{"id":"https://openalex.org/W1964669081","doi":"https://doi.org/10.1126/scisignal.2004762","title":"Intronic miR-3151 Within BAALC Drives Leukemogenesis by Deregulating the TP53 Pathway","display_name":"Intronic miR-3151 Within BAALC Drives Leukemogenesis by Deregulating the TP53 Pathway","publication_year":2014,"publication_date":"2014-04-15","ids":{"openalex":"https://openalex.org/W1964669081","doi":"https://doi.org/10.1126/scisignal.2004762","mag":"1964669081","pmid":"https://pubmed.ncbi.nlm.nih.gov/24736457","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4165404"},"language":"en","primary_location":{"id":"doi:10.1126/scisignal.2004762","doi":"https://doi.org/10.1126/scisignal.2004762","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scisignal.2004762","pdf_url":null,"source":{"id":"https://openalex.org/S155937366","display_name":"Science Signaling","issn_l":"1937-9145","issn":["1937-9145","1945-0877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Signaling","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4165404","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086647663","display_name":"Ann\u2010Kathrin Eisfeld","orcid":"https://orcid.org/0000-0001-6442-1419","observed_orcids":["https://orcid.org/0000-0001-6442-1419"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann-Kathrin Eisfeld","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004233773","display_name":"Sebastian Schwind","orcid":"https://orcid.org/0000-0002-1315-2332","observed_orcids":["https://orcid.org/0000-0002-1315-2332"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sebastian Schwind","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048012003","display_name":"Ravi K. Patel","orcid":"https://orcid.org/0000-0001-5203-899X","observed_orcids":["https://orcid.org/0000-0001-5203-899X"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Patel","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031915047","display_name":"Xiaomeng Huang","orcid":"https://orcid.org/0000-0001-9651-7503","observed_orcids":["https://orcid.org/0000-0001-9651-7503","https://orcid.org/0009-0007-0506-3114"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaomeng Huang","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047855185","display_name":"Ramasamy Santhanam","orcid":"https://orcid.org/0000-0002-8471-1699","observed_orcids":["https://orcid.org/0000-0002-8471-1699"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramasamy Santhanam","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015187893","display_name":"Christopher James Walker","orcid":"https://orcid.org/0000-0002-1819-7388","observed_orcids":["https://orcid.org/0000-0002-1819-7388"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J. Walker","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044766130","display_name":"Joseph Markowitz","orcid":"https://orcid.org/0000-0003-2490-5464","observed_orcids":["https://orcid.org/0000-0003-2490-5464"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Markowitz","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082878312","display_name":"Kevin W. Hoag","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin W. Hoag","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060465986","display_name":"Tiina M. J\u00e4rvinen","orcid":"https://orcid.org/0000-0002-8646-314X","observed_orcids":["https://orcid.org/0000-0002-8646-314X"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tiina M. Jarvinen","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Benjamin Leffel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Leffel","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022067885","display_name":"Danilo Perrotti","orcid":"https://orcid.org/0000-0003-0726-8766","observed_orcids":["https://orcid.org/0000-0003-0726-8766"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danilo Perrotti","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060897770","display_name":"William Edgar Carson","orcid":"https://orcid.org/0000-0001-7024-7533","observed_orcids":["https://orcid.org/0000-0001-7024-7533"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E. Carson","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060959458","display_name":"Guido Marcucci","orcid":"https://orcid.org/0000-0002-3983-5908","observed_orcids":["https://orcid.org/0000-0002-3983-5908"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guido Marcucci","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062108544","display_name":"Clara Derber Bloomfield","orcid":"https://orcid.org/0000-0001-5465-7591","observed_orcids":["https://orcid.org/0000-0001-5465-7591"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Clara D. Bloomfield","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063189075","display_name":"Albert de la Chapelle","orcid":"https://orcid.org/0000-0001-9345-9248","observed_orcids":["https://orcid.org/0000-0001-9345-9248"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Albert de la Chapelle","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I2799885155"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5062108544","https://openalex.org/A5063189075"],"corresponding_institution_ids":["https://openalex.org/I2799885155"],"apc_list":null,"apc_paid":null,"fwci":1.2807,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.76769666,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"321","first_page":"ra36","last_page":"ra36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.7919999957084656,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.7919999957084656,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.20010000467300415,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/baalc","display_name":"BAALC","score":0.9890000224113464},{"id":"https://openalex.org/keywords/intronic-microrna","display_name":"intronic