{"id":"https://openalex.org/W1964798047","doi":"https://doi.org/10.1021/bi9812017","title":"Effects on Substrate Reduction of Substitution of Histidine-195 by Glutamine in the \u03b1-Subunit of the MoFe Protein of Azotobacter vinelandii Nitrogenase","display_name":"Effects on Substrate Reduction of Substitution of Histidine-195 by Glutamine in the \u03b1-Subunit of the MoFe Protein of Azotobacter vinelandii Nitrogenase","publication_year":1998,"publication_date":"1998-11-21","ids":{"openalex":"https://openalex.org/W1964798047","doi":"https://doi.org/10.1021/bi9812017","mag":"1964798047","pmid":"https://pubmed.ncbi.nlm.nih.gov/9860864"},"language":"en","primary_location":{"id":"doi:10.1021/bi9812017","doi":"https://doi.org/10.1021/bi9812017","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi9812017","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113682266","display_name":"Michael J. DILWORTH","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Dilworth","raw_affiliation_strings":["Department of Biochemistry, The Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, The Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008637684","display_name":"Karl Fisher","orcid":"https://orcid.org/0000-0003-3539-8939","observed_orcids":["https://orcid.org/0000-0003-3539-8939"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Karl Fisher","raw_affiliation_strings":["Department of Biochemistry, The Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, The Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018905527","display_name":"Chul\u2010Hwan Kim","orcid":"https://orcid.org/0000-0002-3418-9687","observed_orcids":["https://orcid.org/0000-0002-3418-9687"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chul-Hwan Kim","raw_affiliation_strings":["Department of Biochemistry, The Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, The Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011735129","display_name":"William E. Newton","orcid":"https://orcid.org/0009-0001-4602-0977","observed_orcids":["https://orcid.org/0009-0001-4602-0977"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E. Newton","raw_affiliation_strings":["Department of Biochemistry, The Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, The Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061","institution_ids":["https://openalex.org/I859038795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008637684"],"corresponding_institution_ids":["https://openalex.org/I859038795"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.6042,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.55287081,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"37","issue":"50","first_page":"17495","last_page":"17505"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12112","display_name":"Ammonia Synthesis and Nitrogen Reduction","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1503","display_name":"Catalysis"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mofe-protein","display_name":"MoFe protein","score":0.8510000109672546},{"id":"https://openalex.org/keywords/glutamine-substitution","display_name":"glutamine substitution","score":0.8700000047683716},{"id":"https://openalex.org/keywords/substrate-reduction","display_name":"substrate reduction","score":0.6809999942779541},{"id":"https://openalex.org/keywords/hydrogen-evolution-suppression","display_name":"hydrogen evolution suppression","score":0.7210000157356262},{"id":"https://openalex.org/keywords/acetylene-reduction","display_name":"acetylene reduction","score":0.7450000047683716},{"id":"https://openalex.org/keywords/cyanide-inhibition","display_name":"cyanide inhibition","score":0.8790000081062317},{"id":"https://openalex.org/keywords/fe-protein","display_name":"Fe protein","score":0.33500000834465027},{"id":"https://openalex.org/keywords/temperature-dependence","display_name":"temperature dependence","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C141280058","wikidata":"https://www.wikidata.org/wiki/Q410381","display_name":"Nitrogenase","level":4,"score":0.8140974044799805},{"id":"https://openalex.org/C2778460671","wikidata":"https://www.wikidata.org/wiki/Q485277","display_name":"Histidine","level":3,"score":0.7554721832275391},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.6867940425872803},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.6708793640136719},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.624820351600647},{"id":"https://openalex.org/C2776740245","wikidata":"https://www.wikidata.org/wiki/Q132995","display_name":"Azotobacter","level":3,"score":0.5857265591621399},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.578658401966095},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5769416689872742},{"id":"https://openalex.org/C2778220771","wikidata":"https://www.wikidata.org/wiki/Q1522579","display_name":"Substitution (logic)","level":2,"score":0.49832725524902344},{"id":"https://openalex.org/C2993683473","wikidata":"https://www.wikidata.org/wiki/Q30693176","display_name":"Amino acid substitution","level":4,"score":0.4126586616039276},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3253256678581238},{"id":"https://openalex.org/C181440489","wikidata":"https://www.wikidata.org/wiki/Q272467","display_name":"Nitrogen fixation","level":3,"score":0.2345324456691742},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.22511187195777893},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.21500033140182495},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2011193037033081},{"id":"https://openalex.org/C537208039","wikidata":"https://www.wikidata.org/wiki/Q627","display_name":"Nitrogen","level":2,"score":0.1070713996887207},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09787172079086304},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09008479118347168},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.052346497774124146},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000641","descriptor_name":"Ammonia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001386","descriptor_name":"Azides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003486","descriptor_name":"Cyanides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003903","descriptor_name":"Deuterium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004579","descriptor_name":"Electron Transport","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006859","descriptor_name":"Hydrogen","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D006859","descriptor_name":"Hydrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008983","descriptor_name":"Molybdoferredoxin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008983","descriptor_name":"Molybdoferredoxin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008983","descriptor_name":"Molybdoferredoxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009584","descriptor_name":"Nitrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009584","descriptor_name":"Nitrogen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009591","descriptor_name":"Nitrogenase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009591","descriptor_name":"Nitrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009591","descriptor_name":"Nitrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016948","descriptor_name":"Azotobacter vinelandii","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D016948","descriptor_name":"Azotobacter vinelandii","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi9812017","doi":"https://doi.org/10.1021/bi9812017","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi9812017","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:9860864","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9860864","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3869139127","display_name":"MOFE PROTEIN PROSTHETIC GROUPS IN NITROGENASE CATALYSIS","funder_award_id":"R01DK037255","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W69507110","https://openalex.org/W201023498","https://openalex.org/W1775749144","https://openalex.org/W1968351818","https://openalex.org/W1993903888","https://openalex.org/W2000767190","https://openalex.org/W2007622363","https://openalex.org/W2045187084","https://openalex.org/W2061407935","https://openalex.org/W2071967878","https://openalex.org/W2073974382","https://openalex.org/W2125771483","https://openalex.org/W2224930125","https://openalex.org/W2344516387","https://openalex.org/W2476994481","https://openalex.org/W2479456439","https://openalex.org/W2801370269","https://openalex.org/W2937183664","https://openalex.org/W4246990796"],"related_works":["https://openalex.org/W1994104745","https://openalex.org/W2149196912","https://openalex.org/W2621274325","https://openalex.org/W2318837217","https://openalex.org/W2610656795","https://openalex.org/W3021670924","https://openalex.org/W7099748468","https://openalex.org/W1964