{"id":"https://openalex.org/W1964800874","doi":"https://doi.org/10.1046/j.1365-2141.1999.01353.x","title":"Etoposide-induced DNA strand breaks in relation to p-glycoprotein and topoisomerase II protein expression in leukaemic cells from patients with AML and CLL","display_name":"Etoposide-induced DNA strand breaks in relation to p-glycoprotein and topoisomerase II protein expression in leukaemic cells from patients with AML and CLL","publication_year":1999,"publication_date":"1999-05-01","ids":{"openalex":"https://openalex.org/W1964800874","doi":"https://doi.org/10.1046/j.1365-2141.1999.01353.x","mag":"1964800874","pmid":"https://pubmed.ncbi.nlm.nih.gov/10233413"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2141.1999.01353.x","doi":"https://doi.org/10.1046/j.1365-2141.1999.01353.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2141.1999.01353.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2141.1999.01353.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069305433","display_name":"Rong Zhou","orcid":"https://orcid.org/0000-0003-4018-381X","observed_orcids":["https://orcid.org/0000-0003-4018-381X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Zhou","raw_affiliation_strings":["Departments of, Oncology-Pathology at Radiumhemmet,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of, Oncology-Pathology at Radiumhemmet,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051883242","display_name":"Sigurd Vitols","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vitols","raw_affiliation_strings":["Laboratory Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035259712","display_name":"Astrid Gruber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Gruber","raw_affiliation_strings":["Haematology and Infectious Diseases, Karolinska Institute and Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haematology and Infectious Diseases, Karolinska Institute and Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056318392","display_name":"Jan O. Liliemark","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liliemark","raw_affiliation_strings":["Departments of, Oncology-Pathology at Radiumhemmet,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of, Oncology-Pathology at Radiumhemmet,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042090648","display_name":"Y. Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wang","raw_affiliation_strings":["Departments of, Oncology-Pathology at Radiumhemmet,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of, Oncology-Pathology at Radiumhemmet,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027036862","display_name":"Eva Liliemark","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liliemark","raw_affiliation_strings":["Departments of, Oncology-Pathology at Radiumhemmet,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of, Oncology-Pathology at Radiumhemmet,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5069305433"],"corresponding_institution_ids":[],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":1.3893,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.80185425,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"105","issue":"2","first_page":"420","last_page":"427"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.7856000065803528,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.7856000065803528,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.19699999690055847,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.9959999918937683},{"id":"https://openalex.org/keywords/topoisomerase-ii-beta","display_name":"topoisomerase II beta","score":0.8330000042915344},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9190000295639038},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.8259999752044678},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.878000020980835},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":1.0},{"id":"https://openalex.org/keywords/dna-strand-breaks","display_name":"DNA strand breaks","score":0.921999990940094},{"id":"https://openalex.org/keywords/drug-resistance-mechanisms","display_name":"drug resistance mechanisms","score":0.6330000162124634},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.8842243552207947},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.8189811110496521},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5876429677009583},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.574024498462677},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.5198941230773926},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.47016069293022156},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4642276167869568},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.45052701234817505},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.43233346939086914},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37908273935317993},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.354137659072876},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34137940406799316},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.29747694730758667},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28768494725227356},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19641521573066711}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004250","descriptor_name":"DNA Topoisomerases, Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1046/j.1365-2141.1999.01353.x","doi":"https://doi.org/10.1046/j.1365-2141.1999.01353.