{"id":"https://openalex.org/W1964653499","doi":"https://doi.org/10.1242/dev.030544","title":"Follistatin modulates a BMP autoregulatory loop to control the size and patterning of sensory domains in the developing tongue","display_name":"Follistatin modulates a BMP autoregulatory loop to control the size and patterning of sensory domains in the developing tongue","publication_year":2009,"publication_date":"2009-05-28","ids":{"openalex":"https://openalex.org/W1964653499","doi":"https://doi.org/10.1242/dev.030544","mag":"1964653499","pmid":"https://pubmed.ncbi.nlm.nih.gov/19474151","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2729339"},"language":"en","primary_location":{"id":"doi:10.1242/dev.030544","doi":"https://doi.org/10.1242/dev.030544","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.030544","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2729339","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064753354","display_name":"Crestina L. Beites","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Crestina L. Beites","raw_affiliation_strings":["Department of Anatomy and Neurobiology and Center for Complex Biological Systems, University of California, Irvine, CA 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology and Center for Complex Biological Systems, University of California, Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019604339","display_name":"Piper L. W. Hollenbeck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Piper L. W. Hollenbeck","raw_affiliation_strings":["Department of Anatomy and Neurobiology and Center for Complex Biological Systems, University of California, Irvine, CA 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology and Center for Complex Biological Systems, University of California, Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100662520","display_name":"Joon Kim","orcid":"https://orcid.org/0000-0002-9379-3243","observed_orcids":["https://orcid.org/0000-0002-9379-3243","https://orcid.org/0000-0003-0914-4273"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joon Kim","raw_affiliation_strings":["Department of Anatomy and Neurobiology and Center for Complex Biological Systems, University of California, Irvine, CA 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology and Center for Complex Biological Systems, University of California, Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005885916","display_name":"Robin Howard Lovell-Badge","orcid":"https://orcid.org/0000-0001-9364-4179","observed_orcids":["https://orcid.org/0000-0001-9364-4179"]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robin Lovell-Badge","raw_affiliation_strings":["Division of Stem Cell Biology and Developmental Genetics, Medical Research Council, National Institute of Medical Research, The Ridgeway, Mill Hill,London NW7 1AA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Stem Cell Biology and Developmental Genetics, Medical Research Council, National Institute of Medical Research, The Ridgeway, Mill Hill,London NW7 1AA, UK","institution_ids":["https://openalex.org/I4405285715","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030125759","display_name":"Arthur D. Lander","orcid":"https://orcid.org/0000-0002-4380-5525","observed_orcids":["https://orcid.org/0000-0002-4380-5525"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur D. Lander","raw_affiliation_strings":["Department of Developmental and Cell Biology and Center for Complex Biological Systems, University of California, Irvine, CA 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Cell Biology and Center for Complex Biological Systems, University of California, Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020125811","display_name":"Anne L. Calof","orcid":"https://orcid.org/0000-0003-3676-2499","observed_orcids":["https://orcid.org/0000-0003-3676-2499"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anne L. Calof","raw_affiliation_strings":["Department of Anatomy and Neurobiology and Center for Complex Biological Systems, University of California, Irvine, CA 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology and Center for Complex Biological Systems, University of California, Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5020125811"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":null,"apc_paid":null,"fwci":1.3749,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.78111746,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"136","issue":"13","first_page":"2187","last_page":"2197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.8140000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.8140000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":0.04230000078678131,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.03660000115633011,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/follistatin","display_name":"follistatin","score":0.996999979019165},{"id":"https://openalex.org/keywords/bmp-7","display_name":"BMP-7","score":0.9800000190734863},{"id":"https://openalex.org/keywords/taste-papillae","display_name":"taste