{"id":"https://openalex.org/W1964730875","doi":"https://doi.org/10.1121/1.4831336","title":"Prediction of the reversibility of the ultrasound-induced blood-brain barrier opening using passive cavitation detection with magnetic resonance imaging validation","display_name":"Prediction of the reversibility of the ultrasound-induced blood-brain barrier opening using passive cavitation detection with magnetic resonance imaging validation","publication_year":2013,"publication_date":"2013-11-01","ids":{"openalex":"https://openalex.org/W1964730875","doi":"https://doi.org/10.1121/1.4831336","mag":"1964730875"},"language":"en","primary_location":{"id":"doi:10.1121/1.4831336","doi":"https://doi.org/10.1121/1.4831336","is_oa":false,"landing_page_url":"https://doi.org/10.1121/1.4831336","pdf_url":null,"source":{"id":"https://openalex.org/S11296630","display_name":"The Journal of the Acoustical Society of America","issn_l":"0001-4966","issn":["0001-4966","1520-8524","1520-9024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","ccf-b","cwts-core","dongbi-b","erih-plus","jufo-3","ki-jl-1","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320226","host_organization_name":"Acoustical Society of America","host_organization_lineage":["https://openalex.org/P4310320226"],"host_organization_lineage_names":["Acoustical Society of America"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the Acoustical Society of America","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100640634","display_name":"Tao Sun","orcid":"https://orcid.org/0000-0002-3853-971X","observed_orcids":["https://orcid.org/0000-0002-3853-971X"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tao Sun","raw_affiliation_strings":["Dept. of Biomedical Eng., Columbia Univ., 630 West 168th St., Physicians & Surgeons 19-418, New York, NY 10032, ts2765@columbia.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Biomedical Eng., Columbia Univ., 630 West 168th St., Physicians & Surgeons 19-418, New York, NY 10032, ts2765@columbia.edu","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031209498","display_name":"Gesthimani Samiotaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gesthimani Samiotaki","raw_affiliation_strings":["Dept. of Biomedical Eng., Columbia Univ., 630 West 168th St., Physicians & Surgeons 19-418, New York, NY 10032, ts2765@columbia.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Biomedical Eng., Columbia Univ., 630 West 168th St., Physicians & Surgeons 19-418, New York, NY 10032, ts2765@columbia.edu","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000454252","display_name":"Elisa E. Konofagou","orcid":"https://orcid.org/0000-0002-9636-7936","observed_orcids":["https://orcid.org/0000-0002-9636-7936"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elisa E. Konofagou","raw_affiliation_strings":["Dept. of Biomedical Eng., Columbia Univ., 630 West 168th St., Physicians & Surgeons 19-418, New York, NY 10032, ts2765@columbia.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Biomedical Eng., Columbia Univ., 630 West 168th St., Physicians & Surgeons 19-418, New York, NY 10032, ts2765@columbia.edu","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"134","issue":"5_Supplement","first_page":"4183","last_page":"4183"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blood-brain-barrier-opening","display_name":"blood-brain barrier opening","score":0.9459999799728394},{"id":"https://openalex.org/keywords/passive-cavitation-detection","display_name":"passive cavitation detection","score":0.9559999704360962},{"id":"https://openalex.org/keywords/inertial-cavitation","display_name":"inertial cavitation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/stable-cavitation","display_name":"stable cavitation","score":0.796999990940094},{"id":"https://openalex.org/keywords/microbubbles","display_name":"microbubbles","score":0.7419999837875366},{"id":"https://openalex.org/keywords/focused-ultrasound","display_name":"focused ultrasound","score":0.7080000042915344},{"id":"https://openalex.org/keywords/contrast-enhanced-mri","display_name":"contrast-enhanced MRI","score":0.7319999933242798},{"id":"https://openalex.org/keywords/transendothelial-permeability","display_name":"transendothelial permeability","score":0.6399999856948853},{"id":"https://openalex.org/keywords/bubble-size-dependence","display_name":"bubble size dependence","score":0.6190000176429749},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C207057113","wikidata":"https://www.wikidata.org/wiki/Q201666","display_name":"Cavitation","level":2,"score":0.8316537141799927},{"id":"https://openalex.org/C64012434","wikidata":"https://www.wikidata.org/wiki/Q6839290","display_name":"Microbubbles","level":3,"score":0.807002067565918},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.6412830352783203},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6308695077896118},{"id":"https://openalex.org/C104628117","wikidata":"https://www.wikidata.org/wiki/Q3964828","display_name":"Sonication","level":2,"score":0.5510693788528442},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5229957103729248},{"id":"https://openalex.org/C138010386","wikidata":"https://www.wikidata.org/wiki/Q6804531","display_name":"Mechanical