{"id":"https://openalex.org/W1964894262","doi":"https://doi.org/10.1074/jbc.m114.609016","title":"Inhibition of Transforming Growth Factor \u03b2 (TGF-\u03b2) Signaling can Substitute for Oct4 Protein in Reprogramming and Maintain Pluripotency","display_name":"Inhibition of Transforming Growth Factor \u03b2 (TGF-\u03b2) Signaling can Substitute for Oct4 Protein in Reprogramming and Maintain Pluripotency","publication_year":2014,"publication_date":"2014-12-30","ids":{"openalex":"https://openalex.org/W1964894262","doi":"https://doi.org/10.1074/jbc.m114.609016","mag":"1964894262","pmid":"https://pubmed.ncbi.nlm.nih.gov/25548277","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4326853"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m114.609016","doi":"https://doi.org/10.1074/jbc.m114.609016","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m114.609016","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m114.609016","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018234790","display_name":"Fangzhi Tan","orcid":"https://orcid.org/0000-0002-8230-1784","observed_orcids":["https://orcid.org/0000-0002-8230-1784","https://orcid.org/0009-0007-2962-0552"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]},{"id":"https://openalex.org/I4391767705","display_name":"State Key Laboratory of Cell Biology","ror":"https://ror.org/024btyy46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4391767705"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fangzhi Tan","raw_affiliation_strings":["From the State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210121447","https://openalex.org/I4391767705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100651524","display_name":"Cheng Qian","orcid":"https://orcid.org/0000-0003-1500-9991","observed_orcids":["https://orcid.org/0000-0003-1500-9991","https://orcid.org/0009-0006-5392-1657"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]},{"id":"https://openalex.org/I4391767705","display_name":"State Key Laboratory of Cell Biology","ror":"https://ror.org/024btyy46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4391767705"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Qian","raw_affiliation_strings":["From the State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210121447","https://openalex.org/I4391767705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080961279","display_name":"Ke Tang","orcid":"https://orcid.org/0000-0002-0516-4667","observed_orcids":["https://orcid.org/0000-0002-0516-4667"]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke Tang","raw_affiliation_strings":["the Institute of Life Science, Nanchang University, Nanchang, Jiangxi 330031, China, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Institute of Life Science, Nanchang University, Nanchang, Jiangxi 330031, China, and","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052648515","display_name":"Saber Mohamed Abd-Allah","orcid":"https://orcid.org/0000-0002-9261-0070","observed_orcids":["https://orcid.org/0000-0002-9261-0070"]},"institutions":[{"id":"https://openalex.org/I113643904","display_name":"Beni-Suef University","ror":"https://ror.org/05pn4yv70","country_code":"EG","type":"education","lineage":["https://openalex.org/I113643904"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Saber Mohamed Abd-Allah","raw_affiliation_strings":["the Theriogenology Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Theriogenology Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, Egypt","institution_ids":["https://openalex.org/I113643904"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019291511","display_name":"Naihe Jing","orcid":"https://orcid.org/0000-0003-1509-6378","observed_orcids":["https://orcid.org/0000-0003-1509-6378"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]},{"id":"https://openalex.org/I4391767705","display_name":"State Key Laboratory of Cell Biology","ror":"https://ror.org/024btyy46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4391767705"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Naihe Jing","raw_affiliation_strings":["From the State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China, njing@sibcb.ac.cn","From the \u2021State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China, njing@sibcb.ac.cn","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210121447","https://openalex.org/I4391767705"]},{"raw_affiliation_string":"From the \u2021State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China,","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210121447","https://openalex.org/I4391767705"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5019291511"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210121447","https://openalex.org/I4391767705"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.1016,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.73957954,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"290","issue":"7","first_page":"4500","last_page":"4511"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8769999742507935},{"id":"https://openalex.org/keywords/oct4","display_name":"Oct4","score":0.8759999871253967},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.8069999814033508},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9369999766349792},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cellular-reprogramming","display_name":"cellular reprogramming","score":0.7549999952316284},{"id":"https://openalex.org/keywords/sb-431542","display_name":"SB431542","score":0.9319999814033508},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9210000038146973},{"id":"https://openalex.org/keywords/early-embryonic-development","display_name":"early embryonic