{"id":"https://openalex.org/W1964618776","doi":"https://doi.org/10.1002/jcp.22152","title":"Autocrine fibroblast growth factor 18 mediates dexamethasone\u2010induced osteogenic differentiation of murine mesenchymal stem cells","display_name":"Autocrine fibroblast growth factor 18 mediates dexamethasone\u2010induced osteogenic differentiation of murine mesenchymal stem cells","publication_year":2010,"publication_date":"2010-04-12","ids":{"openalex":"https://openalex.org/W1964618776","doi":"https://doi.org/10.1002/jcp.22152","mag":"1964618776","pmid":"https://pubmed.ncbi.nlm.nih.gov/20432451"},"language":"en","primary_location":{"id":"doi:10.1002/jcp.22152","doi":"https://doi.org/10.1002/jcp.22152","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.22152","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065029732","display_name":"Zahia Hamidouche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210119095","display_name":"H\u00f4pital Lariboisi\u00e8re","ror":"https://ror.org/02mqtne57","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210119095"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Zahia Hamidouche","raw_affiliation_strings":["Inserm U606, Hopital Lariboisiere, Paris, France","U606 (France)","UPD7 - Universit\u00e9 Paris Diderot - Paris 7 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U606, Hopital Lariboisiere, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210119095"]},{"raw_affiliation_string":"U606 (France)","institution_ids":[]},{"raw_affiliation_string":"UPD7 - Universit\u00e9 Paris Diderot - Paris 7 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)","institution_ids":["https://openalex.org/I4387154366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021166422","display_name":"Olivia Fromigu\u00e9","orcid":"https://orcid.org/0000-0002-3050-6155","observed_orcids":["https://orcid.org/0000-0002-3050-6155"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210119095","display_name":"H\u00f4pital Lariboisi\u00e8re","ror":"https://ror.org/02mqtne57","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210119095"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivia Fromigu\u00e9","raw_affiliation_strings":["Inserm U606, Hopital Lariboisiere, Paris, France","University Paris Diderot, France","U606 (France)","UPD7 - Universit\u00e9 Paris Diderot - Paris 7 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U606, Hopital Lariboisiere, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210119095"]},{"raw_affiliation_string":"University Paris Diderot, France","institution_ids":["https://openalex.org/I4387154366"]},{"raw_affiliation_string":"U606 (France)","institution_ids":[]},{"raw_affiliation_string":"UPD7 - Universit\u00e9 Paris Diderot - Paris 7 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)","institution_ids":["https://openalex.org/I4387154366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034541463","display_name":"Ulrike A. Nuber","orcid":"https://orcid.org/0000-0002-7268-4136","observed_orcids":["https://orcid.org/0000-0002-7268-4136"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ulrike Nuber","raw_affiliation_strings":["Lund Strategic Research Center for Stem Cell Biology, Lund University, Lund, Sweden","Skane University Hospital [Lund] (Getingev\u00e4gen 4, 222 41 Lund - Sweden)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lund Strategic Research Center for Stem Cell Biology, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Skane University Hospital [Lund] (Getingev\u00e4gen 4, 222 41 Lund - Sweden)","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032780288","display_name":"Pascal Vaudin","orcid":"https://orcid.org/0000-0003-4875-3434","observed_orcids":["https://orcid.org/0000-0003-4875-3434"]},"institutions":[{"id":"https://openalex.org/I110017253","display_name":"Universit\u00e9 de Tours","ror":"https://ror.org/02wwzvj46","country_code":"FR","type":"education","lineage":["https://openalex.org/I110017253"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210116130","display_name":"Physiologie de la Reproduction et des Comportements","ror":"https://ror.org/02c6p9834","country_code":"FR","type":"facility","lineage":["https://openalex.org/I110017253","https://openalex.org/I1294671590","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210116130","https://openalex.org/I4210123595","https://openalex.org/I4210154307"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pascal Vaudin","raw_affiliation_strings":["Inserm U966, Tours, France","University