","display_name":"Tg2576 mice","score":0.9240000247955322},{"id":"https://openalex.org/keywords/age-related-changes","display_name":"age-related changes","score":0.8529999852180481},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.7770000100135803},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7950000166893005},{"id":"https://openalex.org/keywords/cortex","display_name":"cortex","score":0.8920000195503235},{"id":"https://openalex.org/keywords/bace1","display_name":"BACE1","score":0.8019999861717224},{"id":"https://openalex.org/keywords/gsk-3beta","display_name":"GSK3\u03b2","score":0.75},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.9049999713897705},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.8009999990463257},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C171350616","wikidata":"https://www.wikidata.org/wiki/Q61506","display_name":"SUMO protein","level":4,"score":0.9266945123672485},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.7127221822738647},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.6857396364212036},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5885224342346191},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5391433835029602},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.524142324924469},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.505317747592926},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5019121170043945},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4963570237159729},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4910123646259308},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4810662269592285},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.45960238575935364},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3516954183578491},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.309653103351593},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25334489345550537},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17473113536834717},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.14274471998214722},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1389487385749817},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.3389/fphar.2014.00063","doi":"https://doi.org/10.3389/fphar.2014.00063","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2014.00063","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2014.00063/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2977917","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3985012","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:24778618","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24778618","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3985012","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3985012/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmh:oai:art.torvergata.it:2108/133122","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2108/133122","pdf_url":"http://hdl.handle.net/2108/133122","source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:42137059c9384e198f9fcfca8f8e299f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/42137059c9384e198f9fcfca8f8e299f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 5 (2014)","raw_type":"article"},{"id":"pmh:oai:iris.uniroma1.it:11573/560719","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/560719","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2014.00063","doi":"https://doi.org/10.3389/fphar.2014.00063","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2014.00063","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2014.00063/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3363101102","display_name":null,"funder_award_id":"Ricerca Corrente 2013-2015","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G670098279","display_name":null,"funder_award_id":"2013\u20132015","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"}],"funders":[{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"},{"id":"https://openalex.org/F4320321999","display_name":"Lundbeckfonden","ror":"https://ror.org/03hz8wd80"},{"id":"https://openalex.org/F4320327918","display_name":"H. Lundbeck A/S","ror":"https://ror.org/0564cd633"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1964985138.pdf","grobid_xml":"https://content.openalex.org/works/W1964985138.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1765834125","https://openalex.org/W1831252856","https://openalex.org/W1929267935","https://openalex.org/W1964708473","https://openalex.org/W1973629574","https://openalex.org/W1974643117","https://openalex.org/W1982522415","https://openalex.org/W1984839366","https://openalex.org/W2000269915","https://openalex.org/W2001210466","https://openalex.org/W2006537865","https://openalex.org/W2009364690","https://openalex.org/W2020042771","https://openalex.org/W2021124577","https://openalex.org/W2022285303","https://openalex.org/W2023241993","https://openalex.org/W2033605213","https://openalex.org/W2034666854","https://openalex.org/W2042396800","https://openalex.org/W2049192526","https://openalex.org/W2052495973","https://openalex.org/W2059696821","https://openalex.org/W2070744261","https://openalex.org/W2075481535","https://openalex.org/W2081126811","https://openalex.org/W2085081787","https://openalex.org/W2090651976","https://openalex.org/W2104079111","https://openalex.org/W2125960394","https://openalex.org/W2130473558","https://openalex.org/W2132223509","https://openalex.org/W2136901555","https://openalex.org/W2139061567","https://openalex.org/W2139180375","https://openalex.org/W2145965566","https://openalex.org/W2147730369","https://openalex.org/W2148789090","https://openalex.org/W2150092076","https://openalex.org/W2154492443","https://openalex.org/W2158064353","https://openalex.org/W2161136070","https://openalex.org/W2754878449"],"related_works":["https://openalex.org/W2090651976","https://openalex.org/W2884686615","https://openalex.org/W66606965","https://openalex.org/W1956441082","https://openalex.org/W2801243713","https://openalex.org/W2530691653","https://openalex.org/W989148906","https://openalex.org/W2781393646","https://openalex.org/W2095111250","https://openalex.org/W2772050974"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1,211],"(AD)":[2],"is":[3,142],"a":[4,14,44],"complex":[5],"disorder":[6],"that":[7,185,198],"affects":[8,19],"the":[9,28,32,53,57,83,90,95,98,162,179,192,208],"central":[10],"nervous":[11],"system":[12],"causing":[13],"severe":[15],"neurodegeneration.":[16],"This":[17],"pathology":[18,96],"an":[20,117,204],"increasing":[21],"number":[22],"of":[23,31,52,60,94,102,148,159,195],"people":[24],"worldwide":[25],"due":[26],"to":[27,73,133],"overall":[29],"aging":[30],"human":[33],"population.":[34],"In":[35],"recent":[36],"years":[37],"SUMO":[38,75],"protein":[39,74,121],"modification":[40],"has":[41],"emerged":[42],"as":[43],"possible":[45],"cellular":[46],"mechanism":[47],"involved":[48],"in":[49,56,70,97,119,128,135,152,171,178,187,207],"AD.":[50,103],"Some":[51],"proteins":[54,88],"engaged":[55],"physiopathological":[58],"process":[59],"AD,":[61],"like":[62],"BACE1,":[63],"GSK3-\u03b2":[64],"tau,":[65],"A\u03b2PP,":[66],"and":[67,86,92,114,125,138,150,175],"JNK,":[68],"are":[69],"fact":[71,184],"subject":[72],"modifications":[76,201],"or":[77],"interactions.":[78],"Here,":[79],"we":[80],"have":[81],"investigated":[82],"SUMO/deSUMOylation":[84,188],"balance":[85],"SUMO-related":[87],"during":[89],"onset":[91],"progression":[93],"Tg2576":[99],"mouse":[100],"model":[101],"We":[104],"examined":[105],"four":[106],"age-stages":[107],"(1.5,":[108],"3,":[109],"6,":[110],"17":[111],"months":[112,127,158],"old)":[113],"observed":[115],"shows":[116],"increase":[118],"SUMO-1":[120,163],"conjugation":[122],"at":[123],"3":[124],"6":[126,157],"transgenic":[129,173],"mice":[130,174],"with":[131],"respect":[132],"WT":[134],"both":[136,153],"cortex":[137],"hippocampus.":[139],"Interestingly":[140],"this":[141],"paralleled":[143],"by":[144],"increased":[145],"expression":[146],"levels":[147],"Ubc9":[149],"SENP1":[151],"brain":[154],"regions.":[155],"At":[156],"age":[160],"also":[161],"mRNA":[164],"resulted":[165],"augmented.":[166],"SUMO-2-ylation":[167],"was":[168,176],"surprisingly":[169],"decreased":[170],"old":[172],"unaltered":[177],"other":[180],"time":[181],"windows.":[182],"The":[183],"alterations":[186],"equilibrium":[189],"occur":[190],"from":[191],"early":[193],"phases":[194],"AD":[196],"suggests":[197],"global":[199],"posttranslational":[200],"may":[202],"play":[203],"important":[205],"role":[206],"mechanisms":[209],"underlying":[210],"pathogenesis,":[212],"thus":[213],"providing":[214],"potential":[215],"targets":[216],"for":[217],"pharmacological":[218],"interventions.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}