{"id":"https://openalex.org/W1964896591","doi":"https://doi.org/10.1358/mf.2005.27.2.876286","title":"Solid lipid nanoparticles as drug delivery systems","display_name":"Solid lipid nanoparticles as drug delivery systems","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W1964896591","doi":"https://doi.org/10.1358/mf.2005.27.2.876286","mag":"1964896591","pmid":"https://pubmed.ncbi.nlm.nih.gov/15834465"},"language":"en","primary_location":{"id":"doi:10.1358/mf.2005.27.2.876286","doi":"https://doi.org/10.1358/mf.2005.27.2.876286","is_oa":false,"landing_page_url":"https://doi.org/10.1358/mf.2005.27.2.876286","pdf_url":null,"source":{"id":"https://openalex.org/S17778739","display_name":"Methods and Findings in Experimental and Clinical Pharmacology","issn_l":"0379-0355","issn":["0379-0355","2013-0155"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310313017","host_organization_name":"Thomson Reuters","host_organization_lineage":["https://openalex.org/P4310313017"],"host_organization_lineage_names":["Thomson Reuters"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods and Findings in Experimental and Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004123032","display_name":"K Manjunath","orcid":"https://orcid.org/0000-0003-2301-4539","observed_orcids":["https://orcid.org/0000-0003-2301-4539"]},"institutions":[{"id":"https://openalex.org/I28210344","display_name":"Kakatiya University","ror":"https://ror.org/012zpbg81","country_code":"IN","type":"education","lineage":["https://openalex.org/I28210344"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manjunath, K.","raw_affiliation_strings":["Novel Drug Delivery System Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novel Drug Delivery System Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India","institution_ids":["https://openalex.org/I28210344"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Reddy, J.S.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reddy, J.S.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5017473916","display_name":"Vobalaboina Venkateswarlu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Venkateswarlu, V.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4015,"has_fulltext":false,"cited_by_count":309,"citation_normalized_percentile":{"value":0.91147168,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"27","issue":"2","first_page":"127","last_page":"127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.055799998342990875,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.048900000751018524,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/solid-lipid-nanoparticles","display_name":"solid lipid nanoparticles","score":1.0},{"id":"https://openalex.org/keywords/drug-delivery-systems","display_name":"drug delivery systems","score":0.9929999709129333},{"id":"https://openalex.org/keywords/surfactants","display_name":"surfactants","score":0.9729999899864197},{"id":"https://openalex.org/keywords/freeze-drying","display_name":"freeze-drying","score":0.8199999928474426},{"id":"https://openalex.org/keywords/sterilization","display_name":"sterilization","score":0.906000018119812},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.9380000233650208},{"id":"https://openalex.org/keywords/drug-release-mechanism","display_name":"drug release mechanism","score":0.7720000147819519},{"id":"https://openalex.org/keywords/nanoparticle-stability","display_name":"nanoparticle stability","score":0.8859999775886536},{"id":"https://openalex.org/keywords/nanoparticle-characterization","display_name":"nanoparticle characterization","score":0.8330000042915344},{"id":"https://openalex.org/keywords/in-vivo-evaluation","display_name":"in vivo evaluation","score":0.656000018119812},{"id":"https://openalex.org/keywords/route-of-administration","display_name":"route of administration","score":0.9620000123977661}],"concepts":[{"id":"https://openalex.org/C199529486","wikidata":"https://www.wikidata.org/wiki/Q7557912","display_name":"Solid lipid nanoparticle","level":3,"score":0.979104220867157},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.7250801920890808},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7219840884208679},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.709844172000885},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.5392966866493225},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4970555603504181},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47354620695114136},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.43220382928848267},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.42916885018348694},{"id":"https://openalex.org/C84403425","wikidata":"https://www.wikidata.org/wiki/Q3491348","display_name":"Carrier system","level":2,"score":0.4282761216163635},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41808587312698364},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.41373714804649353},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2849862575531006},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.25156116485595703},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17537114024162292},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.11385834217071533},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.11245837807655334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0675477385520935},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045703","descriptor_name":"Emulsifying Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1358/mf.2005.27.2.876286","doi":"https://doi.org/10.1358/mf.2005.27.2.876286","is_oa":false,"landing_page_url":"https://doi.org/10.1358/mf.2005.27.2.876286","pdf_url":null,"source":{"id":"https://openalex.org/S17778739","display_name":"Methods and Findings in Experimental and Clinical Pharmacology","issn_l":"0379-0355","issn":["0379-0355","2013-0155"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310313017","host_organization_name":"Thomson