{"id":"https://openalex.org/W1964850004","doi":"https://doi.org/10.1002/tox.20728","title":"Metiram\u2010induced nephrotoxicity in albino mice: Effect of licorice aqueous extract","display_name":"Metiram\u2010induced nephrotoxicity in albino mice: Effect of licorice aqueous extract","publication_year":2011,"publication_date":"2011-05-04","ids":{"openalex":"https://openalex.org/W1964850004","doi":"https://doi.org/10.1002/tox.20728","mag":"1964850004","pmid":"https://pubmed.ncbi.nlm.nih.gov/21544926"},"language":"en","primary_location":{"id":"doi:10.1002/tox.20728","doi":"https://doi.org/10.1002/tox.20728","is_oa":false,"landing_page_url":"https://doi.org/10.1002/tox.20728","pdf_url":null,"source":{"id":"https://openalex.org/S172436580","display_name":"Environmental Toxicology","issn_l":"1520-4081","issn":["1520-4081","1522-7278"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113521520","display_name":"Saber A. Sakr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63601056","display_name":"Menoufia University","ror":"https://ror.org/05sjrb944","country_code":"EG","type":"education","lineage":["https://openalex.org/I63601056"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Saber Sakr","raw_affiliation_strings":["Department of Zoology, Faculty of Science, Menoufiya University, Shebin El-kom, Egypt. sabsak@yahoo.com","Department of Zoology, Faculty of Science, Menoufiya University, Shebin El-kom, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, Faculty of Science, Menoufiya University, Shebin El-kom, Egypt. sabsak@yahoo.com","institution_ids":["https://openalex.org/I63601056"]},{"raw_affiliation_string":"Department of Zoology, Faculty of Science, Menoufiya University, Shebin El-kom, Egypt","institution_ids":["https://openalex.org/I63601056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027252817","display_name":"Ayman El-Meghawry El-Kenawy","orcid":"https://orcid.org/0000-0002-0818-2393","observed_orcids":["https://orcid.org/0000-0002-0818-2393"]},"institutions":[{"id":"https://openalex.org/I63601056","display_name":"Menoufia University","ror":"https://ror.org/05sjrb944","country_code":"EG","type":"education","lineage":["https://openalex.org/I63601056"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ayman EL\u2010Kenawy","raw_affiliation_strings":["Department of Molecular Biology, Genetic Engineering and Biotechnology Institute, Menoufiya University, Shebin El-kom, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Genetic Engineering and Biotechnology Institute, Menoufiya University, Shebin El-kom, Egypt","institution_ids":["https://openalex.org/I63601056"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079308231","display_name":"Doaa Galal El-Sahra","orcid":"https://orcid.org/0000-0001-8791-6844","observed_orcids":["https://orcid.org/0000-0001-8791-6844"]},"institutions":[{"id":"https://openalex.org/I63601056","display_name":"Menoufia University","ror":"https://ror.org/05sjrb944","country_code":"EG","type":"education","lineage":["https://openalex.org/I63601056"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Doaa EL\u2010Sahra","raw_affiliation_strings":["Department of Zoology, Faculty of Science, Menoufiya University, Shebin El-kom, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, Faculty of Science, Menoufiya University, Shebin El-kom, Egypt","institution_ids":["https://openalex.org/I63601056"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113521520"],"corresponding_institution_ids":["https://openalex.org/I63601056"],"apc_list":{"value":4120,"currency":"USD","value_usd":4120},"apc_paid":null,"fwci":0.6536,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.72448542,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"28","issue":"7","first_page":"372","last_page":"379"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.548799991607666,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.548799991607666,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12817","display_name":"Pharmacological Effects of Natural Compounds","score":0.25589999556541443,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12962","display_name":"Nephrotoxicity and Medicinal Plants","score":0.020600000396370888,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metiram","display_name":"metiram","score":0.9929999709129333},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.5040000081062317},{"id":"https://openalex.org/keywords/kidney-histopathology","display_name":"kidney histopathology","score":0.7879999876022339},{"id":"https://openalex.org/keywords/proliferating-cell-nuclear-antigen","display_name":"proliferating cell nuclear antigen","score":0.875},{"id":"https://openalex.org/keywords/glomerular-atrophy","display_name":"glomerular atrophy","score":0.8619999885559082},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.8560000061988831},{"id":"https://openalex.org/keywords/blood-urea-nitrogen","display_name":"blood urea nitrogen","score":0.9789999723434448},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9079999923706055},{"id":"https://openalex.org/keywords/ameliorative-effect","display_name":"ameliorative effect","score":0.671999990940094},{"id":"https://openalex.org/keywords/herb-drug-interactions","display_name":"herb-drug interactions","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.884587824344635},{"id":"https://openalex.org/C34688535","wikidata":"https://www.wikidata.org/wiki/Q418732","display_name":"Proliferating cell nuclear antigen","level":3,"score":0.7734037637710571},{"id":"https://openalex.org/C2778176769","wikidata":"https://www.wikidata.org/wiki/Q764079","display_name":"Blood urea