of Tours, Tours, France","PRC - Physiologie de la reproduction et des comportements [Nouzilly] (Centre de Recherches de Tours 37380 Nouzilly - France)","U966 (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U966, Tours, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"University of Tours, Tours, France","institution_ids":["https://openalex.org/I110017253"]},{"raw_affiliation_string":"PRC - Physiologie de la reproduction et des comportements [Nouzilly] (Centre de Recherches de Tours 37380 Nouzilly - France)","institution_ids":["https://openalex.org/I4210116130"]},{"raw_affiliation_string":"U966 (France)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061639336","display_name":"Jean\u2010Christophe Pag\u00e8s","orcid":"https://orcid.org/0000-0002-6852-5546","observed_orcids":["https://orcid.org/0000-0002-6852-5546"]},"institutions":[{"id":"https://openalex.org/I110017253","display_name":"Universit\u00e9 de Tours","ror":"https://ror.org/02wwzvj46","country_code":"FR","type":"education","lineage":["https://openalex.org/I110017253"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean\u2010Christophe Pages","raw_affiliation_strings":["Inserm U966, Tours, France","University of Tours, Tours, France","U966 (France)","UPD7 - Universit\u00e9 Paris Diderot - Paris 7 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U966, Tours, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"University of Tours, Tours, France","institution_ids":["https://openalex.org/I110017253"]},{"raw_affiliation_string":"U966 (France)","institution_ids":[]},{"raw_affiliation_string":"UPD7 - Universit\u00e9 Paris Diderot - Paris 7 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)","institution_ids":["https://openalex.org/I4387154366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066487421","display_name":"Regina Ebert","orcid":"https://orcid.org/0000-0002-8192-869X","observed_orcids":["https://orcid.org/0000-0002-8192-869X"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Regina Ebert","raw_affiliation_strings":["Orthopedic Center for Musculoskeletal Research, Experimental and Clinical Osteology, University of Wu\u0308rzburg, Germany","JMU - Julius-Maximilians-Universit\u00e4t W\u00fcrzburg =  University of W\u00fcrzburg (Sanderring 2, 97070 W\u00fcrzburg - Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopedic Center for Musculoskeletal Research, Experimental and Clinical Osteology, University of Wu\u0308rzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"JMU - Julius-Maximilians-Universit\u00e4t W\u00fcrzburg =  University of W\u00fcrzburg (Sanderring 2, 97070 W\u00fcrzburg - Germany)","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079690974","display_name":"Franz Josef Jakob","orcid":"https://orcid.org/0000-0001-6560-8437","observed_orcids":["https://orcid.org/0000-0001-6560-8437"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Franz Jakob","raw_affiliation_strings":["Orthopedic Center for Musculoskeletal Research, Experimental and Clinical Osteology, University of Wu\u0308rzburg, Germany","JMU - Julius-Maximilians-Universit\u00e4t W\u00fcrzburg =  University of W\u00fcrzburg (Sanderring 2, 97070 W\u00fcrzburg - Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopedic Center for Musculoskeletal Research, Experimental and Clinical Osteology, University of Wu\u0308rzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"JMU - Julius-Maximilians-Universit\u00e4t W\u00fcrzburg =  University of W\u00fcrzburg (Sanderring 2, 97070 W\u00fcrzburg - Germany)","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060545233","display_name":"Hichem Miraoui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210119095","display_name":"H\u00f4pital Lariboisi\u00e8re","ror":"https://ror.org/02mqtne57","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210119095"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Hichem Miraoui","raw_affiliation_strings":["Inserm U606, Hopital Lariboisiere, Paris, France","University Paris Diderot, France","U606 (France)","UPD7 - Universit\u00e9 Paris Diderot - Paris 7 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U606, Hopital Lariboisiere, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210119095"]},{"raw_affiliation_string":"University Paris Diderot, France","institution_ids":["https://openalex.org/I4387154366"]},{"raw_affiliation_string":"U606 (France)","institution_ids":[]},{"raw_affiliation_string":"UPD7 - Universit\u00e9 Paris Diderot - Paris 7 