{"id":"https://openalex.org/W1964741828","doi":"https://doi.org/10.1097/00001756-200008210-00006","title":"Parkin is metabolized by the ubiquitin/proteosome system","display_name":"Parkin is metabolized by the ubiquitin/proteosome system","publication_year":2000,"publication_date":"2000-08-01","ids":{"openalex":"https://openalex.org/W1964741828","doi":"https://doi.org/10.1097/00001756-200008210-00006","mag":"1964741828","pmid":"https://pubmed.ncbi.nlm.nih.gov/10976934"},"language":"en","primary_location":{"id":"doi:10.1097/00001756-200008210-00006","doi":"https://doi.org/10.1097/00001756-200008210-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001756-200008210-00006","pdf_url":null,"source":{"id":"https://openalex.org/S121278948","display_name":"Neuroreport","issn_l":"0959-4965","issn":["0959-4965","1473-558X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroReport","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Peter Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Choi","raw_affiliation_strings":["Department of Pharmacology, Loyola University Medical Center, Maywood, IL 60153, USA","Departments of Pharmacology and Pathology, Loyola University Medical Center, 2160 South 1st Avenue, Bldg 102, Room 3634, Maywood, IL 60153"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Loyola University Medical Center, Maywood, IL 60153, USA","institution_ids":["https://openalex.org/I1304196042"]},{"raw_affiliation_string":"Departments of Pharmacology and Pathology, Loyola University Medical Center, 2160 South 1st Avenue, Bldg 102, Room 3634, Maywood, IL 60153","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I4210159390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054049162","display_name":"Natalie Golts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalie Ostrerova-Golts","raw_affiliation_strings":["Departments of Pharmacology and Pathology, Loyola University Medical Center, 2160 South 1st Avenue, Bldg 102, Room 3634, Maywood, IL 60153"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Pathology, Loyola University Medical Center, 2160 South 1st Avenue, Bldg 102, Room 3634, Maywood, IL 60153","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I4210159390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030418193","display_name":"Dennis R. Sparkman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis Sparkman","raw_affiliation_strings":["Department of Chemistry, University of Texas at Dallas, Dallas, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Texas at Dallas, Dallas, Texas","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109553905","display_name":"Elizabeth J. Cochran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Cochran","raw_affiliation_strings":["Departments of Pathology and Neurological Sciences, Rush-Presbyterian-St. Lukes Medical Center, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Neurological Sciences, Rush-Presbyterian-St. Lukes Medical Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000331309","display_name":"John Michael Lee","orcid":"https://orcid.org/0000-0001-8473-4674","observed_orcids":["https://orcid.org/0000-0001-8473-4674"]},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Lee","raw_affiliation_strings":["Pathology, Loyola University Medical Center, 2160 South 1st Avenue, Bldg 102, Room 3634, Maywood, IL 60153"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Loyola University Medical Center, 2160 South 1st Avenue, Bldg 102, Room 3634, Maywood, IL 60153","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I4210159390"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071579004","display_name":"Benjamin L. Wolozin","orcid":"https://orcid.org/0000-0003-2068-1475","observed_orcids":["https://orcid.org/0000-0003-2068-1475"]},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Wolozin","raw_affiliation_strings":["Corresponding Author: Benjamin Wolozin","Departments of Pharmacology and Pathology, Loyola University Medical Center, 2160 South 1st Avenue, Bldg 102, Room 3634, Maywood, IL 60153"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corresponding Author: Benjamin Wolozin","institution_ids":[]},{"raw_affiliation_string":"Departments of Pharmacology and Pathology, Loyola University Medical Center, 2160 South 1st Avenue, Bldg 102, Room 3634, Maywood, IL 60153","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I4210159390"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.4439,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.94608092,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"11","issue":"12","first_page":"2635","last_page":"2638"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkin","display_name":"Parkin","score":0.8889999985694885},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.9039999842643738},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.7509999871253967},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8640000224113464},{"id":"https://openalex.org/keywords/juvenile-parkinsonism","display_name":"juvenile