Reuters","host_organization_lineage":["https://openalex.org/P4310313017"],"host_organization_lineage_names":["Thomson Reuters"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods and Findings in Experimental and Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:15834465","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15834465","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods and findings in experimental and clinical pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":93,"referenced_works":["https://openalex.org/W37840549","https://openalex.org/W119525742","https://openalex.org/W137791175","https://openalex.org/W179797399","https://openalex.org/W230709115","https://openalex.org/W1495600513","https://openalex.org/W1579046626","https://openalex.org/W1880932432","https://openalex.org/W1964026121","https://openalex.org/W1971339070","https://openalex.org/W1971874586","https://openalex.org/W1974050571","https://openalex.org/W1974139131","https://openalex.org/W1977755432","https://openalex.org/W1978467463","https://openalex.org/W1980673622","https://openalex.org/W1980733502","https://openalex.org/W1983090757","https://openalex.org/W1983692314","https://openalex.org/W1984584366","https://openalex.org/W1988820611","https://openalex.org/W1989266538","https://openalex.org/W1989492660","https://openalex.org/W1996897622","https://openalex.org/W1997988583","https://openalex.org/W2000076998","https://openalex.org/W2000398863","https://openalex.org/W2001486202","https://openalex.org/W2002150064","https://openalex.org/W2002319574","https://openalex.org/W2007765995","https://openalex.org/W2007918267","https://openalex.org/W2011607617","https://openalex.org/W2012427617","https://openalex.org/W2019049349","https://openalex.org/W2019395934","https://openalex.org/W2020882358","https://openalex.org/W2020975942","https://openalex.org/W2021976373","https://openalex.org/W2023409826","https://openalex.org/W2023435253","https://openalex.org/W2024570894","https://openalex.org/W2025418692","https://openalex.org/W2028258807","https://openalex.org/W2028617112","https://openalex.org/W2029555055","https://openalex.org/W2033390870","https://openalex.org/W2042382047","https://openalex.org/W2044681516","https://openalex.org/W2045746229","https://openalex.org/W2046017386","https://openalex.org/W2046168735","https://openalex.org/W2050706602","https://openalex.org/W2050795398","https://openalex.org/W2054189154","https://openalex.org/W2057211213","https://openalex.org/W2057460376","https://openalex.org/W2060300443","https://openalex.org/W2063088902","https://openalex.org/W2069572791","https://openalex.org/W2069947692","https://openalex.org/W2071306094","https://openalex.org/W2071631289","https://openalex.org/W2071872569","https://openalex.org/W2071896997","https://openalex.org/W2075579043","https://openalex.org/W2075778114","https://openalex.org/W2077623418","https://openalex.org/W2080031538","https://openalex.org/W2082314452","https://openalex.org/W2082345840","https://openalex.org/W2086319321","https://openalex.org/W2091024871","https://openalex.org/W2107682048","https://openalex.org/W2111023720","https://openalex.org/W2114918609","https://openalex.org/W2117374217","https://openalex.org/W2123174763","https://openalex.org/W2123624166","https://openalex.org/W2128156533","https://openalex.org/W2129411530","https://openalex.org/W2132534186","https://openalex.org/W2141085937","https://openalex.org/W2142404968","https://openalex.org/W2146408988","https://openalex.org/W2151291833","https://openalex.org/W2169946060","https://openalex.org/W2171424874","https://openalex.org/W2171638781","https://openalex.org/W2183279552","https://openalex.org/W2288796799","https://openalex.org/W2417938582","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2354043164","https://openalex.org/W2144489656","https://openalex.org/W2896399282","https://openalex.org/W2999103050","https://openalex.org/W4389393691","https://openalex.org/W4247336856","https://openalex.org/W1579046626","https://openalex.org/W4328037286","https://openalex.org/W7220504537","https://openalex.org/W4390978050"],"abstract_inverted_index":{"For":[0],"a":[1],"decade,":[2],"trials":[3],"have":[4],"been":[5],"made":[6],"to":[7,18,100,108],"utilize":[8],"solid":[9],"lipid":[10,25,32],"nanoparticles":[11],"(SLNs)":[12],"as":[13,24],"alternative":[14],"drug":[15,20,56,64,120],"delivery":[16,21],"systems":[17,22],"colloidal":[19],"such":[23],"emulsions,":[26],"liposomes,":[27],"and":[28,35,44,58,66,74,80,118],"polymeric":[29],"nanoparticles.":[30],"Various":[31,86],"matrices,":[33],"surfactants,":[34],"other":[36],"excipients":[37],"used":[38],"in":[39,50,78,87,98,101],"formulation,":[40],"preparation":[41],"methods,":[42],"sterilization":[43],"lyophilization":[45],"of":[46,55,69,82,106,113],"SLNs":[47,83,107,123],"are":[48,72,84,96,115,124],"discussed":[49],"this":[51],"article.":[52],"Entrapment":[53],"efficiency":[54],"carrier":[57],"its":[59],"effect":[60],"on":[61],"physical":[62],"parameters,":[63],"release,":[65],"release":[67],"mechanisms":[68],"various":[70,111],"compositions":[71],"reviewed":[73],"discussed.":[75],"Important":[76],"points":[77],"characterization":[79],"stability":[81],"outlined.":[85],"vitro":[88],"studies":[89],"carried":[90],"out":[91],"by":[92,110],"different":[93],"research":[94],"groups":[95],"mentioned":[97],"addition":[99],"vivo":[102],"evaluation.":[103],"Exploitation":[104],"potential":[105],"administer":[109],"routes":[112],"administration":[114],"covered.":[116],"Passive":[117],"active":[119],"targeting":[121],"using":[122],"presented.":[125]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":26},{"year":2023,"cited_by_count":28},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":31},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}