development","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.7202591300010681},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7193344831466675},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.6703177094459534},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.6439262628555298},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6240861415863037},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.6123898029327393},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.5395881533622742},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5269154906272888},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4633055329322815},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.4545636773109436},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36677247285842896},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.16130438446998596},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10371643304824829},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004149","descriptor_name":"Dioxoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016220","descriptor_name":"Fibroblast Growth Factor 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016220","descriptor_name":"Fibroblast Growth Factor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048369","descriptor_name":"MAP Kinase Kinase 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048369","descriptor_name":"MAP Kinase Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050814","descriptor_name":"Octamer Transcription Factor-3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050814","descriptor_name":"Octamer Transcription Factor-3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065150","descriptor_name":"Cellular Reprogramming","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m114.609016","doi":"https://doi.org/10.1074/jbc.m114.609016","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m114.609016","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3709300","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4326853","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25548277","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25548277","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4326853","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4326853/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1074/jbc.m114.609016","doi":"https://doi.org/10.1074/jbc.m114.609016","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m114.609016","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1840163537","https://openalex.org/W1965276147","https://openalex.org/W1965742882","https://openalex.org/W1970774026","https://openalex.org/W1974012180","https://openalex.org/W1976443290","https://openalex.org/W1976454147","https://openalex.org/W1978173381","https://openalex.org/W1981406615","https://openalex.org/W1992160731","https://openalex.org/W1992663780","https://openalex.org/W1993519688","https://openalex.org/W1994760449","https://openalex.org/W1999492066","https://openalex.org/W2010685617","https://openalex.org/W2014643937","https://openalex.org/W2018113993","https://openalex.org/W2019818957","https://openalex.org/W2022959322","https://openalex.org/W2030299771","https://openalex.org/W2035047647","https://openalex.org/W2035203405","https://openalex.org/W2047015004","https://openalex.org/W2050280041","https://openalex.org/W2057641653","https://openalex.org/W2058521801","https://openalex.org/W2061758394","https://openalex.org/W2063399102","https://openalex.org/W2074405326","https://openalex.org/W2074908308","https://openalex.org/W2086943348","https://openalex.org/W2090260381","https://openalex.org/W2101569447","https://openalex.org/W2105427659","https://openalex.org/W2105683352","https://openalex.org/W2109479865","https://openalex.org/W2110737932","https://openalex.org/W2117814548","https://openalex.org/W2118430622","https://openalex.org/W2125987139","https://openalex.org/W2126409708","https://openalex.org/W2134440878","https://openalex.org/W2135854261","https://openalex.org/W2137440275","https://openalex.org/W2138977668","https://openalex.org/W2142482111","https://openalex.org/W2144578935","https://openalex.org/W2148272837","https://openalex.org/W2151220680","https://openalex.org/W2154241165","https://openalex.org/W2163679188","https://openalex.org/W7097749369"],"related_works":["https://openalex.org/W2092243068","https://openalex.org/W2030299771","https://openalex.org/W2149300531","https://openalex.org/W2921086847","https://openalex.org/W4400930833","https://openalex.org/W1823838513","https://openalex.org/W1199760748","https://openalex.org/W2346010923","https://openalex.org/W1976443290","https://openalex.org/W6907867846"],"abstract_inverted_index":{"Mouse":[0],"pluripotent":[1],"stem":[2],"cells":[3,8,88],"(PSCs),":[4],"such":[5],"as":[6],"ES":[7,87],"and":[9,21,38,86,107],"induced":[10],"PSCs":[11],"(iPSCs),":[12],"are":[13],"an":[14],"excellent":[15],"system":[16],"to":[17],"investigate":[18],"the":[19,44,49,82,105],"molecular":[20],"cellular":[22],"mechanisms":[23],"involved":[24],"in":[25,43,54,104],"early":[26],"embryonic":[27],"development.":[28],"The":[29],"signaling":[30,53,65,79,102],"pathways":[31],"orchestrated":[32],"by":[33],"leukemia":[34],"inhibitor":[35,68],"factor/STAT3,":[36],"Wnt/\u03b2-catenin,":[37],"FGF/MEK/ERK":[39,91],"play":[40],"key":[41],"roles":[42],"generation":[45,106],"of":[46,51,84,100,109],"pluripotency.":[47],"However,":[48],"function":[50,99],"TGF-\u03b2":[52,64,78,101],"this":[55,94],"process":[56],"remains":[57],"elusive.":[58],"Here":[59],"we":[60],"show":[61],"that":[62],"inhibiting":[63,77],"with":[66],"its":[67],"SB431542":[69],"can":[70,80],"substitute":[71],"for":[72],"Oct4":[73],"during":[74],"reprogramming.":[75],"Moreover,":[76],"sustain":[81],"pluripotency":[83],"iPSCs":[85],"through":[89],"modulating":[90],"signaling.":[92],"Therefore,":[93],"study":[95],"reveals":[96],"a":[97],"novel":[98],"inhibition":[103],"maintenance":[108],"PSCs.":[110]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