microRNA","score":0.8840000033378601},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9639999866485596},{"id":"https://openalex.org/keywords/leukemogenesis","display_name":"leukemogenesis","score":0.7919999957084656},{"id":"https://openalex.org/keywords/tp53","display_name":"TP53","score":0.8339999914169312},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.8230000138282776},{"id":"https://openalex.org/keywords/sp1","display_name":"Sp1","score":0.7609999775886536},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9800000190734863},{"id":"https://openalex.org/keywords/runx1","display_name":"RUNX1","score":0.996999979019165},{"id":"https://openalex.org/keywords/caspase-activity","display_name":"caspase activity","score":0.7080000042915344},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.7670000195503235},{"id":"https://openalex.org/keywords/oncogenic-microrna","display_name":"oncogenic microRNA","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5397335886955261},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4201841354370117},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36191055178642273},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33749157190322876},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2728334069252014},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24735942482948303}],"mesh":[{"descriptor_ui":"D000069286","descriptor_name":"Bortezomib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001897","descriptor_name":"Boronic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002875","descriptor_name":"Chromosomes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D003582","descriptor_name":"Cytogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015973","descriptor_name":"Gene Expression Regulation, Leukemic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050676","descriptor_name":"Core Binding Factor Alpha 2 Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1126/scisignal.2004762","doi":"https://doi.org/10.1126/scisignal.2004762","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scisignal.2004762","pdf_url":null,"source":{"id":"https://openalex.org/S155937366","display_name":"Science Signaling","issn_l":"1937-9145","issn":["1937-9145","1945-0877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Signaling","raw_type":"journal-article"},{"id":"pmid:24736457","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24736457","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science signaling","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3134790","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4165404","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4165404","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4165404","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Sci Signal","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3134790","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4165404","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1069145923","display_name":null,"funder_award_id":"CA 10114 0","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G115269961","display_name":"Molecular characterization of normal cytogenetics AML in older patients","funder_award_id":"R21CA129657","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1713549810","display_name":null,"funder_award_id":"TRTH73","funder_id":"https://openalex.org/F4320310646","funder_display_name":"European Hematology Association"},{"id":"https://openalex.org/G20154349","display_name":null,"funder_award_id":"CA 77658","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2279923822","display_name":null,"funder_award_id":"CA114725","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2317848681","display_name":"BCI2 Antisense Against Chemoresistance in Elderly AML","funder_award_id":"R21CA094552","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2468812564","display_name":"ITSC for Leukemia: Novel Molecular Strategies for NCTN: \"Individualized\" Therapie","funder_award_id":"U10CA180861","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2606285615","display_name":"Experimental Therapeutics of Leukemia","funder_award_id":"P50CA140158","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2646040624","display_name":null,"funder_award_id":"CA129657","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2647518335","display_name":null,"funder_award_id":"CA-33601","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2714647962","display_name":null,"funder_award_id":"CA16058","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3054160986","display_name":"Cancer and Leukemia Group B Statistical Center","funder_award_id":"U10CA033601","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3591778097","display_name":"Cancer and Leukemia Group B - Leukemia Correlative Sciences","funder_award_id":"U10CA101140","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4091703554","display_name":"Role of microRNAs in the regulation of CML stem cell self renewal and survival","funder_award_id":"R01CA163800","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4118974396","display_name":null,"funder_award_id":"CA 095512","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6593449295","display_name":"Cancer