{"id":"https://openalex.org/W1964825625","doi":"https://doi.org/10.4161/sgtp.1.3.14935","title":"Inhibition of Cdc42-mediated activation of mixed lineage kinase 3 by the tumor suppressor protein merlin","display_name":"Inhibition of Cdc42-mediated activation of mixed lineage kinase 3 by the tumor suppressor protein merlin","publication_year":2010,"publication_date":"2010-11-01","ids":{"openalex":"https://openalex.org/W1964825625","doi":"https://doi.org/10.4161/sgtp.1.3.14935","mag":"1964825625","pmid":"https://pubmed.ncbi.nlm.nih.gov/21686274","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3116608"},"language":"en","primary_location":{"id":"doi:10.4161/sgtp.1.3.14935","doi":"https://doi.org/10.4161/sgtp.1.3.14935","is_oa":true,"landing_page_url":"https://doi.org/10.4161/sgtp.1.3.14935","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/sgtp.1.3.14935?needAccess=true","source":{"id":"https://openalex.org/S34533772","display_name":"Small GTPases","issn_l":"2154-1248","issn":["2154-1248","2154-1256"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Small GTPases","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/sgtp.1.3.14935?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031040196","display_name":"Yu Zhan","orcid":"https://orcid.org/0000-0002-7551-5039","observed_orcids":["https://orcid.org/0000-0002-7551-5039"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Zhan","raw_affiliation_strings":["Department of Biological Sciences; University of Toledo; Toledo, OH USA","Department of Biological Sciences","Toledo, OH USA","University of Toledo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences; University of Toledo; Toledo, OH USA","institution_ids":["https://openalex.org/I90871651"]},{"raw_affiliation_string":"Department of Biological Sciences","institution_ids":[]},{"raw_affiliation_string":"Toledo, OH USA","institution_ids":[]},{"raw_affiliation_string":"University of Toledo","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024588859","display_name":"Deborah N. Chadee","orcid":"https://orcid.org/0000-0002-5223-4701","observed_orcids":["https://orcid.org/0000-0002-5223-4701"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Deborah N. Chadee","raw_affiliation_strings":["Department of Biological Sciences; University of Toledo; Toledo, OH USA","Department of Biological Sciences","Toledo, OH USA","University of Toledo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences; University of Toledo; Toledo, OH USA","institution_ids":["https://openalex.org/I90871651"]},{"raw_affiliation_string":"Department of Biological Sciences","institution_ids":[]},{"raw_affiliation_string":"Toledo, OH USA","institution_ids":[]},{"raw_affiliation_string":"University of Toledo","institution_ids":["https://openalex.org/I90871651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024588859"],"corresponding_institution_ids":["https://openalex.org/I90871651"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"3","first_page":"183","last_page":"186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.023099999874830246,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/merlin","display_name":"Merlin","score":0.8479999899864197},{"id":"https://openalex.org/keywords/mlk3","display_name":"MLK3","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cdc42","display_name":"Cdc42","score":0.9430000185966492},{"id":"https://openalex.org/keywords/map3k","display_name":"MAP3K","score":0.5149999856948853},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8550000190734863},{"id":"https://openalex.org/keywords/rho-gtpases","display_name":"Rho GTPases","score":0.8690000176429749},{"id":"https://openalex.org/keywords/neurofibromatosis-type-2","display_name":"neurofibromatosis type 2","score":0.9300000071525574},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.871999979019165},{"id":"https://openalex.org/keywords/kinase-inhibition","display_name":"kinase inhibition","score":0.6980000138282776},{"id":"https://openalex.org/keywords/rac","display_name":"Rac","score":0.3630000054836273}],"concepts":[{"id":"https://openalex.org/C178628643","wikidata":"https://www.wikidata.org/wiki/Q410233","display_name":"Merlin (protein)","level":4,"score":0.8290853500366211},{"id":"https://openalex.org/C137361374","wikidata":"https://www.wikidata.org/wiki/Q6714442","display_name":"MAP kinase kinase kinase","level":4,"score":0.7097363471984863},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6998945474624634},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6425290703773499},{"id":"https://openalex.org/C2780040266","wikidata":"https://www.wikidata.org/wiki/Q15311701","display_name":"CDC42","level":3,"score":0.6392712593078613},{"id":"https://openalex.org/C99405784","wikidata":"https://www.wikidata.org/wiki/Q410434","display_name":"c-Raf","level":5,"score":0.6274417042732239},{"id":"https://openalex.org/C59143045","wikidata":"https://www.wikidata.org/wiki/Q15314942","display_name":"Cyclin-dependent kinase 9","level":5,"score":0.5477785468101501},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.5430060029029846},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5174475312232971},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5056934356689453},{"id":"https://openalex.org/C159479382","wikidata":"https://www.wikidata.org/wiki/Q18030801","display_name":"MAP2K7","level":5,"score":0.4774266183376312},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.46262168884277344},{"id":"https://openalex.org/C51853150","wikidata":"https://www.wikidata.org/wiki/Q14911754","display_name":"Cyclin-dependent