parkinsonism","score":0.8360000252723694},{"id":"https://openalex.org/keywords/lewy-bodies","display_name":"Lewy bodies","score":0.9760000109672546},{"id":"https://openalex.org/keywords/axonal-swellings","display_name":"axonal swellings","score":0.996999979019165},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.8420000076293945},{"id":"https://openalex.org/keywords/mg132","display_name":"MG132","score":0.7940000295639038},{"id":"https://openalex.org/keywords/neuroblastoma-cells","display_name":"neuroblastoma cells","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C2777668072","wikidata":"https://www.wikidata.org/wiki/Q2472777","display_name":"Parkin","level":4,"score":0.9798195362091064},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.7875168919563293},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5228446125984192},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.49096205830574036},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.48254650831222534},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.41449376940727234},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.325398713350296},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2703624367713928},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2675750255584717},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19167879223823547},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1653861701488495},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.16491004824638367},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.12951987981796265},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10094460844993591}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007976","descriptor_name":"Leupeptins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008025","descriptor_name":"Ligases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008025","descriptor_name":"Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011233","descriptor_name":"Precipitin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014452","descriptor_name":"Ubiquitins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00001756-200008210-00006","doi":"https://doi.org/10.1097/00001756-200008210-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001756-200008210-00006","pdf_url":null,"source":{"id":"https://openalex.org/S121278948","display_name":"Neuroreport","issn_l":"0959-4965","issn":["0959-4965","1473-558X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroReport","raw_type":"journal-article"},{"id":"pmid:10976934","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10976934","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroreport","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W1982290796","https://openalex.org/W2090180239","https://openalex.org/W2097807975","https://openalex.org/W2166987747"],"related_works":["https://openalex.org/W1976217716","https://openalex.org/W1512872045","https://openalex.org/W2162979967","https://openalex.org/W1967211381","https://openalex.org/W2008784665","https://openalex.org/W2047766237","https://openalex.org/W2148869194","https://openalex.org/W2411532818","https://openalex.org/W2224915829","https://openalex.org/W43683727"],"abstract_inverted_index":{"Mutations":[0],"in":[1,25,29,99],"the":[2,52,61,100,117],"parkin":[3],"gene":[4],"cause":[5],"autosomal":[6],"recessive":[7],"juvenile":[8],"parkinsonism.":[9],"Immunostaining":[10],"of":[11,39,56,102],"substantia":[12],"nigra":[13],"sections":[14],"from":[15],"sporadic":[16,103],"Parkinson's":[17],"disease":[18],"(PD)":[19],"cases":[20],"shows":[21],"that":[22,72,94,106,113],"Parkin":[23,48,71,95,107],"accumulates":[24],"axonal":[26,43],"spheroids":[27],"and":[28,42,105],"some":[30],"Lewy":[31,40],"bodies.":[32],"Because":[33],"ubiquitin":[34],"is":[35,49,108,114],"a":[36,66,97,109],"major":[37],"component":[38],"bodies":[41],"spheroids,":[44],"we":[45],"investigated":[46],"whether":[47],"metabolized":[50],"via":[51],"ubiquitin/proteosomal":[53],"pathway.":[54],"Treatment":[55],"BE-M17":[57],"neuroblastoma":[58],"cells":[59],"with":[60,89],"proteosomal":[62,118],"inhibitor,":[63],"MG132,":[64],"produced":[65],"band":[67,86],"corresponding":[68],"to":[69],"di-ubiquitinated":[70],"was":[73],"apparent":[74],"by":[75,116],"immunoblot":[76],"using":[77],"two":[78],"different":[79],"anti-Parkin":[80],"antibodies.":[81],"This":[82],"higher":[83],"mol.":[84],"wt":[85],"also":[87],"co-immunoprecipitated":[88],"Parkin.":[90],"These":[91],"data":[92],"suggest":[93],"plays":[96],"role":[98],"pathophysiology":[101],"PD,":[104],"substrate":[110],"for":[111],"ubiquitination":[112],"degraded":[115],"complex.":[119]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}