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2141.1999.01353.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},{"id":"doi:10.1111/j.1365-2141.1999.01353.x","doi":"https://doi.org/10.1111/j.1365-2141.1999.01353.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2141.1999.01353.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2141.1999.01353.x","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:10233413","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10233413","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of haematology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1365-2141.1999.01353.x","doi":"https://doi.org/10.1111/j.1365-2141.1999.01353.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2141.1999.01353.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2141.1999.01353.x","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313607","display_name":"Swedish Cancer Foundation","ror":null},{"id":"https://openalex.org/F4320332697","display_name":"University of Illinois at Chicago","ror":"https://ror.org/02mpq6x41"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1964800874.pdf","grobid_xml":"https://content.openalex.org/works/W1964800874.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W78711663","https://openalex.org/W87583817","https://openalex.org/W1579234620","https://openalex.org/W1597583171","https://openalex.org/W1775749144","https://openalex.org/W1973416721","https://openalex.org/W1975843196","https://openalex.org/W1976827909","https://openalex.org/W1987196091","https://openalex.org/W1995824574","https://openalex.org/W2008249338","https://openalex.org/W2016629856","https://openalex.org/W2016676192","https://openalex.org/W2016972487","https://openalex.org/W2022172998","https://openalex.org/W2023528629","https://openalex.org/W2026074295","https://openalex.org/W2028706407","https://openalex.org/W2030254087","https://openalex.org/W2052848470","https://openalex.org/W2063703890","https://openalex.org/W2064331784","https://openalex.org/W2069019428","https://openalex.org/W2088817932","https://openalex.org/W2096065245","https://openalex.org/W2118234018","https://openalex.org/W2122210452","https://openalex.org/W2123126235","https://openalex.org/W2138445641","https://openalex.org/W2140600345","https://openalex.org/W2303327195","https://openalex.org/W2405562562","https://openalex.org/W2416220740","https://openalex.org/W2419518566","https://openalex.org/W2472105031","https://openalex.org/W2472343488","https://openalex.org/W2802372723","https://openalex.org/W2950249768","https://openalex.org/W4212818772","https://openalex.org/W4236670183","https://openalex.org/W4238234479"],"related_works":["https://openalex.org/W288564611","https://openalex.org/W78711663","https://openalex.org/W2396472512","https://openalex.org/W2140600345","https://openalex.org/W2086465175","https://openalex.org/W1978719206","https://openalex.org/W2146862660","https://openalex.org/W4320061162","https://openalex.org/W1960038589","https://openalex.org/W2015170463"],"abstract_inverted_index":{"Elevated":[0],"expression":[1,10,157,161,174],"of":[2,11,31,61,205],"the":[3,12,56,59,152,178],"membrane":[4],"transporter":[5],"p-glycoprotein":[6],"(pgp)":[7],"and":[8,42,64,66,87,124,208],"impaired":[9],"nuclear":[13],"enzyme":[14],"topoisomerase":[15],"II":[16,33,63],"(topo":[17],"II)":[18],"are":[19],"well-known":[20],"mechanisms":[21],"for":[22],"in":[23,48,67,72,119,177,188,210,223],"vitro":[24,68],"acquired":[25],"drug":[26],"resistance.":[27],"The":[28,171],"clinical":[29],"relevance":[30],"topo":[32,62,125,146,155,172,206,215],"remains":[34],"unclear,":[35],"whereas":[36,114,145],"a":[37,104,133,201,218],"relationship":[38],"between":[39,58,136],"pgp":[40,160,209],"levels":[41,60],"treatment":[43],"results":[44,199],"has":[45],"been":[46],"shown":[47],"acute":[49],"myelogenous":[50],"leukaemia":[51,85],"(AML).":[52],"We":[53],"have":[54],"investigated":[55],"relationships":[57],"pgp,":[65],"sensitivity":[69],"to":[70,186],"etoposide":[71,121],"mononuclear":[73],"blood":[74,90],"cells":[75,97,110,181,191],"from":[76],"24":[77],"patients":[78],"with":[79,82,94,141,159],"AML,":[80,211],"16":[81],"chronic":[83],"lymphocytic":[84],"(CLL)":[86],"five":[88],"healthy":[89],"donors.":[91],"Following":[92],"incubation":[93],"etoposide,":[95],"AML":[96,153,180,190],"showed":[98,132],"more":[99],"DNA":[100,105,143],"damage,":[101,144],"determined":[102,128],"by":[103,129],"unwinding":[106],"technique,":[107],"than":[108],"CLL":[109],"(P":[111,195],"=":[112,163,166,169,183,193,196],"0.001),":[113],"there":[115],"was":[116,149,175],"no":[117,139],"difference":[118],"cellular":[120],"accumulation.":[122],"Pgp":[123],"IIbeta":[126,156,173,207,216],"levels,":[127],"Western":[130],"blot,":[131],"pronounced":[134],"variation":[135],"patients,":[137],"but":[138],"correlation":[140],"induced":[142],"IIalpha":[147],"protein":[148],"undetectable.":[150],"In":[151],"group,":[154],"correlated":[158],"(rho":[162],"0.7,":[164],"P":[165],"0.001,":[167],"n":[168],"24).":[170],"147.4(+/-74.6)%":[176],"pgp+":[179],"(n":[182,192],"10),":[184],"compared":[185],"33.4(+/-27.8)%":[187],"pgp-":[189],"14)":[194],"0.0001).":[197],"Our":[198],"show":[200],"previously":[202],"unknown":[203],"coexpression":[204],"thereby":[212],"suggesting":[213],"that":[214],"is":[217],"potentially":[219],"interesting":[220],"resistance":[221],"factor":[222],"AML.":[224]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
