{"id":"https://openalex.org/W1964838992","doi":"https://doi.org/10.1016/s0167-4838(00)00043-1","title":"Dissecting the nucleotide binding properties of Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase with fluorescent 3\u2032(2)\u2032-o-anthraniloyladenosine 5\u2032-triphosphate","display_name":"Dissecting the nucleotide binding properties of Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase with fluorescent 3\u2032(2)\u2032-o-anthraniloyladenosine 5\u2032-triphosphate","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W1964838992","doi":"https://doi.org/10.1016/s0167-4838(00)00043-1","mag":"1964838992","pmid":"https://pubmed.ncbi.nlm.nih.gov/10825540"},"language":"en","primary_location":{"id":"doi:10.1016/s0167-4838(00)00043-1","doi":"https://doi.org/10.1016/s0167-4838(00)00043-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0167-4838(00)00043-1","pdf_url":null,"source":{"id":"https://openalex.org/S4394735818","display_name":"Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology","issn_l":"0167-4838","issn":["0167-4838","1879-2588"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108518641","display_name":"Genbin Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Genbin Shi","raw_affiliation_strings":["Department of Biochemistry, Michigan State University, East Lansing 48824, USA","Department of Biochemistry, Michigan State University, East Lansing, MI, 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Michigan State University, East Lansing 48824, USA","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Department of Biochemistry, Michigan State University, East Lansing, MI, 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107378956","display_name":"Yunchen Gong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunchen Gong","raw_affiliation_strings":["Department of Biochemistry, Michigan State University, East Lansing, MI 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Michigan State University, East Lansing, MI 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062569953","display_name":"Alexei V. Savchenko","orcid":"https://orcid.org/0000-0002-5256-9237","observed_orcids":["https://orcid.org/0000-0002-5256-9237"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexei Savchenko","raw_affiliation_strings":["Department of Biochemistry, Michigan State University, East Lansing, MI 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Michigan State University, East Lansing, MI 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110089491","display_name":"J. Gregory Zeikus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.Gregory Zeikus","raw_affiliation_strings":["Department of Biochemistry, Michigan State University, East Lansing, MI 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Michigan State University, East Lansing, MI 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052568577","display_name":"Bing Xiao","orcid":"https://orcid.org/0000-0002-3350-2678","observed_orcids":["https://orcid.org/0000-0002-3350-2678"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bing Xiao","raw_affiliation_strings":["ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, P.O. Box B, Frederick, MD 21702, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, P.O. Box B, Frederick, MD 21702, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069231811","display_name":"Xinhua Ji","orcid":"https://orcid.org/0000-0001-6942-1514","observed_orcids":["https://orcid.org/0000-0001-6942-1514"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xinhua Ji","raw_affiliation_strings":["ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, P.O. Box B, Frederick, MD 21702, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, P.O. Box B, Frederick, MD 21702, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109980378","display_name":"Honggao Yan A","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Honggao Yan","raw_affiliation_strings":["Department of Biochemistry, Michigan State University, East Lansing, MI 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Michigan State University, East Lansing, MI 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109980378"],"corresponding_institution_ids":["https://openalex.org/I87216513"],"apc_list":null,"apc_paid":null,"fwci":0.4813,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.59238441,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"1478","issue":"2","first_page":"289","last_page":"299"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Chemical Reaction Mechanisms","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/6-hydroxymethyl-7-8-dihydropterin-pyrophosphokinase","display_name":"6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase","score":0.9789999723434448},{"id":"https://openalex.org/keywords/nucleotide-binding","display_name":"nucleotide binding","score":0.6359999775886536},{"id":"https://openalex.org/keywords/atp-binding-site","display_name":"ATP binding site","score":0.5709999799728394},{"id":"https://openalex.org/keywords/nucleotide-specificity","display_name":"nucleotide specificity","score":0.765999972820282},{"id":"https://openalex.org/keywords/mgatp","display_name":"MgATP","score":0.7620000243186951},{"id":"https://openalex.org/keywords/nucleoside-triphosphates","display_name":"nucleoside triphosphates","score":0.8569999933242798},{"id":"https://openalex.org/keywords/folate-biosynthesis","display_name":"folate biosynthesis","score":0.8220000267028809},{"id":"https://openalex.org/keywords/metal-ion-effects","display_name":"metal ion effects","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C2776043855","wikidata":"https://www.wikidata.org/wiki/Q55506489","display_name":"Pyrophosphate","level":3,"score":0.7958642244338989},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7479332685470581},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.6955083012580872},{"id":"https://openalex.org/C2776543447","wikidata":"https://www.wikidata.org/wiki/Q28734","display_name":"Nucleoside","level":2,"score":0.5548515915870667},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5412741303443909},{"id":"https://openalex.org/C2776352584","wikidata":"https://www.wikidata.org/wiki/Q418533","display_name":"Nucleoside triphosphate","level":4,"score":0.5259789824485779},{"id":"https://openalex.org/C2779564974","wikidata":"https://www.wikidata.org/wiki/Q80863","display_name":"Adenosine triphosphate","level":2,"score":0.4963563084602356},{"id":"https://openalex.org/C2780591741","wikidata":"https://www.wikidata.org/wiki/Q899405","display_name":"Hydroxymethyl","level":2,"score":0.4395589232444763},{"id":"https://openalex.org/C2908737895","wikidata":"https://www.wikidata.org/wiki/Q67198600","display_name":"Pyrophosphatases","level":3,"score":0.4370481073856354},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.43661007285118103},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.41247886419296265},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38538575172424316},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D005470","descriptor_name":"Fluorometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009711","descriptor_name":"Nucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017854","descriptor_name":"Diphosphotransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017854","descriptor_name":"Diphosphotransferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0167-4838(00)00043-1","doi":"https://doi.org/10.1016/s0167-4838(00)00043-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0167-4838(00)00043-1","pdf_url":null,"source":{"id":"https://openalex.org/S4394735818","display_name":"Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology","issn_l":"0167-4838","issn":["0167-4838","1879-2588"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology","raw_type":"journal-article"},{"id":"pmid:10825540","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10825540","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1068429566","display_name":null,"funder_award_id":"GM51901","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3786901134","display_name":"STRUCTURE/FUNCTION RELATIONSHIPS OF GUANYLATE KINASE","funder_award_id":"R01GM051901","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W63225481","https://openalex.org/W975718057","https://openalex.org/W1873199501","https://openalex.org/W1977890842","https://openalex.org/W1984053379","https://openalex.org/W1985768853","https://openalex.org/W1989161091","https://openalex.org/W2000045534","https://openalex.org/W2004473597","https://openalex.org/W2013841985","https://openalex.org/W2022236106","https://openalex.org/W2033735656","https://openalex.org/W2044597760","https://openalex.org/W2055678123","https://openalex.org/W2057498265","https://openalex.org/W2061731390","https://openalex.org/W2069079485","https://openalex.org/W2074618456","https://openalex.org/W2116773257","https://openalex.org/W2122767035","https://openalex.org/W2126778256","https://openalex.org/W2146544311","https://openalex.org/W2149248159","https://openalex.org/W2149655920","https://openalex.org/W2158707826","https://openalex.org/W2219088846","https://openalex.org/W2320073971","https://openalex.org/W2438782321","https://openalex.org/W4300349822"],"related_works":["https://openalex.org/W2169040732","https://openalex.org/W1518566581","https://openalex.org/W1971453322","https://openalex.org/W2063716058","https://openalex.org/W2055678123","https://openalex.org/W2061852161","https://openalex.org/W1963704837","https://openalex.org/W2342138477","https://openalex.org/W2019188685","https://openalex.org/W2333492583"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