index","level":4,"score":0.5146502256393433},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.46517133712768555},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.4624692499637604},{"id":"https://openalex.org/C157915830","wikidata":"https://www.wikidata.org/wiki/Q2928001","display_name":"Bubble","level":2,"score":0.4517471492290497},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.42056939005851746},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2942027151584625},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.26515573263168335},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.126022070646286},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1173408031463623},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11105436086654663},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.10655760765075684},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.10054782032966614},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1121/1.4831336","doi":"https://doi.org/10.1121/1.4831336","is_oa":false,"landing_page_url":"https://doi.org/10.1121/1.4831336","pdf_url":null,"source":{"id":"https://openalex.org/S11296630","display_name":"The Journal of the Acoustical Society of America","issn_l":"0001-4966","issn":["0001-4966","1520-8524","1520-9024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","ccf-b","cwts-core","dongbi-b","erih-plus","jufo-3","ki-jl-1","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320226","host_organization_name":"Acoustical Society of America","host_organization_lineage":["https://openalex.org/P4310320226"],"host_organization_lineage_names":["Acoustical Society of America"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the Acoustical Society of America","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2265706680","https://openalex.org/W2054368317","https://openalex.org/W2540471261","https://openalex.org/W2103225095","https://openalex.org/W1969129866","https://openalex.org/W2084355055","https://openalex.org/W2141964733","https://openalex.org/W4414233504","https://openalex.org/W1992888440","https://openalex.org/W2012103360"],"abstract_inverted_index":{"Various":[0],"molecules":[1],"have":[2],"been":[3],"shown":[4],"to":[5,13,81,108,193,209],"cross":[6],"the":[7,29,44,48,88,118,126,133,139,155,164,167,173,184,203,213],"blood-brain":[8],"barrier":[9],"(BBB)":[10],"upon":[11],"exposure":[12],"focused":[14],"ultrasound":[15],"combined":[16],"with":[17,138,163],"microbubbles":[18],"and":[19,52,62,65,97,106,114,177,186,197,205,211],"exhibit":[20],"therapeutic":[21],"effects.":[22],"Real-time":[23],"monitoring,":[24],"thereof,":[25],"remains":[26],"one":[27],"of":[28,35,40,47,117,141,166,216],"key":[30],"elements":[31],"before":[32],"clinical":[33],"translation":[34],"this":[36,217],"technique.":[37,218],"The":[38,200],"dependence":[39,201],"acoustic":[41],"emissions":[42],"on":[43,202],"closing":[45,145],"timelines":[46],"BBB":[49,127,178],"opening":[50,179],"volume":[51,185],"its":[53],"permeability":[54,187],"was":[55,79,130,181],"investigated":[56],"under":[57],"different":[58],"pressures":[59],"(0.30,":[60],"0.45,":[61],"0.60":[63],"MPa)":[64],"microbubble":[66],"sizes":[67],"(diameters:":[68],"1\u20132,":[69],"4\u20135,":[70],"or":[71],"6\u20138":[72],"\u03bcm).":[73],"A":[74,169],"10-MHz":[75],"passive":[76],"cavitation":[77,83,135,157,175],"detector":[78],"used":[80],"acquire":[82],"signals":[84],"during":[85],"sonication":[86,105],"at":[87],"mouse":[89],"right":[90],"hippocampus":[91],"(n":[92],"=":[93],"45).":[94],"Contrast-enhanced":[95,112],"dynamic":[96],"T1-weighted":[98],"MR":[99],"scans":[100],"were":[101,121,191],"performed":[102],"immediately":[103],"after":[104,151],"up":[107],"6":[109],"days":[110,142,180],"thereafter.":[111],"volumes":[113],"diffusion":[115],"rates":[116],"contrast":[119],"agent":[120],"quantified":[122],"as":[123],"indicators":[124],"for":[125,144],"opening.":[128,168],"It":[129],"found":[131,192],"that":[132],"stable":[134],"dose":[136,158,176],"increased":[137],"number":[140],"required":[143],"while":[146],"it":[147],"reached":[148],"a":[149],"plateau":[150],"day":[152],"4.":[153],"However,":[154],"inertial":[156],"exhibited":[159],"an":[160],"exponential":[161],"increase":[162],"duration":[165],"linear":[170],"correlation":[171],"between":[172],"total":[174],"found.":[182],"Moreover,":[183],"indicator":[188],"K":[189],"trans":[190],"be":[194],"both":[195],"pressure-":[196],"bubble":[198],"size-dependent.":[199],"bubble-diameter":[204],"pressure":[206],"allows":[207],"us":[208],"predict":[210],"control":[212],"safety":[214],"profile":[215]},"counts_by_year":[{"year":2015,"cited_by_count":2}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2016-06-24T00:00:00"}