papillae","score":0.8069999814033508},{"id":"https://openalex.org/keywords/taste-buds","display_name":"taste buds","score":0.8650000095367432},{"id":"https://openalex.org/keywords/sox2","display_name":"SOX2","score":0.906000018119812},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-interactions","display_name":"epithelial-mesenchymal interactions","score":0.8450000286102295},{"id":"https://openalex.org/keywords/tongue-development","display_name":"tongue development","score":0.6119999885559082},{"id":"https://openalex.org/keywords/turing-instability","display_name":"Turing instability","score":0.6520000100135803},{"id":"https://openalex.org/keywords/epithelial-stem-cells","display_name":"epithelial stem cells","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9634414911270142},{"id":"https://openalex.org/C2778831791","wikidata":"https://www.wikidata.org/wiki/Q408122","display_name":"Follistatin","level":2,"score":0.8605749011039734},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.6077041029930115},{"id":"https://openalex.org/C2779744641","wikidata":"https://www.wikidata.org/wiki/Q9614","display_name":"Tongue","level":2,"score":0.5656518936157227},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47982120513916016},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3803538382053375},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.36937904357910156},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07041797041893005},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013649","descriptor_name":"Taste","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014059","descriptor_name":"Tongue","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D014059","descriptor_name":"Tongue","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D038681","descriptor_name":"Follistatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D038681","descriptor_name":"Follistatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055419","descriptor_name":"Bone Morphogenetic Protein 7","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055419","descriptor_name":"Bone Morphogenetic Protein 7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055748","descriptor_name":"SOXB1 Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055748","descriptor_name":"SOXB1 Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1242/dev.030544","doi":"https://doi.org/10.1242/dev.030544","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.030544","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2729339","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2729339","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"Text"},{"id":"pmid:19474151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19474151","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt8cp8f5nm","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/8cp8f5nm","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Development (Cambridge, England), vol 136, iss 13","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt8cp8f5nm","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/8cp8f5nm","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Development, vol 136, iss 13","raw_type":"article"},{"id":"pmh:qt8cp8f5nm","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/8cp8f5nm","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Beites, CL; Hollenbeck, PLW; Kim, J; Lovell-Badge, R; Lander, AD; & Calof, AL. (2009). Follistatin modulates a BMP autoregulatory loop to control the size and patterning of sensory domains in the developing tongue. Development, 136(13), 2187 - 2197. doi: 10.1242/dev.030544. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8cp8f5nm","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2729339","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2729339","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3061672855","display_name":null,"funder_award_id":"DC03583","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G3624937362","display_name":null,"funder_award_id":"GM076516","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G479823528","display_name":"Systems Biology of Morphogeneisis and Spatial Information Flow","funder_award_id":"P50GM076516","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G681785920","display_name":"Training Program in Systems Biology of Development","funder_award_id":"T32HD060555","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7264898069","display_name":"FEEDBACK REGULATION OF NEUROGENESIS IN