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)","institution_ids":["https://openalex.org/I4387154366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110304409","display_name":"Pierre J. Marie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210119095","display_name":"H\u00f4pital Lariboisi\u00e8re","ror":"https://ror.org/02mqtne57","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210119095"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Pierre J. Marie","raw_affiliation_strings":["Inserm U606, Hopital Lariboisiere, Paris, France","University Paris Diderot, France","U606 (France)","UPD7 - Universit\u00e9 Paris Diderot - Paris 7 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U606, Hopital Lariboisiere, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210119095"]},{"raw_affiliation_string":"University Paris Diderot, France","institution_ids":["https://openalex.org/I4387154366"]},{"raw_affiliation_string":"U606 (France)","institution_ids":[]},{"raw_affiliation_string":"UPD7 - Universit\u00e9 Paris Diderot - Paris 7 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)","institution_ids":["https://openalex.org/I4387154366"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5110304409"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210119095","https://openalex.org/I4387154366"],"apc_list":{"value":5230,"currency":"USD","value_usd":5230},"apc_paid":null,"fwci":1.0268,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.70301331,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"224","issue":"2","first_page":"509","last_page":"515"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.8804000020027161,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.8804000020027161,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.07660000026226044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgf18","display_name":"FGF18","score":0.9610000252723694},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9129999876022339},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.996999979019165},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9290000200271606},{"id":"https://openalex.org/keywords/autocrine-signaling","display_name":"autocrine signaling","score":0.8669999837875366},{"id":"https://openalex.org/keywords/fgfr1","display_name":"FGFR1","score":0.8460000157356262},{"id":"https://openalex.org/keywords/fgfr2","display_name":"FGFR2","score":1.0},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9259999990463257},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.996999979019165},{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.972000002861023}],"concepts":[{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.7596414089202881},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7492853403091431},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.6841094493865967},{"id":"https://openalex.org/C2776363554","wikidata":"https://www.wikidata.org/wiki/Q14907085","display_name":"RUNX2","level":4,"score":0.6549647450447083},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6297681331634521},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.6038277745246887},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4867708683013916},{"id":"https://openalex.org/C49418065","wikidata":"https://www.wikidata.org/wiki/Q14914258","display_name":"Fibroblast growth factor receptor 1","level":4,"score":0.45544034242630005},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4196779131889343},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33361387252807617},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.14874500036239624},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06294751167297363},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06102907657623291},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05154526233673096},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0510733425617218}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019898","descriptor_name":"Autocrine Communication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051496","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051497","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/jcp.22152","doi":"https://doi.org/10.1002/jcp.22152","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.22152","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmid:20432451","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20432451","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-01129484v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-01129484","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Cellular