and Leukemia Group B","funder_award_id":"U10CA031946","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7338240445","display_name":null,"funder_award_id":"CA140158","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7715050869","display_name":"Cancer and Leukemia Group B - The Ohio State University","funder_award_id":"U10CA077658","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7830551707","display_name":"Role of RNA Binding Proteins in BCR/ABL Leukemogenesis","funder_award_id":"R01CA095512","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8473585937","display_name":"Cancer and Leukemia Group B Human Specimen Repositories","funder_award_id":"U24CA114725","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8740451518","display_name":"Alliance for Clinical Trials in Oncology Operations Center","funder_award_id":"U10CA180821","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000887552","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016058","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G973482110","display_name":null,"funder_award_id":"CA-31946","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320307896","display_name":"Life Technologies Corporation","ror":"https://ror.org/03x1ewr52"},{"id":"https://openalex.org/F4320309374","display_name":"Ohio State University","ror":"https://ror.org/00rs6vg23"},{"id":"https://openalex.org/F4320310646","display_name":"European Hematology Association","ror":"https://ror.org/05hk0hn26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1968110789","https://openalex.org/W1982631665","https://openalex.org/W1991494214","https://openalex.org/W1992820945","https://openalex.org/W1998260014","https://openalex.org/W2002801096","https://openalex.org/W2006116919","https://openalex.org/W2008301561","https://openalex.org/W2034295250","https://openalex.org/W2041825143","https://openalex.org/W2049722365","https://openalex.org/W2053204982","https://openalex.org/W2057346914","https://openalex.org/W2057652101","https://openalex.org/W2063107989","https://openalex.org/W2074114480","https://openalex.org/W2077453421","https://openalex.org/W2081349322","https://openalex.org/W2082684480","https://openalex.org/W2102749300","https://openalex.org/W2107203759","https://openalex.org/W2112998845","https://openalex.org/W2113915484","https://openalex.org/W2128942433","https://openalex.org/W2129951747","https://openalex.org/W2142718844","https://openalex.org/W2159170728","https://openalex.org/W2161149887","https://openalex.org/W2165687491","https://openalex.org/W2170846829","https://openalex.org/W2523562238"],"related_works":["https://openalex.org/W4246411035","https://openalex.org/W2071588599","https://openalex.org/W6983434100","https://openalex.org/W7100498028","https://openalex.org/W1992820945","https://openalex.org/W2960586167","https://openalex.org/W2335582806","https://openalex.org/W2583061754","https://openalex.org/W2898478324","https://openalex.org/W4281648734"],"abstract_inverted_index":{"The":[0],"BAALC/miR-3151":[1,74],"locus":[2],"on":[3],"chromosome":[4],"8q22":[5],"contains":[6,130],"both":[7,37,170],"the":[8,40,69,73,81,96,107,111,143,156,186,194,208,219],"BAALC":[9,41,52,119,144,173,201],"gene":[10],"(for":[11],"brain":[12],"and":[13,17,39,49,51,83,89,106,150,160,172,200,223],"acute":[14,28],"leukemia,":[15],"cytoplasmic)":[16],"miR-3151,":[18,182],"which":[19],"is":[20,54],"located":[21],"in":[22,92,101,203,211,245],"intron":[23],"1":[24],"of":[25,36,60,72,78,85,95,115,142,155,166,177,198,216,221,225],"BAALC.":[26],"Older":[27],"myeloid":[29],"leukemia":[30,102],"(AML)":[31],"patients":[32],"with":[33,56],"high":[34],"expression":[35,53,139,176,197],"miR-3151":[38,50,66,79,105,108,129,138,171,199,217,226,231,239],"mRNA":[42],"transcript":[43],"have":[44,242],"a":[45,153,191,243],"low":[46],"survival":[47,58],"prognosis,":[48],"associated":[55],"poor":[57],"independently":[59],"each":[61],"other.":[62],"We":[63,126],"found":[64,127],"that":[65,128,141],"functioned":[67],"as":[68],"oncogenic":[70,124,238],"driver":[71],"locus.":[75],"Increased":[76],"production":[77],"reduced":[80,169,218,233],"apoptosis":[82,98],"chemosensitivity":[84],"AML":[86,204,209],"cell":[87,213],"lines":[88],"increased":[90,227],"leukemogenesis":[91],"mice.":[93],"Disruption":[94,165],"TP53-mediated":[97],"pathway":[99],"occurred":[100],"cells":[103],"overexpressing":[104],"bound":[109,149],"to":[110,207],"3'":[112],"untranslated":[113],"region":[114],"TP53.":[116],"In":[117],"contrast,":[118],"alone":[120],"had":[121],"only":[122,178],"limited":[123],"activity.":[125,235],"its":[131],"own":[132],"regulatory":[133],"element,":[134],"thus":[135],"partly":[136,195],"uncoupling":[137],"from":[140],"transcript.":[145],"Both":[146],"genes":[147],"were":[148],"stimulated":[151,184],"by":[152,185],"complex":[154],"transcription":[157,187],"factors":[158],"SP1":[159],"nuclear":[161],"factor":[162,188],"\u03baB":[163],"(SP1/NF-\u03baB).":[164],"SP1/NF-\u03baB":[167],"binding":[168],"expression.":[174],"However,":[175],"BAALC,":[179],"but":[180],"not":[181],"was":[183],"RUNX1,":[189],"suggesting":[190],"mechanism":[192],"for":[193],"discordant":[196],"observed":[202],"patients.":[205],"Similar":[206],"cells,":[210],"melanoma":[212],"lines,":[214],"overexpression":[215,232],"abundance":[220],"TP53,":[222],"knockdown":[224],"caspase":[228,234],"activity,":[229],"whereas":[230],"Thus,":[236],"this":[237],"may":[240],"also":[241],"role":[244],"solid":[246],"tumors.":[247]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}