MAMMALS","funder_award_id":"R01DC003583","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G9000877839","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA062203","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1516984117","https://openalex.org/W1549510991","https://openalex.org/W1698663755","https://openalex.org/W1774637004","https://openalex.org/W1970527253","https://openalex.org/W1977672159","https://openalex.org/W1979281691","https://openalex.org/W1980011657","https://openalex.org/W1980417700","https://openalex.org/W1990001694","https://openalex.org/W1991075591","https://openalex.org/W1991980706","https://openalex.org/W1992865216","https://openalex.org/W1997785401","https://openalex.org/W2004201400","https://openalex.org/W2006632995","https://openalex.org/W2009578263","https://openalex.org/W2011717046","https://openalex.org/W2015272152","https://openalex.org/W2020250544","https://openalex.org/W2025106191","https://openalex.org/W2025234765","https://openalex.org/W2026279127","https://openalex.org/W2032779135","https://openalex.org/W2034316793","https://openalex.org/W2034780781","https://openalex.org/W2035524441","https://openalex.org/W2036983038","https://openalex.org/W2038860268","https://openalex.org/W2042351431","https://openalex.org/W2043109346","https://openalex.org/W2043861102","https://openalex.org/W2044182000","https://openalex.org/W2046006768","https://openalex.org/W2048686290","https://openalex.org/W2053956027","https://openalex.org/W2056916657","https://openalex.org/W2057658774","https://openalex.org/W2064694357","https://openalex.org/W2075720621","https://openalex.org/W2076425777","https://openalex.org/W2077252116","https://openalex.org/W2084385289","https://openalex.org/W2084662109","https://openalex.org/W2085484334","https://openalex.org/W2090806860","https://openalex.org/W2091643574","https://openalex.org/W2092472216","https://openalex.org/W2092925239","https://openalex.org/W2106133121","https://openalex.org/W2111048777","https://openalex.org/W2111724542","https://openalex.org/W2115438940","https://openalex.org/W2118548518","https://openalex.org/W2122109009","https://openalex.org/W2123221507","https://openalex.org/W2136260549","https://openalex.org/W2139470337","https://openalex.org/W2146717124","https://openalex.org/W2148922553","https://openalex.org/W2151885701","https://openalex.org/W2154473845","https://openalex.org/W2169529166","https://openalex.org/W2169630576","https://openalex.org/W2265145646","https://openalex.org/W4298370949"],"related_works":["https://openalex.org/W2767712030","https://openalex.org/W4210742039","https://openalex.org/W2117524382","https://openalex.org/W2087808824","https://openalex.org/W7006178632","https://openalex.org/W2056916657","https://openalex.org/W2007041251","https://openalex.org/W2038860268","https://openalex.org/W4362594605","https://openalex.org/W2614124915"],"abstract_inverted_index":{"The":[0],"regenerative":[1],"capacity":[2],"of":[3,10,17,48,77,87,102,109,113,122,150,161,187,205,209,236],"many":[4,208],"placode-derived":[5],"epithelial":[6,18,123,224],"structures":[7],"makes":[8],"them":[9],"interest":[11],"for":[12],"understanding":[13],"the":[14,27,30,41,49,85,91,125,146,159,210,231],"molecular":[15],"control":[16],"stem":[19],"cells":[20,81],"and":[21,33,44,64,75,82,106,119,143,148,164,223,234,239],"their":[22,240],"niches.":[23],"Here,":[24],"we":[25,136,172,216],"investigate":[26],"interaction":[28],"between":[29,220],"developing":[31,69],"epithelium":[32],"its":[34],"surrounding":[35],"mesenchyme":[36],"in":[37,68,90,94,158,176,180,196,213,230],"one":[38],"such":[39],"system,":[40],"taste":[42,46,70,79,88,104,162,165,177,237],"papillae":[43,89,163,178],"sensory":[45],"buds":[47,238],"mouse":[50],"tongue.":[51],"We":[52,139],"identify":[53],"follistatin":[54],"(FST)":[55],"as":[56],"a":[57,134,197,227],"mesenchymal":[58],"factor":[59],"that":[60,141,154,192,218],"controls":[61],"size,":[62],"patterning":[63,179],"gustatory":[65,110],"cell":[66],"differentiation":[67,76,108],"papillae.":[71],"FST":[72,142,222],"limits":[73],"expansion":[74],"Sox2-expressing":[78,103],"progenitor":[80],"negatively":[83],"regulates":[84],"development":[86,101,160],"lingual":[92],"epithelium:":[93],"Fst(-/-)":[95,181,214],"tongue,":[96,215],"there":[97],"is":[98,128],"both":[99],"ectopic":[100],"progenitors":[105],"accelerated":[107],"cells.":[111,242],"Loss":[112],"Fst":[114],"leads":[115],"to":[116],"elevated":[117],"activity":[118,147],"increased":[120],"expression":[121,149],"Bmp7;":[124],"latter":[126],"effect":[127],"consistent":[129],"with":[130],"BMP7":[131,144,225],"positive":[132],"autoregulation,":[133],"phenomenon":[135],"demonstrate":[137],"directly.":[138],"show":[140,173],"influence":[145],"other":[151],"signaling":[152],"systems":[153],"play":[155,226],"important":[156],"roles":[157],"buds.":[166],"In":[167],"addition,":[168],"using":[169],"computational":[170],"modeling,":[171],"how":[174],"aberrations":[175],"mice":[182],"could":[183],"result":[184],"from":[185],"disruption":[186],"an":[188],"FST-BMP7":[189],"regulatory":[190],"circuit":[191],"normally":[193],"suppresses":[194],"noise":[195],"process":[198],"based":[199],"on":[200],"diffusion-driven":[201],"instability.":[202],"Because":[203],"inactivation":[204],"Bmp7":[206],"rescues":[207],"defects":[211],"observed":[212],"conclude":[217],"interactions":[219],"mesenchyme-derived":[221],"central":[228],"role":[229],"morphogenesis,":[232],"innervation":[233],"maintenance":[235],"stem/progenitor":[241]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}