Physiology, 2010, 224 (2), pp.509-515. ⟨10.1002/jcp.22152⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:lup.lub.lu.se:10758a48-550f-4fc5-b318-7f1762f849f6","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/1629063","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1097-4652","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1935346479","https://openalex.org/W1965574057","https://openalex.org/W1986457784","https://openalex.org/W1990854759","https://openalex.org/W1993271552","https://openalex.org/W1993640536","https://openalex.org/W1993825627","https://openalex.org/W1994117751","https://openalex.org/W1996058081","https://openalex.org/W2000706451","https://openalex.org/W2012549032","https://openalex.org/W2025991178","https://openalex.org/W2026082315","https://openalex.org/W2035087930","https://openalex.org/W2036287488","https://openalex.org/W2038675898","https://openalex.org/W2042545863","https://openalex.org/W2056983875","https://openalex.org/W2062076773","https://openalex.org/W2070345664","https://openalex.org/W2070466054","https://openalex.org/W2072506593","https://openalex.org/W2078716026","https://openalex.org/W2087124418","https://openalex.org/W2101469591","https://openalex.org/W2102894828","https://openalex.org/W2105054202","https://openalex.org/W2107576625","https://openalex.org/W2108281583","https://openalex.org/W2108698814","https://openalex.org/W2127056741","https://openalex.org/W2128406041","https://openalex.org/W2130876797","https://openalex.org/W2144268541","https://openalex.org/W2145470200","https://openalex.org/W2151497881","https://openalex.org/W2151860786","https://openalex.org/W2153720415","https://openalex.org/W2159999899","https://openalex.org/W2161392800","https://openalex.org/W2163780400","https://openalex.org/W2167074133"],"related_works":["https://openalex.org/W2016625153","https://openalex.org/W2389282222","https://openalex.org/W2738791543","https://openalex.org/W2072506593","https://openalex.org/W1977681806","https://openalex.org/W2163780400","https://openalex.org/W1541873345","https://openalex.org/W418275830","https://openalex.org/W2045865822","https://openalex.org/W4220831736"],"abstract_inverted_index":{"The":[0,21],"potential":[1,39],"of":[2,23,26,40,57,76,84,93,119,143,156,166,184],"mesenchymal":[3],"stem":[4],"cells":[5,13],"(MSC)":[6],"to":[7,35],"differentiate":[8],"into":[9],"functional":[10],"bone":[11,19],"forming":[12],"provides":[14],"an":[15,179],"important":[16],"tool":[17],"for":[18],"regeneration.":[20],"identification":[22],"factors":[24],"capable":[25],"promoting":[27],"osteoblast":[28,64,95,102,124,137,158],"differentiation":[29,65,138,187,196],"in":[30,69,108,139,171,189,200],"MSCs":[31,85,140,191,201],"is":[32,61,162,178,202],"therefore":[33],"critical":[34],"enhance":[36],"the":[37,58,91,94,154,185],"osteogenic":[38,186,195],"MSCs.":[41,71,172],"Using":[42],"microarray":[43],"analysis":[44],"combined":[45],"with":[46,86],"biochemical":[47],"and":[48,100,107,149,168,192,207],"molecular":[49],"approach,":[50],"we":[51],"found":[52],"that":[53,74,117,134,153,176,194],"FGF18,":[54],"a":[55],"member":[56],"FGF":[59],"family,":[60],"upregulated":[62],"during":[63],"induced":[66,127,197],"by":[67,78,128,160,164,198,204],"dexamethasone":[68],"murine":[70,190],"We":[72],"showed":[73,152],"overexpression":[75],"FGF18":[77,135,177,199],"lentiviral":[79,114],"(LV)":[80],"infection,":[81],"or":[82,121,131,145],"treatment":[83],"recombinant":[87],"human":[88],"(rh)FGF18":[89],"increased":[90],"expression":[92,106,126],"specific":[96],"transcription":[97],"factor":[98],"Runx2,":[99],"enhanced":[101],"phenotypic":[103,157],"marker":[104],"gene":[105,125],"vitro":[109],"osteogenesis.":[110],"Molecular":[111],"silencing":[112],"using":[113],"shRNA":[115],"demonstrated":[116],"downregulation":[118],"FGFR1":[120,144],"FGFR2":[122,146],"abrogated":[123],"either":[129],"LV-FGF18":[130,161],"rhFGF18,":[132],"indicating":[133],"enhances":[136],"via":[141],"activation":[142,165],"signaling.":[147,209],"Biochemical":[148],"pharmacological":[150],"analyses":[151],"induction":[155],"markers":[159],"mediated":[163],"ERK1/2-MAPKs":[167,206],"PI3K":[169,208],"signaling":[170],"These":[173],"results":[174],"reveal":[175],"essential":[180],"autocrine":[181],"positive":[182],"regulator":[183],"program":[188],"indicate":[193],"triggered":[203],"FGFR1/FGFR2-mediated":[205]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}