{"id":"https://openalex.org/W1964919981","doi":"https://doi.org/10.1016/0091-6749(94)90377-8","title":"Affinity purification of the major bovine allergen by a novel monoclonal antibody","display_name":"Affinity purification of the major bovine allergen by a novel monoclonal antibody","publication_year":1994,"publication_date":"1994-05-01","ids":{"openalex":"https://openalex.org/W1964919981","doi":"https://doi.org/10.1016/0091-6749(94)90377-8","mag":"1964919981","pmid":"https://pubmed.ncbi.nlm.nih.gov/8182227"},"language":"en","primary_location":{"id":"doi:10.1016/0091-6749(94)90377-8","doi":"https://doi.org/10.1016/0091-6749(94)90377-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0091-6749(94)90377-8","pdf_url":null,"source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113520404","display_name":"Jaana Yl\u00f6nen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jaana Yl\u00f6nen","raw_affiliation_strings":["Department of Clinical Microbiology, University of Kuopio, Finland","Department Iof Dermatology, University of Kuopio","Department of Clinical Microbiology, University of Kuopio, P.O.B. 1627, 70211 Kuopio, Finland","Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Microbiology, University of Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Department Iof Dermatology, University of Kuopio","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Department of Clinical Microbiology, University of Kuopio, P.O.B. 1627, 70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Kuopio, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049691461","display_name":"Tuomas I. Virtanen","orcid":"https://orcid.org/0000-0002-4604-9729","observed_orcids":["https://orcid.org/0000-0002-4604-9729"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Tuomas Virtanen","raw_affiliation_strings":["Department Iof Dermatology, University of Kuopio","Department of Clinical Microbiology, University of Kuopio, P.O.B. 1627, 70211 Kuopio, Finland","Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Iof Dermatology, University of Kuopio","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Department of Clinical Microbiology, University of Kuopio, P.O.B. 1627, 70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Kuopio, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052039912","display_name":"Leena Horsmanheimo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Leena Horsmanheimo","raw_affiliation_strings":["Department Iof Dermatology, University of Kuopio","Department of Clinical Microbiology, University of Kuopio, P.O.B. 1627, 70211 Kuopio, Finland","Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Iof Dermatology, University of Kuopio","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Department of Clinical Microbiology, University of Kuopio, P.O.B. 1627, 70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Kuopio, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059032784","display_name":"Sinikka Parkkinen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Sinikka Parkkinen","raw_affiliation_strings":["Department Iof Dermatology, University of Kuopio","Department of Clinical Microbiology, University of Kuopio, P.O.B. 1627, 70211 Kuopio, Finland","Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Iof Dermatology, University of Kuopio","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Department of Clinical Microbiology, University of Kuopio, P.O.B. 1627, 70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Kuopio, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110474790","display_name":"Jukka Pelkonen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jukka Pelkonen","raw_affiliation_strings":["Department Iof Dermatology, University of Kuopio","Department of Clinical Microbiology, University of Kuopio, P.O.B. 1627, 70211 Kuopio, Finland","Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Iof Dermatology, University of Kuopio","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Department of Clinical Microbiology, University of Kuopio, P.O.B. 1627, 70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Kuopio, Finland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110269082","display_name":"R. A. M\u00c4NTYJ\u00c4RVI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Rauno M\u00e4ntyjarvi","raw_affiliation_strings":["Department Iof Dermatology, University of Kuopio","Department of Clinical Microbiology, University of Kuopio, P.O.B. 1627, 70211 Kuopio, Finland","Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Iof Dermatology, University of Kuopio","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Department of Clinical Microbiology, University of Kuopio, P.O.B. 1627, 70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Kuopio, Finland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I175532246"],"apc_list":{"value":4900,"currency":"USD","value_usd":4900},"apc_paid":null,"fwci":1.5034,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.8151689,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"93","issue":"5","first_page":"851","last_page":"858"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9089999794960022},{"id":"https://openalex.org/keywords/affinity-purification","display_name":"affinity purification","score":0.753000020980835},{"id":"https://openalex.org/keywords/allergen-purification","display_name":"allergen purification","score":0.722000002861023},{"id":"https://openalex.org/keywords/cross-reactivity","display_name":"cross-reactivity","score":0.8330000042915344},{"id":"https://openalex.org/keywords/ige-immunoblotting","display_name":"IgE immunoblotting","score":0.7179999947547913},{"id":"https://openalex.org/keywords/skin-prick-test","display_name":"skin prick test","score":0.9120000004768372},{"id":"https://openalex.org/keywords/isoelectric-point","display_name":"isoelectric point","score":0.8730000257492065},{"id":"https://openalex.org/keywords/amino-acid-composition","display_name":"amino acid composition","score":0.8029999732971191},{"id":"https://openalex.org/keywords/acidic-amino-acids","display_name":"acidic amino acids","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C2780510475","wikidata":"https://www.wikidata.org/wiki/Q186752","display_name":"Allergen","level":3,"score":0.8837350010871887},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.7532488107681274},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7010790705680847},{"id":"https://openalex.org/C179247698","wikidata":"https://www.wikidata.org/wiki/Q382799","display_name":"Affinity chromatography","level":3,"score":0.7009183764457703},{"id":"https://openalex.org/C96294017","wikidata":"https://www.wikidata.org/wiki/Q308708","display_name":"Isoelectric point","level":3,"score":0.6383085250854492},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5859487056732178},{"id":"https://openalex.org/C50476208","wikidata":"https://www.wikidata.org/wiki/Q898861","display_name":"Isoelectric focusing","level":3,"score":0.5519933104515076},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.5250052213668823},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5241416096687317},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.4643661677837372},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39293158054351807},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35881149768829346},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22996103763580322},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2100476324558258},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.18761548399925232},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10598540306091309}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002846","descriptor_name":"Chromatography, Affinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006736","descriptor_name":"Horses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007158","descriptor_name":"Immunologic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012882","descriptor_name":"Skin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0091-6749(94)90377-8","doi":"https://doi.org/10.1016/0091-6749(94)90377-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0091-6749(94)90377-8","pdf_url":null,"source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},{"id":"pmid:8182227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8182227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of allergy and clinical immunology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322861","display_name":"Emil Aaltosen S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/005rt3g54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1565727701","https://openalex.org/W1775749144","https://openalex.org/W1966631706","https://openalex.org/W1977461031","https://openalex.org/W2008180079","https://openalex.org/W2012555910","https://openalex.org/W2018530329","https://openalex.org/W2021570802","https://openalex.org/W2029252960","https://openalex.org/W2029911290","https://openalex.org/W2029939111","https://openalex.org/W2034217943","https://openalex.org/W2042381017","https://openalex.org/W2065861447","https://openalex.org/W2067212034","https://openalex.org/W2068604841","https://openalex.org/W2074523393","https://openalex.org/W2091220580","https://openalex.org/W2099277553","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2104641141","https://openalex.org/W2402592934"],"related_works":["https://openalex.org/W2034217943","https://openalex.org/W1989385413","https://openalex.org/W1989495482","https://openalex.org/W2060346573","https://openalex.org/W2118207429","https://openalex.org/W2943985220","https://openalex.org/W1988433717","https://openalex.org/W2129625149","https://openalex.org/W198061714","https://openalex.org/W2157769805"],"abstract_inverted_index":null,"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}