{"id":"https://openalex.org/W1964651098","doi":"https://doi.org/10.1016/s0024-3205(97)00860-6","title":"Hypothalamic aromatase cytochrome P450 and 5\u03b1-reductase enzyme activities in pregnant and female rats","display_name":"Hypothalamic aromatase cytochrome P450 and 5\u03b1-reductase enzyme activities in pregnant and female rats","publication_year":1997,"publication_date":"1997-10-01","ids":{"openalex":"https://openalex.org/W1964651098","doi":"https://doi.org/10.1016/s0024-3205(97)00860-6","mag":"1964651098","pmid":"https://pubmed.ncbi.nlm.nih.gov/9366509"},"language":"en","primary_location":{"id":"doi:10.1016/s0024-3205(97)00860-6","doi":"https://doi.org/10.1016/s0024-3205(97)00860-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0024-3205(97)00860-6","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058094660","display_name":"David R. Ladle","orcid":"https://orcid.org/0000-0001-8447-899X","observed_orcids":["https://orcid.org/0000-0001-8447-899X"]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David R. Ladle","raw_affiliation_strings":["Department of Zoology-Cellular Biology Division, Brigham Young University, Provo, Utah 84602, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology-Cellular Biology Division, Brigham Young University, Provo, Utah 84602, U.S.A","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083144379","display_name":"Nathan A. Jacobson","orcid":"https://orcid.org/0000-0001-7260-2084","observed_orcids":["https://orcid.org/0000-0001-7260-2084"]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan A. Jacobson","raw_affiliation_strings":["Department of Zoology \u2014 Cellular Biology Division, Brigham Young University Provo, Utah 84602 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology \u2014 Cellular Biology Division, Brigham Young University Provo, Utah 84602 U.S.A","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031905494","display_name":"Edwin D. Lephart","orcid":"https://orcid.org/0000-0003-2027-9187","observed_orcids":["https://orcid.org/0000-0003-2027-9187"]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Edwin D. Lephart","raw_affiliation_strings":["Department of Zoology \u2014 Cellular Biology Division, Brigham Young University Provo, Utah 84602 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology \u2014 Cellular Biology Division, Brigham Young University Provo, Utah 84602 U.S.A","institution_ids":["https://openalex.org/I100005738"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031905494"],"corresponding_institution_ids":["https://openalex.org/I100005738"],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":null,"fwci":0.3753,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.59634015,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"61","issue":"20","first_page":"2017","last_page":"2026"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.6488999724388123,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.6488999724388123,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.25270000100135803,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.06120000034570694,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5alpha-reductase","display_name":"5\u03b1-reductase","score":0.8450000286102295},{"id":"https://openalex.org/keywords/medial-basal-hypothalamus","display_name":"medial basal hypothalamus","score":0.8489999771118164},{"id":"https://openalex.org/keywords/steroid-hormone-metabolism","display_name":"steroid hormone metabolism","score":0.7110000252723694},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.6909999847412109},{"id":"https://openalex.org/keywords/postnatal-development","display_name":"postnatal development","score":0.8999999761581421},{"id":"https://openalex.org/keywords/androgen-metabolism","display_name":"androgen metabolism","score":0.6299999952316284},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.8119999766349792},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.7749999761581421},{"id":"https://openalex.org/keywords/adrenalectomy","display_name":"adrenalectomy","score":0.9879999756813049},{"id":"https://openalex.org/keywords/female-rats","display_name":"female rats","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C2776166826","wikidata":"https://www.wikidata.org/wiki/Q415287","display_name":"Aromatase","level":4,"score":0.9225925803184509},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7736634016036987},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7586616277694702},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.5674015283584595},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.511380136013031},{"id":"https://openalex.org/C2910366748","wikidata":"https://www.wikidata.org/wiki/Q4639645","display_name":"5 Alpha-Reductase Inhibitor","level":5,"score":0.4885779321193695},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4873691201210022},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.47857216000556946},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.4676368236541748},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.4662671685218811},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.45126038789749146},{"id":"https://openalex.org/C2778504769","wikidata":"https://www.wikidata.org/wiki/Q3040305","display_name":"Aromatase inhibitor","level":5,"score":0.4124950170516968},{"id":"https://openalex.org/C2775874879","wikidata":"https://www.wikidata.org/wiki/Q424167","display_name":"Finasteride","level":4,"score":0.37611567974090576},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.36815476417541504},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3305509686470032},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16958844661712646},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13016468286514282},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001141","descriptor_name":"Aromatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011270","descriptor_name":"Pregnancy, Animal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013741","descriptor_name":"3-Oxo-5-alpha-Steroid 4-Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018120","descriptor_name":"Finasteride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058891","descriptor_name":"5-alpha Reductase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0024-3205(97)00860-6","doi":"https://doi.org/10.1016/s0024-3205(97)00860-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0024-3205(97)00860-6","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},{"id":"pmid:9366509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9366509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1513652543","https://openalex.org/W1775749144","https://openalex.org/W1963951882","https://openalex.org/W1963954790","https://openalex.org/W1965064917","https://openalex.org/W1968492978","https://openalex.org/W1972869752","https://openalex.org/W1982249222","https://openalex.org/W1983155075","https://openalex.org/W1987927510","https://openalex.org/W2000992902","https://openalex.org/W2002997625","https://openalex.org/W2007155895","https://openalex.org/W2023417087","https://openalex.org/W2027606344","https://openalex.org/W2028420316","https://openalex.org/W2040979296","https://openalex.org/W2048982634","https://openalex.org/W2050171333","https://openalex.org/W2053381331","https://openalex.org/W2059996754","https://openalex.org/W2070975009","https://openalex.org/W2151426978","https://openalex.org/W2160217393","https://openalex.org/W2409686106"],"related_works":["https://openalex.org/W1985899364","https://openalex.org/W2001043244","https://openalex.org/W2053381331","https://openalex.org/W2337886765","https://openalex.org/W1905341992","https://openalex.org/W1992227820","https://openalex.org/W7095238003","https://openalex.org/W2032924870","https://openalex.org/W1968492978","https://openalex.org/W2070975009"],"abstract_inverted_index":null,"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}