kinase 4","level":5,"score":0.42952072620391846},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.42951256036758423},{"id":"https://openalex.org/C124160383","wikidata":"https://www.wikidata.org/wiki/Q14914383","display_name":"ASK1","level":5,"score":0.42547282576560974},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36717408895492554},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.24570715427398682},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24184226989746094},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06728857755661011}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.4161/sgtp.1.3.14935","doi":"https://doi.org/10.4161/sgtp.1.3.14935","is_oa":true,"landing_page_url":"https://doi.org/10.4161/sgtp.1.3.14935","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/sgtp.1.3.14935?needAccess=true","source":{"id":"https://openalex.org/S34533772","display_name":"Small GTPases","issn_l":"2154-1248","issn":["2154-1248","2154-1256"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Small GTPases","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3116608","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3116608","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Small GTPases","raw_type":"Text"},{"id":"pmid:21686274","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21686274","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Small GTPases","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/sgtp.1.3.14935","doi":"https://doi.org/10.4161/sgtp.1.3.14935","is_oa":true,"landing_page_url":"https://doi.org/10.4161/sgtp.1.3.14935","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/sgtp.1.3.14935?needAccess=true","source":{"id":"https://openalex.org/S34533772","display_name":"Small GTPases","issn_l":"2154-1248","issn":["2154-1248","2154-1256"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Small GTPases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6076177241","display_name":"Regulation of Mixed Lineage Kinase 3 by the tumor suppressor protein Merlin","funder_award_id":"R15CA132006","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1964825625.pdf"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W29946730","https://openalex.org/W1495670687","https://openalex.org/W1990621728","https://openalex.org/W2010453590","https://openalex.org/W2011826559","https://openalex.org/W2012819315","https://openalex.org/W2020466484","https://openalex.org/W2046687410","https://openalex.org/W2046944279","https://openalex.org/W2047517401","https://openalex.org/W2053136253","https://openalex.org/W2062483095","https://openalex.org/W2064335255","https://openalex.org/W2079496856","https://openalex.org/W2079712059","https://openalex.org/W2083064598","https://openalex.org/W2087073346","https://openalex.org/W2092861767","https://openalex.org/W2097073373","https://openalex.org/W2102312968","https://openalex.org/W2102787965","https://openalex.org/W2105024940","https://openalex.org/W2105746559","https://openalex.org/W2122057254","https://openalex.org/W2151763534","https://openalex.org/W2171635900","https://openalex.org/W2422556493","https://openalex.org/W2790805946"],"related_works":["https://openalex.org/W2083064598","https://openalex.org/W2047517401","https://openalex.org/W2105024940","https://openalex.org/W2047330178","https://openalex.org/W262432215","https://openalex.org/W2061051826","https://openalex.org/W2472120761","https://openalex.org/W1988369032","https://openalex.org/W2151446275","https://openalex.org/W2158584175"],"abstract_inverted_index":{"Mammalian":[0],"mitogen-activated":[1],"protein":[2],"kinase":[3,21,31,35],"(MAPK)":[4],"signaling":[5,44,120],"pathways":[6],"respond":[7],"to":[8,40],"diverse":[9],"extracellular":[10],"signals":[11],"and":[12,54,65,118],"coordinate":[13],"a":[14,25,88],"range":[15],"of":[16,27,33,48,78,91,111,116],"cellular":[17],"responses.":[18],"Mixed":[19],"lineage":[20,30],"3":[22],"(MLK3)":[23],"is":[24,87],"member":[26],"the":[28,49,60,76,79,103,109],"mixed":[29],"family":[32],"MAPK":[34,43,119],"kinases":[36],"(MAP3Ks)":[37],"that":[38,74,96],"functions":[39],"regulate":[41],"multiple":[42],"pathways.":[45],"Activated":[46],"forms":[47],"Rho":[50],"GTP":[51],"ases,":[52],"Rac":[53],"Cdc42,":[55],"interact":[56],"with":[57],"MLK3":[58,67,99,117],"through":[59],"Cdc42/Rac-interactive":[61],"binding":[62],"(CRIB)":[63],"motif":[64],"promote":[66],"catalytic":[68],"activity.":[69],"Our":[70,93],"recent":[71],"findings":[72],"demonstrate":[73],"merlin,":[75],"product":[77],"neurofibromatosis":[80],"type":[81],"2":[82],"(NF2)":[83],"tumor":[84],"suppressor":[85],"gene,":[86],"physiological":[89],"inhibitor":[90],"MLK3.":[92],"results":[94],"suggest":[95],"merlin":[97,112],"inhibits":[98],"activity":[100],"by":[101],"blocking":[102],"Cdc42-MLK3":[104],"interaction.":[105],"In":[106],"this":[107],"commentary,":[108],"effect":[110],"on":[113],"Cdc42-mediated":[114],"activation":[115],"will":[121],"be":[122],"discussed.":[123]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
