{"id":"https://openalex.org/W1964700796","doi":"https://doi.org/10.1034/j.1600-051x.2000.027001053.x","title":"Concentration of 3 tetracyclines in plasma, gingival crevice fluid and saliva","display_name":"Concentration of 3 tetracyclines in plasma, gingival crevice fluid and saliva","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W1964700796","doi":"https://doi.org/10.1034/j.1600-051x.2000.027001053.x","mag":"1964700796","pmid":"https://pubmed.ncbi.nlm.nih.gov/10674962"},"language":"en","primary_location":{"id":"doi:10.1034/j.1600-051x.2000.027001053.x","doi":"https://doi.org/10.1034/j.1600-051x.2000.027001053.x","is_oa":false,"landing_page_url":"https://doi.org/10.1034/j.1600-051x.2000.027001053.x","pdf_url":null,"source":{"id":"https://openalex.org/S61859066","display_name":"Journal Of Clinical Periodontology","issn_l":"0303-6979","issn":["0303-6979","1600-051X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Periodontology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072282774","display_name":"Dimitra Sakellari","orcid":"https://orcid.org/0000-0002-4365-8406","observed_orcids":["https://orcid.org/0000-0002-4365-8406"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"D. Sakellari","raw_affiliation_strings":["Department of Periotontology, Dental School, Aristotelian University of Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periotontology, Dental School, Aristotelian University of Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045117023","display_name":"J. Max Goodson","orcid":"https://orcid.org/0000-0003-4225-9160","observed_orcids":["https://orcid.org/0000-0003-4225-9160"]},"institutions":[{"id":"https://openalex.org/I4405268108","display_name":"The Forsyth Institute","ror":"https://ror.org/05tr9gt18","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405268108"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. M. Goodson","raw_affiliation_strings":["Department of Periodontology, Forsyth Dental Center, Boston MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, Forsyth Dental Center, Boston MA, USA","institution_ids":["https://openalex.org/I4405268108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109945575","display_name":"S. S. Socransky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268108","display_name":"The Forsyth Institute","ror":"https://ror.org/05tr9gt18","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405268108"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. S. Socransky","raw_affiliation_strings":["Department of Periodontology, Forsyth Dental Center, Boston MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, Forsyth Dental Center, Boston MA, USA","institution_ids":["https://openalex.org/I4405268108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111528345","display_name":"Alexandros E. Kolokotronis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"A. Kolokotronis","raw_affiliation_strings":["Department of Periotontology, Dental School, Aristotelian University of Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periotontology, Dental School, Aristotelian University of Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071511816","display_name":"Alexandros O. Konstantinidis","orcid":"https://orcid.org/0000-0002-0445-2229","observed_orcids":["https://orcid.org/0000-0002-0445-2229"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"A. Konstantinidis","raw_affiliation_strings":["Department of Periotontology, Dental School, Aristotelian University of Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periotontology, Dental School, Aristotelian University of Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5510,"currency":"USD","value_usd":5510},"apc_paid":null,"fwci":3.06,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.89396887,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"27","issue":"1","first_page":"53","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.03099999949336052,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13768","display_name":"Oral and gingival health research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetracycline","display_name":"tetracycline","score":0.9950000047683716},{"id":"https://openalex.org/keywords/minocycline","display_name":"minocycline","score":0.8560000061988831},{"id":"https://openalex.org/keywords/doxycycline","display_name":"doxycycline","score":1.0},{"id":"https://openalex.org/keywords/gingival-crevicular-fluid","display_name":"gingival crevicular fluid","score":0.972000002861023},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.7889999747276306},{"id":"https://openalex.org/keywords/saliva","display_name":"saliva","score":0.6430000066757202},{"id":"https://openalex.org/keywords/periodontal-treatment","display_name":"periodontal treatment","score":0.7329999804496765},{"id":"https://openalex.org/keywords/drug-absorption","display_name":"drug absorption","score":0.6930000185966492},{"id":"https://openalex.org/keywords/periodontal-disease","display_name":"periodontal disease","score":0.6340000033378601},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.8894466757774353},{"id":"https://openalex.org/C2778275353","wikidata":"https://www.wikidata.org/wiki/Q415336","display_name":"Minocycline","level":3,"score":0.6022240519523621},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.544766366481781},{"id":"https://openalex.org/C3020079912","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma concentration","level":2,"score":0.5234127640724182},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.5208088159561157},{"id":"https://openalex.org/C2780923616","wikidata":"https://www.wikidata.org/wiki/Q193045","display_name":"Tetracycline","level":3,"score":0.49047204852104187},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.4889439642429352},{"id":"https://openalex.org/C2777179404","wikidata":"https://www.wikidata.org/wiki/Q422442","display_name":"Doxycycline","level":3,"score":0.4870448410511017},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.46757012605667114},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.385952889919281},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3554244041442871},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.309917151927948},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2987678050994873},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06384500861167908},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004318","descriptor_name":"Doxycycline","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004318","descriptor_name":"Doxycycline","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004318","descriptor_name":"Doxycycline","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004318","descriptor_name":"Doxycycline","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005883","descriptor_name":"Gingival