nitrogen","level":3,"score":0.6630153059959412},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6594471335411072},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.6371780633926392},{"id":"https://openalex.org/C2993907526","wikidata":"https://www.wikidata.org/wiki/Q1259977","display_name":"Aqueous extract","level":2,"score":0.5980084538459778},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5880429148674011},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5763841271400452},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.563227117061615},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.48369675874710083},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.4516942501068115},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3261266052722931},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3027656376361847},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2879658639431},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.27446550130844116},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25127363204956055},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.24848681688308716}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001806","descriptor_name":"Blood Urea Nitrogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004050","descriptor_name":"Ditiocarb","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005659","descriptor_name":"Fungicides, Industrial","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006035","descriptor_name":"Glycyrrhiza","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018809","descriptor_name":"Proliferating Cell Nuclear Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051437","descriptor_name":"Renal Insufficiency","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D051437","descriptor_name":"Renal Insufficiency","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D051437","descriptor_name":"Renal Insufficiency","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/tox.20728","doi":"https://doi.org/10.1002/tox.20728","is_oa":false,"landing_page_url":"https://doi.org/10.1002/tox.20728","pdf_url":null,"source":{"id":"https://openalex.org/S172436580","display_name":"Environmental Toxicology","issn_l":"1520-4081","issn":["1520-4081","1522-7278"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Toxicology","raw_type":"journal-article"},{"id":"pmid:21544926","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21544926","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W6263635","https://openalex.org/W306335882","https://openalex.org/W1486490528","https://openalex.org/W1869991540","https://openalex.org/W1969811404","https://openalex.org/W1970360497","https://openalex.org/W1978666796","https://openalex.org/W1983450621","https://openalex.org/W1987367266","https://openalex.org/W1990007922","https://openalex.org/W1994716500","https://openalex.org/W1997371891","https://openalex.org/W2001386543","https://openalex.org/W2014099110","https://openalex.org/W2015564388","https://openalex.org/W2066679122","https://openalex.org/W2067796733","https://openalex.org/W2073251747","https://openalex.org/W2077232152","https://openalex.org/W2081216494","https://openalex.org/W2088357316","https://openalex.org/W2091223805","https://openalex.org/W2094544968","https://openalex.org/W2096428903","https://openalex.org/W2105965621","https://openalex.org/W2114948126","https://openalex.org/W2152760690","https://openalex.org/W2153708719","https://openalex.org/W2165150995","https://openalex.org/W2183815838","https://openalex.org/W2186057122","https://openalex.org/W2267610543","https://openalex.org/W2395014503","https://openalex.org/W2411662059","https://openalex.org/W2419426350","https://openalex.org/W2798078005","https://openalex.org/W4211218613","https://openalex.org/W4250764040","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W6263635","https://openalex.org/W2024450072","https://openalex.org/W2994699534","https://openalex.org/W7125414609","https://openalex.org/W2013111171","https://openalex.org/W7160277329","https://openalex.org/W6950900729","https://openalex.org/W3199714087","https://openalex.org/W2781301550","https://openalex.org/W2904192124"],"abstract_inverted_index":{"The":[0,42,56,67],"present":[1],"study":[2],"was":[3],"designed":[4],"to":[5,113,143],"estimate":[6],"the":[7,39,61],"effect":[8,130,139],"of":[9,12,27,88],"aqueous":[10,110],"extract":[11,111],"licorice":[13,109,126],"on":[14],"metiram":[15,22,107,136],"toxicity":[16],"in":[17,38,79,86,97,116],"mice.":[18],"Treating":[19,104],"mice":[20],"with":[21,106],"at":[23],"a":[24],"dose":[25],"level":[26],"[1/2]":[28],"LD(50)":[29],"daily":[30],"for":[31],"3":[32],"weeks":[33],"induced":[34,134],"many":[35],"histological":[36],"changes":[37],"kidney":[40,132],"cortex.":[41],"renal":[43,62],"tubules":[44],"lost":[45],"their":[46,50],"characteristic":[47],"appearance":[48],"and":[49,60,100,108,119,137],"lining":[51],"epithelial":[52,90],"cells":[53],"were":[54,58,65],"degenerated.":[55],"glomeruli":[57],"atrophied":[59],"blood":[63,101],"vessels":[64],"congested.":[66],"intertubular":[68],"spaces":[69],"infiltrated":[70],"by":[71,135],"inflammatory":[72],"leukocytic":[73],"cells.":[74,91],"Metiram":[75,92],"caused":[76,94],"an":[77,114,128],"increase":[78],"proliferating":[80],"cell":[81],"nuclear":[82],"antigen":[83],"(PCNA)":[84],"expression":[85],"nuclei":[87],"tubular":[89],"also":[93],"marked":[95],"elevation":[96],"serum":[98],"creatinine":[99],"urea":[102],"nitrogen.":[103],"animals":[105],"led":[112],"improvement,":[115],"both":[117],"biochemical":[118],"histopathological":[120],"alterations.":[121],"These":[122],"results":[123],"proved":[124],"that":[125],"had":[127],"ameliorative":[129],"against":[131],"injury":[133],"this":[138],"may":[140],"be":[141],"attributed":[142],"its":[144],"antioxidant":[145],"activity.":[146]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
