{"id":"https://openalex.org/W1964847747","doi":"https://doi.org/10.2174/1570160054864049","title":"Genetic Susceptibility to Risk for Bladder Cancer in Individuals Working in High Risk Occupations","display_name":"Genetic Susceptibility to Risk for Bladder Cancer in Individuals Working in High Risk Occupations","publication_year":2005,"publication_date":"2005-08-30","ids":{"openalex":"https://openalex.org/W1964847747","doi":"https://doi.org/10.2174/1570160054864049","mag":"1964847747"},"language":"en","primary_location":{"id":"doi:10.2174/1570160054864049","doi":"https://doi.org/10.2174/1570160054864049","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1570160054864049","pdf_url":null,"source":{"id":"https://openalex.org/S19792597","display_name":"Current Pharmacogenomics","issn_l":"1570-1603","issn":["1570-1603","1875-6204"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmacogenomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110054479","display_name":"Robert A. Branch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Branch","raw_affiliation_strings":["University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070504775","display_name":"Nancy Paulsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy Paulsen","raw_affiliation_strings":["Carnegie Mellon University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carnegie Mellon University","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012325128","display_name":"Raj A. Persad","orcid":"https://orcid.org/0000-0002-9121-0550","observed_orcids":["https://orcid.org/0000-0002-9121-0550"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Raj Persad","raw_affiliation_strings":["University of Bristol"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bristol","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Patrick Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Patrick Smith","raw_affiliation_strings":["University of Bristol"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bristol","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Christopher Collins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher Collins","raw_affiliation_strings":["University of Bristol"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bristol","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000445673","display_name":"Ann G. Schwartz","orcid":"https://orcid.org/0000-0002-9525-1157","observed_orcids":["https://orcid.org/0000-0002-9525-1157"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ann Schwartz","raw_affiliation_strings":["Oncology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011638017","display_name":"Alfred A. Cecchetti","orcid":"https://orcid.org/0000-0002-6249-7310","observed_orcids":["https://orcid.org/0000-0002-6249-7310"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Al Cecchetti","raw_affiliation_strings":["University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034314595","display_name":"Vincent C. Arena","orcid":"https://orcid.org/0000-0002-1634-7207","observed_orcids":["https://orcid.org/0000-0002-1634-7207"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent Arena","raw_affiliation_strings":["University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008369135","display_name":"Kendra T. Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kendra Jones","raw_affiliation_strings":["University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067472279","display_name":"Marjorie Romkes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marjorie Romkes","raw_affiliation_strings":["University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14433972,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"3","first_page":"165","last_page":"175"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.9779999852180481},{"id":"https://openalex.org/keywords/slow-acetylator-phenotype","display_name":"slow acetylator phenotype","score":0.8550000190734863},{"id":"https://openalex.org/keywords/n-acetyltransferase-activity","display_name":"N-acetyltransferase activity","score":0.796999990940094},{"id":"https://openalex.org/keywords/occupational-exposure","display_name":"occupational exposure","score":0.9129999876022339},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.871999979019165},{"id":"https://openalex.org/keywords/urothelial-carcinoma","display_name":"urothelial carcinoma","score":0.6970000267028809},{"id":"https://openalex.org/keywords/synergistic-risk","display_name":"synergistic risk","score":0.6200000047683716},{"id":"https://openalex.org/keywords/procarcinogen-metabolism","display_name":"procarcinogen metabolism","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.8485738039016724},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6716312766075134},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6046141386032104},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4884578287601471},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.452169269323349}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2174/1570160054864049","doi":"https://doi.org/10.2174/1570160054864049","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1570160054864049","pdf_url":null,"source":{"id":"https://openalex.org/S19792597","display_name":"Current Pharmacogenomics","issn_l":"1570-1603","issn":["1570-1603","1875-6204"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmacogenomics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305"},{"id":"https://openalex.org/F4320310207","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2409517251","https://openalex.org/W2083100404","https://openalex.org/W2155331961","https://openalex.org/W2060867647","https://openalex.org/W7098057729","https://openalex.org/W2031068881","https://openalex.org/W1574130256","https://openalex.org/W2735739809","https://openalex.org/W2420456958","https://openalex.org/W293147294"],"abstract_inverted_index":{"We":[0],"investigated":[1],"the":[2,69,88,98,132,154,168],"relative":[3],"contribution":[4],"of":[5,9,23,75,87,91,100,124,144,171],"a":[6,21,112],"pharmacogenomic":[7],"measure":[8],"slow":[10,70,101,128,157],"acetylation":[11,102],"phenotype":[12,72,130],"to":[13,160],"susceptibility":[14],"for":[15,61,167],"bladder":[16,40,92,120,149,174,183],"cancer":[17,41,44,48,52,96],"in":[18,33,83,109,117,131,142],"subjects":[19],"with":[20,37,111,146],"history":[22,74],"high":[24],"risk":[25,81,110,166],"occupational":[26,76,104,125],"exposure.":[27],"The":[28,122],"dapsone":[29,185],"-acetylation":[30],"was":[31,135,140],"determined":[32],"107":[34],"incident":[35],"patients":[36,145],"transitional":[38],"cell":[39],"(organ-confined,":[42],"non-aggressive":[43],"(n=43),":[45],"organ-confined,":[46],"aggressive":[47,51,119,148,173,181],"(n=32),":[49],"non-organ-confined,":[50,118,147],"(n=32)":[53],"and":[54,66,73,103,127],"age,":[55,62],"sex":[56],"matched":[57],"controls":[58],"(n=85).":[59],"Adjusting":[60],"sex,":[63],"alcohol":[64],"consumption":[65],"smoking":[67],"habits,":[68],"acetylator":[71,129],"exposure":[77,105,126,190],"were":[78],"independent;":[79],"significant":[80,107],"factors":[82],"at":[84,164],"least":[85],"one":[86],"three":[89],"subgroups":[90],"cancer.":[93,121,150,175],"In":[94],"each":[95],"group,":[97],"combination":[99,139],"conferred":[106],"increases":[108],"synergistic":[113],"substantially":[114],"greater":[115],"increase":[116],"frequency":[123],"control":[133],"group":[134],"6%":[136],"while":[137],"this":[138],"present":[141],"86%":[143],"These":[151],"results":[152],"support":[153],"hypothesis":[155],"that":[156],"acetylators":[158],"exposed":[159],"high-risk":[161],"occupations":[162],"are":[163],"increased":[165],"subsequent":[169],"development":[170],"non-organconfined,":[172],"Keywords:":[176],"procarcinogen,":[177],"gene-environment":[178],"interaction,":[179],"metabolism,":[180],"(gIII)":[182],"cancer,":[184],"acetylation,":[186],"nacetyltransferase":[187],"activity,":[188],"industrial":[189]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