Crevicular Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008911","descriptor_name":"Minocycline","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008911","descriptor_name":"Minocycline","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008911","descriptor_name":"Minocycline","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008911","descriptor_name":"Minocycline","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D010512","descriptor_name":"Periodontal Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013752","descriptor_name":"Tetracycline","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013752","descriptor_name":"Tetracycline","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013752","descriptor_name":"Tetracycline","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013752","descriptor_name":"Tetracycline","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013754","descriptor_name":"Tetracyclines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013754","descriptor_name":"Tetracyclines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D013754","descriptor_name":"Tetracyclines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013754","descriptor_name":"Tetracyclines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1034/j.1600-051x.2000.027001053.x","doi":"https://doi.org/10.1034/j.1600-051x.2000.027001053.x","is_oa":false,"landing_page_url":"https://doi.org/10.1034/j.1600-051x.2000.027001053.x","pdf_url":null,"source":{"id":"https://openalex.org/S61859066","display_name":"Journal Of Clinical Periodontology","issn_l":"0303-6979","issn":["0303-6979","1600-051X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Periodontology","raw_type":"journal-article"},{"id":"pmid:10674962","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10674962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical periodontology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1707937236","display_name":"BOSTON ORAL HEALTH CLINICAL RESOURCE CENTER","funder_award_id":"P30DE011814","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G5084013850","display_name":"CLINICAL CENTER FOR RESEARCH IN PERIODONTAL DISEASES","funder_award_id":"P50DE004881","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320330704","display_name":"Universidad Nacional de Entre R\u00edos","ror":"https://ror.org/01wgfva68"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2079733537","https://openalex.org/W2022831073","https://openalex.org/W2088465233","https://openalex.org/W2795828831","https://openalex.org/W1980834410","https://openalex.org/W2066742156","https://openalex.org/W2076695017","https://openalex.org/W2064898607","https://openalex.org/W2116467827","https://openalex.org/W2414964948"],"abstract_inverted_index":{"BACKGROUND:":[0],"Systemically-administered":[1],"tetracyclines":[2,31,185,197,262],"have":[3],"been":[4],"used":[5],"widely":[6,236],"for":[7,268],"treatment":[8],"of":[9,15,29,40,47,65,168,182,191,196,210,216,224,245,250,260,270],"periodontal":[10,20,227],"diseases":[11],"with":[12,203,242],"little":[13],"understanding":[14],"their":[16],"delivery":[17,215],"characteristics":[18],"to":[19,26,221,276],"tissues.":[21],"This":[22],"study":[23],"was":[24,55,79,117,200],"designed":[25],"measure":[27],"concentrations":[28,103,123,133,148,160],"3":[30,170],"in":[32,57,107,139,151,198,213,226,233,263,273,279],"gingival":[33,58],"crevice":[34,59,76],"fluid":[35,60,77],"(GCF),":[36,61],"plasma":[37,62,140,192,204],"and":[38,52,63,86,91,95,101,239],"saliva":[39,64,102],"following":[41,68,98],"systemic":[42,73],"administration.":[43,99,120,129],"METHOD:":[44],"The":[45,121,131,194,229],"concentration":[46,78,181,195,232],"tetracycline":[48],"(TC),":[49],"minocycline":[50],"(MN)":[51],"doxycycline":[53],"(DX)":[54],"measured":[56,80,105,125,150],"20":[66],"subjects":[67],"single":[69],"sequential":[70],"standard":[71],"oral":[72],"doses.":[74],"Gingival":[75],"at":[81,92,109,134],"4":[82],"sites":[83],"(2":[84],"shallow":[85],"2":[87,96,126,135],"deep)":[88],"before":[89,119],"administration,":[90],"1":[93,251],"h":[94,97,127,136],"Plasma":[100],"were":[104,124,137,149,165],"from":[106],"samples":[108,246],"the":[110,166,169,178,189,214,222,271],"same":[111],"time":[112],"points.":[113],"No":[114],"antibacterial":[115],"activity":[116],"detected":[118],"highest":[122,138],"after":[128],"RESULTS:":[130],"average":[132,179,230],"(TC":[141],"=":[142],"1.02,":[143],"MN=2.18,":[144],"DX=2.35":[145],"microg/ml).":[146,158],"Intermediate":[147],"GCF":[152,180,199,231],"(TC=0.61,":[153],"MN=":[154],"1.49,":[155],"DX=":[156],"1.65":[157],"Saliva":[159],"(TC=0.09":[161],"MN=0.31,":[162],"DX=0.47":[163],"microg/ml)":[164,241],"lowest":[167],"fluids":[171],"monitored.":[172],"Data":[173],"are":[174],"presented":[175],"indicating":[176,206],"that":[177,190,257],"systemically":[183,218],"administered":[184,219],"is":[186],"less":[187],"than":[188],"concentration.":[193],"strongly":[201],"associated":[202],"concentration,":[205],"a":[207],"primary":[208],"role":[209],"drug":[211],"absorption":[212,259],"these":[217],"antibiotics":[220,277],"site":[223],"action":[225],"therapy.":[228],"individuals":[234,265],"varied":[235],"(between":[237],"0":[238],"8":[240],"approximately":[243],"50%":[244],"not":[247],"achieving":[248],"levels":[249],"microg/ml.":[252],"CONCLUSION:":[253],"These":[254],"observations":[255],"suggest":[256],"poor":[258],"orally-administered":[261],"many":[264],"may":[266],"account":[267],"much":[269],"variability":[272],"clinical":[274],"response":[275],"observed":[278],"practice.":[280]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}