473371","https://openalex.org/W4210543756","https://openalex.org/W2787731014"],"abstract_inverted_index":{"Studies":[0],"of":[1,5,13,18,57,59,65,68,80,98,112,114,145,158,184,198,204,276,288,301,315,334,338,345,358,360,413,451],"the":[2,41,60,78,106,110,142,177,185,202,219,223,238,262,277,293,297,307,311,325,335,343,361,365,376,403,409,421,442],"substrate-reducing":[3],"capabilities":[4],"an":[6,24,103,152,437],"altered":[7,72],"nitrogenase":[8,217,423],"MoFe":[9,43,73,179,327],"protein":[10,44,155,180],"(alpha-195(Gln)":[11],"instead":[12],"alpha-195(His))":[14],"from":[15,124,230,399],"a":[16,52,149,163,182,192,274],"mutant":[17],"Azotobacter":[19],"vinelandii":[20],"show,":[21],"contrary":[22],"to":[23,48,122,133,176,209,213,244,281,319,348,428,441],"earlier":[25],"report":[26],"[Kim,":[27],"C.-H.,":[28],"Newton,":[29],"W.":[30],"E.,":[31],"and":[32,201,296,374,384,418,424,446],"Dean,":[33],"D.":[34],"R.":[35],"(1995)":[36],"Biochemistry":[37],"34,":[38],"2798-2808],":[39],"that":[40,54,58,162,282,333,359,396,433],"alpha-195(Gln)":[42,178,263,308,366,422],"can":[45],"reduce":[46],"N2":[47,69,143,172,174,255,350,397,417],"NH3":[49,234],"but":[50,90,241,310],"at":[51,93,130,136,151],"rate":[53,197],"is":[55,83,88,267,303,322,329,353,401],"<2%":[56],"wild":[61,186,239,362],"type.":[62],"The":[63,196,406],"extent":[64,344],"effective":[66],"binding":[67,175],"by":[70,77,188,253,261,269,313,386,420],"this":[71],"protein,":[74,328],"as":[75,86,248],"monitored":[76],"inhibition":[79,97,144,266,312],"H2":[81,99,146,249,372,430],"evolution,":[82],"markedly":[84,354],"increased":[85],"temperature":[87],"lowered":[89],"virtually":[91],"eliminated":[92],"45":[94,131],"degreesC.":[95,138],"This":[96,265],"evolution":[100,147,247,373,431],"results":[101],"in":[102,105,237,273],"increase":[104],"ATP:2e-":[107,279,377],"ratio,":[108],"i.e.,":[109],"number":[111],"molecules":[113],"MgATP":[115],"hydrolyzed":[116],"for":[117,171,215,415,449],"each":[118],"electron":[119,206,317],"pair":[120],"transferred":[121],"substrate,":[123,294,320],"ca.":[125,159],"5":[126],"(the":[127],"wild-type":[128,140,216,326],"level)":[129],"degreesC":[132],"nearly":[134],"25":[135],"13":[137],"Like":[139],"nitrogenase,":[141,309],"reaches":[148],"maximum":[150],"Fe":[153],"protein:MoFe":[154],"molar":[156],"ratio":[157,280],"2.5,":[160],"suggesting":[161],"highly":[164],"reduced":[165],"enzyme":[166],"may":[167,435],"not":[168,228,304,391,402],"be":[169,436],"necessary":[170],"binding.":[173],"retains":[181],"hallmark":[183],"type":[187],"producing":[189,233],"HD":[190,199,210,226],"under":[191,218,284],"mixed":[193],"N2/D2":[194],"atmosphere.":[195],"production":[200],"fraction":[203],"total":[205,316],"flow":[207,318],"allocated":[208],"are":[211,242,381],"similar":[212],"those":[214,231,245],"same":[220],"conditions.":[221],"However,":[222],"electrons":[224],"forming":[225],"do":[227],"come":[229],"normally":[232],"(as":[235],"occurs":[236],"type)":[240,363],"equivalent":[243],"whose":[246],"had":[250],"been":[251],"inhibited":[252],"N2.":[254],"also":[256],"inhibits":[257,371],"C2H2":[258],"reduction":[259,300,337,347,414,450],"catalyzed":[260,336],"nitrogenase.":[264,367],"relieved":[268],"added":[270],"H2,":[271],"resulting":[272],"lowering":[275],"elevated":[278],"found":[283],"Ar.":[285],"With":[286],"solutions":[287],"NaCN,":[289],"which":[290,321],"contain":[291],"both":[292,416],"HCN,":[295,340],"inhibitor,":[298],"CN-,":[299],"HCN":[302],"impaired":[305],"with":[306,324,364],"CN-":[314],"observed":[323],"completely":[330],"absent.":[331],"Unlike":[332],"H+,":[339],"or":[341,351],"C2H2,":[342],"azide":[346,419],"either":[349,393],"N2H4":[352],"decreased":[355],"(to":[356],"5-7%":[357],"Azide,":[368],"like":[369],"N2,":[370],"increases":[375],"ratio.":[378],"Both":[379],"effects":[380],"freely":[382],"reversible":[383],"abolished":[385],"CO.":[387],"Added":[388],"D2":[389],"does":[390],"relieve":[392],"effect,":[394],"implying":[395],"produced":[398],"N3-":[400],"inhibitory":[404],"species.":[405],"correlation":[407],"between":[408],"extremely":[410],"low":[411],"rates":[412],"their":[425],"common":[426],"ability":[427],"inhibit":[429],"suggests":[432],"alpha-histidine-195":[434],"important":[438],"proton":[439],"conductor":[440],"FeMo":[443],"cofactor":[444],"center":[445],"specifically":[447],"required":[448],"these":[452],"two":[453],"substrates.":[454]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
